人物經歷
1962年6月,謝曉亮出生於北京,父親謝有暢與母親楊駿英皆為北京大學化學系的教授,因此他在北京大學附屬國小和北京大學附屬中學度過國小與中學階段 。
1980年,考入北京大學化學系,業餘時間還旁聽了物理系和數學系的課程,還利用暑假到實驗室做實驗,學有機合成,又寫電腦程式做化學計算。
1985年夏,赴加州大學聖地亞哥分校攻讀博士,師從研究超快雷射研究化學動力學的約翰·西蒙(John Simon)。
1989年,博士畢業後去芝加哥大學物理化學教授格雷厄姆·弗萊明(Graham Fleming)的實驗室做博士後。
1992年,進入美國太平洋西北國家實驗室(PNNL)工作,從事單個分子光譜和動力學、超高分辨光學成像研究,是PNNL自1965年成立以來第一位來自中國大陸的科學家。
1999年,被聘為哈佛大學化學與化學生物系終身教授,是改革開放以後哈佛大學聘任的第一位來自中國大陸的終身教授。2000年,在哈佛大學的第一年,謝曉亮寫了6個申請書,全部獲得資助。
2001年9月7日,受聘北京大學化學學院客座教授,同一天,受聘為分子動態與穩態結構國家重點實驗室學術委員會委員。
2004年,獲得了美國國立衛生研究院(NIH)的先鋒獎,在之後五年中每年獲得50萬美元的自由支配經費 。
2008年,被北京大學生命科學學院聘為長江學者獎勵計畫講座教授 。
2009年,謝曉亮擔任哈佛大學Mallinckrodt講席教授,是改革開放後大陸學者獲得哈佛大學冠名講席教授的第一人。
2010年12月,在北京大學主持創辦了北京大學生物動態光學成像中心(BIOPIC),擔任主任。2013年,第二次獲得NIH先鋒獎 。
2015年,謝曉亮與史丹福大學教授Karl Deisseroth共同獲得阿爾伯尼生物醫學獎,成為該獎項的首位華人獲得者;同年獲得美國化學會德拜獎 。
2016年,組建了北京未來基因診斷高精尖創新中心(ICG),擔任主任。10月17日,當選為美國國家醫學院院士 。
2017年9月16日,獲得求是傑出科學家獎 。11月,當選中國科學院外籍院士 。
主要成就
科研成就
•研究領域
謝曉亮課題組的研究方向包含基礎科學研究領域、技術研究領域和醫學研究領域三個領域。
基礎研究:單分子酶學、單分子生物物理化學、基因表達和調控、表觀遺傳學、細胞分化和重編程機理、基因組不穩定性。
技術發展:單分子成像、單細胞基因組學、相干拉曼散射顯微成像、DNA 測序。
醫學研究:體外受精胚胎植入前遺傳學篩查與診斷、早期癌症診斷 。
•學術貢獻
謝曉亮是單分子酶學的創始人、單分子生物物理化學的奠基人之一、相干拉曼散射顯微成像技術和單細胞基因組學的開拓者。謝曉亮教授作為單分子生物物理化學家,他勇於突破學科界限,從物理化學、生物物理到生物化學,再到分子生物學、基因組學及臨床醫學,無畏探索,不斷創新,在相關新興交叉學科做出了創造性貢獻 。
謝曉亮不僅是生物物理化學基礎科學研究的國際領軍人物,近年來大力推動了無標記光學成像技術和新型單細胞基因組測序技術在醫學中的套用。2012年謝曉亮在單細胞全基因組學研究有了突破性進展,開發了單細胞全基因組均勻擴增的新方法—多重退火循環擴增法(MALBAC)。2014年9月19日,世界上第一例“MALBAC嬰兒”在北醫三院誕生,標誌著中國胚胎植入前遺傳診斷技術處於世界領先水平。迄今為止,謝曉亮團隊利用MALBAC技術為中國三百多個患有單基因遺傳病的家庭成功避免了疾病的子代傳遞,為數千位孕婦避免了染色體異常胚胎的移植,減少了流產和唐氏綜合徵等染色體異常疾病的發生 。
謝曉亮曾獲得美國物理化學領域最高的獎項“Peter Debye”獎、美國生物物理學會的最高得獎項“Founders”獎和美國醫學領域最高的獎項之一Albany醫學獎;2017年9月,謝曉亮教授獲得“求是傑出科學家獎”,以表彰他在國內單分子生物學和精準醫療領域的卓越成就。2017年11月,謝曉亮教授當選為中國科學院外籍院士,這是繼當選美國國家科學院院士、美國國家醫學院院士和美國藝術與科學學院院士後,斬獲的第四頂院士桂冠。
•代表論文
截至2017年4月,謝曉亮教授共發表SCI收錄科學論文210餘篇。
Single Molecule Spectroscopy and Imaging
Xie, X. Sunney; Dunn, Robert C. "Probing Single Molecule Dynamics" Science 265: 361-364 (1994).
