![陳子林[武漢大學藥學院教授]](/img/d/e9d/nBnauM3XxYTO2ITN5EDN2YTM1UTM1QDN5MjM5ADMwAjMwUzLxQzLyYzLt92YucmbvRWdo5Cd0FmLzE2LvoDc0RHa.jpg "陳子林[武漢大學藥學院教授]")
人物簡介
歷任江西工業大學助教（ 1984 － 1988 ）、中德聯合研究院講師（ 1991 － 1996 ）、東京都立大學日本學術振興會 (JSPS)特別研究員（ 2000 － 2002 ）、日本NTT先端技術綜合研究所博士後研究員（ 2002 － 2004 ）、 美國聖母大學 (University of Notre Dame) 研究助理教授 （ 2004 － 2007，2），現任武漢大學珞珈學者特聘教授、博士生導師、藥學院副院長、藥物分析與篩選研究所所長、藥學實驗中心主任。
業績概要
以中、英、日三國文字在國內外學術刊物上共發表論文60餘篇，其中SCI收錄論文38篇，論文被二十餘種國內外學術刊物（SCI源）引用600 次（他引500 次）。合著專著 2 部 (Elsevier 出版社 , Transworld Research Network 出版社 ) 。 2002 年獲日本分析化學會關東分會“ 新世紀獎”，2003 年 獲 日本色 譜 科學會 “ 獎 勵 獎 ” 。
人物學歷
江西大學化學系理學學士（1984）
武漢大學化學系理學碩士 （1991）
日本東京都立大學套用化學系工學博士（2000）
社會兼職
Editorial board, Drug Discoveries & Therapeutics
Associate Editor, Journal of Pharmaceutical Analysis
編委, 醫藥導報
中國藥學會藥物分析專業委員會委員
教育部藥學類專業教學指導委員會委員
國家留學基金評審專家
教育部留學回國人員啟動基金評審專家
國家自然科學基金評審專家
武漢市醫藥行業協會常務副會長
業績概要
以中、英、日三國文字在國內外學術刊物上共發表論文80餘篇，其中SCI收錄論文50餘篇，論文被二十餘種國內外學術刊物（SCI源）引用600餘次（他引500餘次）。合著專著2部(Elsevier出版社, Transworld Research Network出版社)。
獲獎
2002年 日本分析化學會關東分會 “新世紀獎”
2003年 日本色譜科學會 “獎勵獎”
2010 年武漢大學醫學部“2008-2009年度醫學突出貢獻獎”
2012年 武漢大學優秀本科教學管理工作者
2013年 武漢大學“朱裕璧醫學獎”
2014年 武漢大學“2013年度醫學突出貢獻獎”
研究領域:藥物分析學
研究興趣與方向
生物及藥物樣品的微柱色譜、電泳分離及其與質譜聯用技術
微/納流控分析裝置的研製及集成化
生物感測器及藥物分子識別材料
疾病診斷標記物的分析新方法
藥物篩選與質量控制
藥物代謝動力學
承擔課題
在研項目：
1．國家自然科學基金面上項目：基於雌激素受體及芳香化酶靶向識別分析新方法 及其在抗乳腺癌藥物分析中套用（Grant No. 21375101, 2014-2017）
2. 湖北省自然科學基金重點項目:新型固相微萃取-色譜-質譜聯用技術及其在腫 瘤診斷標誌物篩選中 套用（Grant No. 2014CFA077， 2014-2016)
3. 教育部博士點博導基金(Grant No. 20110141110024, 2012-2014)
4. 武漢市科技局套用基礎研究計畫項目：抗乳腺癌藥物篩選與分析新技術（GrantNo：20140601001010057， 2014-2015）
已結題項目
1．國家自然科學基金重大研究計畫重點項目:茉莉酸類植物激素高效分離與高靈敏度檢測及其在水稻穎花開放機理研究中套用（Grant No：90817103， 2009-2012）
2. 國家自然科學基金面上項目： 二醯胺類手性矽膠整體柱技術及雜環類手性藥物分離分析新方法研究 (Grant No: 30973672, 2010-2012)
3．國家自然科學基金面上項目：新型毛細管電色譜－電噴霧離子化－質譜聯用技術及其在生物與藥物分析中的套用研究 （Grant No:20775055, 2008-2010）
4．教育部留學回國人員啟動基金（No.教外司留[2008]890）
5．中央高校專項研究基金 (Grant Nos: 306275547, 306275866, 2010-2011)
6．湖北省自然科學基金“基於生物感測識別中藥有效成分篩選分析新方法”（Grant No 2011CDB475, 2011-2012)
7．武漢綜合性新藥研究開發技術大平台(參加.負責人：吳建國,No.2009ZX09301-14)
8. 武漢大學“珞珈學者特聘教授”啟動基金（Grant Nos: 306276216, 306271159）
教學
1． 本科生課程：中藥分析、儀器分析
2． 藥學院研究生必修課程：藥物分離與檢測科學
藥物分析專業研究生必修課程：藥物分析前沿文獻導讀
3. 研究生班：綜合藥物分析
近年論文
(2007以來)
2014
1. H. Zhao, Z. Chen*, Screening of neuraminidase inhibitors from traditional Chinese medicines by integrating capillary electrophoresis with immobilized enzyme microreactor, J. Chromatogr. A, 1340(2014)139-145.
