蘇自奮

Cation Cation edion

蘇自奮 研究員,男 1958 年 12 月生
研究方向: 同位素及輻射生物醫學技術研究
工作單位: 四川大學原子核科學與技術研究所
研究員。 1988 年 3 月年從中科院化學所分析化學專業研究生畢業並獲得博士學位。 1989 年德國洪堡學者。從 1989 年起從事放射藥物開發及研究,先後在德國、加拿大、美國的國際知名科研單位與眾多的化學家、藥物學家、藥劑師、腫瘤科專家、以及核醫學科專家共同工作過。
研究領域:
腫瘤特異性藕聯藥物的開發研究 ;
特異性多肽抗癌藥物的開發研究 ;
疾病的分子顯像研究;
新型高性能乏氧腫瘤細胞顯像劑及放射藥物的研究開發
新型高靈敏高特異性腫瘤新生血管顯像劑及放射藥物的研究開發;
結合中藥研究提高抗癌藥物效果的基礎及套用問題;
結合分子顯像技術研究具有優越抗癌效果的中草藥、合成藥、生化藥以及相關基礎問題的研究;
腦瘤放射藥物的研究開發。
發表文章選錄
1. Zi-Fen Su, Jiang He, Mary Rusckowski, and Donald J. Hnatowich. (2003) In Vitro Cell Studies of technetium -99m labelled RGD-HYNIC Peptide, a comparison of Tricine and EDDA as Co-ligands. Nucl. Med. Biol. 30, 141-9.
2. Zi-Fen Su, Guozheng Liu, Suresh Gupta, Zhihong Zhu, Mary Rusckowski and Donald J. Hnatowich (2002) In Vitro and In Vivo Evaluations of a Technetium -99m Labeled Cyclic RGD Peptide as a Specific Marker of a V b 3 Integrin for Tumor Imaging. Bioconjug. Chem ., 13 , 561-70.
3. Zi-Fen Su, James R. Ballinger, A. M. Rauth, Douglas N. Abrams, and Mervyn W. Billinghurst. (2000) A Novel amine-dioxime Chelator for Technetium -99m : Synthesis and Evaluation of 2-Nitroimidazole-containing Analogs as Markers for Hypoxic Cells. Bioconjugate Chemistry, 11 , 652-63.
4. Zi-Fen Su, Xiuguo Zhang, James R. Ballinger, A. M. Rauth, Alfred Pollak, and John R. Thornback. (1999) Synthesis and Evaluation of Two Technetium-99mTc-Labeled Peptidic 2-Nitroimidazoles for Imaging Hypoxia. Bioconjugate Chemistry , 10 , 897-904.
5. Wang J, Chen P, Su ZF, Vallis K, Sandhu J, Cameron R, Hendler A, Reilly RM.(2001) Amplified delivery of indium-111 to EGFR-positive human breast cancer cells. Nucl Med Biol . 28 (8):895-902.
6. Li YQ, Ballinger JR, Nordal RA, Su ZF, Wong CS. (2001) Hypoxia in radiation-induced blood-spinal cord barrier breakdown. Cancer Res. 61 , 3348-54.
7. Xiuguo Zhang, Zi-Fen Su, James R. Ballinger, A. M. Rauth, Alfred Pollak, and John R. Thornback, Targeting Hypoxia in Tumors Using 2-Nitroimidazole with Peptidic Chelator for Technetium -99m : Effect of Lipophilicity. Bioconjugate Chemistry , 11 , 401-7.
8. K Utsunomiya , J R Ballinger, X. Zhang, Z-F Su, T Tsuchida, and M Ichise. (1999) Comparison Of The Kinetics Of 99m Tc-Sestamibi and 99m Tc-Tetrofosmin In A Multidrug-Resistant Tumour Cell Line. Eur. J. Nucl. Med . 26 (9), 1047
9. K. Schwochau, K.H. Linse and Z.F. Su. (1992) Synthesis, Characterization and Biodistribution of the Cationic Technetium(I)-1,10-Phenanthroline chelate., Appl. Radiat. Isotope , 43(9), 1079-82.
10. Z.F. Su, K.H. Linse, H.J. Steinmetz and K. Schwochau. (1992) Preparation and Evaluation of Cationic 99 Tc/ 99m Tc Dimethoxy- and Diethoxyl-Hexanedione Dioxime Complexes. J. Labelled Comp. Radiopharm. , XXXI(1), 61-70.

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