Sánchez, Erik J; Novotny, Lukas; Xie, X. Sunney. "Near-field Fluorescence Microscopy Based on Two-photon Excitation with Metal Tips" Phys Rev Lett 82: 4014-4017 (1999).
Min, Wei; Lu, Sijia; Chong, Shasha; Roy, Rahul; Holtom, Gary R.; Xie, X. Sunney. "Imaging Chromophores with Undetectable Fluorescence by Stimulated Emission Microscopy" Nature 461: 1105-1109 (2009).
Chong, Shasha; Min, Wei; Xie, X. Sunney. "Ground-State Depletion Microscopy: Detection Sensitivity of Single-Molecule Optical Absorption at Room Temperature" J Phys Chem Lett 1:3316-3322 (2010).
Zhou, Yuexin; Wang, Ping; Tang, Feng; Gao, Ge; Huang, Lei; Wei, Wensheng; Xie, X. Sunney “Painting a specific chromosome with CRISPR/Cas9 for live-cell imaging”, Cell Research, doi:10.1038/cr.2017.9 (2017).
Single Molecule Enzymology
Lu, H. Peter; Xun, Luying; Xie, X. Sunney. "Single-Molecule Enzymatic Dynamics" Science 282: 1877-1882 (1998).
Yang, Haw; Luo, Guobin; Karnchanaphanurach, Pallop; Louie, Tai-Man; Rech, Ivan; Cova, Sergio; Xun, Luying; Xie, X. Sunney. "Protein Conformational Dynamics Probed by Single-Molecule Electron Transfer" Science 302: 262-266 (2003).
Min, Wei; Luo, Guobin; Cherayil, Binny J.; Kou, S. C.; Xie, X. Sunney. "Observation of a Power-Law Memory Kernel for Fluctuations within a Single Protein Molecule" Phys Rev Lett 94: 198302(1-4) (2005).
English, Brian P.; Min, Wei; van Oijen, Antoine M.; Lee, Kang Taek; Luo, Guobin; Sun, Hongye; Cherayil, Binny J.; Kou, S.C.; Xie, X. Sunney. "Ever-Fluctuating Single Enzyme Molecules: Michaelis-Menten Equation Revisited" Nat Chem Bio 2: 87-94 (2006).
Blainey, Paul C.; Luo, Guobin; Ko9u, S.C.; Mangel, Walter F.; Verdine, Gregory L.; Bagchi, Biman; Xie, X. Sunney. "Nonspecifically Bound Proteins Spin While Diffusing Along DNA" Nat Struct Mol Biol 16: 1224-1229 (2009).
Kim, Sangjin; Brostr?mer, Erik, Xing, Dong; Jin, Jianshi; Chong, Shasha; Ge, Hao, Wang, Siyuan; Gu, Chan; Yang, Lijiang; Gao, Yiqin; Su, Xiao-dong; Sun, Yujie; Xie, X. Sunney. “Probing Allostery Through DNA” Science 339: 816-819 (2013).
Chong, Shasha; Chen, Chongyi; Ge, Hao; Xie, X. Sunney. "Mechanism of Transcriptional Bursting in Bacteria" Cell 158: 314-326 (2014).
