人物經歷
1997年6月 在中山醫科大學獲得醫學(生物化學專業)博士學位;1999年晉升副教授;2004年晉升教授、博士生導師並獲中山大學教師特別津貼。
主編人民衛生出版社規劃教材護理本科《生物化學》、參加人民衛生出版社規劃教材《醫學分子生物學》的編寫;負責國家級繼續醫學項目“疾病的分子生物學基礎”;中山大學精品課程“生物化學與分子生物學”負責人。
1999.1-2002.5期間,在美國進行博士後研究工作並晉升為研究助理教授,研究糖尿病視網膜病的分子機制和治療,成果發表在國際著名雜誌上,如Diabetes,Journal of Biological Chemistry,FASEB Journal 等。
研究方向
2002年6月回國後,先後獲得中山大學985學科建設基金200萬元,組建了先進的分子生物學實驗室,建立了一支結構合理、基礎紮實、積極進取的科研隊伍。研究方向為:病理性血管增生的生化改變、分子機制及血管增生性疾病的生物治療。課題組成員包括副教授1名,副主任技師1名,講師3名,在讀博士生9名、碩士生6名。已畢業博士2名、碩士3名。截至目前已獲得國家自然科學基金(3項,70萬)、CMB學者項目(5萬美元)、教育部新世紀優秀人才支持計畫(50萬)、廣東省科技攻關重大專項(2項,40萬)、廣東省自然科學基金團隊項目(150萬,核心成員)、廣東省自然科學基金面上項目(10萬,2項)、廣州市科技攻關重點項目(2項,50萬)、廣東省醫學科學基金(3.5萬,4項)等基金近300萬元的資助,研究工作進展順利,已發表SCI論文25篇(通訊作者12篇,第一作者1篇),中文論文10篇,發表論文被國際同行引用總次數為368次,最高單篇他引106次,研究成果作為第一完成人獲得教育部、廣東省自然科學二等獎各一項。
主要貢獻
⒈ Xia Yang,Rui Cheng,Chaoyang Li,Weibin Cai,Jian-xing Ma,Qianping Liu,Zhonghan Yang,Zhihong Song,Zuguo Liu,and Guoquan Gao (corresponding author). Kringle 5 of human plasminogen suppresses hepatocellular carcinoma growth both in grafted and xenografted mice by anti-angiogenic activity. Cancer Biology & Therapy,5⑷:399-405,2006. (Impact factor 3.3)
⒉ Qingsong Wang,Xia Yang,Zhonghan Yang,Guoquan Gao (corresponding author). A novel method for expression and purification of human Pigment Epithelium-derived Factor with biological activities in Escherichia coli. Preparative Biochemistry & Biotechnology,36⑵:127-138,2006. (Impact factor 1.0)
⒊ Weibin Cai,Jianfang Ma,Chaoyang Li,Zhonghan Yang,Xia Yang,Wei Liu,Zuguo Liu,Mintao Li,and Guoquan Gao (corresponding author). Enhanced anti-angiogenic effect of a deletion mutant of plasminogen kringle 5 on neovascularization. J Cell Biochem,96⑹:1254-1261,2005. (Impact factor 3.5)
⒋ Gao G,Shao C.,Zhang S.X.,Dudley A.,Fant J,and Ma J-x. Kallikrein-binding protein inhibits retinal neovascularization and decreases vascular leakage. Diabetologia,46,689-698,2003. (Impact factor 5.7)
⒌ Gao G,Li Y,Fant J,Becerra SP,Crosson C and Ma J-x. Difference in ischemic regulation of vascular endothelial growth factor and pigment epithelium--derived factor in brown norway and sprague dawley rats contributing to different susceptibilities to retinal neovascularization. Diabetes,51⑷,1218-1225,2002. (Impact factor 9.1)
⒍ Gao G,Li Y,Gee S,Dudley A,Fant J,Crosson C and Ma J-x. Down-regulation of endogenous VEGF and up-regulation of PEDF: a possible mechanism for the anti-angiogenic activity of plasminogen kringle 5. J Biol Chem,277⑾,9492-9497,2002. (Impact factor 7.7)
⒎ Gao G and Ma J-x. Tipping the balance for angiogenic disorders. Drug Discovery Today,7⑶,171-172,2002. (Impact factor 4.1)
⒏ Gao G,Li Y,Zhang D,Gee S,Crosson CE and Ma J-x. Unbalanced expression of VEGF and PEDF in ischemia-induced retinal neovascularization. FEBS Lett,489,270-276,2001. (Impact factor 3.7)
⒐ Yousufzai SYK,Gao G,and Abdel-Latif AA. Mitogen-activated protein kinase inhibitors suppress prostaglandin F2a-induced myosin-light chain phosphorylation and contraction in iris sphincter smooth muscle. Eur J Pharmacol,407,17-26,2000. (Impact factor 2.2)
⒑Zhang D,Kaufman PL,Gao G,Saunders RA,and Ma J-x. Intravitreal injection of plasminogen kringle 5,an endogenous angiogenic inhibitor,arrests retinal neovascularization in rats. Diabetologia,44,757-765,2001. (Impact factor 5.7)
⒒Jin J,Guan M,Sima J,Gao G,Zhang M,Liu Z,Fant J and Ma J-x. Decreased pigment epithelium-derived factor and increased Vascular endothelial growth factor in pterygia. Cornea,22⑸:473-477,2003. (Impact factor 1.4)
⒓Zhang S.X.,Sima J,Shao C.,Fant J,Chen Y,Rohrer B,Gao G,and Ma J-x. Plasminogen kringle 5 reduces vascular leakage in the retina in rat models of oxygen-induced retinopathy and diabetes. Diabetologia,47⑴,124-131,2004. (Impact factor 5.7)
⒔Xie Y.,Liu Y.,Ma C.,Yuan Z.,Wang W.,Zhu Z.,Gao G.,Liu X.,Yuan H.,Chen Y.,Huang S.,Wang X.,Zhu X.,Wang X.,Mao Z.,and Li M. Indirubin-3’-oxime inhibits c-Jun NH2-terminal kinase: anti-apoptotic effect in cerebellar granule neurons. Neuroscience Letters,367:355-359,2004. (Impact factor 2.1)
⒕Zhang Z.,Ma J-x.,Gao G.,Li C.,Luo L.,Zhang M.,Chen J. and Liu,Z. Plasminogen kringle 5 inhibits alkali burn-induced corneal neovascularization. Invest. Ophthalmol. Vis. Sci.,46:4062-4071,2005. (Impact factor 3.58)
⒖Zhang,S.X.,Wang,J.J.,Gao,G.,Shao,C. Mott,R.,Longeras,R. and Ma,J-x. Pigment epithelium-derived factor (PEDF) is an endogenous anti-inflammatory factor. FASEB J.,20⑵:32-35,2006. (Impact factor 6.82)
⒗Zhang,S.X.,Wang,J.J.,Gao,G.,Park,K. and Ma,J-x. Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy. J Mol Endocrinol.,37⑴:1-12,2006. (Impact factor 3.85)
獲獎記錄
⒈ 人纖溶酶原K5及其突變體治療血管增生性疾病的作用及分子機制。高等學校科學研究優秀成果獎自然科學二等獎(2009),第一完成人。
⒉ 人纖溶酶原K5及其突變體治療血管增生性疾病的作用及分子機制。廣東省科學技術自然科學二等獎(2009),第一完成人。
入選教育部首屆“新世紀優秀人才”(2004年),入選廣東省高等學校“千百十工程”培養對象(2006年),入選2009年寶鋼優秀教師。