氟尼縮松 Flunisolide
中文別名：中國醫學健康網氟尼縮松
英文別名：NasalideSyntaris
藥品類別：腎上腺皮質激素類藥
性狀：本品適用於防治過敏性鼻炎，通過鼻孔給藥極少引起全身不良反應。成人每鼻孔50μg/次，2-3次/d；維持量為每鼻孔25μg/d。5歲以上兒童每鼻子25μg/次，2次/d。
CAS：3385-03-3
分子式：C24H31FO6
分子量：434.5
藥理藥動
Classification:Corticosteroid
Action/Kinetics:Minimalsystemiceffectswithintranasaluse.Significantfirst-passafterinhalation;rapidlymetabolizedbytheliver.Severaldaysmayberequiredforfullbeneficialeffects.t1/2:1.8hr.Excretedbythefeces(40%)andurine(50%).
適應症
Inhalation:Prophylaxisofbronchialasthmaincombinationwithothertherapy.Forasthmaclientsrequiringsystemicsteroidswhereaddinganinhaledsteroidmaydecreaseoreliminatetheneedforsysltemicsteroids.Intranasal:Seasonalorperennialrhinitis,especiallyifothertreatmenthasprovenunsatisfactory.
用法用量
InhalationBronchialasthma.Adults:2inhalations(totalof500mcgflunisolide)ina.m.andp.m.,nottoexceed4inhalationsb.i.d.(i.e.,totaldailydoseof2,000mcg).Pediatric,6-15years:2inhalationsinthemorningandevening,withtotaldailydosenottoexceed1,000mcg.IntranasalRhinitis.Adults,initial:50mcg(2sprays)ineachnostrilb.i.d.;maybeincreasedto2sprayst.i.d.,uptomaximumdailydoseof400mcg(i.e.,8spraysineachnostril).Pediatric,6-14years,initial:25mcg(1spray)ineachnostrilt.i.d.or50mcg(2sprays)ineachnostrilb.i.d.,uptomaximumdailydoseof200mcg(i.e.,4spraysineachnostril).Maintenance,adults,children:Smallestdosenecessarytocontrolsymptoms.Someclients(approximately15%)arecontrolledon1sprayineachnostrildaily.
不良反應
Respiratory:Hoarseness,coughing,throatirritation;Candidainfectionsofnose,larynx,andpharynx.Afterintranasaluse:Nasopharyngealirritation,stinging,burning,dryness,headache.GI:Drymouth.Systemiccorticosteroideffects,especiallyifrecommendeddoseisexceeded.
注意事項
PregnancyCategory:C
Contraindications:ActiveorquiescentTB,especiallyoftherespiratorytract.Untreatedfungal,bacterial,systemicviralinfections.Ocularherpessimplex.Useuntilhealingoccursfollowingrecentulcerationofnasalseptum,nasalsurgery,ortrauma.Lactation.
SpecialConcerns:Safetyandeffectivenessinchildrenlessthan6yearsofagehavenotbeendetermined.