Gene Expression and Regulation
Yu, Ji; Xiao, Jie; Ren, Xiaojia; Lao, Kaiqin; Xie, X. Sunney. "Probing Gene Expression in Live Cells, One Protein Molecule at a Time" Science 311: 1600-1603 (2006).
Cai, Long; Friedman, Nir; Xie, X. Sunney. "Stochastic Protein Expression in Individual Cells at the Single Molecule Level" Nature 440: 358-362 (2006).
Elf, Johan; Li, Gene-Wei; Xie, X. Sunney. "Probing Transcription Factor Dynamics at the Single-Molecule Level in a Living Cell" Science 316: 1191-1194 (2007).
Choi, Paul J.; Cai, Long; Frieda, Kirsten; Xie, X. Sunney. "A Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell" Science 322: 442-446 (2008).
Taniguchi, Yuichi; Choi, Paul J.; Li, Gene-Wei; Chen, Huiyi; Babu, Mohan; Hearn, Jeremy; Emili, Andrew; Xie, X. Sunney. "Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells" Science 329: 533-538 (2010).
Chong, Shasha; Chen, Chongyi; Ge, Hao; Xie, X. Sunney. "Mechanism of Transcriptional Bursting in Bacteria" Cell 158: 314-326 (2014).
Ge, Hao; Qian, Hong; and Xie, X. Sunney. "Stochastic Phenotype Transition of a Single Cell in an Intermediate Region of Gene State Switching" Phys Rev Lett 114(7) (2015).
Coherent Raman Microscopy
Zumbusch, Andreas; Holtom, Gary R.; Xie, X. Sunney. “Vibrational Microscopy Using Coherent Anti-Stokes Raman Scattering" Phys Rev Lett 82: 4142-4145 (1999).
Evans, Conor L.; Potma, Eric O.; Puoris'haag, Mehron; C?té, Daniel; Lin, Charles P.; Xie, X. Sunney. "Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy" Proc Nat. Aca Sci 102: 16807-16812 (2005).
Freudiger, Christian W.; Min, Wei; Saar, Brian G.; Lu, Sijia; Holtom, Gary R.; He, Chengwei; Tsai, Jason C.; Kang, Jing X.; Xie, X. Sunney. "Label-Free Biomedical Imaging with High sensitivity by Stimulated Raman Scattering Microscopy" Science 322:1857-1860 (2008).
Saar, Brian G.; Freudiger, Christian W.; Reichman, Jay; Stanley, C. Michael; Holtom, Gary R.; Xie, X. Sunney. "Video-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering" Science 330: 1368-1370 (2010).
Wang, Meng C.; Min, Wei; Freudiger, Christian W.; Ruvkun, Gary; Xie, X. Sunney. "RNAi Screening for Fat Regulatory Genes with SRS Microscopy" Nat Methods 8: 135-138 (2011).
Fu, Dan; Zhou, Jing; Zhu, Wenjing Suzanne; Manley, Paul W.; Wang, Y. Karen; Hood, Tami; Wylie, Andrew; Xie, X. Sunney. "Imaging the Intracellular Distribution of Tyrosine Kinase Inhibitors in Living Cells with Quantitative Hyperspectral Stimulated Raman Scattering" Nat Chem 6: 614-622 (2014).
Single Cell Genomics
Zong, Chenghang; Lu, Sijia; Chapman, Alec R.; Xie, X. Sunney. "Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell" Science 338: 1622-1626 (2012).
Lu, Sijia; Zong, Chenghang; Fan, Wei; Yang, Mingyu; Li, Jinsen; Chapman, Alec R.; Zhu, Ping; Hu, Xuesong; Xu, Liya; Bai, Fan; Qiao, Jie; Tang, Fuchou; Li, Ruiqiang; Xie, X. Sunney. "Probing Meiotic Recombination and Aneuploidy of Single Sperm Cells by Whole-Genome Sequencing" Science 338: 1627-1630 (2012).
