周翊峰

ogen ation Zhen

教授，中國抗癌協會腫瘤病因學會專業委員會委員，現就職於蘇州大學醫學部基礎醫學與生物科學學院。2005畢業於北京協和醫科大學/中國醫學科學院，獲得博士學位。2005-2008年期間在美國華盛頓大學（University of Washington）從事腫瘤免疫學方面的博士後研究。2008年，作為蘇州大學引進人才，經招聘到蘇州大學工作，並被聘為教授。近年來，已在國內外專業雜誌發表論文40篇，其中SCI雜誌35篇。總I.F.超過260，總引用次數531次，其中他引473次（引證文獻作者不包括被引文獻的任意作者）；第一和通訊作者18篇（總I.F.超過80）：包括“Journal of ExperimentalMedicine” (I.F. 14.48) 、“Cancer Research”(2篇，I.F. 8.23)、“Carcinogenesis”(3篇，I.F. 5.40)、“International Journal of Cancer”(I.F. 4.93) 、“Breast Cancer Research and Treatment”(I.F. 4.86) 和“Cancer Science” (I.F.3.85)等；個人H因子14（H-index）。並以第一發明人申請國家發明專利三項，授權專利一項。此外，主持國家自然基金項目兩項、江蘇省自然基金一項、華南腫瘤國家重點實驗室開放課題和教育部歸國留學人員科研啟動基金項目各一項。
專 利
一種慢病毒載體及其製備和套用（專利號：ZL 200910027636.4） 周翊峰，鄧傑瓊，劉海燕，李雲森
項 目
國家自然科學基金（No.81171895） “X染色體失活中心區域內遺傳變異與乳腺癌發生髮展關聯研究”2012.01-2015.12；60萬 在研；
主持國家自然科學基金（No.81001278） “11p13拷貝數多態與正常核型急性髓系白血病發生髮展的關聯研究”2011.01-2013.12；22萬 在研；主持
江蘇省自然科學基金（No. BK2011297）“Xq13染色體區域內遺傳變異與宮頸癌發生髮展的關聯研究”2011.07-2014.06；8萬 在研；主持
教育部歸國留學人員科研啟動基金（No.20101561）“CD25基因遺傳變異與乳腺癌的相關性研究”2011.05-2012.04；3.5萬 在研；主持
華南腫瘤學國家重點實驗室開放課題 “cd226基因3’UTR區域microRNA結合位點內遺傳多態與乳腺癌的相關性研究”2010.05-2012.04；5萬 在研；主持
獲 獎
1、2004年中國腫瘤學大會優秀論文一等獎
2、2005北京市科學技術一等獎
近期發表的主要論著目錄
Zheng J, Liu B, Zhang L, Jiang L, Huang B,You Y, Jiang Q, Zhang S, Lu J, Zhou Y*. Theprotective role of polymorphism MKK4-1304T>G in nasopharyngeal carcinoma is modulated by Epstein-Barr virus’infection status. Int J Cancer.2012 130:1981-1990.（*通訊作者）
Hu M, Jian L, Zhang L, Zheng J, You Y, DengJ, Li H, Zhou Y*. Functional polymorphism inthe EpCAM gene is associated with occurrence and advanced disease status ofcervical cancer in Chinese population. Mol Biol Rep. 2012 Feb 10. [Epub aheadof print]（*通訊作者）
Zheng J, Chen S, Jiang L, You Y, Wu D, Zhou Y*. Functional Genetic Variations of Cyclooxygenase-2 andSusceptibility to Acute Myeloid Leukemia in a Chinese Population. Eur J Haematol.2011 87:486-493.（*通訊作者）
Jiang L, Zhou P, Sun A, Zheng J, Liu B, YouY, Zhang C, Wu D, Zhou Y*. Functionalvariant (-1304T>G) in the MKK4 promoter is associated with decreased risk ofacute myeloid leukemia in a southern Chinese population. CancerSci. 2011 102:1462-1468.（*通訊作者）
Jiang L, Zhang C, Li Y, Yu X, Zheng J, ZouP, Li Y, Bin X, Lu J, Zhou Y*. A non-synonymous polymorphismThr115Met in the EpCAM gene is associated with an increased risk of breastcancer in Chinese population.BreastCancer Res Treat. 2011 126:487-495.（*通訊作者）
Zheng J, Zhang C, Jiang L, You Y, Liu Y, Lu J, Zhou Y*. Functional NBS1 polymorphism is associated withoccurrence and advanced disease status of nasopharyngeal carcinoma. Mol Carcinog. 2011 50:689-696.（*通訊作者）
Xu J, He X, Jin L, Jiang L, Zhou Y*,Kang Z, Peng R, Lee ST. A protein-based electrochemical method for label-freecharacterization of sequence-specific protein-DNA interactions. Electrochim Acta. 2011 56:5759-5765.（*通訊作者）
Hu Y, Jiang L, Zheng J,You Y, Zhou Y*, Jiao S. Association between the P73 exon2 G4C14-to-A4T14polymorphism and cancer risk: a meta-analysis. DNA and Cell Biology. 2011Oct 19.[Epub ahead of print]（*通訊作者）
Wang Y, Zheng J, Liu P,Yu X, Zhou D, Jiang L, You Y, Zhou Y*. Association between theInterleukin 10 -1082G>Apolymorphism and coronary heart disease risk in a Caucasian population: ameta-analysis.INTJ Immunogenet.2011 Accepted.（*通訊作者）
Yu X, Zhang C,Sun A, Jiang L, Zheng J, You Y, Wu D, Zhou Y*. Genetic variationsin cd14 promoter and acute lymphoblasticleukemia susceptibility in aChinese population. DNA and Cell Biology.2011 30:777-782.（*通訊作者）
