舒紅兵:舒紅兵，男，漢族，1967年1月出生，重慶市榮昌縣人，無黨派人士 -百科知識中文網

人物簡介

在蘭州大學生物學系，中國醫學科學院基礎醫學研究所細胞生物學室，美國Emory大學細胞與發育生物學專業分別獲得學士（1987）、碩士（1990）和博士（1995）學位；在美國Tularik公司完成博士後訓練（1995-1997）。曾任美國猶太醫學研究中心及科羅拉多大學醫學院免疫學系助理教授、副教授（1998-2005），北京大學生命科學學院長江學者特聘教授（2000-2004）。2005-2013年任武漢大學生命科學學院院長，2013年9月任武漢大學副校長，2014年起兼任武漢大學醫學研究院院長。

2010年3-5月，在國家教育行政學院第33期中青班學習；2015年3月-2016年1月，在中共中央黨校第15期中青年幹部培訓二班學習。

主要從事免疫相關的細胞信號轉導研究。發現了多個抗病毒天然免疫與炎症反應的關鍵信號和調節蛋白，闡述了這些過程的分子調控機制；發現了新的腫瘤壞死因子家族成員，闡述了其信號轉導的分子事件。這些研究為相關感染與免疫性疾病的防治奠定了重要基礎。

已在國際刊物發表論文140餘篇，被SCI引用10000餘次，其中通訊作者論文單篇最高被引用1000餘次，第一作者論文單篇最高被引用300餘次。

教育經歷

1983-1987 蘭州大學生物學系動物學專業，學士

1987-1990 中國醫學科學院基礎醫學研究所細胞生物學研究室，碩士

1992-1995 美國Emory大學細胞及發育生物學專業，博士

1995-1997 美國Tularik公司David Goeddel實驗室，博士後

工作經歷

1990-1992 美國密西根大學醫學中心，研究助理

1997-1998 美國Magainin製藥公司，資深科學家

1998-2003 美國猶太醫學研究中心及科羅拉多大學健康科學中心免疫學系，助理教授

2003-2005 美國猶太醫學研究中心及科羅拉多大學健康科學中心免疫學系，副教授

2000-2004 北京大學生命科學學院，長江學者計畫特聘教授

2005-2013 武漢大學生命科學學院，教授、院長

2013- 武漢大學教授、副校長

2014-武漢大學醫學研究院，院長

第十二屆全國政協委員，第十三屆全國政協常務委員。

主要貢獻

已在國際刊物發表論文140餘篇，被SCI引用10000餘次，其中通訊作者論文單篇最高被引用1000餘次，第一作者論文單篇最高被引用300餘次。

主持國家科技部973項目、國家自然科學基金重點項目、國家自然科學基金委創新研究群體項目等、國家蛋白質重大科技專項。作為首席科學家承擔了2項973/重大科學計畫項目，是國家自然科學基金委“抗病毒天然免疫”創新研究群體負責人（獲三期延續資助）。

獲獎、榮譽、兼職

中國科學院院士

開發中國家科學院院士

第十二屆全國政協委員

《自然》傑出導師獎

國家自然科學二等獎兩次（第一完成人，2010，2015）

中國細胞生物學學會－CST傑出成就獎（首屆, 2009）

談家禎生命科學創新獎

中國教育部自然科學獎一等獎兩次(第一完成人, 2006, 2014)

國務院學位委員會第七屆學科評議組（生物組）成員

教育部科技委生物與醫學學部委員

教育部高等學校生物技術學科教學指導委員會副主任委員

湖北省知識分子聯誼會常務副會長

湖北省人民政府參事

湖北省人民政府第五屆諮詢委員會委員

萬人計畫科技創新領軍人才入選者

十佳全國優秀科技工作者提名獎

中國學位與研究生教育學會研究生教育成果獎二等獎

教育部長江學者計畫特聘教授

國家傑出青年基金獲得者

新世紀百千萬人才工程國家級人選

武漢大學研究生教育傑出貢獻獎

武漢大學10大“我心目中的好導師”

美國白細胞生物學學會Dolph Adams獎

美國猶太醫學及研究中心首屆“傑出青年教授獎”

美國Harmon基金會Harmon關節炎研究獎

美國Ellison醫學基金會新學者獎

中國細胞生物學學會副理事長

代表性論文

1. Shu HB,Agranoff A, Nabel EG, Leung K, Neish AS, Collins , Nabel GJ* (1993).Differential regulation of VCAM-1 gene expression by specific NF-kB subunits in endothelial and epithelial cells. Mol Cell Biol13:6283-6289.

2. Shu HB,Li Z, Palacios MJ, Li Q, Joshi HC* (1995). A transient association of g-tubulin at the midbody is required for the completion of cytokinesis during the mammalian cell division. J Cell Sci108: 2955-2962.