2. W. Zhang, Z. Zhang, J. Zhang, J. Meng, T. Bao, Z. Chen*, Covalent immobilization of graphene onto stainless steel wire for jacket-free stir bar sorptive extraction, J.Chromatogr. A, 1351(2014)12-20.
3. J. Zhang, W. Zhang, T. Bao, Z. Chen*, Enhancement of capillary electrochromatographic separation performance by conductive polymer in a layer-by-layer fabricated graphene stationary phase, J. Chromatogr. A,1339(2014)192-199.
4. W. Zhang, Z. Zhang, J. Meng, W. Zou, Z. Chen*, Adsorptive behavior and solid-phase microextraction of bare stainless steel sample loop in high performance liquid chromatography, J. Chromatogr. A, 1365(2014)19-28.
5. J. Zhang, W. Zhang, T. Bao, Z. Chen*, Mussel-inspired polydopamine-assisted hydroxyapatite as stationary phase for capillary electrochromatography, Analyst, 139(2014)242-250.
6. H. Zhao, Z. Chen*, Screening of neuraminidase inhibitors from traditional Chinese medicines by transverse diffusion mediated capillary electrophoresis, Biomicrofluidics, 8 (2014) 052003
7. L. Ren, H. Zhao, Z. Chen*, Study on pharmacokinetic and tissue distribution of lycorine in mice plasma and tissues by liquid chromatography–mass spectrometry, Talanta, 119(2014)401-406
8. Y. Chen, Q. Xiang, Z. Chen*, Simultaneous and highly sensitive quantification of five bioactive components in Fructus Psoraleae and in rat plasma by HPLC with fluorescent detection, Anal. Methods, 2014, 6 (1), 269 - 275
9. J. Chen, J. Zhang, W. Zhang, Z. Chen*, Sensitive determination of potential biomarker sarcosine for prostate cancer by liquid chromatography-mass spectrometry with DCC derivatization, J. Sep. Sci. 37(2014)14-19.
10. Y. Long, W. Zhang, F. Wang, Z. Chen*,Simultaneous determination of three curcuminoids in Curcuma longa L. by high performance liquid chromatography coupled with electrochemical detection, J. Pharm. Anal. 4(2014)325-330
11. W. Zhang†, W. Zhou†, Z. Chen,Graphene/polydopamine-modified polytetrafluoroethylene micro-tube for sensitive determination of three active components in Fructus Psoraleae by online solid-phase microextraction-high performance liquid chromatography, J. Sep. Sci. 2014, in press. (†co-first author)
12. W. Ma, P. Gao, J. Fan, Y. Hashi*, Z. Chen*,Determination of breath gas composition of lung cancer patients using gas chromatography/mass spectrometry with monolithic material sorptive extraction, Biomedical Chromatography, 2014, in press.
