Classification: Antiarthritic Action/Kinetics: The goldcontent of aurothioglucose is 50%. Time to peakeffect: 4-6 hr. Meansteady-state plasma levels: 1-6 mc/mL. Is 95%-99% protein bound. t1/2,after 11th dose: Up to 168 days. Seventy percent is excreted in the urine and 30% isexcreted through the urine.
【用法用量】
IM Only Rheumatoid arthritis. Adults: W eek 1: 10 mg; weeks 2 and 3: 25 mg; then, 25-50(maximum) mg/week until a total of 0.8-1 g has been administered. If client tolerates thedose and has improved, 50 mg may be given q 3-4 weeks for several months. Pediatric,6-12 years: W eek 1: 2.5 mg; weeks 2 and 3: 6.25 mg; then, 12.5mg/week until a total dose of 200-250 mg has been administered. Maintenance: 6.25-12.5mg q 3-4 weeks.
Treatment: discontinue and give dimercaprol. Provide supportive therapy for renal and hematologicsymptoms. In acute overdose, induce emesis or gastric lavage immediately.