個人簡介：
研究領域：
· 闡明代謝性氧化損傷引起神經元死亡的可能細胞、分子生物學機制，尋找能客觀反映老齡健康的生物學標記，和防治延緩老年性神經元死亡的分子靶點。
· 探討酒精濫用等環境因素對神經系統發育和衰老影響的細胞、分子生物學機制。
· 神經退行性疾病的營養干預。尋找可以延緩老年性神經退行性疾病的生物活性小分子。為神經退行性疾病的預防性營養干預和膳食指導提供生物學理論基礎。
近期論文：
Yang G, Meng Y, Li W, Yong Y, Fan Z, Ding HQ, Wei YZ, Luo J, Ke ZJ*. Neuronal MCP-1 Mediates Microglia Recruitment and Neurodegeneration Induced by the Mild Impairment of Oxidative Metabolism. Brain Pathol. 2011;21(3):279-297.
Yong Y, Ding H, Fan Z, Luo J, Ke ZJ*. Lithium Fails to Protect Dopaminergic Neurons in the 6-OHDA Model of Parkinson's disease. Neurochem Res. 2011, 36(3):367-74.
Lee SC, Yang G, Liu Y, Zhao L, Xu J, Zhang X, Wan Y, Feng C, Fan ZQ, Liu Y, Luo J, Ke ZJ*. ADAR2-dependent RNA editing of GluR2 is involved in thiamine deficiency-induced alteration of calcium dynamics. Mol Neurodeger. 2010, 5:54. (27 November 2010)
Xu M, Bower KA, Wang S, Frank JA, Chen G, Ding M, Wang S, Shi X, Ke ZJ, Luo J. Cyanidin-3-Glucoside Inhibits Ethanol-induced Invasion of Breast Cancer Cells Overexpressing ERBB2. Mol. Cancer2010 Oct 29;9:285.
Zhang QP, Yang G, Li WX, Fan Z, Sun AY, Luo J, Ke ZJ*. Thiamine deficiency increases b-secretase activity and accumulation of β-amyloid peptides. Neurobiol. Aging. 2011;32(1):42-53.
Wang X, Meng D, Chang Q, Pan J, Zhang Z, Chen G, Ke ZJ, Luo J, Shi X. Arsenic Inhibits Neurite outgrowth by Inhibiting LKB1-AMPK Signaling Pathway. Environ Health Perspect. 2010;118(5):627-34.
Xu M, Bower KA, Chen G, Shi X, Dong Z, Ke ZJ, Luo J. Ethanol Enhances the Interaction of Breast Cancer Cells Over-Expressing ErbB2 with Fibronectin. Alcohol Clin Exp Res. 2010;34(5):751-60.
Xu G, Xiong Z, Yong Y, Wang Z, Ke ZJ, Xia Z, Hu Y. Catalpol attenuates MPTP induced neuronal degeneration of nigral-striatal dopaminergic pathway in mice through elevating glial cell derived neurotrophic factor in striatum. Neuroscience. 2010;167(1):174-84.
You J, Yu Y, Jiang L, Li W, Yu X, Gonzalez L, Yang G, Ke ZJ, Li W, Li C, Liu Y. Signaling through Tyr985 of Leptin Receptor as an Age/diet-dependent Switch in the Regulation of Energy Balance. Mol Cell Biol. 2010;30(7):1650-9.
Ke ZJ, Wang X, Fan Z, Luo J. Ethanol promotes thiamine deficiency-induced neuronal death: involvement of double-stranded RNA-activated protein kinase. Alcohol Clin Exp Res. 2009;3 3(6):1097-103.
Chen, G., Bower, KA., Xu, M., Ding, M., Wang SY., Shi, X., Ke, ZJ., Luo, J. Cyaniding-3-glucoside reverses ethanol-induced inhibition of neurite outgrowth: role of Glycogen synthase 3 beta. Neurotox. Res. 2009, 15:321-331.
Liu Y., Chen, G., Ma, C., Bower, KA., Xu, M., Fan, Z., Shi, X., Ke, ZJand Luo, J. Over-expression of GSK3beta sensitizes neuronal cells to ethanol toxicity. J. Neurosci Res. 2009; 87: 2793-2802.
Zhang, Q., Ding, H., Li, W., Fan, Z., Sun, A., Luo, J., Ke, ZJ*. Senscence accelerated mouse strain is sensitive to neurodegeneration induced by mild impairment of oxidative metabolism. Brain Res. 2009; 1264: 111-118.
Chen YY, Chen G, Fan Z, Luo J, Ke ZJ. GSK3beta and endoplasmic reticulum stress mediate rotenone-induced death of SK-N-MC neuroblastoma cells. Biochem Pharmacol. 2008; 76(1):128-138.
Ma C, Bower KA, Chen G, Shi X, Ke ZJ, Luo J. Interaction between ERK and GSK3beta mediates basic fibroblast growth factor-induced apoptosis in SK-N-MC neuroblastoma cells. J Biol Chem. 2008; 283(14):9248-56.
Chen G, Ma C, Bower KA, Shi X, Ke ZJ, Luo J. Ethanol promotes endoplasmic reticulum stress-induced neuronal death: Involvement of oxidative stress. J Neurosci Res. 2008; 86(4):937-46.
Wang X, Fan ZQ, Wang B, Luo J, Ke ZJ. Activation of PKR by mild impairment of oxidative metabolism in neurons. J Neurochem. 2007, 103(6):2380-2390.
Ma C, Wang J, Gao Y, Gao TW, Chen G, Bower KA, Odetallah M, Ding M, Ke ZJ, Luo J. The Role of Glycogen Synthase Kinase 3 beta in the Transformation of Epidermal Cells. Cancer Res. 2007, 67(16):7756-64.
Cai G, Wang J, Xin X, Ke ZJ, Luo J. Phosphorylation of Glycogen Synthase Kinase-3 beta at Serine 9 Confers Cisplatin Resistance in Ovarian Cancer Cells. Int J Oncol. 2007, 31(3):657-62.
Chen G, Fan ZQ, Wang X, Ma C, Bower KA, Shi X, Ke ZJ, Luo J. Brain-derived Neurotrophic Factor Suppresses Tunicamycin-induced Upregulation of CHOP in Neurons. J Neurosci Res. 2007, 85(8):1674-1684.
Wang X, Wang BW, Fan ZQ, Shi XL, Ke ZJ, and Luo J. Thiamine Deficiency Induces Endoplasmic Reticulum Stress in Neurons. Neurosciences. 2007, 144(3):1045-56.
