簡介
男，博士，首都師範大學教授。學術研究及工作經歷
1988 華中農業大學微生物專業 獲理學學士學位1991 華中農業大學微生物專業 獲理學碩士學位
1995 華中農業大學微生物系 獲博士學位
1991-1995 華中農業大學微生物系 擔任大學生“普通生物學”課程教學任務
1995-1997 中國農業大學 承擔碩士、博士生“分子系統學和微生物進化”全部課程，“細菌遺傳學”部分內容：分子細菌與植物的相互關係
1998-1999 阿拉巴馬大學，口腔醫學院(Birmingham, USA)博士後, 從事口腔微生物和口腔生物學研究
2000-2001 依利諾伊大學醫學院(Chicago, USA)助理研究員(Research associate),從事細胞調亡和癌症研究
2001-2002 依利諾伊大學醫學院(Chicago, USA)講師(Instructor), 從事細胞調亡和癌症研究
2003-現在 依利諾伊大學醫學院(Chicago, USA)助理研究教授(Assistant Research Professor/Assistant Professor), 從事細胞調亡和癌症以及分子藥物學研究
2005-現在 首都師範大學生命科學學院, 特聘教授, 從事細胞調亡和癌症以及分子藥物學研究
學術研究協會會員
American Association for Cancer Research
American Society for Microbiology
目前基金資助項目
2002-2005 Role of CDC25A in transformation and breast cancer development. (No. BC010557)美國國防部 .(CDMRP/Breast Cancer Research Program).共主持人(Co-Investigator)
2002-2007 Role of G1-Cdks in immortalization and oncogenesis. (No.CA100204) 美國衛生部(NIH/R01), 共主持人(Co-Investigator)
2006-2008 Cdk4在Ink4a/Arf/p53失活相關的乳腺癌中的作用(30571006)
國家自然科學基金, 主持人
2005-2010 Role of Cdks in B cell lymphoma (R01 CA113579)
美國衛生部(NIH/R01), 主持人
2007-2009 細胞周期蛋白依賴性激酶4在B細胞淋巴瘤中的作用。國家自然科學基金, 主持人
發表的文章
（部分）Zou X, F Li and H Chen (1997). Characteristics of different plasmids in Rhizobium huakuii strains. Current Microbiology, 35: 215-220.
Zou X, Feng X, Chen W and Li F (1998). Biological behavior of plasmid in Rhizobium sp.strain S25 from Tephrosia candida. Plasmid, 40:158-163.•Caufield P, Y Li and Zou X (1999). Evidence for clonality among African-derived strains of S. mutans. J. Dent. Res. 78, 290.
Zou X, P Caufield, Y Li and F Qi .(2001). Complete nucleotide sequence and characterization ofpUA140, a cryptic plasmid from Streptococcus mutans. Plasmid, 46:77-85
Zou X, Tsutsui T, Ray D, Blomquist JF, Ichijo H, Ucker DS and Kiyokawa H. (2001). The cell cycle-regulatory CDC25A phosphatase inhibits Apoptosis Signal-regulating Kinase 1 . Mol. Cell. Biol. 21:4818-4828.
Zou X, Ray D, Aziyu A, Christov-Tzelkov K, Boiko A, Gudkov A, Kiyokawa H.(2002). Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence. Genes Dev. 16: 2923- 2934.
Work featured in the selected news（相關研究被國內外新聞媒體大量的報導）
http://www.eurekalert.org/pub_releases/2002-11/cshl-sdr110102.php
http://www.ovarian.org/press.asp?releaseID=199
http://www.diariomedico.com/edicion/noticia/0,2458,207605,00.html
http://www.i-s-b.org/aktuelles/news/news02e.htm#cdk
http://bric.postech.ac.kr/trend/retrend/2002/0211/021119-4.html
Jirawatnotai S, Aziyu A, Osmundson E, Moons DS, Zou X, Kineman R, Kiyokawa H.(2004). Cdk4 is indispensable specifically for postnatal proliferation of somato/lactotrophsof the murine pituitary. JBC 279(49):51100-51106.
Ray D, Terao Y,Donzelli M,Ghosh AK,Tsutsui T, Zou X, Varga J, Draetta GF, Kiyokawa H. (2005). The Smad3-mediated signaling of TGF-beta facilitates proteasome-dependent degradation of Cdc25A. Mol. Cell. Biol. 25(8): 3338-3347.
Li Y , Caufield P, Qi F and Zou X. IS1216 and IS199, two functional insertion sequences (IS) in Streptococcus mutans isolated from human dental caries. (submitted).
Aziyu A, Hirai H, Kiyokawa H, Christov-Tzelkov K, Zou X. Cdk4 is required for developmental and oncogenic proliferation of p53-deficient cells. (submitted)
Sandoval R, Xue J, Tian X, Barrett K, Pilkinton M, Ucker DS, Raychaudhuri P, Kineman RD, Luque RM, Baida G, Zou X et al(2006). A mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by releasing the repression on E2F-regulated genes. Exp Cell Res. 1;312(13):2465-75.
其它
Zou X etc. (2005). Induction of Cellular Senescence by Cdk4 Disruption:A Prospective Tool for Tumor Suppression and Regression. (International Patent, ID
No: CW06/NPU)
擅長微生物發酵,曾獨立設計與創建兩個小型微生物發酵工廠
