人物經歷
1989年獲博士學位後留南開大學高分子所任講師，1992年晉升為副教授，1996年晉升為教授。2000年7月，任南開大學化學院副院長，高分子所所長。
現任南開大學化學院副院長，高分子所所長，民盟天津市委副主任委員。
2017年6月，民盟天津市第十一屆委會召開第一次全體會議，選舉袁直為副主任委員。
研究方向
1、吸附分離材料的結構設計及吸附機制研究
2、納米肝靶向給藥系統研究
3、誘導抗凝血生物化表面的設計和構建
主要貢獻
國家自然科學基金重點項目及多項面上項目，“973項目”課題，天津市科技支撐重點項目，天津市自然科學基金重點項目。
部分論文（原文）
(1) Zhi Yuan*. Doxorubicin-loadedglycyrrhetinicacid-modified alginate nanoparticles for liver tumor chemotherapy. Biomaterials, 2012, 33, 2187–2196.
(2) ZhiYuan*. Self-assembly and liver targeting of sulfatedchitosan nanoparticlesfunctionalized with glycyrrhetinic acid. Nanomedicine: nanotechnology, biology, and medicine, 2012, 8, 870–9.
(3) ZhiYuan*. Synthetic receptor and its association with CTDpeptides. Tetrahedron, 2012, 68, 2357–2362.
(4) ZhiYuan*. In vitro evaluation of polymeric micelles basedonhydrophobically-modified sulfated chitosan as a carrier of doxorubicin. Journal of Materials Science: Materials in Medicine, 2012, 23,1663–1674.
(5) ZhiYuan*. Selective removal of caffeine from tea extracts using macroporouscrosslinked polyvinyl alcohol adsorbents. Journal of Separation Science, 2012, 35, 36–44.
(6) ZhiYuan*. Effects of oligopeptide’s conformational changes on itsadsorption. Colloids andsurfaces. B,Biointerfaces, 2011, 83,229–236.
(7) ZhiYuan*. HUVEC cell affinity evaluation and integrin-mediated mechanismstudy on PHSRN-modified polymer. Colloidsand surfaces B Biointerfaces, 2011, 84,6–12.
(8) ZhiYuan*. A comparison study between polymeric ligand and monomeric ligandfor oligopeptide adsorption. Journalofcolloid and interface science , 2011, 355, 478–85.
(9) ZhiYuan*. Glycyrrhetinic acid-functionalized degradable micelles asliver-targeted drug carrier. Journalof Materials Science-Materials in Medicine, 2011, 22, 853–863.
(10) ZhiYuan*. An efficient molecular docking method for adsorbentscreening. Journal OfChromatography B, 2011, 879,1605–1609.
(11) Wang, J.; Wang, W.;Wei, Q.; Zhang, S.;Yuan, Z. New method for affinity adsorbent screening usinggold colloids. Langmuir, 2011, 27, 11457–65.
(12) ZhiYuan*. Understanding the role of the C3-hydroxyl group inglycyrrhetinicacid on liver targeting. Journalof controlled release, 2011, 152, 237–239.
(13) ZhiYuan*. Antitumor activity of drug loaded glycyrrhetinicacid modifiedalginate nanoparticles on mice bearing orthotopic liver tumor. Journal of controlled release, 2011, 152, 111–113.
(14) ZhiYuan*. The potential for blood vessel engineering of PHSRN-modifiedpolymer:HUVEC cell affinity evaluation and integrin-mediated mechanismstudy. Journal of controlledrelease, 2011, 152, 243–245.
(15) ZhiYuan*. Blood compatibility evaluation of poly(D,L-lactide-co-beta-malicacid) modified with the GRGDS sequence. Colloids and surfaces. B, Biointerfaces, 2010, 75, 370–6.
(16) Tian, Q.; Zhang,C.-N.; Wang, X.-H.; Wang,W.; Huang, W.; Cha, R.-T.; Wang, C.-H.; Yuan, Z.; Liu,M.; Wan, H.-Y.; Tang, H.Glycyrrhetinic acid-modified chitosan/poly(ethyleneglycol) nanoparticles for liver-targeted delivery. Biomaterials, 2010, 31, 4748–4756.
(17) ZhiYuan*. Adsorbents with high selectivity for uremic middle molecularpeptides containing the Asp-Phe-Leu-Ala-Glusequence. Langmuir, 2010, 26, 7181–7187.
