個人簡介
錢永常，博士，浙江農林大學特聘教授、浙江省“千人計畫”創業人才、教授級高級工程師、浙江省特聘專家、中國醫藥生物技術協會理事、杭州市蕭山海創會副會長。
科研興趣
神經元細胞和星形膠質細胞在大腦功能中的相互作用
神經退行性疾病中蛋白質的質控
蛋白質聚合和分子神經毒理學
生物技術在生物製藥和環境治理中的套用
學習經歷
1993-1998, 美國德州A&M大學生化與分子營養學博士後
1991-1993, 美國加州大學戴維斯分校植物生理與生化博士後
1985-1990, 中國科學院上海分院獲植物生理學博士學位
1981-1985, 中國上海復旦大學獲生物學學士學位
科研經歷
1999-2009, 美國德州A&M大學神經科學與毒理學計畫的實驗室主任, 研究助理教授，副教授.
1993-1998, 美國德州A&M大學生化與生物物理系博士後.
1991-1993, 美國加州大學戴維斯分校博士後.
1985-1990, 中國科學院上海分院研究生研究助理.
1984-1985, 中國上海復旦大學生物系研究助理.
科研成果
1995年，錢永常博士在國際上第一次確定了在神經退行性疾病中起極其重要作用的大鼠銅泵Atp7a基因序列，直接被美國國家生物技術信息中心（NCBI）收錄
2000-2005年間，國際上第一次確認對兒童的智力發育有嚴重危害的重金屬鉛專一性攻擊銅泵Atp7a，在分子水平上對重金屬鉛的神經毒性研究是一個極其重要的發現，相關工作被發表在毒理學和神經毒理學的國際頂級雜誌上
2008年，錢永常博士研究組在國際上第一次報導，重金屬鉛可以直接攻擊淋巴細胞中參與免疫球蛋白分泌的伴侶分子，為重金屬鉛的免疫毒性研究提出了一個全新的分子機理，工作發表在中國預防醫學的權威雜誌上
2009年，錢永常博士國際上首次報導目前在臨床上廣泛使用的抗驚厥和癲癇藥，2-丙基戊酸鈉（valproate），嚴重影響人類神經細胞突觸的生長，相關工作發表在著名的《大腦研究》雜誌上
2010年，錢永常博士帶領的杭州紐龍生物科技有限公司的技術團隊，研發出一種生物活性蛋白/多肽的新型純化技術，目前正在申請技術專利，同時相應的專利產品即將面市。生物活性蛋白/多肽的純化技術是生物製藥領域的關鍵技術，是此領域的難點和熱點，紐龍生物在此領域的技術突破，為神經活性多肽的微生物工程生產提供極其重要的保證.
受邀審稿人的科學期刊
中國生化與生物物理學報(Acta Biochimica et Biophysica Sinica)
毒理學的化學研究(Chemical Research in Toxicology)
細胞生物化學雜誌(Journal of Cellular Biochemistry）
神經化學雜誌(Journal of Neurochemistry)
毒理學雜誌(Journal of Toxicology)
毒理學與環境健康雜誌(Journal of Toxicology and Environmental Health)
環境健康展望(Environmental Health Perspectives)
神經毒性研究(Neurotoxicity Research)
神經毒理學(Neurotoxicology)
藥物學研究(Pharmacological Research)
整體環境的科學(Science of the Total Environment)
體外毒理學(Toxicology in Vitro)
專業機構會員
美國毒理學會(Society of Toxicology)
美國神經化學學會(American Society of Neurochemistry)
獲獎與科研資助
1999, 優秀博士後獎Gulf Coast Chapter Society of Toxicology Annual Meeting, Houston, Texas
2000-2001, 美國德州A&M大學CVM優先計畫, "Lead and copper Competitively Bind to HMB of ATP7A and GRP78" (項目主任, 25%貢獻), 資助金額9,780美元
2000-2005, 美國國立環境與健康研究所項目NIEHS P42 ES04917, “Stress Gene Induction in Mammalian Cells”(項目副主任, 40%貢獻), 資助金額840,000美元.
2005-2006, 美國國防部項目DOD-CDMRP Concept Award W81XWH-05-1-0163, "The Function of Neurofibromin in Astrocytes" (項目副主任, 40%貢獻), 資助金額100,000美元.
2008-2008, 美國德州A&M大學基金, “The Function of Astrocytes in Brain Glucose Utilization”(項目主任, 50% 貢獻), 資助金額8,000美元.
2009-2010, 美國國立環境與健康研究所項目NIH-NIEHS R21, “Long-Term Monitoring of dementia-Related Markers in Lead Workers from China”(項目主任, 30% 貢獻), 資助金額515,000美元.
發表的文章
1.錢永常, Ying Zheng, Evelyn Tiffany-Castiglioni. Hspa5 Depletion Predisposes Glioma Cells to Curcumin Treatment. In preparation.
2.錢永常, Ying Zheng, Bingchao Meng2, Robert Taylor, Evelyn Tiffany-CastiglioniHSPA5 specifically Forms Complexes with Copper. In preparation to Neurochemical Research.