3. Shu HB, Joshi HC* (1995). g-Tubulin can both neacleate microtubule assembly and self-assemble into tubular structures in mammalian cells. J Cell Biol130:1137-1147.

4. Hsu H, Shu HB,Pan MG, Goeddel DV* (1996). TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor-1 signal transduction pathways. Cell84:299-308.

5. Shu HB,Takeuchi M, Goeddel DV* (1996). The TNF receptor 2 signal transducers TRAF2 and c-IAP1 are components of the TNF receptor 1 signaling complex. P Natl Acad Sci USA93:13973-13978.

6. Shu HB,Halpins DR, Goeddel DV* (1997). Casperis a FADD and Caspase-related Inducer of Apoptosis. Immunity6:751-763.

7. Yeh WC, Pompa JL, McCurrach ME, Shu HB,Elia AJ, Shahinian A, Ng M, Wajegam A, Mithchell K, El-Deiry WS, Lowe SW, Goeddel DV M,ak TW* (1998). FADD: essential for embryonic development and signaling from some, but not all, inducers of apoptosis. Science279:1954-1958.

8. Shu HB*,Hu WH, Johnson H (1999). TALL-1 is a novel member of the TNF family that is downregulated by mitogens. J Leukocyte Biol65:680-683.

9. Hu WH, Johnson H, Shu HB*(1999). TRAIL signal NF-kB and JNK activation and apoptosis through distinct pathways . J Biol Chem274:30603-30610.

10. Hu WH, Johnson H, Shu HB* (2000). Activation of NF-kB by FADD, Casper and Caspase-8. J Biol Chem275:10838-10844.

11. Shu HB*,Johnson H (2000). BCMA is a receptor for the TNF family member TALL-1. P Natl Acad Sci USA97:9156-9161.

12. Chen D, Li X, Zhai Z, Shu HB*(2002).A novel zinc finger protein interacts with RIP and inhibits TNF- and IL-1-induced NF-kB activation. J Biol Chem.277:15985-15991.

13. Liu Y, Xu L, Opalka N, Kappler J, Shu HB,Zhang G* (2002). Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands. Cell108: 383-394.

14. Wu M, Xu L, Li X, Zhai Z , Shu HB* (2002). AMID, an AIF homologous mitochondrion-associated protein, induces caspase-independent apoptosis . J Biol Chem277:25617-25623.

15. Xu L, Shu HB*(2002). TRAF3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kB activation and IL10 production. J Immunol169: 6883-6889.

16. Chen D, Xu LG, Chen L, Li L, Zhai Z, and Shu HB*(2003). NIK is a component of the EGF/Heregulin receptor signaling complex. Oncogene22:4348-4355.

17. Wu M, Xu L, Zhai Z, Shu HB* (2003). SINK: a p65-interacting protein that negatively regulates NF-kB-dependent transcription . J Biol Chem278:27072-27079.

18. Bin L, Xu L, Shu HB*(2003). TIRP: a novel TIR domain-containing adapter protein involved in toll/interleukin-1 receptor signaling . J Biol Chem27:24526-24532.

19. Bin L, Nielson LD, Liu X, Mason RJ, Shu HB*(2003). Identification of UGRP1 and MARCO as a lung-specific ligand-receptor pair. J Immunol171:924-930.

20. Zhang J, Xu LG, Han KJ, Shu HB*(2004). Identification of a ZU5 and death domain containing inhibitor of NF-kB. J Biol Chem279:17819-17825.

21. Han KJ, Su X, Xu LG, Bin LH, Zhang J, Shu HB*(2004). Mechanisms of TRIF-induced ISRE and NF-kappa B activation and apoptosis pathways. J Biol Chem279:15652-15661.

22. Huang J, Teng L, Li L, Liu T, Li L, Chen D, Xu LG, Zhai Z, Shu HB*(2004).ZNF216 is an A20-like and IKKgamma -interacting inhibitor of NF-kappa B activation. J Biol Chem279:16847-16853.

23. Xu LG, Li LY, Shu HB* (2004). TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. J Biol Chem279:17278-17282.

24. Wu M, Xu LG, Su T, Huang J, Zhai Z, Shu HB*(2004).AMID is a p53-inducible gene down-regulated in tumors. Oncogene23:6815-6819.

25. Li L, Bin LH, Li F, Liu Y, Chen D, Zhai Z, Shu HB*(2005). TRIP6 is a RIP2-associated common signaling component of multiple NF-kB activation pathways. J Cell Sci118:555-563.

26. Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB*(2005). VISA is an adapter protein required for virus-triggered signaling. Mol Cell19:727-740 .

27. Huang J, Liu T, Chen D, Zhai Z, Shu HB*(2005).SIKE is an IKK-relative kinases-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways. EMBO J24:4018-4028.

