人物簡介
中國科學院動物研究所黨委書記
段恩奎1990年在西北農業大學獲博士學位，1995年-1996年和1998年，先後赴澳大利亞New England大學和美國Kansas大學醫學中心從事動物生殖免疫和胚胎植入分子機理的合作研究。曾多次赴美、澳、加、德、日、希臘、蒙古國開展學術交流，4次應邀在國際會議上做報告。作為學術委員會副主席和會議共同主席參與主辦了三次國際和雙邊學術會議。目前的主要研究方向為胚胎植入分子機理和幹細胞生物學。主編（譯）、參編專（譯）著6部、在國內外發表論文105篇，其中SCI收錄論文58篇，有2篇被Mol Hum Reprod和Hum Reprod作為封面文章，有1篇合作研究成果被Biol Reprod主編作為當期Highlight 加以介紹。獲省、部級科技成果獎3項、國際會議優秀Poster獎2次，並獲新世紀千百萬人才工程國家級人選、國務院政府特殊津貼和國家重點實驗室先進個人等榮譽稱號和獎勵。
研究領域
主要從事胚胎植入分子機理和幹細胞生物學研究，目前正在以基因敲除鼠為模型開展胚胎植入和胚胎髮育機制的相關研究，另一方面研究人和小鼠表皮發育與皮膚幹細胞相關信號轉導通路及調控
獲獎榮譽
1992年 “陝西科協新秀”榮譽稱號 陝西省科協
1993年 國務院政府特殊津貼 國務院
1995年 “優秀中青年留學人員” 國家教委
1998年 中科院“百人計畫” 中國科學院
2000年 遼寧省“科技進步二等獎”（主要完成人） 遼寧省人民政府
2001年 中科院“百人計畫”優秀入選者 中國科學院
2004年 “國家重點實驗室先進個人”、 科技部
2004年 “百千萬人才工程國家級人選” 中組部、人事部等六部委
2006年 “全國人口與計畫生育科技工作先進個人” 國家人口計生委
2007年 上海市科技進步二等獎（主要完成人） 上海市人民政府
2011年 中國科學院朱李月華優秀教師獎 中國科學院
2011年 全國人口和計畫生育優秀科技成果一等獎 國家人口計生委
2011年 第七屆中華人口獎 國家計畫生育委員會
2015年 全國婦幼健康科學技術一等獎 國家婦幼健康研究會 中國婦女發展基金會
科研項目
國家自然科學基金重大項目，胚胎著床過程中母-胎互作關鍵調控通路的生理和病理作用機制
代表論著
Chen Q, Yan M, Cao Z, Li X, Zhang Y, Shi J, Feng G, Peng H, Zhang X, Zhang Y, Qian J, Duan E*, Zhai Q*, Zhou Q*. Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder
Shi J, Chen Q, Li X, Zheng X, Zhang Y, Qiao J, Tang F, Tao Y*, Zhou Q*, and Duan E*. Dynamic transcriptional symmetry-breaking in pre-implantation mammalian embryo development revealed by single-cell RNA-seq.Development
Zhao Q, Liu S, Zhang H, Li N, Wang X, Cao Y, Ning L, Duan E*, and Xia G*. Spatiotemporal Expression of p63 in Mouse Epidermal Commitment. Int J Mol Sci
Zhang H, Zhang S, Zhao H, Qiao J, Liu S, Deng Z, Lei X, Ning L, Cao Y, Zhao Y, and Duan E*. Ovine Hair Follicle Stem Cells Derived from Single Vibrissae Reconstitute Haired Skin
Zhang S, and Duan E*. Epigenetic regulations on skin wound healing: implications from current researches. Ann Transl Med
Ning L, Lei X, Cao Y, Zhang Y, Cao Z, Chen Q, and Duan E*. Effect of Short-Term Hypergravity Treatment on Mouse 2-Cell Embryo Development. Microgravity Sci
Liu S, Wang X, Zhao Q, Liu S, Zhang H, Shi J, Li N, Lei X, Zhao H, Deng Z, Cao Y, Ning L, Xia G, Duan E*. Senescence of human skin-derived precursors regulated by Akt-FOXO3-p27KIP1/p15 INK4b signaling
Deng Z, Lei X, Zhang X, Zhang H, Liu S, Chen Q, Hu H, Wang X, Ning L, Cao Y, Zhao T, Zhou J, Chen T, Duan E*. mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration. J Mol Cell Biol
Zhao H, Qiao J, Zhang S, Zhang H, Lei X, Wang X, Deng Z, Ning L, Cao Y, Guo Y, Liu S, Duan E*. GPR39 marks specific cells within the sebaceous gland and contributes to skin wound healing
Zhang Y, Chen Q, Zhang H, Wang Q, Li R, Jin Y, Wang H, Ma T*, Qiao J*, Duan E*. Aquaporin-dependent excessive intrauterine fluid accumulation is a major contributor in hyper-estrogen induced aberrant embryo implantation. Cell Res
Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang YL, Li B, Chen Q*, Duan E*, Wang H*. Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms.Cell Res
Lei X, Deng Z, Zhang H, Zhao H, Zhou J, Liu S, Chen Q, Ning L, Cao Y, Wang X, Zhang X, Duan E*. Rotary Suspension Culture Enhances Mesendoderm Differentiation of Embryonic Stem Cells Through Modulation of Wnt/β-catenin Pathway. Stem Cell Rev
Wang X, Liu S, Zhao Q, Li N, Zhang H, Zhang X, Lei X, Zhao H, Deng Z, Qiao J, Cao Y, Ning L，Liu S*, Duan E*. Three-dimensional hydrogel scaffolds facilitate in vitro self-renewal of human skin-derived precursors
Zhang Y, Zhang Y, Shi J, Zhang H, Cao Z, Gao X, Ren W, Ning Y, Ning L, Cao Y, Chen Y, Ji W, Chen Z*, Chen Q*, Duan E*. Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection
Chen Q, Zhang Y, Elad D, Jaffa AJ, Cao Y, Ye X*, Duan E*. Navigating the site for embryo implantation: Biomechanical and molecular regulation of intrauterine embryo distribution
Liu S, Zhang H and Duan E* Epidermal Development in Mammals: Key Regulators, Signals from Beneath, and Stem Cells. Int J Mol Sci