Hou, Yu; Fan, Wei; Yan, Liying; Li, Rong; Lian, Ying; Huang, Jin; Li, Jinsen; Xu, Liya; Tang, Fuchou; Xie, X. Sunney; Qiao, Jie. "Genome Analyses of Single Human Oocytes" Cell 155: 1492-1506 (2013).
Yan, Liying; Huang, Lei; Xu, Liya; Huang, Jin; Ma, Fei; Zhu, Xiaohui; Tang, Yaqiong; Liu, Mingshan; Lian, Ying; Liu, Ping; Li, Rong; Lu, Sijia; Tang, Fuchou; Qiao, Jie; Xie, X Sunney "Live Births after Simultaneous Avoidance of Monogenic Diseases and Chromosome Abnormality by Next-generation Sequencing with Linkage Analyses," Proc Natl Acad Sci USA, 112(52), 15964-15969, (2015).
Chen, Chongyi; Xing, Dong; Tan, Longzhi; Li, Heng; Zhou, Guangyu; Huang, Lei; Xie, X. Sunney "Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI)," Science 356, 189-194 (2017).
Key Review Articles
Min, Wei; Freudiger, Christian W.; Lu, Sijia; Xie, X. Sunney. "Coherent Nonlinear Optical Imaging: beyond Fluorescence Microscopy" Annu. Rev. Phys. Chem. 62: 507-530 (2011).
Li, Gene-Wei; Xie, X. Sunney. "Central Dogma at the Single-Molecule Level in Living Cells" Nature 475: 308-315 (2011).
Xie, X. Sunney. "Enzyme Kinetics, Past and Present" Science 342: 1457-1459 (2013).
Xie, X. Sunney. "Single Molecules Meet Genomics: Pinpointing Precision Medicine" JAMA 20: 2021-2 (2015).
Huang Lei; Ma Fei; Chapman Alec; Lu Sijia; Xie X. Sunney. “Single-Cell Whole-Genome Amplification and Sequencing” Annu. Rev. Genomics Hum. Genet. 16: 79-102 (2015).
Cheng, Ji-xin; Xie, X. Sunney. “Vibrational Spectroscopic Imaging of Living Systems: An Emerging Platform for Biology and Medicine” Science 350, aaa8870 (2015).
人才培養
1999年謝曉亮進入哈佛大學任教來,培養了多名博士和博士後,截止到2017年,他所培養的學生在世界四十多所大學任教,其中一些學生的具體信息如下 :
Graduate Students | ||
Srinjan Basu | 2006-2012 | Cambridge University |
Paul Blainey | 2001-2007 | Assistant Professor, Department of Biological Engineering, MIT, Broad Institute |
Long Cai | 2001-2006 | Assistant Professor of Chemistry, CalTech |
Chongyi Chen | 2009-2014 | Harvard Univerisity, Cambridge, Massachusetts |
Huiyi Chen | 2006-2011 | Nanyang Technological Univerisity, Lee Kong Chian School of Medicine, Singapore |
Paul J. Choi | 2005-2009 | Senior Research Scientist , Genome Institute of Singapore |
Shasha Chong | 2009-2014 | Department of Molecular & Cell Biology, University of California, Berkeley, California |
Brian English | 2001-2007 | Albert Einstein College of Medicine |
Conor Evans | 2002-2007 | Assistant Professor, Harvard Medical School |
Christian Freudiger | 2007-2011 | CTO and Cofounder, Invenio Imaging |
Sangjin Kim | 2004-2010 | Department of Molecular, Cellular & Developmental Biology, Yale University |
John Krug | 1998-2004 | Roche |
Gene-Wei Li | 2005-2010 | University of California, San Francisco |
Sijia Lu | 2008-2012 | CTO and Cofounder, Yikon Genomics, Taizhou, China |
Guobin Luo | 2000-2006 | Life Technologies |