28. Zha J, Han K, Xu LG, Zhou Q, Chen D, Zhai Z, Shu HB*(2006). The Ret finger protein inhibits signaling mediated by the noncanonical and canonical IKK family members. J Immunol176:1072-1080.

29. Tian Y, Zhang Y, Zhong B, Wang YY, Diao FC, Wang RP, Zhang M, Chen DY, Zhai ZH, Shu HB*(2007). RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. J Biol Chem282:16776-16782.

30. Diao F, Li S, Tian Y, Zhang M, Xu LG, Zhang Y, Wang RP, Chen D, Zhai Z, Zhong B, Tien P, Shu HB*(2007). Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase. P Natl Acad Sci USA104:11706-11711.

31. Zhang M, Tian Y, Wang RP, Gao D, Zhang Y, Diao FC, Chen DY, Zhai ZH, Shu HB*(2008). Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3. Cell Res18:1096-1014.

32. Zhang B, Huang J, Li HL, Liu T, Wang YY, Waterman P, Mao AP, Xu LG, Zhai Z, Liu D, Marrack P, Shu HB*(2008). GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth. Cell Res18:900-910.

33. Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao F, Lei C, He X, Zhang L, Tien P, Shu HB*(2008). The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation. Immunity29:538-550.

34. Zhong B, Zhang L, Lei Z, Li Y, Mao AP, Yang Y, Wang YY, Zhang XL, Shu HB*(2009). RNF5 negatively regulates virus-induced IRF3 activation via ubiquitination and degradation of MITA. Immunity30:397-407.

35. Li Y, Li C, Xue P, Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang F, Shu HB*(2009). ISG56 is a negative feedback regulator of virus-triggered signaling and cellular antiviral response. P Natl Acad Sci USA106:7945-7950.

36. Wang YY, Liu LJ, Zhong B, Liu TT, Li Y, Yang Y, Ran Yong, Li S, Tien P, Shu HB*(2010). WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kB activation. P Natl Acad Sci USA107:815-820.

37. Li S, Zheng H, Mao AP, Zhong B, Li Y, Liu Y, Gao Y, Ran Y, Tien P, Shu, HB*(2010).Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6. J Biol Chem285:4291-4297.

38. Mao AP, Li S, Zhong B, Li Y, Yan J, Li Q, Teng C, Shu HB*(2010). Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response. J Biol Chem285:9470-9476.

39. Han KJ, Yang Y, Xu LG, Shu HB*(2010).Analysis of a TIR-less splice variant of TRIF reveals an unexpected mechanism of TLR3-mediated signaling. J Biol Chem285:12543-12550.

40. Chen R, Zhang L, Zhong B, Tan B, Liu Y, Shu HB*(2010).The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling. Cell Res20:802-811.

41. Zhong B, Zhang Y, Tan B, Liu TT, Wang YY, Shu HB* (2010).The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation. J Immunol184:6249-6255.

42. Lei CQ, Zhong B, Zhang Y, Zhang J, Shu HB*(2010). GSK3bregulates virus-triggered IRF3 activation and cellular antiviral response by promoting TBK1 activation. Immunity33:878-889.

43.Li Q, Yan J, Mao AP, Li C, Ran Y, Shu HB*, Wang YY *(2011). Tripartite motif 8 (TRIM8) modulates TNFa- and IL-1b-triggered NF-kB activation by targeting TAK1 for K63-linked polyubiquitination. P Natl Acad Sci USA108:19341-19346.

44. Ran Y, Liu TT, Zhou Q, Li S, Mao AP, Li Y, Liu LJ, Cheng JK, Shu HB*(2011).SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation. J Mol Cell Biol2:283-292.

45. Liu Y, Song R, Gao Y, Li Y, Wang S, Liu HY, Wang Y, Hu YH, Shu HB*(2012).Protein kinase C-δ negatively regulates T cell receptor-induced NF-kB activation by inhibiting the assembly of CARMA1 signalosome. J Biol Chem287:20081-20087.

46. He X, Li Y, Li C, Liu LJ, Zhang XD, Liu Y, Shu HB*(2012).USP2a negatively regulates IL-1β- and virus-induced NF-κB activation by deubiquitinating TRAF6. J Mol Cell Biol5:39-47.

47. Zhang J, Hu MM, Wang YY, Shu HB*(2012).TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination. J Biol Chem287:28646-28655.

48. Li Y, Chen R, Zhou Q, Xu Z, Li C, Wang S, Mao A, Zhang X, He W, Shu HB*(2012).LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. P Natl Acad Sci USA109:11770-11775.

49. Wang YY *, Ran Y, Shu HB*(2012).Linear ubiquitination of NEMO brakes the antiviral response. Cell Host Microbe12:129-131.