13. 13. Q. Xiang, Y. Chen, Z. Chen*, Sensitive and simultaneous determination of active components in Lycoris radiata by high-performance liquid chromatography with fluorescence detection, Anal. Methods, 2014, in press.
2013
1. W. Zhang, J. Zhang, T. Bao, W. Zhou, J. Meng, Z. Chen*, Universal multilayer assemblies of graphene in chemically resistant micro-tubes for microextraction, Anal. Chem. 85(2013)6845-6854.
2. L. Wang, P. Hu, X. Deng, F. Wang, Z. Chen*, Fabrication of Electrochemical NO sensor Based on Nanostructured Film and Its Application in Drug Screening, Biosensors & Bioelectronics, 50(2013)57-61.
3. W. Ma, S. Fu, Y. Hashi, Z. Chen*, Determination of chiral jasmonates in flowers by GC-MS after monolithic material sorptive extraction, J.Agric & Food Chem. 61(2013)6288-6292.
4. H. Zhao, Z. Chen*, Screening of aromatase inhibitors from traditional Chinese medicines by electrophoretically mediated microanalysis in partially filled capillary, J. Sep. Sci. 36(2013)2691-2697.
5. W. Zhang, Z. Chen*, Mussel inspired polydopamine functionalized poly(ether ether ketone) tube for online solid-phase microextraction-high performance liquid chromatography and its application in analysis of protoberberine alkaloids in rat plasma, J. Chromatogr. A, 1278(2013)29-36.
6. W. Zhang, J. Du, C. Su, L. Zhu, Z. Chen*, Development of β-cyclodextrin- modified silica and polyporous polymer particles for solid-phase extraction of methyl jasmonate in aqueous and plant samples, Anal. Lett. 46(2013) 900-911.
7. F. Wang, X. Sun, Y. Chen, S. Xie, Z. Chen*,Non-enzymatic Glucose Sensor Based on Copper Nanoparticles Modified Microelectrode, Nanosci. and Nanotech. Lett, 5(2013)624-629.
8. J. Liu, J. Zhang, Z. Chen*, Determination of bavachinin enantiomers in Fructus Psoraleae and rat plasma by liquid chromatography using permethylated-β-CD as a chiral selector, J. Pharm. Anal. 5(2013) 349-353.
9. X. Mou, W. Zhang, Z. Chen*，Highly selective extraction of baicalin in natural herbs and medicinal preparations by molecularly imprinted polymer, J. Applied Polymer Sci. 130(2013)1873-1878.
10. Y. Rang, W. Zhang, Z. Chen*, Determination of kynurenine and tryptophan in human plasma by stacking-micellar electrokinetic chromatography, Anal.Lett. 46(2013)2503-2513.
11. H. Zhao, Z. Chen*, An HPLC-ESI-MS method for Analysis of loureirin A and B in dragon’s blood and Application in Pharmacokinetics and tissue distribution in rats, Fitoterapia, 86(2013)149-158.
12. Y. Zhang, Z. Chen*, Nonaqueous Capillary Electrophoresis Electrospray Ionization-Ion Trap-Mass Spectrometric Analysis of Amaryllidaceae Alkaloids, J. Sep.Sci. 36(2013)1078-1084.
13. Y. Chen, Z. Chen*, Simultaneous separation of jasmonic acid conjugates with amino acids by micellar electrokinetic chromatography, J. Sep. Sci., 36(2013)892-897.
14. J. Zhang, Z. Chen*, Determination of matrine and oxymatrine in Sophora Flavescens by non-aqueous capillary electrophoresis-electrospray ionization-ion trap-mass spectrometry, Anal. Lett. 46(2013)651-662.
