人物經歷
學習經歷
1989年9月-1993年7月:吉林大學生物化學系,獲理學學士學位。
1993年9月-1996年7月:北京大學生物化學系,獲理學碩士學位。
2000年9月-2003年1月:復旦大學生物化學系,獲理學博士學位。
工作經歷
1996年9月-現在:復旦大學生命科學學院生物化學系,歷任助教、講師、副教授、教授,博士生導師,現任生化系主任。
1999年、2001年和2003年: 法國科學研究中心植物分子生物學研究所(Institut de Biologie Moléculaire des Plantes/C.N.R.S.),訪問學者。
研究方向
利用生物化學、分子生物學、細胞生物學、遺傳學等方法研究植物細胞分裂和生長發育過程中的表觀遺傳調控機制。
(1) 組蛋白分子伴侶對植物細胞分裂及生長發育的表觀遺傳調控。
(2) 組蛋白甲基化修飾與識別對植物生長發育的表觀遺傳調控。
主要貢獻
代表性論文和專著:
(* 通信作者):
1 LIU, Z., ZHU, Y., GAO, J., YU, F., DONG, A. *, and SHEN, W.-H.* (2009) Molecular and reverse genetic characterization of NUCLEOSOME ASSEMBLY PROTEIN1 (NAP1) genes unravels their function in transcription and nucleotide excision repair in Arabidopsis thaliana. Plant J. , in press.
2 ZHU, Y., LI, Z., XU, B., LI, H., WANG, L., DONG, A., HUANG,H. (2008) Subcellular localizations of AS1 and AS2 suggest their common and distinct roles in plant development. J. Integr. Plant Biol. 50, 897-905.
3 XU, B., LI, Z., ZHU, Y., WANG, H., MA, H., DONG, A. & HUANG,H. (2008) Arabidopsis genes AS1, AS2, and JAG negatively regulate boundary-specifying genes to promote sepal and petal development. Plant Physiol. 146, 566-575.
4 XU, L., ZHAO, Z., DONG, A., SOUBIGOU-TACONNAT, L., RENOU, J.P., STEINMETZ, A. & SHEN, W.-H. (2008) Di- and tri- but not monomethylation on histone H3 lysine 36 marks active transcription of genes involved in flowering time regulation and other processes in Arabidopsis thaliana. Mol. Cell Biol. 28, 1348-1360.
5 DING, B., ZHU, Y., GAO, J., YU, Y., CAO, K., SHEN, W.-H. & DONG, A. * (2007) Molecular characterization of three rice SET-domain proteins. Plant Sci. 172, 1072-1078.
6 ZHU, Y., DONG, A. *, MEYER, D., PICHON, O., RENOU, J.P., CAO, K. & SHEN, W.-H. * (2006) Arabidopsis NRP1 and NRP2 encode histone chaperones and are required for maintaining post-embryonic root growth. Plant Cell 18,2879-2892.
7 YANG, L., LIU, Z.,LU, F., DONG, A. * & HUANG,H. * (2006) SERRATE is a novel nuclear regulator in primary microRNA processing in Arabidopsis. Plant J., 47, 841–850 (cover story).
8 DONG, A. *, LIU, Z., ZHU, Y., YU, F., LI, Z., CAO, K. & SHEN, W.-H. (2005) Interacting proteins and differences in nuclear transport reveal specific functions for the NAP1 family proteins in plants. Plant Physiol. 138,1446–1456.
9 YU, Y., DONG, A. & SHEN, W.-H. (2004). Molecular characterization of the tobacco SET-domain protein NtSET1 unravels its role in histone methylation, chromatin binding and segregation. Plant J., 40, 699-711.
10 DONG, A., ZHU, Y., YU, Y., CAO, K., SUN, C. & SHEN, W.-H. (2003) Regulation of biosynthesis and intracellular localization of rice and tobacco homologues of nucleosome assembly protein 1. Planta 216,561-570.
11 XU, L., XU, Y., DONG, A., SUN, Y., XU, Y. & HUANG, H. (2003) The novel as1 and as2 defects in leaf adaxial-abaxial polarity reveal the requirement for ASYMMETRIC LEAVES1 and 2 and ERECTA functions in specifying leaf adaxial identity. Development 130,4097-4107.
12 CAPRON, A., SERRALBO, O., FULOP, K., FRUGIER, F., PARMENTIER, Y., DONG, A., LECUREUIL, A., GUERCHE, P., KONDOROSI, E., SCHERES, B. & GENSCHIK, P. (2003) The Arabidopsis Anaphase-Promoting Complex or Cyclosome: Molecular and Genetic Characterization of the APC2 Subunit. Plant Cell 15, 2370–2382.
13 DONG, A. *, XIN, H., YU, Y., SUN, C., CAO, K. & SHEN, W.-H. (2002) The subcellular localization of unusual rice calmodulin isoform, OsCaM61, depends on its prenylation status. Plant Mol. Biol., 48, 203-210.
綜述:
1 朱炎,劉自強,高娟,沈文輝, 董愛武* (2008)植物組蛋白分子伴侶研究進展 自然科學進展 18,734-741 (invited paper).
2 YU,Y., BU, Z.Y., SHEN W.-H., DONG, A.* (2009) An update on histone lysine methylation in plants. Prog. Nat. Sci., 19, 407-413 (invited paper)。
獲獎記錄
2003年 上海市科技啟明星;
2003年 教育部優秀青年教師;
2007年 第四屆中國青年女科學家獎;
2008年 上海市“曙光”學者;
2009年 上海市“三八”紅旗手。