3. Tiffany-Castiglioni, E., 錢永常. ER Chaperone-Metal Interactions: Links to Protein Folding Disorders. Neurotoxicology In press, 2012.
4. 錢永常, Zheng, Y., Taylor, R., Tiffany-Castiglioni, E. Involvement of the Molecular Chaperone HSPA5 in Copper Homeostasis in Astrocytes. Brain Research 1447: 9-19, 2012.
5. Tiffany-Castiglioni, E., Hong, S., 錢永常. Copper Handling by Astrocytes: Insights into Neurodegenerative Diseases. International Journal of Developmental Neuroscience 29: 811-818, 2011.
6. Barhoumi, R., 錢永常, Burghardt, R., Tiffany-Castiglioni, E. Image Analysis of Ca2+ Signals as a Basis for Neurotoxicity Assays: Promises and Challenges. Neurotoxicology and Teratology. 32: 16-24, 2010.
7. 錢永常, Zheng, Y, Tiffany-Castiglioni, E. Valproate Reversibly Reduces Neurite outgrowth by Human SY5Y Neuroblastoma Cells. Brain Research 1302:21-33, 2009.
8. Wang, LJ, Zheng, Y, 錢永常.斷乳仔鼠器官中鉛分布和78000糖調蛋白的變化. 《中華預防醫學雜誌》第42卷，第10期：731-734頁, 2008(abstract in English).
9. White, LD., Cory-Slechta, DA., Gilbert, ME., Tiffany-Castiglioni, E., Zawia, NH., Virgolini, M., Rossi-George, A., Lasley, SM., 錢永常, Basha, MR. New and Evolving Concepts in the Neurotoxicology of Lead. Toxicology and Applied Pharmacology225: 1-27, 2007.
10.錢永常, Zheng, Y, Weber, D, Tiffany-Castiglioni, E. A 78kD Glucose-Regulated Protein Is Involved In Decrease Of Interleukin-6 secretion By Lead Treatment From Astrocytes. American Journal of Physiology-Cell Physiology293: C897-C905, 2007.
11. Wang, L. J., Zheng, Y., 錢永常. 低水平鉛暴露對仔鼠白細胞78kd糖調蛋白表達的影響. 《國際醫藥衛生導報》第13卷，第12期：8-12頁，2007(abstract in English).
12. Falahatpisheh, H., Nanez, A., Montoya-Durago, D., 錢永常, Tiffany-Castiglioni, E., Ramos, KS. Activation Profiles of HSPA5 During the Glomerular Mesangial Cell Stress Response to Chemical Injury. Cell Stress & Chaperones 12: 209-218, 2007.
13. Barhoumi, R., Burghardt, R., 錢永常, Tiffany-Castiglioni, E. Effects of propofol on intracellular Ca2+ homeostasis in human astrocytoma cells. Brain Research 1145: 11-18, 2007.
14.錢永常, Venkatraj, J., Barhoumi, R., Pal, R., Datta, A., Wild, J. R., Tiffany-Castiglioni, E. Comparative non-cholinergic neurotoxic effects of paraoxon and diisopropyl fluorophosphate (DFP) human neuroblastoma and astrocytoma cell lines. Toxicology and Applied Pharmacology219: 162-171, 2007.
15. Tiffany-Castiglioni, E., Hong, S., 錢永常, Tang, Y., Donnelly, K.C. COMMENTARY: In Vitro Models for Assessing Neurotoxicity of Mixtures. Neurotoxicology 27: 835-839, 2006.
16. Tiffany-Castiglioni, E., Venkatraj, J.S., 錢永常. Genetic polymorphisms and mechanisms of neurotoxicity: overview. Neurotoxicology 26: 641-649, 2005.
17.錢永常, Zheng, Y., Ramos, K.S., Tiffany-Castiglioni, E. The Involvement of Copper Transporter in Lead-induced Oxidative Stress in Astroglia. Neurochemical Research 30: 429-438, 2005.
18.錢永常, Zheng, Y., Abraham, L., Ramos, K.S., Tiffany-Castiglioni, E. Differential Profiles of Copper-induced ROS Generation in Human Neuroblastoma and Astrocytoma Cells. Molecular Brain Research 134: 323-332, 2005.
19.錢永常, Zheng, Y., Ramos, K.S., Tiffany-Castiglioni, E. GRP78 compartmentalized redistribution in pb-treated glia: role of grp78 in lead-induced oxidative stress. Neurotoxicology26: 267-275, 2005.