15. Q. Chen, W. Zhang, Y. Zhang, J. Chen, Z. Chen*, Identification and quantification of active alkaloids in Catharanthus roseus by liquid chromatography-ion trap mass spectrometry, Food Chem. 139(2013)845-852.
16. Y. Chen, Z. Chen*, Fluorescein-core piperazine as a fluorescent labeling reagent for highly sensitive determination of jasmonic acid by high-performance liquid chromatography, Anal. Method, 5(2013)1733-1738.
17. Q. Chen, J. Zhang, W. Zhang, Z. Chen*, Analysis of active alkaloids in family Menispermaceae by nonaqueous capillary electrophoresis- ion trap mass spectrometry, J. Sep. Sci. 36(2013)341-349.
18. S. Xie, F. Wang, Z. Chen*, Determination of Endogenous Jasmonic Acid in Plant Samples by Liquid Chromatography-Electrochemical Detection Based on Derivatization with Dopamine, Analyst, 128(2013)1226-1231.
19. W. Zhang, Z. Chen*, A polymer monolith microextraction coupled with HPLC for determination of jasmonates in wintersweet flowers, Anal. Lett. 46(2013)74-86.
20. W. Zhang, Z. Chen*, Preparation of micropipette tip-based molecularly imprinted monolith for selective micro-solid phase extraction of berberine in plasma and urine samples, Talanta, 103(2013)103-109.
2012
1. J. Zhang, T. Bao, Z. Chen*, Determination of polycyclic aromatic hydrocarbons on polymeric SMA-EGDMA mononlith column by capillary electrochromatography, Anal. Method. 4(2012)4140-4145.
2. J. Chen, Q. Chen, Z. Chen*Enhancing Sensitivity of Liquid Chromatographic/Ion-trap Mass Spectrometric Determination of Jasmonic Acid by Derivatization with N, N –Dicyclohexylcarbodiimide, Analyst,137( 2012)5436-5440.
3. Y. Wu, W. Zhang, Z. Chen*, A poly (4-vinylpridine-co-ethylene glycol dimethacrylate) monolithic concentrator for in-line concentration-capillary electrophoresis analysis of phenols in water samples, Electrophoresis, 33(2012)2911-2919.
4. X. Dang, C. Dang, Z. Chen, S. Wang, S. Hu, Electrochemical characteristics of cis-jasmone in acid media at multi-wall carbon nanotube-Nafion composite film modified electrode and its analytical application, Electrochem. Acta, 81(2012)239-245.
5. Y. Zhang, Z. Chen*, Separation of isomeric bavachin and isobavachalcone in the Fructus Psoraleae by capillary electrophoresis-electrospray-mass spectrometry, J. Sep. Sci. 35(2012)1644-1650.
6. L. Liu, Z. Chen*, Analysis of four alkaloids of Coptis chinensis in rat plasma by high performance liquid chromatography with electrochemical detection, Anal. Chim. Acta, 737(2012)99-104.
7. S. Fu, J. Fan, Y. Hashi*, Z. Chen*, Determination of polycyclic aromatic hydrocarbons in water samples using online microextraction by packed sorbent coupled with gas chromatography-mass spectrometry, Talanta, 94(2012)152-157.
8. Y. Zhang, L. Huang, Q. Chen, Z. Chen*, A silica monolithic column chemically bonded L-pipecolic acid as chiral stationary phase for enantiomeric separations of dansyl amino acids by capillary electrochromatography-mass spectrometry, Chromatographia, 75(2012)289-296.
9. Q.Chen, Y. Li, Z. Chen*, Separation, identification and quantification of active constituents in Fructus Psoraleae by high-performance liquid chromatography with UV, ion trap mass spectrometry and electrochemical detection, J. Pharma. Anal. 2(2012)143-151.
10. L. Liu, S. Li, Z. Chen*, Simultaneous determination of tetrandrine and fangchinoline in herbal medicine Stephania tetrandra S. Moore by liquid chromatography with electrochemical detection, J. Pharma.& Biomed. Anal. 61(2012)251-255.