Jiang L, Liang J, Jiang M, Yu X, Zheng J,Liu H, Wu D, Zhou Y*.Functional polymorphisms in the NBS1 gene and acute lymphoblastic leukemiasusceptibility in a Chinese population. Eur J Haematol. 2011 86:199-205.（*通訊作者）
Zheng J, Yu X, Jiang L, Xiao M, Bai B, LuJ, Zhou Y*. Association between the Cytotoxic T-LymphocyteAntigen 4 +49G>A polymorphismand cancer risk: a meta-analysis.BMC Cancer.2010 10:522. （*通訊作者）
Gao Y, He Y, Ding J, Wu K, Hu B, Liu Y, WuY, Guo B, Shen Y, landi D, Landi S, Zhou Y*, Liu H. Aninsertion/deletion polymorphism at miRNA-122 binding site in the interleukin- 1a 3’untranslated region confers risk for hepatocellular carcinoma. Carcinogenesis. 2009 30:2064-2069. （*通訊作者）
Sun T, ZhouY*, Yang M, Hu Z, Tan W, Han X, Shi Y, Yao J, Guo Y, Yu D, Tian T, ZhouX, Shen H, Lin D. Functional geneticvariations in CTLA-4 andsusceptibility to multiple types of cancer. Cancer Res. 2008 68:7025-7034.（*共同第一作者）
Sun T, Zhou Y*, Li H, Han X, Shi Y, Wang L, Miao X, Tan W, Zhao D, Zhang X, Guo Y, Lin D. FASL -844C polymorphism is associated withincreased activation-induced T cell death and risk of cervical cancer. J Exp Med.2005202:967-974.（*共同第一作者）
Zhou Y, Yu C,Miao X, Wang Y, Tan W, Sun T, Zhang X, Xiong P, Lin D. Functional haplotypes in thepromoter of matrix metalloproteinase-2 and lung cancer susceptibility. Carcinogenesis.2005 26:1117-1121.
Yu C, Zhou Y*, Miao X, Xiong P, Tan W, Lin D.Functional haplotypes in the promoter of matrix metalloproteinase-2 predictrisk of the occurrence and metastasis of esophageal cancer. Cancer Res. 2004 64:7622-7628.（*共同第一作者）
Zhou Y, Yu C,Miao X, Tan W, Liang G, Xiong P, Sun T, Lin D.Substantial reduction in risk of breast cancer associated with geneticpolymorphisms in the promoters of the matrix metalloproteinase-2 and tissueinhibitor of metalloproteinase-2 genes. Carcinogenesis. 2004 25:399-404.
Huang B, Liu B,Yang L, Li Y, Cheng M, Huang D, Wang H, Zhang X, Zheng J, Li Q, Ji W, ZhouY, Lu J. Functional genetic variants of c-Jun and their interactionwith smoking and drinking increase the susceptibility to lung cancer insouthern and eastern chinese.Int JCancer. 2011 Dec 20. [Epub ahead of print]
Wu C, Miao X,Huang L, Che X, Jiang G, Yu D, Yang X, Cao G, Hu Z, Zhou Y, Zuo C, Wang C, Zhang X, Zhou Y,Yu X, Dai W, Li Z, Shen H, Liu L, Chen Y, Zhang S, Wang X, Zhai K, Chang J, LiuY, Sun M, Cao W,Gao J, Ma Y, Zheng X, Cheung ST, Jia Y, Xu J, Tan W, Zhao P, Wu T, Wang C, LinD. Genome-wide association study identifies five loci associated withsusceptibility to pancreatic cancer in Chinese populations. Nat Genet. 2011 Dec 11. [Epubahead of print]
Yang L, Li Y, Cheng M, Huang D, Zheng J, Liu B, Ling X, Li Q,Zhang X, Ji W, Zhou Y, Lu J. A functionalpolymorphism at microRNA-629 binding site in the 3'-untranslated region of NBS1gene confers an increased risk of lung cancer in Southern and Eastern Chinesepopulation. Carcinogenesis.2011 Nov 22. [Epub ahead of print]
Shi Y, Hu Z, Wu C, Dai J, Li H, Dong J, Wang M, Miao X, Zhou Y, Lu F, Zhang H, Hu L,Jiang Y, Li Z, Chu M,Ma H, Chen J, Jin G, Tan W, Wu T, Zhang Z, Lin D, Shen H.A genome-wide association study identifiesnew susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. Nat Genet.2011 Oct 30. [Epub ahead of print]
Lu J, Yang L, Zhao H, Liu B, Li Y, Wu H, LiQ, Zeng B, Wang Y, Ji W, Zhou Y.The polymorphism and haplotypes of PIN1 gene are associated with the risk oflung cancer in Southern and Eastern Chinese populations.Hum Mutat. 2011 32:1299-1308.