(18) ZhiYuan*. Colorimetric detection of bis-phosphorylated peptides usingzinc(ii) dipicolylamine-appended gold nanoparticles. Sensors and Actuators B: Chemical, 2010, 147, 687–690.
(19) ZhiYuan*. Glycyrrhetinicacid-modified poly(ethylene glycol)-b-poly(gamma-benzyll-glutamate) micelles for liver targeting therapy. Acta biomaterialia, 2010, 6,3927–3935.
(20) ZhiYuan*. Silk fibroin/montmorillonite nanocomposites: effect of pH on theconformational transition and clay dispersion. Biomacromolecules, 2010, 11, 1796–1801.
(21) ZhiYuan*. Insight into glycyrrhetinic acid: the role of the hydroxyl group onliver targeting. Internationaljournal of pharmaceutics, 2010, 400, 153–7.
(22) ZhiYuan*. Design, optimization and evaluation of specific affinity adsorbent foroligopeptides. Journal ofChromatography A , 2010, 1217, 7539–7546.
(23) ZhiYuan*. A novel copolymer poly(lactide-co-beta-malic acid) with extendedcarboxyl arms offering better cell affinity and hemacompatibility for bloodvessel engineering. Tissue engineeringPart A, 2009, 15, 65–73.
(24) ZhiYuan*. Affinity adsorption mechanis mstudies of adsorbents foroligopeptides using model polymer. Polymer , 2009, 50, 1602–1608.
(25) ZhiYuan*. Rapid and efficient screening of adsorbent for oligopeptide usingmolecular docking and isothermal titration calorimetry. Journal of Separation Science, 2009, 32, 2462–2468.
(26) ZhiYuan*. Synthesis, degradability, and cell affinity ofpoly(DL-lactide-co-RS-hydroxyethyl-beta-malolactonate). Journal of Biomedical Materials Research Part A, 2008, 87, 459–469.
(27) ZhiYuan*. Studies on adsorption isotherms of endotoxin and BSA using anaffinity column. ProcessBiochemistry, 2007, 42, 285–288.
(28) ZhiYuan*. Studies on endotoxin removal mechanism of adsorbents with aminoacid ligands. Journal OfChromatography B, 2007, 852, 288–292.
(29) ZhiYuan*. Adsorption mechanism at the molecularlevel between polymers anduremic octapeptide by the 2D 1H NMR Technique. Biomacromolecules, 2006, 7, 1811–1818.
(30) ZhiYuan*. Synthesis and characterization of a functionalized amphiphilicdiblock copolymer: MePEG-b-poly(DL-lactide-co-RS-β-malic acid). Colloid and Polymer Science, 2006, 285, 273–281.
(31) ZhiYuan*. Synthesis and characterization of novel functionalized polylactideswith pendent hydroxyl arms. Polymer , 2006, 47, 6978–6985.
(32) ZhiYuan*. Endotoxin adsorbent using dimethylamine ligands. Biomaterials , 2005, 26, 2741–7.
(33) ZhiYuan*. Separation, identification of uremic middle molecules, andpreliminary study ontheir toxicity. Clinica chimica acta , 2004, 350,89–98.
專利
1. 袁直等, 中國發明專利, ZL 93107357.x。
2. 袁直等, 中國發明專利, ZL 93107356.1。
3. 袁直等, 中國發明專利, ZL 03 144231.5。
4. 袁直等, 中國發明專利, ZL 03 144383.4。
5. 袁直等, 中國發明專利, ZL200510015172.7。
6. 袁直等, 中國發明專利, ZL 200810052636.5。
7. 袁直等, 中國發明專利, ZL 200810052635.0,。
8. 袁直等, 中國發明專利, CN101444720。
9. 袁直等, 國際專利, 申請號PCT/CN2009/000150。
10. Zhi Yuan et al, US Patent, Application Number 12338966。
11. 袁直等, 中國發明專利, 申請號200910068769.6。
12. 袁直等, 中國發明專利, 申請號200910070231.9。
獲獎記錄
曾獲中國化學會青年化學獎、國家科技進步二等獎，天津青年科技獎、科技部杜邦科技創新獎、天津市科技進步二等獎、教育部科技進步三等獎；榮獲全國先進女職工稱號。