2011
1. F. Yan, F. Wang, Z. Chen*, label-free aptamer-based biofunctional electtrochemical biosensor for thrombin and adenosine, Sensors and Actuators B Chemical. 160(2011)1380-1385.
2. Q. Chen, N. Li, W. Zhang, J. Chen and Z. Chen*, Simultaneous determination of vinblastine and its monomeric precursors vindoline and catharanthine in Catharanthus roseus by capillary electrophoresis-mass spectrometry, J. Sep. Sci. 34(2011)2885-2892
3. Q. Chen, Y. Zhang, W. Zhang, Z. Chen*, Identification and quantification of oleanolic acid and ursolic acid in Chinese herbs by liquid chromatography-ion trap mass spectrometry, Biomed. Chromatogr. 25(2011)1381-1388.
4. Q. Chen, S. Luo, Y. Zhang, Z. Chen*, Development of a liquid chromatography-mass spectrometry method for the determination of ursolic acid in rat plasma and tissue: Application to the pharmacokinetic and tissue distribution study, Anal. Bioanal Chem. 399(2011)2877-2884.
5. Y. Li, F. Wang, Z. Chen*, Determination of bavachin and isobavachalcone in Fructus Psoraleae by high-performance liquid chromatography with electrochemical detection, J. Sep. Sci. 34(2011) 514-519.
6. F. Wang, X. Chen, Z. Chen*, Eletrodeposited nickel oxide on a film of carbon nanotubes
For monitoring nitric oxide release from rat kidney and drug samples，Microchim. Acta, 173(2011)65-72.
7. L. Liu, Y. Chen, Y. Zhang, F. Wang and Z. Chen*, Determination of tryptophan and kynurenine in human plasma by liquid chromatography-electrochemical detection with multi-wall carbon nanotube-modified glassy carbon electrode, Biomed. Chromato., 25(2011)938-942.
8. F. Wang, X. Deng, W. Wang, Z. Chen*, Nitric oxide measurement in biological and pharmaceutical samples by a novel electrochemical sensor, J. Solid State Electrochem., 15(2011)829-836.
9. L. Yang, Z. Chen*, Direct evaluation of ligand-receptor interaction by a novel imaging model based on fluorescent silica nanoparticle as ligand probe and molecular imprinting polymer as artificial receptor, Anal. Lett. 44(2011)687-697
10. Tian Gan, Chengguo Hu, Zilin Chen, Shengshui Hu, A disposable electrochemical sensor for the determination of indole–3–acetic acid based on poly(safranine T)–reduced graphene oxide nanocomposite, Talanta，85(2011)310-316
11. Tian Gan, Chengguo Hu, Zilin Chen, Shengshui Hu, Novel electrocatalytic system for the oxidation of methyl jasmonate based on layer-by-layer assembling of montmorillonite and phosphotungstic acid nanohybrid on graphite electrode, Electrochimica Acta, 56(2011)4512-4517
12. X. Dang, C. Hu, Z. Chen，S. Hu, A novel electrochemical method for determination of cis-jasmone based on enhancement effect of cetyltrimethylammonium bromide, J. Electroanal. Chem., 657(2011)39-45
2010
1. W. Zhang, Y. Wu, Y. Chen, H. Jiang, Z. Chen*, Simultaneous separation of four metal ions by capillary electrophoresis using bis (2-pyridylmethyl) (8-pyridylmethyloxy-quinoline-2-methyl)-amine as chelating agent, Chromatographia, 72(2010)1201-1205.
2. T. Gan, C. Hu, Z. Chen, S. Hu*, Direct electrochemical determination of methyl jasmonate in wheat spikelet at a nano-montmorillonite film modified electrode by derivative square wavevoltammetry, J. Agric Food Chem.,58(2010)8942-8947.
3. T. Gan, C. Hu, Z. Chen, S. Hu*, Fabrication and application of a novel plant hormone sensor for the determination of methyl jasmonate based on self-assembling of phosphotungstic acid-graphene oxide nanohybrid on graphite electrode, Sensor and Actuators B: Chemical, 151(2010)8-14.
