李江華[江南大學生物工程學院教授]

李江華分別在無錫輕工業學院、無錫輕工大學和江南大學獲得學士、碩士、博士學位,現為江南大學生物工程學院教授、博士生導師。

個人簡介

姓名:李江華

出生年月:1966年4月6日

主要論著

•近5年在發表論文80餘篇(SCI收錄60餘篇)。

•其中代表性的論文如下:

•[1] Zhang Chunyu, Liu Long*,Teng Liping, Chen Jinghua, Liu Jian, Li Jianghua,Du Guocheng, Chen Jian*.Metabolic engineering of Escherichia coli BL21 for biosynthesis of heparosan, a bioengineered heparin precursor. Metab Eng. 2012, 14(5):521-527.

•[2] Liu Yanfeng, Liu Long, Shin Hyun-dong, Chen Rachel R, Li Jianghua, Du Guocheng, Chen Jian.Pathway engineering of Bacillus subtilis for microbial production of N-acetylglucosamine. Metab Eng. 2013, 19: 107-115.

•[3] Liu Yanfeng, Zhu Yanqiu, Ma Wenlong, Shin Hyun-dong, Li Jianghua, Liu Long, Du Guochen, Chen Jian. Spatial modulation of key pathway enzymes by DNA-guided scaffold system and respiration chain engineering for improved N-acetylglucosamine production by Bacillus subtilis. Metab Eng. 2014,24: 61-69.

•[4] Liu Yanfeng, Zhu Yanqiu, Li Jianghua, Shin Hyun-dong,Chen Rachel R. Du Guochen, Liu Long, Chen Jian. Modular pathway engineering of Bacillus subtilis for improved N-acetylglucosamine production. Metab Eng. 2014, 23: 42-52.

•[5] Han Ruizhi, Li Jianghua, Shin Hyun-dong,Rachel R. Chen,Du Guochen, Liu Long, Chen Jian. Recent advances in discovery, heterologous expression, and molecular engineering of cyclodextrin glycosyltransferase for versatile applications. Biotechnology Advances, 2014, 32: 415-428.

•[6] Zhuge Xin, Li Jianghua, Shin Hyun-dong, Chen Rachel R., Du Guocheng, Liu Long, Chen Jian. Development of a Propionibacterium-Escherichia coli shuttle vector as a useful tool for metabolic engineering of Propionibacterium jensenii, an efficient producer of propionic acid. Applied and Environmental Microbiology, 2013, 79: 4595-4602.

•[7] Yang Haiquan, Liu Long, Shin Hyun-dong, Chen Rachel R, Li Jianghua, Du Guocheng, Chen Jian. Integrating terminal truncation and oligopeptide fusion as a novel protein engineering strategy to improve specific activity and catalytic efficiency: Alkaline α-amylase as a case study. Applied and Environmental Microbiology, 2013,79: 6429-6438.

•[8] Han Ruizhi, Shin Hyun-dong, Chen Rachel R., Li Jianghua, Du Guocheng, Liu Long, Chen Jian. Carbohydrate binding module fusion of cyclodextrin glycosyltransferase enables the efficient synthesis of 2-O-D-glucopyranosyl-L-ascorbic acid with soluble starch as the glycosyl donor. Applied and Environmental Microbiology, 2013, 79: 3234-3240.

•[9] Yang Haiquan, Lu Xinyao, Liu Long, Shin Hyun-dong, Chen Rachel R, Li Jianghua, Du Guocheng, Chen Jian. Fusion of an Oligopeptide to the N Terminus of an Alkaline-Amylase from Alkalimonas amylolytica Simultaneously Improves the Enzyme’s Catalytic Efficiency, Thermal Stability, and Resistance to Oxidation. Applied and Environmental Microbiology. 2013, 79: 3049-3058.

•[10] Liu Long,Zhu Yunfeng, Li Jianghua,Wang Miao, Lee Pengsoon, Du Guocheng, Chen Jian. Microbial production of propionic acid from propionibacteria: Current state, challenges and perspectives. Crit Rev Biotechnol. 2012, 32(4): 374-381.

科研項目

近5年來主持或完成863計畫、江蘇省科技支撐計畫項目2項。

其中代表性的科研項目如下:

(1)“L-異亮氨酸高效清潔生產的關鍵技術”,“863”項目(2007AA02Z229),2007-2010

(2)“紡織精煉用高效酶製劑製備和套用”,江蘇省科技支撐技術(BE200900022),2009-2010

科研成果及獎勵

•6項成果被鑑定達到國內領先或國際先進水平。1項科研成果獲國家技術發明二等獎,1項科研成果獲教育部科技進步二等獎,2項科研成果獲中國輕工業聯合會科技發明一等獎。

•其中代表性的成果獎勵如下:

•(1)“棉織物染整前處理關鍵酶製劑的發酵生產和套用技術”,國家技術發明二等獎,第三完成人,2012年

•(2)“L-異亮氨酸高效清潔發酵生產”, 教育部科技進步二等獎,第一完成人,2013年

•(3)“發酵法生產用於紡織品染整加工的鹼性果膠酶和過氧化氫酶”, 中國輕工業聯合會科技發明一等獎,第三完成人,2010年

•(4)“新型有機酸的發酵法製備技術” , 中國輕工業聯合會科技發明一等獎,第四完成人,2013年

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