![楊崇林[中科院遺傳與發育生物學研究所研究員]](/img/d/8a7/nBnauM3X4QzM0IzMxATO1kTO0UTMyITNykTO0EDMwAjMwUzLwkzL2MzLt92YucmbvRWdo5Cd0FmLzE2LvoDc0RHa.jpg "楊崇林[中科院遺傳與發育生物學研究所研究員]")
簡介
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楊崇林[中科院遺傳與發育生物學研究所研究員]楊崇林，男，博士，中國科學院遺傳與發育生物學研究所研究員，博士生導師。
1998年於北京大學獲博士學位。
1998-1999為義大利 International school for advanced studies 分子神經生物學實驗室訪問學者。
1999-2005年先後在University of Maryland School of Medicine和University of Colorado從事博士後研究。
2006年入選中國科學院 "百人計畫"，終期獲評優秀。
2010年獲國家傑出青年基金資助。
2013年被中國科協授予“全國優秀科技工作者”榮譽稱號。
2016年雲南大學生命科學學院院長、生命科學研究中心主任、教授（二級）
2017年入選國家“百千萬人才工程”。
FEBS Journal, Journal of Genetics and Genomic等國際國內外學術期刊編委。
細胞程式性死亡又稱細胞凋亡，是多細胞有機體生長和發育過程中最重要的生命現象之一。通過程式性死亡，多細胞有機體可抑制細胞的過量增殖，清除衰老和畸形細胞以維持健康細胞的正常數量。細胞凋亡對組織和器官發育、免疫耐受性以及神經細胞的生長與發育等起著決定性的作用。大多數重大疾病均與細胞凋亡的失調直接或間接相關。譬如，神經退行性疾病包括老年痴呆症(Alzheimer’s disease)、帕金森氏綜合症(Parkinson’s disease)和亨廷頓氏綜合症(Huntington’s disease)等均源於神經系統細胞的過量凋亡；反之，細胞凋亡不足通常是各類癌症的直接原因。現已發現，細胞程式性死亡在進化上是一個非常保守的過程。在從原生動物線蟲到高等動物人的多細胞生物中，細胞程式性死亡的相關基因十分保守且調控途徑基本相似。因此，研究線蟲的細胞程式性死亡能夠使我們更好地了解人體細胞凋亡的調控機制。
楊崇林實驗室主要以秀麗線蟲(Caenorhabditis elegans)為模式，運用正向和反向遺傳、生化以及細胞生物學等綜合手段，探索細胞程式性死亡的調控規律。同時尋找能特異性地結合人體細胞凋亡因子的小分子化合物，包括小分子RNA 適配物(aptamer)和天然化合物等，從化學遺傳學的角度研究細胞凋亡的調控機制。
人物言論
1.基礎研究者不能急功近利，需要找到自己的興趣點，然後長時間地探索下去。
2.做科研，是苦行僧式的生活，要熱愛探索未知世界，才能有動力；要堅持下去，就會有收穫。
3.任何一個生命科學現象都需要很多人的研究積累，才能得到一個合理的解釋。我們做的是非常基礎的研究，是坐冷板凳，但要把冷板凳坐穩坐好。不要隨波逐流、盲目追逐熱門，找準方向，堅持下去就會有收穫。
發表論文
Yang Li,Meng Xu, Xiao Ding, Chen Yan, Zhiqin Song, Lianwan Chen, Xiahe Huang, XinWang,Youli Jian, Guihua Tang, Changyong Tang, Yingtong Di, Shuzhen Mu, Xuezhao Liu, Kai Liu, Ting Li,Yingchun Wang, Long Miao, Weixiang Guo, Xiaojiang Hao and Chonglin Yang
Xiaochen Wang, Chonglin Yang. (2016). Programmed cell death and clearance of cell corpses in Caenorhabditis elegans
Kai Liu, Youli Jian, Xiaojuan Sun,Chengkui Yang,Zhiyang Gao, Zhili Zhang, Xuezhao Liu,Yang Li,Jing Xu,Yudong Jing,Shohei Mitani,Sudan He, Chonglin Yang
Meng Xu, Yubing Liu, Liyuan Zhao, Qiwen Gan, Xiaochen Wang, and Chonglin Yang. (2014). The lysosomal cathepsin protease CPL-1 plays a leading role in phagosomal degradation of apoptotic cells in Caenorhabditis elegans. Molecular Biology of the Cell
Didi Chen, Youli Jian, Xuezhao Liu, Yuanya Zhang, Jingjing Liang, Xiaying Qi, Hongwei Du, Wei Zou, Lianwan Chen, Yongping Chai, Guangshuo Ou, Long Miao, Yingchun Wang, and Chonglin Yang. (2013). Clathrin and AP2 are required for phagocytic receptor-mediated apoptotic cell clearance in Caenorhabditis elegans
Jing Xu, Xiaojuan Sun, Yudong Jing, Mo Wang, Kai Liu, Youli Jian, Mei Yang, Zhukuan Cheng, Chonglin Yang. (2012). MRG-1 is required for genomic integrity in Caenorhabditis elegans germ cells