Cao Q, Chen H, Deng Z, Yue J, Chen Q, Cao Y, Ning L, Lei X, Duan E* Genetic deletion of Cxcl14 in mice alters uterine NK Cells, Biochem Biophys Res Commun
Zhang H, Zhang Y, Zhao H, Zhang Y, Chen Q, Peng H, Lei L, Qiao J, Shi J, Cao Z, Enkui Duan E*, Jin Y*Hormonal regulation of ovarian bursa fluid in mice and involvement of aquaporins
Duan EK*, Wang H*, Zernicka-Goetz M*. Introduction to the special issue "Molecular Players in Early Pregnancy"
Lu S, Peng H, Zhang H, Zhang L, Cao Q, Li R, Zhang Y*, Yang L*, Duan E, Qiao J. Excessive Intrauterine Fluid Cause Aberrant Implantation and Pregnancy Outcome in Mice
Wang Q, Lu J, Zhang S, Wang S, Wang W, Wang B, Wang F, Chen Q, Duan E, Leitges M, Kispert A, Wang H. 2013 Wnt6 Is Essential for Stromal Cell Proliferation During Decidualization in Mice
Zhang Q, Chen Q, Lu X, Zhou Z, Zhang H, Lin HY, Duan E, Zhu C, Tan Y, Wang H. CUL1 promotes trophoblast cell invasion at the maternal-fetal interface
Kong S, Zhang S, Chen Y, Wang W, Wang B, Chen Q, Duan E* & Wang H* Determinants of uterine aging: lessons from rodent models
Peng H, Shi J, Zhang Y, Zhang H, Liao S, Li W, Lei L, Han C, Ning L, Cao Y, Zhou Q, Chen Q*,Duan E*A novel class of tRNA-derived small RNAs extremely enriched in mature mouse sperm.Cell Res
Hu HM, Zhang SB, Lei XH, Deng ZL, Guo WX, Qiu ZF, Liu S, Wang XY, Zhang H, Duan EK* Estrogen Leads to Reversible Hair Cycle Retardation through Inducing Premature Catagen and Maintaining Telogen
Zhang S, Hu H, Zhang H, Liu S, Liu S, Zhang Y, Lei X, Ning L, Cao Y, Duan E*. Hair Follicle Stem Cells Derived from Single Rat Vibrissa via Organ Culture Reconstitute Hair Follicles in vivo. Cell Transplant
Liu S, Liu S, Wang X, Zhou J, Cao Y, Wang F, Duan E*. The PI3K-Akt pathway inhibits senescence and promotes self-renewal of human skin-derived precursors in vitro. Aging Cell
Lei XH, Ning LN, Cao YJ, Liu S, Zhang SB, Qiu ZF, Hu HM, Zhang HS, Liu S, Duan EK*. NASA-approved rotary bioreactor enhances proliferation of human epidermal stem cells and supports formation of 3D epidermis-like structure
Zhang Y, Zhao H, Peng H, Hu Z, Ning L, Cao Y, Tan Y, Duan E*. GPR39, a putative receptor of Zn2+, is region specifically localized in different lobes of the mouse prostate
Chen Q, Zhang Y, Peng H, Lei L, Kuang H, Zhang L, Ning L, Cao Y, Duan E*. Transient β2-Adrenoceptor activation confers pregnancy loss by disrupting embryo spacing at implantation. J Biol Chem
Chen Q, Duan EK*. Aquaporins in sperm osmoadaptation: an emerging role for volume regulation. Acta Pharmacol Sin
Chen Q, Peng H, Lei L, Zhang Y, Kuang H, Cao Y, Shi QX, Ma T, Duan E*. Aquaporin3 is a sperm water channel essential for postcopulatory sperm osmoadaptation and migration
Zhao P, Qiao J, Huang S, Zhang Y, Liu S, Yan LY, Hsueh AJ, Duan EK*.Gonadotrophin-induced paracrine regulation of human oocyte maturation by BDNF and GDNF secreted by granulosa cells
Peng H, Zhang Y, Lei L, Chen Q, Yue J, Tan Y*, Duan E*.2011 Aquaporin 7 expression in postimplantation mouse uteri: a potential role for glycerol transport in uterine decidualization. Fertil Steril
Li D, Zhou J, Wang L, Shin ME, Su P, Lei X, Kuang H, Guo W, Yang H, Cheng L, Tanaka TS, Leckband DE, Reynolds AB, Duan E, Wang F*. Integrated biochemical and mechanical signals regulate multifaceted human embryonic stem cell functions
Zhou J, Su P, Li D, Tsang S, Duan E, Wang F*. High-efficiency induction of neural conversion in human ESCs and human induced pluripotent stem cells with a single chemical inhibitor of transforming growth factor beta superfamily receptors. Stem Cells
Li J, Kawamura K, Cheng Y, Liu S, Klein C, Liu S, Duan EK, Hsueh AJ*. Activation of dormant ovarian follicles to generate mature eggs. Proc Natl Acad Sci U S A