Wei Min | 2001-2007 | Assistant Professor, Columbia University |
Xiaolin Nan | 2001-2007 | Assistant Professor, Oregon Health Science University |
Brian Saar | 2005-2010 | Lincoln Laboratory, Massachusetts Institute of Technology |
ErikSánchez | 1995-1999 | Assistant Professor, Portland State University |
Peter Sims | 2005-2009 | Assistant Professor of Systems Biology, Department of Biochemistry & Molecular Physics, Columbia University Medical Center |
Zi Hertz He | 2011-2014 | Bloomberg L.P., London |
Ziqing Winston Zhao | 2009-2015 | Postdoc, Institute for Molecular and Cell Biology (IMCB), Singapore |
Xu Zhang | 2010-2015 | Postdoctoral Fellow, Harvard University |
Wenlong Yang | 2011-2017 | Postdoctoral Fellow, Harvard University |
Postdoctoral Fellows | ||
Dr. David Arnett | 1998-1999 | Associate Professor, Northwestern College, Iowa |
Dr. Lewis Book | 2000-2001 | Northrop Grumman Space Technology, California |
Dr. Erik Brostromer | 2010-2011 | |
Dr. Silvia Carrasco | 2005-2006 | Knowledge and Technology Transfer (KTT) director, ICFO |
Dr. Huiyi Chen | 2011-2012 | Nanyang Technological Univerisity, Lee Kong Chian School of Medicine, Singapore |
Dr. Peng Chen | 2004-2005 | Peter Debye Professor of Chemistry, Cornell University, Deptartment of Chemistry and Chemical Biology |
Dr. Ji-Xin Cheng | 2000-2003 | Professor, Purdue University, Weldon School of Biomedical Engineering |
Dr. James Chesko | 1997 | Novartis Vaccines and Diagnostics, Emeryville, California |
Dr. Jonathan Choi | 1999-2000 | |
Dr. Paul J. Choi | 2009-2010 | Senior Research Scientist , Genome Institute of Singapore |
Dr. Robert A. Crowell | 1994-1995 | Brookhaven National Laboratory |
Dr. Haifeng Duan | 2009-2011 | Biodynamic Optical Imaging Center (BIOPIC), Peking University, China |
Dr. Xiaojie Duan | 2007-2008 | Assistant Professor, Peking University |
Dr. Robert C. Dunn | 1992-1995 | Professor of Chemistry, University of Kansas |
Dr. Johan Elf | 2005-2007 | Associate Professor in Molecular Biotechnology, University of Uppsala, Sweden |
Dr. Wagner Faustino | 2008-2010 | Adjunct Professor, Federal University of Paraiba, Brazil |
Dr. Kevin Fiala | 2007-2009 | MIT, Office of Technology Development |
Dr. Christian Freudiger | 2011-2013 | CTO and Cofounder, Invenio Imaging |
Dr. Nir Friedman | 2003-2007 | Weizmann Institute, Israel |
Dr. Marcel Friedrich | 2007-2008 | Siemens Management Consulting, Munich, Germany |
Dr. Feruz Ganikhanov | 2004-2006 | Assistant Professor, West Virginia University |
Dr. Christof Gebhardt | 2010-2013 | Deputy Head, Institute of Biophysics, Ulm University, Germany |
Dr. William Greenleaf | 2008-2011 | Assistant Professor, Genetics Dept., Stanford University School of Medicine |
Dr. Terumasa Ito | 2011-2012 | Sony Coporation Research & Development |
Dr. Minbiao Ji | 2011-2014 | Professor, Department of Physics, Fudan University, Shanghai, China |