Didi Chen, Hui Xiao, Kai Zhang, Bin Wang,Zhiyang Gao, Youli Jian, Xiaying Qi, Jianwei Sun, Long Miao, Chonglin Yang. (2010). Retromer Is Required for Apoptotic Cell Clearance by Phagocytic Receptor Recycling
Qinfang Shen, Fengsong Qin, Zhiyang Gao, Jie Cui, Hui Xiao, Zhiheng Xu, and Chonglin Yang. (2009). Adenine Nucleotide Translocator Cooperates with Core Cell Death Machinery to Promote Apoptosis in Caenorhabditis elegans
Mei Yang, Jianwei Sun, Xiaojuan Sun, Qinfang Shen, Zhiyang Gao, Chonglin Yang. (2009). Caenorhabditis elegans Protein Arginine Methyltransferase PRMT-5 Negatively Regulates DNA Damage-Induced Apoptosis
Hui Xiao, Didi Chen, Zhou Fang, Xiaojuan Sun, Jing Xu, Song Song, Jiajia Liu and Chonglin Yang. (2009). Lysosome biogenesis mediated by vps-18 affects apoptotic cell degradation in Caenorhabditis elegans
Youli Jian, Zhiyang Gao,Jianwei Sun, Qinfang Shen, Feng Feng,Yudong Jing and Chonglin Yang. (2009). RNA aptamers interfering with nucleophosmin oligomerization induce apoptosis of cancer cells
Chonglin Yang , Myoung Sook Kim, Devulapalli Chakravarty, Fred E. Indig and France Carrier. (2009). Nucleolin Binds to the Proliferating Cell Nuclear Antigen and Inhibits Nucleotide Excision Repair
Xiaochen Wang, Jin Wang, Keiko Gengyo-Ando, Lichuan Gu, Chun-Ling Sun, Chonglin Yang, Yong Shi, Tetsuo Kobayashi, Yigong Shi,Shohei Mitani, Xiao-Song Xie & Ding Xue (2007). C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1
Chonglin Yang, Nieng Yan, Jay Parish, Xiaochen Wang, Yigong Shi and Ding Xue. (2006). RNA aptamers targeting the cell death inhibitor CED-9 induce cell killing in C
2005年前論文
Dony A Maiguel, Leslie Jones, Devulapalli Chakravardy, Chonglin Yang and France Carrier. (2004). Nucleophosmin sets a threshold for p53 response to UV radiation
Jay Z Parrish, Chonglin Yang, Binghui Shen and Ding Xue. (2003). C. elegans CRN-1 nuclease cooperates with CPS-6 to promote stepwise apoptotic DNA fragmentation
Xiaochen Wang*, Chonglin Yang*, Jijie Cai, Yigong Shi and Ding Xue. (2002). Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans
Chonglin Yang and France Carrier. (2001). The UV inducible RNA binding protein A18 (A18 hnRNP) plays a protective role in the genotoxic stress response
Chonglin Yang, Dony A Maiguel and France Carrier. (2002). Identification of nucleolin and nucleophosmin as genotoxic stress-responsive RNA binding proteins
Jianlong Lou, Roberto Marzari, Vittorio Verzillo, Frederica Ferreco, Daniel Pak, Morgan Shen, Chonglin Yang, Danielle Sblattero, Andrew Bradbury. (2001). Antibodies in haystacks: how selection strategy influences the outcome of selection from the molecular diversity libraries