4. Y. Liao, F. Wang, Z. Chen*, Electrochemical behavior and the determination of methyl jasmonates, Chinese Sci. Bull, 55(21)(2010)2225-2230
5. X. Deng, F. Wang Z. Chen*, A novel electrochemical sensor based on nano-structured film electrode for monitoring nitric oxide in living tissues, Talanta, 82(2010)1218-1224.
6. F. Wang, Y. Liao, Y. Ren, Z. Chen*, A novel method for D-arabinitol determination based on a nano-structured sensing film by one-step electrodeposition, Microchim. Acta, 17(2010)9-15, 2009.
7. Q. Chen, S. Weißig, S. Luo, Z. Chen*, Simultaneous determination of five anti-epilepsy drugs in human plasma using liquid chromatography-mass spectrometry, Sci China B Chem, 53(2010)2373-2378.
2009
1. L. Liu, Z. Chen*, “Separation of small molecular peptides with the same amino acid composition but different sequences by high performance liquid chromatography-electrospray ionization-mass spectrometry”, Sci China B Chem, 52(12) (2009)2264-2268.
2. Y. Weng, Z. Chen*, F. Wang, L. Xue H. Jiang "High sensitive determination of zinc with novel water-soluble small molecular fluorescent sensor" Anal. Chim. Acta, 647(2009) 215-218.
3. D. Feng, F. Wang, Z. Chen*, “Electrochemical glucose sensor based on one step construction of gold nanoparticle-chitosan composite film”, Sensors & Actuators: B. Chemical, 138 (2009) 539-544
4. Y. Wu, J. Xie, F. Wang, Z. Chen*, ‘Separation of small molecular peptides with same amino acid composition and different sequences by capillary electrophoresis’, J. Sep. Sci. 32(2009)437-440.
2008
1. X. Chen, F. Wang, Z. Chen*, “An electropolymerized Nile Blue sensing film-based nitrite sensor and application in food analysis”, Anal. Chim.Acta, 623(2008)213-220.
2. Y. Wu, J. Xue, F. Wang, Z. Chen*, ‘Electrokinetic separation of peptides and proteins using polyvinylamine-coated capillary with UV and ESI-MS detections’, J. Sep. Sci. 31(2008) 814-823.
2007
1. Z. Chen, B. Boggess, H. C. Chang, ‘Open-tubular capillary electrochromatography-mass spectrometry with sheathless nanoflow electrospray ionization for analysis of amino acids and peptides’, J. Mass Spec. 42(2007)244-253.
2. Z. Chen, F.-C. Hsu, D. Battigelli, H. C. Chang, ‘Capture and release of virus using amino-funcitonalized silica particles, Anal. Chim. Acta, 569(2006)76-82.
3. P. Wang, Z. Chen, and H. C. Chang, ‘An integrated micropump and electrospray emitter based on porous silica monliths’, Electrophoresis, 27(2006)3964-3970.
4. P. Wang, Z. Chen, and H. C. Chang, ‘A new electroosmotic pump based on silica monoliths’, Sensors and Actuators B, 113 (2006)500-509.
5. C. Hu, Z. Chen, A. Shen, X. Shen, J. Li, S.S.Hu, ‘Water-soluble single-walled carbon nanotubes via noncovalent functionalization by rigid, planar and conjugated diazo dye’ Carbon, 44(2006)428-434.
6. Z. Chen, P. Wang, H. C. Chang, ‘An electroosmotic micro-pump based on monolithic silica for micro flow analyses and electrosprays’, Anal.& Bioanal. Chem., 382(2005)817-824.
7. Z. Chen, H. C. Chang, T. Hobo, ‘Application of monolithic silica matrix in microfluidic analysis’(invited), Bunseki Kagaku (Japanese Anal. Chem.), 54(2005)583.