50. Chen R, Li M, Zhang Y, Zhou Q, Shu HB*(2012).The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation. P Natl Acad Sci USA109:14128-14133.

51. Zheng H, Li Q, Chen R, Zhang J, Ran Y, He X, Li S, Shu HB*(2012).Dual-specificity phosphatase 14 (DUSP14) negatively regulates TNF-aand IL-1-induced NF-κB activation by dephosphorylating the protein kinase TAK1. J Biol Chem288:819-825.

52. Yang Y, Liao B, Wang S, Jin Y, Shu HB*, Wang YY*(2013). The E3 ubiquitin ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation. PNAS110(13):5115-20.

53. Li C, Wei J, Li Y, He X, Zhou Q, Yan J, Zhang J, Liu Y, Liu Y, Shu HB*(2013).Transmembrane protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase-4 activation and apoptosis. J Biol Chem288

54. Lei CQ, Zhang Y, Xia T, Jiang LQ, Zhong B, Shu HB*(2013).FoxO1 Negatively Regulates Cellular Antiviral Response by Promoting Degradation of IRF3. J Biol Chem288:12596-12604.

55. Chen H, Li Y, Zhang J, Ran Y, Wei J, Yang Y, Shu HB*(2013).RAVER1 is a coactivator of MDA5-mediated cellular antiviral response. J Mol Cell Biol5:111-119.

56. Hu MM, Yang Q, Zhang J, Liu SM, Zhang Y, Lin H, Huang ZF, Wang YY, Zhang XD, Zhong B, Shu HB*(2013). TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3. Proc. Natl. Acad. Sci. USA.111:1509-1514.

57.Yan J, Li Q, Mao AP, Hu MM, Shu HB*(2013). TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination. J. Mol. Cell Biol.6:154-163.

58. Zhang Y, Lei CQ, Hu YH, Xia T, Li M, Zhong B, Shu HB*(2013).Kruppel-like Factor 6 Is a Co-activator of NF-κB That Mediates p65-dependent Transcription of Selected Downstream Genes. J. Biol. Chem289:12876-12885.

59. Qin Y, Zhou MT, Hu MM ,Hu YH, Zhang J, Guo L, Zhong B, Shu HB*(2014). RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms. Plos Pathog10:e1004358.

60. Zhou Q, Lin H, Wang SY, Wang S, Ran Y, Liu Y, Ye W, Xiong XZ, Zhong B, Shu HB*,Wang YY*(2014). The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling. Cell Host Microbe16:450-61.

61. Ran Y, Shu HB, Wang YY*(2014). MITA/STING: A central and multifaceted mediator in innate immune response. Cytokine & Growth F R25: 631-639.

62. Shu HB*, Wang YY*(2014). Adding to the STING. Immunity41:871-3.

63. Hu YH, Zhang Y, Jiang LQ, Wang S, Lei CQ, Sun MS, Shu HB, Liu Y*(2015).WDFY1 mediates TLR3/4 signaling by recruiting TRIF. EMBO REP16: 447-455

64. Wei J, Lian H, Zhong B, Shu HB*(2015). Parafibromin Is a Component of IFN-γ-Triggered Signaling Pathways That Facilitates JAK1/2-Mediated Tyrosine Phosphorylation of STAT1. J Immunol195 : 2870-2878.

65. Hu MM, Xie XQ, Yang Q, Liao CY, Ye W, Lin H, Shu HB*(2015).TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms. J Immunol195: 4415-4425.

66. Luo WW, Li S, Li C , Lian H, Yang Q, Zhong, B, Shu, HB*.iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING. Nat. Immunol.17: 1057-1066.

67. Hu MM, Yang Q, Xie XQ, Liao CY, Lin H, Liu TT, Yin L, Shu HB*. Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus. Immunity.45: 555-569.

68. Fu YZ, Su S, Gao YQ, Wang PP, Huang ZF, Hu MM, Luo WW, Li S, Luo MH, Wang YY, Shu HB*(2017).Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity. Cell Host Microbe. 21(2):231-243.

69.Hu MM, Liao CY, Yang Q, Xie XQ, Shu HB*(2017).Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5. J Exp Med. 214(4):973-989.

70. Yang Q, Liu TT, Lin H, Zhang M, Wei J, Luo WW, Hu YH, Zhong B, Hu MM, Shu HB*(2017).TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses. PLoS Pathog. 13(9):e1006600.

71. Yan BR, Zhou L, Hu MM, Li M, Lin H, Yang Y, Wang YY, Shu HB*(2017).PKACs attenuate innate antiviral response by phosphorylating VISA and priming it for MARCH5-mediated degradation. PLoS Pathog.13(9):e1006648.