20. Donnelly, K.C., Lingenfelter, R., Cizmas, L., Falahatpisheh, M.H., 錢永常, Tang, Y., Garcia, S., Ramos, K.S., Tiffany-Castiglioni, E., Mumtaz, M.M. Toxicity assessment of complex mixtures remains a goal. Environmental Toxicology and Pharmacology 18: 135-141, 2004
21.陳益民，孫文浩，錢永常，李梨，蔡捷，董建國。懷念我們的老師－余叔文先生。植物生理學通訊，40卷3期，397-398頁，2004. (in Chinese)
22.錢永常, Tiffany-Castiglioni, E., Lead-induced endoplasmic reticulum (ER) stress responses in the nervous system. Neurochemical Research 28: 153-162, 2003
23. Tiffany-Castiglioni, E.,錢永常, Astroglia as metal depots: molecular mechanisms for metal accumulation, storage and release. Neurotoxicology 55: 1-16, 2001
24.錢永常, Falahatpisheh, M.H., Zheng, Y., Ramos, K.S., Tiffany-Castiglioni, E., Induction of 78 kD Glucose-Regulated Protein (GRP78) Expression and Redox-Regulated Transcription Factor Activity by Lead and Mercury in C6 Rat Glioma Cells. Neurotoxicity Research, 3:581-589, 2001
25.錢永常, Harris, E.D., Zheng, Y., Tiffany-Castiglioni, E., Lead (Pb) targets GRP78, a molecular chaperone, in C6 rat glioma cells. Toxicol. Appl. Pharmacol. 163: 260-266, 2000
26.錢永常, Mikeska, G., Harris, E.D., Bratton, G.R., Tiffany-Castiglioni, E., Effect of lead exposure and accumulation on copper homeostasis in cultured C6 rat glioma cells. Toxicol. Appl. Pharmacol. 158:41-49, 1999
27. Harris, E.D., Reddy M.C.M., 錢永常, Tiffany-Castiglioni, E., Majumdar, S., Nelson, J. Multiple forms of the Menkes Cu-ATPase. Adv. Exp. Med. Biol. 448:39-51, 1999
28. Harris, E.D., 錢永常, Reddy, M.C., Genes regulating copper metabolism. Mol. Cell. Biochem. 188: 57-62, 1998
29.錢永常, Tiffany-Castiglioni, E., Welsh, J., Harris, ED., Copper efflux from murine microvascular cells requires expression of the Menkes disease Cu-ATPase. J. Nutr.128: 1276-1282,1998
30.錢永常, Tiffany-Castiglioni, E., Harris, ED., Sequence of a Menkes-type Cu-transporting ATPase from rat C6 glioma cells: comparison of the rat protein with other mammalian Cu-transporting ATPases. Mol. Cell. Biochem. 181:49-61, 1998
31. Harris, ED., 錢永常, Tiffany-Castiglioni, E., lacy, A., Reddy, MCM., A functional analysis of copper homeostasis in various cell lines: A new perspective on internal copper transport. Am. J. Clin. Nutr. 67:988s-995s, 1998(suppl)
32.錢永常, Tiffany-Castiglioni, E., Harris, ED., A Menkes P-type ATPase involved in Cu homeostasis in the central nervous system of the rat. Mol. Brain Res. 48: 60-66, 1997
33.錢永常, Tiffany-Castiglioni, E., Harris, E.D. Functional Analysis of A Genetic Defect of Copper Transport (Menkes Disease) in Different Cell lines. Am. J. Physiol.: 271(Cell Physiol. 40): C378-C384, 1996
34.錢永常, Majumdar, S., Reddy, M.C.M., and Harris, E.D. Coincident Expression of Menkes Gene with Copper Efflux in Human Placental Cells. Am. J. Physiol.: 270(Cell Physiol. 39): C1880-1884, 1996
35.錢永常, Tiffany-Castiglioni, E., Harris, E.D. Copper transport and kinetics in cultured C6 rat glioma cells. Am. J. Physiol., 269 (Cell Physiol. 38): C892-C898, 1995
36.錢永常, Nguyen, T., Murphy, T.M. Effect of washing on the plasma membrane and on stress reactions of cultured rose cells. Plant Cell, Tissue, and Organ Culture, 35: 245-252, 1993
37.錢永常& Murphy, T.M. Regulation of plasma membrane ATPase by glutathione in rose cells irradiated with UV-C. Plant Physiol. Biochem., 31(6): 901-909, 1993
38.錢永常,余叔文. 二氧化硫對不同作物中昆蟲必需安基酸的影響. 環境科學學報, 12(3):325-332, 1992 （英文摘要）
39.錢永常,余叔文. 大豆苗在適應二氧化硫的過程中表達一個15kDa的蛋白質. 植物生理學學報, 17(4):365-372, 1991 （英文摘要）
40.錢永常,余叔文. 大豆苗對二氧化硫的適應性反應. 植物生理學學報 17(3): 232-238, 1991 （英文摘要）
41.錢永常,余叔文. 二氧化硫對植物的氧化作用和植物的抗氧化作用. 植物生理學通訊. 27(5): 326-331, 1991 （英文摘要）
42.錢永常& Yu, S-W. Change of protein pattern in Glycine max fumigated with SO2. 植物生理學學報, 16(1): 81-85, 1990
43.錢永常,余叔文. 植物中的逆境蛋白. 植物生理學通訊 25(5):5-11, 1989 （英文摘要）