8. Z. Chen, K. Hayashi, Y. Iwasaki, R. Kurita, O. Niwa, K. Sunagawa, ‘On-line monolithic enzyme reactor fabricated by sol-gel process for elimination of ascorbic acid while monitoring dopamine’, Electroanalysis. 17 (2005)231-238.
9. Z. Chen, K. Uchiyama, T. Hobo, ‘Chiral resolution of dansyl amino acids by ligand exchange capillary electrophoresis using Cu(II)-L-Prolinamides as chiral selectors’ Anal. Chim. Acta, 523(1)(2004)1-7.
10. Z. Chen, T. Fuyumuro, K. Watabe, T. Hobo, ‘Influence of spacers and organic modifiers on chromatographic behaviors on chiral diamide stationary phase with N-(3,5-Dimethylbenzoyl)-D-phenylglycine’ Anal. Chim. Acta, 518(1-2)(2004) 181-189.
11. Z. Chen, T. Nishiyama, K. Uchiyama, T. Hobo, ‘Electrochromatographic enantioseparation using chiral ligand exchange monolithic sol-gel column’ Anal. Chim. Acta, 501(1)(2004) 17-23.
12. T. You, O. Niwa, Z. Chen, K. Hayashi, M. Tomita, S. Hirono, ‘A novel amperometric detector formed of highly dispersed Ni nano-particles embedded in a graphite-like carbon film electrode for sugar determination’, Anal. Chem. 75 (2003) 5191-5196.
13. H. Ozawa, Z. Chen, K. Kawata, T. Nakagama, K. Uchiyama, T. Hobo, ‘Capillary electrochromatographic behaviors of dansyl amino acid enantiomers on cyclodextrin-immolilized monolithic silica column’, Bunseki Kagaku, (Japanese Anal. Chem.) 52(12)(2003)1105-1112.
14. T. Nishiyama, Z. Chen, T. Nakagama, K. Uchiyama, T. Hobo, ‘Separation of dansyl amino acid enantiomers by ligand exchange capillary electrochromatography ushing L-lysinamide-modified monolithic silica column’, Bunseki Kagaku (Japanese Anal. Chem.), 52(2003)1005-1010.
15. Z. Chen, M. Niidzma, K. Uchiyama and T. Hobo, ‘Comparisons of enantioseparations using Cu(II) complexes with L-amino acid amides as chiral selectors or chiral stationary phases by CE, CEC and micro-LC’, J. Chromatogr. A, 990 (2003) 75-82.
16. Z. Chen, H. Ozawa, K. Uchiyama and T. Hobo, ‘Cyclodextrin-modified monolithic silica column for resolving of dansyl amino acid enantiomers and positional isomers by capillary electrochromatography’, Electrophoresis, 24(15)(2003)2550-2558.
17. Z. Chen, T. Fuyumuro, T. Nakagama, K. Uchiyama and T. Hobo, ‘New diamide-type chiral stationary phase for chiral separations by normal and reverse phases HPLC’, J. Liquid Chromatogr. & Related Tech., 26(13)(2003)2103-2117.
18. Z. Chen, T. Nakayama, T. Nakagama, K. Uchiyama and T. Hobo, ‘Thermodynamic Approaches to Intermolecular Interaction and Retention Behaviors in Liquid Chromatography’, J. Liquid Chromatogr. & Relative Tech., 26(17)(2003)2809-2838.
19. Z. Chen, K. Uchiyama and T. Hobo, ‘Chemically modified chiral monolithic silica column for the enantioseparation by m-HPLC’, J. Chromatogr. A, 942(2002) 83-91.
20. Z. Chen, M. Niidzma, T. Nakagama, K. Uchiyama and T. Hobo, ‘Enantioseparations of dansyl amino acids unsing Cu(II) complexes with L-amino acylamides as chiral selectors in electrolytes by capillary electrophoresis’, J. Sep. Sci, 25(2002)1197-1201.
21. Z. Chen and T. Hobo, ‘Chemically L-phenylalaninamide-modified monolithic silica column prepared by sol-gel process for enantioseparation of dansyl amino acids by ligand exchange-capillary electrochromatography’, Anal. Chem., 73 (2001) 3348-3357.
