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雖然催化劑的中心金屬的研究範圍很廣,但是總的來講,過渡金屬所體現的催化性能要比其他主族金屬要好一些。稀土金屬催化劑的研究覆蓋了早期氫胺化反應的研究。目前來看,稀土配合物不對稱催化分子內烯烴氫胺化反應已經取得一些的突破,Marks小組對於這方面反應作了不少系統的工作,研究範圍涵蓋了從機理到套用。
相比前過渡金屬,後過渡金屬通常具備更加優越的官能團容忍性,但是它們往往需要酸性條件和氮保護的
胺,更為不利的一點是他們比較低的催化效率和催化劑壽命。Widenhoefer小組成功實現了胺基活化的胺分子內對烯烴及聯烯的氫胺化反應。儘管最近Hartwig小組也取得了重要突破,對部分非活化分子內烯胺實現了有效的催化反應,但是底物限制還是非常大,對於非活化烯胺底物也尚未有不對稱催化的報導。
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