李紅岩[中國海洋大學講師]:李紅岩，女，副教授，目前主要從事教學、科研 -百科知識中文網

人物經歷

2002-至今任中國海洋大學副教授；

2004-2007期間為Université Pierre et Marie Curie, France 博士後。

研究方向

發育生物學：

1）早期發育中基因的功能研究；

2）魚類的免疫與進化。

主要貢獻

科研項目

RNA結合蛋白Seb4的表達調控以及在斑馬魚肌肉發生中的功能國家自然科學基金主持 2009-2011；

RNA結合蛋白在斑馬魚早期發育中的功能研究教育部留學回國人員基金主持 2009-2010；

魚類抗感染免疫的分子與細胞基礎及其調控 973 參加；

IgM的母體傳遞及其免疫保護作用的機理研究海洋所開放課題主持。

發表論文

1. Bourdelas#, H.Y. Li#, C. Carron and D.L. Shi 2009 Dynamic expression pattern of distinct genes in the presomitic and somitic mesoderm during Xenopus development. Int. J. Dev. Biol. 53: 1075-1079；

2. Li HY., Bourdelas A., Carron C., Boucaut J., Gomez C.. Shi DL. 2006, FGF8, Wnt8 and Myf5 are target genes of Tbx6 during anteroposterior specification in Xenopus embryo. Dev. Biol. 290: 470-481.；

3. Shao M, Liu ZZ, Wang CD, Li HY, Carron C, Zhang HW, Shi DL. 2009 Down syndrome critical region protein 5 regulates membrane localization of Wnt receptors, Dishevelled stability and convergent extension in vertebrate embryos. Development 136(12):2121-31.；

4. Grandy D, Shan J, Zhang X, Rao S, Akunuru S, Li HY, Zhang Y, Alpatov I, Zhang XA, Lang RA, Shi DL, Zheng JJ. 2009 Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled. J Biol. Chem. 284(24):16256-63；

5. Liu ZH, Li L, Li HY, Zhang SC, Ji GD, Sun YL. 2009 EST analysis of the immune-relevant genes in Chinese amphioxus challenged with lipopolysaccharide. Fish Shellfish Immunol. 26(6):843-9.；

6. Bourdelas A., Li HY., Boucaut J., Shi D. Identification of distinct genes with restricted expession in the somitic mesoderm in xenopus embryo. Gene Expression Patterns 2004, 4: 695-699.

7. Liu M., Zhang S., Liu Z., Li H., Xu A. Characterization, organization and expression of AmphiLysC, an acidic c-type lysozyme gene in amphioxus Branchiostoma belcheri tsingtauense. Gene 2006, 367: 110-117.；

8. Li H., Zhang vitro cytotoxicity of the organophorous pesticide methylparathion to FG-9307 cells. Cell Biology and Toxicology 2002, 8: 235-241.；

9. Li H., Zhang S. In vitro cytotoxicity of the organophorus pesticide parathion to FG-9307 cells. Toxicology in Vitro 2001, 15: 643-647.

10. Carron C., Bourdelas A., Li HY., Boucaut J., Shi DL. Antagonistic interaction between IGF and Wnt/JNK signaling in convergent extension in Xenopus embryo. Mechanisms of Development 2005, 122: 1234-1247.；

11. H.Y. Li, S.C. Zhang, M. Wang and M. Jiang, 2001 In vitro study on cytotoxic effects of the organophosphorous pesticide profenofos on the gill cell line, FG-9307, of the flounder (Paralichihys olivaceus) Chinese Journal of Oceanology and Limnology 19(1): 57-62；

12. Wang Y, Zhang S, Liu Z, Li H, Wang L. Identification and expression of amphioxus [beta]-microseminoprotein (MSP)-like gene encoding an ancient and rapidly evolving protein in chordates. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 2005; 142:251-57.

13. Wang Y, Zhang S, Liu Z, Li H, Wang L. Characterization and expression of AmphiCL encoding cathepsin l proteinase from amphioxus Branchiostoma belcheri tsingtauense. Marine biotechnology 2005; 7:279-86.

14. Luan J, Liu Z, Zhang S, Li H, Fan C, Li L. Characterization, evolution and expression of the calmodulin1 genes from the amphioxus Branchiostoma belcheri tsingtauense. Acta Biochim Biophys Sin (Shanghai). 2007; 39:255-64.

15. Wang Y, Zhang S, Liu Z, Li H, Wang L. Amphioxus allantoicase: molecular cloning, expression and enzymatic activity. Comparative biochemistry and physiology. 2005; 141:237-43.

16. Wang L, Zhang SC, Liang SD, Liu ZH, Li HY, Wang YJ. Characterization and expression of AmphiARF gene encoding a new member of ARF family from amphioxus Branchiostoma belcheri tsingtauense. DNA Sequence - The Journal of Sequencing and Mapping. 2005; 16:418-25.

17. Liu Z, Zhang S, Li H, et al. Characterization and expression profile of AmphiCD63 encoding a novel member of TM4SF proteins from amphioxus Branchiostoma belcheri tsingtauense. DNA Seq. 2005; 16:195-201.

18. Li X, Zhang S, Liu Z, Li H. Ribosomal Protein Genes S23 and L35 from Amphioxus Branchiostoma belcheri tsingtauense: Identification and Copy Number. Acta Biochimica et Biophysica Sinica. 2005; 37: 573-79.

19. Wang L, Zhang S, Liu Z, Li H, Wang Y, Jiang S. 2007 Characterization and expression of amphioxus ApoD gene encoding an archetype of vertebrate ApoD proteins. Cell Biol Int. 31:74-81.

20. G. S.C. Zhang and H.Y. Li, 2001 Ultrastructural localization and antibacterial activity of phenoloxidase in amphioxus Branchiostoma belcheri tsingtauense. Journal of the Marine Biological Association of the United Kingdom 81: 705-706

21. S.C. Zhang, L. Li, and H.Y. Li, 2002 Histochemical localization of constitutive nitric oxide synthases in amphioxus Branchiostoma belcheri tsingtauense. Journal of the Marine Biological Association of the United Kingdom 82: 1041-1042

22. H.R. Guo, S.C. Zhang, and H.Y. Li, 2003 Spontaneous neoplastic transformation of the cell line FG-9307 of the flounder (Paralichthys olivaceus) North American Journal of Aquaculture 65: 44-48

23. H.R. Guo, S.C. Zhang and H.Y. Li, 2002 Characterization of lactate dehydrogenase isozyme pattern and morphology of three marine fish cell lines of FG, SPH and RSBF. Chinese Journal of Oceanology and Limnology 20(3): 246-251

24. L. Li, S.C. Zhang, J.D.Yuan and H.Y. Li, 2003 Development of inter-family nulear transplant embryos by transplanting the the nuclei from the loach blastulae into the non-enucleated zebrafish eggs. Chinese Journal of Oceanology and Limnology 21(1): 64-71