人物簡介
教授、博導 ，2006年起任美國國立衛生研究院等基金會的評審專家，多種重要國際期刊的審稿人，獲得美國國立衛生研究院等單位15個基金項目
學科專業
生物化學、分子醫學、藥理學
研究方向
神經膠質細胞及幹細胞研究、藥物研究與開發
代表性論文
（共發表具有一定影響的學術論文81篇）
Jiang P(#), Chen C(#), Liu XB, Pleasure DE, Liu Y, Deng W(*), Human iPSC-Derived Immature Astroglia Promote Oligodendrogenesis by Increasing TIMP-1 Secretion., Cell Reports，2016.5.10, 15（6）:1303-15
Daugherty DJ(#), Chechneva O, Mayrhofer F, Deng W(*), The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis., Scientific Reports, 2016.3.1, 6（22556）
Liu XB(#), Shen Y, Pleasure DE, Deng W(*), The vulnerability of thalamocortical circuitry to hypoxic-ischemic injury in a mouse model of periventricular，BMC Neuroscience，2016.1.5, 17（2）
Tian Z (#), Guo F, Biswas S, Deng W(*), Rationale and Methodology of Reprogramming for Generation of Induced Pluripotent Stem Cells and Induced Neural Progenitor Cells., International Journal of Molecular Sciences, 2016.4.20, 17（4）
Liu Y (#), Deng W(*), Reverse engineering human neurodegenerative disease using pluripotent stem cell technology，Brain Research，2016.5.1，1368（(PtA)）:30-41
Chen C(#), Chan A, Wen H, Chung SH, Jiang P(*), Deng W(*), Stem and Progenitor Cell-Derived Astroglia Therapies for Neurological Diseases.，Trends in Molecular Medicine, 2015.11.1, 21（11）：715-29
Chung SH(#), Biswas S, Selvaraj V, Liu XB, Sohn J, Jiang P, Chen C, Chmilewsky F, Marzban H, Horiuchi M, Pleasure DE, Deng W(*), The p38α mitogen-activated protein kinase is a key regulator of myelination and remyelination in the CNS.，Cell Death & Disease, 2015.5.7，6（e1748）
Xiao J(#), Yang R, Biswas S, Qin X, Zhang M, Deng W(*), Mesenchymal stem cells and induced pluripotent stem cells as therapies for multiple sclerosis.，International Journal of Molecular Sciences，2015.5.24，16（5）：9283-302
Chen C (#), Jiang P (#), Xue H, Peterson SE, Tran HT, McCann AE, Parast MM, Li S, Pleasure DE, Laurent LC, Loring JF, Liu Y, Deng W(*), Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells.，Nature Communications，2014.7.18，5（4430）
Chechneva OV(#), Mayrhofer F, Daugherty DJ, Krishnamurty RG, Bannerman P, Pleasure DE, Deng W (*), A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury.，Cell Death & Disease，2014.10.23，5（e1481）
Lo U(#), Selvaraj V, Plane JM, Chechneva OV, Otsu K, Deng W(*), p38α (MAPK14) critically regulates the immunological response and the production of specific cytokines and chemokines in astrocytes., Scientific Reports，2014.12.12，4（7405）
Jiang P(#), Chen C(#), Wang R, Chechneva OV, Chung SH, Rao MS, Pleasure DE, Liu Y, Zhang Q, Deng W(*), hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury.，Nature Communications，2013.01.01，4（2196）
Daugherty DJ(#), Selvaraj V，Chechneva OV，Liu XB，Pleasure DE, Deng W(*), A TSPO ligand is protective in a mouse model of multiple sclerosis EMBO Mol Med., 2013.6.1, 5（6）：891-903
Chung SH(#), Guo F, Jiang P, Pleasure DE, Deng W(*), Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum.，Cell Death &Disease，2013.3.14，4（e546）
Calafiore M(#), Copani A, Deng W(*), DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres., Journal of Neuroscience Research，2013.3.1, 90（3）：559-67
Liu XB(#), Shen Y, Plane JM, Deng W(*), Vulnerability of premyelinating oligodendrocytes to white-matter damage in neonatal brain injury.，Neuroscience Bulletin，2013.4.1，29（2）：229-38
Shen Y(#), Liu XB, Pleasure DE, Deng W(*), Axon-glia synapses are highly vulnerable to white matter injury in the developing brain.，Journal of Neuroscience Research, 2012.1.1，90（1）：105-21
Plane JM(#), Grossenbacher SK, Deng W (*), PARP-1 deletion promotes subventricular zone neural stem cells toward a glial fate.，Journal of Neuroscience Research，2012.8.1，90（8）：1489-506
Liu Y(#), Jiang P, Deng W(*), OLIG gene targeting in human pluripotent stem cells for motor neuron and oligodendrocyte differentiation.，Nature Protocols，2011.5.1，6（5）
Liu W(#), Shen Y, Plane JM, Pleasure DE, Deng W(*), Neuroprotective potential of erythropoietin and its derivative carbamylated erythropoietin in periventricular leukomalacia., Experimental Neurology，2011.8.1, 230（2）：227-39