22. Z. Chen and T. Hobo, ‘Chemically L-prolinamide-modified monolithic silica column for enantiomeric separation of hydroxy acids and dansyl amino acids by capillary electrochromatography and m-HPLC’, Electrophoresis, 22 (2001) 3339-3346.
23. Z. Chen, K. Uchiyama and T. Hobo, ‘Interaction between 18-crown-6-tetracarboxylic acid and positional substituents of enantiomers and simultaneous separation of positional enantiomers of methyl-DL-tryptophans by capillary electrophoresis’, Electrophoresis, 22 (2001) 2136-2142.
24. Z. Chen, K. Yamada, M. Niitsuma, K. Uchiyama and T. Hobo, ‘Separation selectivity in micellar electrokinetic chromatography using different anionic surfactants as pseudo-stationary phases’, Chromatographia, 54 (2001) 629-633.
25. Z. Chen, K. Uchiyama and T. Hobo, ‘18-crown-6-tetracarboxylic acid as a chiral additive for the simultaneous separation of o-, m- and p-enantiomers of phenylalanine family by capillary electrophoresis’, Enantiomer, 6 (2001) 19-25.
26. Z. Chen, ‘Ligand exchange-micellar electrokinetic chromatography and its applications’ (Digest of doctoral dissertation in Japanese), Bunseki Kagaku (Japanese Anal. Chem.), 49 (2000) 713-714.
27. Z. Chen, K. Uchiyama and T. Hobo, ‘Estimation of formation constants of ternary Cu(II) complexes with mixed amino acid enantiomers based on ligand exchange by capillary electrophoresis’, Anal. Sci., 16(8) (2000) 837-841.
28. Z. Chen, K. Uchiyama and T. Hobo, ‘Separation of hydroxy acid enantiomers by ligand exchange-micellar electrokinetic chroamtography’ (in Japanese), Bunseki Kagaku (Japanese Anal. Chem.), 49(10) (2000) 759-764.
29. Z. Chen, J. Lin, K. Uchiyama and T. Hobo, ‘Determination of critical micelle concentration of anionic surfactants by ligand exchange micellar electrokinetic chromatography’, Anal. Chem. Acta, 403 (2000) 173-178.
30. Z. Chen, J. Lin, K. Uchiyama and T. Hobo, ‘Reversal behavior of the enantiomers migration order and the stereo-selectivity of Cu(II) complex with amino acid enantiomers in ligand-exchange micellar electrokinetic chromatography’, Anal. Sci., 16(2) (2000) 131-137.
31. Z. Chen, J. Lin, K. Uchiyama and T. Hobo, ‘Simultaneous separation of sixteen positional and optical isomers of the tryptophan family by ligand-exchange micellar electrokinetic chromatography’, Chromatographia, 49 (1999) 436-443.
32. Z. Chen, J. Lin, K. Uchiyama and T. Hobo, ‘Separation behavior of amino acid enantiomers in ligand-exchange micellar electrokinetic chromatography’, J. Microcol. Sep., 11 (1999) 534-540.
33. Z. Chen, J. Lin, K. Uchiyama and T. Hobo, ‘Simultaneous separation of o-, m-, p-fluoro-DL-phenylalanine and o-, m-, p-DL-tyrosine by ligand exchange micellar electrokinetic capillary chromatography’, J. Chromatogr. A, 813 (1998) 369-378.
34. Z. Chen, G. Xu, K. Specht, R. Yang and S. She, ‘Determination of taurine in biological samples by reversed-phase liquid chromatography with precolumn derivatization with dinitrofluorobenzene’, Anal. Chim. Acta, 296 (1994) 249-253.
35. S. S. Hu, Z. Chen and T. Zhang, ‘Adsorptive stripping voltammetry of testosterone propionate in pharmaceutical preparations’, Fresenius’ J. Anal. Chem., 346 (10-11) (1993) 1008-10.