Dr. Lingjie Kong | 2012-2013 | Janelia Farm Research Campus, Virginia |
Dr. Kang Taek Lee | 2003-2004 | Assistant Professor, Department of Chemistry, Gwangju Institute of Science and Technology (GIST), Korea |
Dr. Nam Ki Lee | 2006-2009 | Assistant Professor, Pohang University of Science and Technology, S. Korea |
Dr. Gene-Wei Li | 2010 | UCSF |
Dr. Jeff Li | 2002-2008 | Massachusetts Institute of Technology |
Dr. Giuseppe Lia | 2006-2009 | CNRS, Centre de Genetique Moleculaire, Paris |
Dr. Hong Peter Lu | 1995-1999 | Professor, Ohio Eminent Scholar, Bowling Green State University |
Dr. Guobin Luo | 2006-2008 | Life Technologies |
Dr. Yuntao Steve Mao | 2011-2012 | Scientific Editor, Cell, Cell Press, Cambridge |
Dr. Wei Min | 2008-2010 | Assistant Professor, Columbia University, Department of Chemistry |
Dr. Lukas Novotny | 1996-1999 | Professor, ETH Zürich |
Dr. Antoine van Oijen | 2001-2004 | Professor, University of Wollongong, Australia |
Dr. Pavel Pospisil | 2001-2002 | Palacky University, Czech Republic, Department of Experimental Physics |
Dr. Eric Potma | 2001-2005 | Associate Professor, University of California at Irvine, Department of Chemistry |
Dr. Maarten Roeffaers | 2009-2010 | Assistant Professor, Katholieke Universiteit Leuven |
Dr. Rahul Roy | 2007-2012 | Assistant Professor, Indian Institute of Science, Department of Chemical Engineering, Bangalore, India |
Dr. Markus Rueckel | 2007-2008 | BASF, Germany |
Dr. Erik Sánchez | 1999-2002 | Assistant Professor of Physics, Portland State University |
Dr. Ahbijit Sarkar | 2002-2003 | Assistant Professor, Dept. of Chemistry & Physics, Virginia State University |
Dr. Charles Schroeder | 2004-2007 | Assistant Professor, University of Illinois, Urbana-Champaign, Department of Biomolecular Engineering |
Dr. Katsuyuki Shiroguchi | 2009-2012 | Laboratory Leader, RIKEN Research Center for Allergy & Immunology, Laboratory for Integrative Genomics |
Dr. Peter Sims | 2009-2011 | Assistant Professor of Systems Biology, Department of Biochemistry & Molecular Physics, Columbia University Medical Center |
Dr. Hongye Sun | 2000-2002 | Vice President of Operation and Technology Platform, Chief Operating Officer, WuXi Genomic Center, WuXi AppTec, Shanghai |
Dr. David Suter | 2011-2013 | Assistant Professor, School of Life Sciences, EPFL, Switzerland |
Dr. Yuichi Taniguchi | 2006-2011 | Unit Leader, Quantitative Biology Center, RIKEN, Japan |
Dr. Andreas Volkmer | 1999-2001 | University of Stuttgart, Germany, Institute of Physics |
Dr. David Ward | 2005-2007 | President and Chairman, Piffany, Inc. |
Dr. Jie Xiao | 2002-2006 | Assistant Professor, Johns Hopkins University School of Medicine, Department of Biophysics and Biophysical Chemistry |
Dr. Haw Yang | 2000-2002 | Associate Professor of Chemistry, Princeton University |