1.Jiang P(#), Chen C(#), Liu XB, Pleasure DE, Liu Y, Deng W(*), Human iPSC-Derived Immature Astroglia Promote Oligodendrogenesis by Increasing TIMP-1 Secretion., Cell Reports，2016.5.10, 15（6）:1303-15
2.Daugherty DJ(#), Chechneva O, Mayrhofer F, Deng W(*), The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis., Scientific Reports, 2016.3.1, 6（22556）
3.Liu XB(#), Shen Y, Pleasure DE, Deng W(*), The vulnerability of thalamocortical circuitry to hypoxic-ischemic injury in a mouse model of periventricular，BMC Neuroscience，2016.1.5, 17（2）
4.Tian Z (#), Guo F, Biswas S, Deng W(*), Rationale and Methodology of Reprogramming for Generation of Induced Pluripotent Stem Cells and Induced Neural Progenitor Cells., International Journal of Molecular Sciences, 2016.4.20, 17（4）
5.Liu Y (#), Deng W(*), Reverse engineering human neurodegenerative disease using pluripotent stem cell technology，Brain Research，2016.5.1，1368（(PtA)）:30-41
6.Chen C(#), Chan A, Wen H, Chung SH, Jiang P(*), Deng W(*), Stem and Progenitor Cell-Derived Astroglia Therapies for Neurological Diseases.，Trends in Molecular Medicine, 2015.11.1, 21（11）：715-29
7.Chung SH(#), Biswas S, Selvaraj V, Liu XB, Sohn J, Jiang P, Chen C, Chmilewsky F, Marzban H, Horiuchi M, Pleasure DE, Deng W(*), The p38α mitogen-activated protein kinase is a key regulator of myelination and remyelination in the CNS.，Cell Death & Disease, 2015.5.7，6（e1748）
8.Xiao J(#), Yang R, Biswas S, Qin X, Zhang M, Deng W(*), Mesenchymal stem cells and induced pluripotent stem cells as therapies for multiple sclerosis.，International Journal of Molecular Sciences，2015.5.24，16（5）：9283-302
9.Chen C (#), Jiang P (#), Xue H, Peterson SE, Tran HT, McCann AE, Parast MM, Li S, Pleasure DE, Laurent LC, Loring JF, Liu Y, Deng W(*), Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells.，Nature Communications，2014.7.18，5（4430）
10.Chechneva OV(#), Mayrhofer F, Daugherty DJ, Krishnamurty RG, Bannerman P, Pleasure DE, Deng W (*), A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury.，Cell Death & Disease，2014.10.23，5（e1481）
11.Lo U(#), Selvaraj V, Plane JM, Chechneva OV, Otsu K, Deng W(*), p38α (MAPK14) critically regulates the immunological response and the production of specific cytokines and chemokines in astrocytes., Scientific Reports，2014.12.12，4（7405）
12.Jiang P(#), Chen C(#), Wang R, Chechneva OV, Chung SH, Rao MS, Pleasure DE, Liu Y, Zhang Q, Deng W(*), hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury.，Nature Communications，2013.01.01，4（2196）
13.Daugherty DJ(#), Selvaraj V，Chechneva OV，Liu XB，Pleasure DE, Deng W(*), A TSPO ligand is protective in a mouse model of multiple sclerosis EMBO Mol Med., 2013.6.1, 5（6）：891-903
14.Chung SH(#), Guo F, Jiang P, Pleasure DE, Deng W(*), Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum.，Cell Death &Disease，2013.3.14，4（e546）
15.Calafiore M(#), Copani A, Deng W(*), DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres., Journal of Neuroscience Research，2013.3.1, 90（3）：559-67
16.Liu XB(#), Shen Y, Plane JM, Deng W(*), Vulnerability of premyelinating oligodendrocytes to white-matter damage in neonatal brain injury.，Neuroscience Bulletin，2013.4.1，29（2）：229-38
17.Shen Y(#), Liu XB, Pleasure DE, Deng W(*), Axon-glia synapses are highly vulnerable to white matter injury in the developing brain.，Journal of Neuroscience Research, 2012.1.1，90（1）：105-21
18.Plane JM(#), Grossenbacher SK, Deng W (*), PARP-1 deletion promotes subventricular zone neural stem cells toward a glial fate.，Journal of Neuroscience Research，2012.8.1，90（8）：1489-506
19.Liu Y(#), Jiang P, Deng W(*), OLIG gene targeting in human pluripotent stem cells for motor neuron and oligodendrocyte differentiation.，Nature Protocols，2011.5.1，6（5）
20.Liu W(#), Shen Y, Plane JM, Pleasure DE, Deng W(*), Neuroprotective potential of erythropoietin and its derivative carbamylated erythropoietin in periventricular leukomalacia., Experimental Neurology，2011.8.1, 230（2）：227-39