Wu C, Hu Z, He Z, Jia W, Wang F, ZhouY, Liu Z, Zhan Q, Liu Y, Yu D, Zhai K, Chang J, Qiao Y, Jin G, Liu Z,Shen Y, Guo C, Fu J, Miao X, Tan W, Shen H, Ke Y, Zeng Y, Wu T, Lin D.Genome-wide association study identifies three new susceptibility loci foresophageal squamous-cell carcinoma in Chinese populations. Nat Genet. 2011 43:679-684.
Ding J, Gao Y, He Y, Zhou Y,Huang M, Liu H. Screening SNPs residing in the microRNA-binding sites ofhepatocellular carcinoma related genes. IntJ Data Min Bioinform. 2011 5:1-21.
Lin D, Liu C, Xue M, Liu R, Jiang L, Yu X,Bao G, Deng F, Yu M, Ao J, Zhou Y,Wu D, Liu H. The role of interleukin-15 polymorphisms in adult acutelymphoblastic leukemia. PLoSOne. 2010 5:e13626
Liu P, Jaffar J, Zhou Y, YangY, Hellström I, Hellström KE. Inhibition of TGFbeta1 Makes Nonimmunogenic TumorCells Effective for Therapeutic Vaccination.JImmunother.2009 32:232-239.
Zhang B, SunT, Xue L, Han X, Zhang B, Lu N, Shi Y, Tan W, Zhou Y, Zhao D, Zhang X, Guo Y, Lin D. Functional polymorphisms in FAS and FASL contribute toincreased apoptosis of tumor infiltration lymphocytes and risk of breastcancer. Carcinogenesis.2007 28:1067-1073.
Yang Y, YangS, Ye Z, Jaffar J, Zhou Y, Cutter E, Lieber A, Hellström I,Hellström KE. Tumor cellsexpressing anti-CD137 scFv induce a tumor-destructive environment.Cancer Res.2007 67:2339-2344.
Hao B, MiaoX, Li Y, Zhang X, Sun T, Liang G, Zhao Y, Zhou Y, Wang H, Chen X, Zhang L, Tan W, Wei Q, Lin D, He F. A novel T-77C polymorphism in DNA repair gene XRCC1contributes to diminished promoter activity and increased risk of non-smallcell lung cancer. Oncogene.2006 25:3613-3620.
Zhang X, MiaoX, Guo Y, Tan W, Zhou Y, Sun T, Wang Y, Lin D.Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 areassociated with susceptibility to lung cancer.Hum Mutat. 200627:110-117.
Zhang X, MiaoX, Sun T, Tan W, Qu S, Xiong P, ZhouY, Lin D. Functionalpolymorphisms in cell death pathway genes FAS and FASL contribute to risk of lungcancer. J Med Genet.2005 42:479-484.
Tan W, MiaoX, Wang L, Yu C, Xiong P, Liang G, Sun T, Zhou Y, Zhang X, Li H, Lin D.Significant increase in risk of gastroesophageal cancer is associated withinteraction between promoter polymorphisms in thymidylate synthase and serumfolate status. Carcinogenesis.2005 26:1430-1435.
Sun T, MiaoX, Wang J, Tan W, Zhou Y, Yu C, Lin D. Functional Phe31Ile polymorphism in Aurora A and risk ofbreast carcinoma.Carcinogenesis. 2004 25:2225-2230.
Liang G, MiaoX, Zhou Y, Tan W,Lin D. A functional polymorphismin the SULT1A1 gene (G638A) is associated with risk of lung cancerin relation to tobacco smoking. Carcinogenesis.200425:773-778.
李華，郭紅燕，孫瞳，周翊峰，林東昕，章文華，喬傑。Fas和Fas配體基因啟動子單核苷酸多態性與子宮頸癌的發病風險。《中華腫瘤雜誌》2009 31: 38-41.
張雪梅，繆小平，譚文，曲世寧，孫瞳，周翊峰，林東昕。亞甲基四氫葉酸還原酶基因遺傳變異與肺癌。《中國醫學科學院學報》 2005 27:700-703.
馮飛躍，梁剛，呂文富，繆小平，於春媛，譚文，周翊峰，孫瞳，康濱，周彤，潘凱楓，張聯，林東昕。尿苷二磷酸葡糖醛酸轉移酶1A7基因多態基礎研究。《癌症》200524:1085-1090.
張雪梅，繆小平，熊萍，於春媛，譚文，曲世寧，孫瞳，周翊峰，林東昕。基質金屬蛋白酶2和9功能性單核苷酸多態與胃癌。《癌症 》200423:1233-1237.
溫文，周翊峰，況春景，陳任生，劉繁榮，熊小亮。mdm2和p53在人腦膠質瘤中的相關性分析。《江西醫學院學報》 2003 43.