Dr. Wei Yuan Yang | 2005-2007 | Researcher, Academia Sinica, Taiwan, Institute of Biological Chemistry |
Dr. Jun Yong | 2011-2013 | Biodynamic Optical Imaging Center (BIOPIC), Peking University, China |
Dr. Ji Yu | 2002-2006 | Assistant Professor of Genetics and Developmental Biology, University of Connecticut Health Center |
Dr. Guoqing Zhang | 2010-2011 | Assistant Professor, University of Science and Technology of China, School of Chemistry and Materials Science |
Dr. Chenghang Zong | 2009-2013 | Assistant Professor, Department of Molecular and Human Genetics. Baylor College of Medicine |
Dr. Andreas Zumbusch | 1997-1999 | Professor of Physical Chemistry, Universität Konstanz, Germany |
Dr. Yan Gu | 2013-2014 | Scientist at Bristol-Myers Squibb |
Dr. Dan Fu | 2010-2015 | Assistant Professor, Department of Chemistry, University of Washington |
Dr. Xiaohui Ni | 2011-2015 | Cynvenio Biosystems, California |
Dr. Yi Yin | 2015-2016 | Postdoc, University of Washington |
Dr. Haisong Liu | 2014-2016 | Postdoctoral Fellow, Salk Institute |
Dr. Asaf Tal | 2015-2017 | |
Dr. Fa-Ke Frank Lu | 2011-2017 | Assistant Professor, Department of Biomedical Engineering, Binghamton University, State University of New York |
Dr. Sabin Mulepati | 2014-2017 | Intellia Therapeutics, Massachusetts |
Visiting Scholars | ||
Prof. Jianming Li | 2011 | Southern Medical University, China |
Prof. Biman Bagchi | 2007 | Indian Institute of Science |
Prof. Paul Champion | 2002-2003 | Department of Physics, Northeastern University |
Prof. Binny Cherayil | 2004-2005 | Department of Inorganic and Physical Chemistry, Indian Institute of Science |
Prof. Nai-Ho Cheung | 2000-2001 | Department of Physics, Hong Kong Baptist University |
Dr. Peijun Cong | 2010 | Invenio Imaging |
Dr. Mircea Cotlet | 2003 | Brookhaven National Laboratory, Center for Functional Nanomaterials |
Prof. Hao Ge | 2010-2011 | Biodynamic Optical Imaging Center (BIOPIC), Peking University, China |
Prof. Casey Hynes | 2011 | Department of Molecular Biophysics, University of Colorado, Boulder |
Prof. Carey Johnson | 1997 | Department of Chemistry, University of Kansas |
Dr. Laura Kaufman | 2002-2004 | Department of Chemistry, Columbia University |
Dr. Francois Legare | 2004-2006 | INRS-EMT, Université du Québec, Varennes, Canada |
Prof. Peter Leung | 1995 | Department of Physics, Portland State University |
Prof. Yuanzong Li | 2002-2003 | College of Chemistry and Molecular Engineering, Peking University, China |
Prof. Vahid Sandoghdar | 2009 | Department of Chemistry, Swiss Federal Institute of Technology, Switzerland |
Prof. Andrei Tokmakoff | 2005-2006 | Department of Chemistry, Massachusetts Institute of Technology |
Dr. Martin Vogel | 2006-2008 | Max Planck Institute of Biophysics, Department of Molecular Neurogenetics |
Prof. Nils Walter | 2006 | Department of Chemistry, University of Michigan |
Prof. Xinhua Wan | 2004-2005 | College of Chemistry and Molecular Engineering, Peking University, China |
Prof. Peng-Ye Wang | 2010 | Institute of Physics, Chinese Academy of Sciences |
Prof. Luying Xun | 2004-2005 | School of Molecular Biosciences, Washington State University |
Prof. Xinsheng Zhao | 2003 | College of Chemistry and Molecular Engineering, Peking University, China |
Prof. Zemin Yao | 2014-2015 | Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Canada |
Yuanzhen Suo | 2015-2017 | Shanghai Jiao Tong University |
Shufang Wang | 2016-2017 | Chinese PLA General Hospital |
榮譽表彰
時間 | 獎項/榮譽 | 參考資料 |
2017年12月 | 入選 “2017年度中國留學人員50人榜單” | |
2017年11月 | 中國科學院外籍院士 | |
2017年 | 求是傑出科學家獎 | |
2016年10月 | 美國國家醫學院院士 | |
2016年 | 華人生物學家協會吳瑞獎 | |
2015年 | 中國生物物理學會貝時璋生物物理獎 | |
2015年 | 美國阿爾伯尼生物醫學獎(Albany) | |
2015年 | 美國化學會Peter Debye 物理化學獎 | |
2014年 | 美國光學會會士 | |
2014年 | 德國洪堡學者 | |
2013年 | 美國NIH Director's Pioneer Award | |
2013年 | 美國光學學會及套用光譜學會Ellis R. Lippincott獎 | |
2012年 | 美國化學會Rochester分部Harrison Howe獎 | |
2012年 | 美國微生物學會會士 | |
2012年 | 美國生物物理學會Founders獎 | |
2011年5月3日 | 美國國家科學院院士 | |
2010年 | 中國化學會榮譽會士 | |
2009年 | 美國能源部勞倫斯獎(化學類) | |
2008年 | 美國物理學會會士 | |
2008年 | 美國藝術與科學學院院士 | |
2008年 | Berthold Leibinger Zukunftspreis雷射技術獎 | |
2007年 | Willis E.Lamb雷射科學與量子光學獎 | |
2006年 | 美國科學促進會會士 | |
2006年 | 美國生物物理學會會士 | |
2004年 | 美國NIH Director's Pioneer Award | |
2003年 | 以色列Raymond and Beverly Sackler 物理科學獎 | |
2003年 | 哈佛大學Hoope獎 | |
2003年 | Joe Markson優秀本科畢業論文指導教師 | |
1996年 | Coblentz獎 |
社會任職
任職時間 | 擔任職務 | 參考資料 |
2009年-2011年 | 《Science》編委 | |
2004年- | 國家納米科學中心學術委員會委員(第一屆、第二屆) | |
2002年-2007年 | 《Ann. Rev. Phys. Chem.》編委 | |
2001年-2006年 | 《Acc. Chem. Res.》編委 | |
2001年-09年 | 中國科學院化學研究所分子動態與穩態結構國家重點實驗室學術委員會委員(第五屆) | |
2001年- | 《Chem. Phys.》編委 | |
2001年- | 《Chem. Phys. Lett.》編委 | |
2000年- | 《Chem. Phys. Chem.》編委 | |
2000年-2008年 | 《J. Phys. Chem.》編委 | |
1999年-2007年 | 《J. Microscopy》編委 | |
1999年-2002年 | 《Single Molecules》編委 | |
2000年-2001年 | 《Biophysical J.》編委 | |
—— | 《物理化學學報》編委 |
人物評價
謝曉亮在非線性拉曼顯微學和高靈敏度分子振動成像領域具有創新研究,在創立單分子生物物理化學領域中處於科學領導地位,而且他在酶反應動力學和活細胞基因表達領域做出了傑出工作 。 (2009年美國歐內斯特·奧蘭多·勞倫斯獎)
謝曉亮是單細胞生物學領域的領軍人物,他已在該領域做出了關於單個分子及其行為影響細胞的生命過程乃至人類疾病的諸多研究成果 。 (2015年美國阿爾伯尼生物醫學獎)
謝曉亮是學科交叉研究的踐行者,從物理化學、生物物理到生物化學,再到分子生物學,基因組學及臨床醫學,他無畏探索,不斷創新,他是單分子酶學的創始人、單分子生物物理化學的奠基人之一、相干拉曼散射顯微成像技術和單細胞基因組學的開拓者,在單分子生物物理和生物醫學光學成像領域作出了傑出的貢獻 。 (2017年求是科學基金會評)
做事情就是要持之以恆,不要放棄,要堅持,要不怕困難的做下去,要有耐心,不要追求那種短期就能出成果的東西。謝曉亮常常會用4年甚至更長的時間來做一個研究,他發現自己做錯的東西,也不放棄,重新開始做,所以,堅持是一個很重要的東西,是他獲得成功肯定的一個很重要的元素,對我也意義重大 。 (美國國家科學院院士、哈佛大學教授莊小威)
謝曉亮的第一個基礎研究工作是1998年開展的單分子酶學,他開創了在單分子層面對生命過程的研究。近年他又開始探探索在醫學上的套用。中國引進現代醫學後,在現代藥學方面只有少數幾個藥物作用領域的發現,在現代醫學技術上唯一的發明和套用就是謝曉亮和湯富酬、喬傑三個團隊合作誕生的‘MALBAC嬰兒’ 。 (北京大學生命科學院饒毅)
謝曉亮的MALBAC技術能夠改變整個生物醫學,其對未來精準醫學的發展和套用的貢獻是不可限量的。“獲得終身教授的人很多,但真正能夠在人類歷史上,特別是科技史上留下印記的科學家非常少見,而謝曉亮將理論和技術結合,用技術解決科學問題,是引領整個科學界發展的真正的一流科學家,他是一個讓你無法預知將來還會做出什麼創造性工作的科學家。這是一個科學家具有潛在創造力、影響力、引領力的標誌 。 (中國醫學科學院院長曹雪濤)