王瑾曄

王瑾曄,女 ,上海交通大學生物醫學工程學院教授。

基本信息

簡介

王瑾曄,現在是中國科學院上海有機化學研究所研究員、上海交通大學兼職教授,在此之前,她在日本獲得博士學位後,一直在日本的頂級研究所擔任特別研究員。在日本工作生活十餘年,獲得一項日本專利後,2000年她回到祖國,申請了9項國內專利。從生物膜模擬、生物醫用材料、生物體自由基反應及抗氧化一直到藥物緩釋和控釋,她追逐的目標是非線性的,她在相鄰甚至不同的領域追逐著想像、驗證和實現的樂趣。

主要學習與工作經歷

1. 1985年畢業於河南師範大學化學系

2. 1986年受中國政府派遣在日本東北大學攻讀碩士,博士學位,1992年獲博士學位

3. 1992年至2000年先後在日本理化學研究所日本國立健康營養研究所工作

4. 2000年9月入選中國科學院百人計畫回國,任中國科學院上海有機化學研究所研究員,博士生導師,上海交通大學兼 職教授

回國以來主持的科研項目有:

科學院百人計畫; 國家自然科學基金; 上海市科委光科技專項; 863國家高技術研究發展計畫;

中國科學院創新重要方向性項目; 973國家重點基礎研究發展計畫一級子課題。

共發表論著3本(章節),各種論文85篇,其中SCI 論文48篇。獲授權中國發明專利6項。

主要研究領域為:

生物醫用材料(含螢光標記分子),藥物緩釋和控釋材料,生物膜模擬,生物體自由基反應及抗氧化

Selected publications from 2004(*IF>5.0):

*1. Dong, J., Sun, Q.S. and Wang, J.Y. Basic Study of Corn Protein, Zein, as a Biomaterial in Tissue Engineering, Surface Morphology and Biocompatibility. (2004) Biomaterials, 25, 4691-4697.

2. Zein: A Potential Biomaterial for Tissue Engineering. (2004) MaterialsToday, July/August, 24.

*3. Liu, X.M., Sun, Q.S., Wang, H.J., Zhang, L. and Wang, J.Y. Microspheres of Corn Protein, Zein, For an Ivermectin Drug Delivery System. (2005) Biomaterials, 26, 109-115.

4. Wang, H.J., Lin, Z.X., Liu, X.M., Sheng, S.Y. and Wang, J.Y. Heparin-loaded Zein Microsphere Film and Hemocompatibility. (2005) J. Control Release, 105, 120-131.

*5. Liu, X.M., Yang, B., Wang, Y.L. and Wang, J.Y. A New Nanoscale Pulsatile Drug Delivery System. (2005) Chem. Mater. 17, 2792-2795.

6. Sun, Q.S., Dong, J., Lin, Z.X., Yang, B., and Wang, J.Y. Comparison of Cytocompatibility of Zein Film with Other Biomaterials and its Degradability in Vitro. (2005) Biopolymer, 78, 268-274.

7. Liu, W., Wang, J.Y. Modifications of Protein by polyunsaturated Fatty Acid Ester Peroxidation Products. (2005) Biochim. Biophys. Acta, 1752, 93-98.

8. Liu, X.M., Wang, Y.L. and Wang, J.Y. Photoisomerisable Cholesterol Derivatives as Photo-trigger of Liposomes: Effect of Lipid Polarity, Temperature, Incorporation Ratio, and Cholesterol. (2005) Biochim. Biophys. Acta, 1720, 28-34.

9. Di, L., Liu, W., Liu, Y., Wang, J.Y. Effect of Asymmetric Distribution of Phospholipids in Ghost Membrane From Rat Blood on Peroxidation Induced by Ferrous Ion. (2006) FEBS Lett., 580, 685-690.

10. Wang, H.J., Liu, X.M., Ji, L.W., Ma, D.L., Wang, J.Y. Film From Peroxidation of an Amino Phospholipid and Its Biocompatibility. (2006) J. Biomed. Mater. Res. B, 79, 411-419.

*11. Gong, S.J., Wang, H.J., Sun, Q.S., Xue, S.T., Wang, J.Y. Mechanical Properties and in vitro Biocompatibility of Porous Zein Scaffolds. (2006) Biomaterials, 27, 3793-3799.

12. Shtykova, E.V., Volkov, V.V., Wang, H.J., Fujisawa, T., Wang, J.Y. Autoxidized Phospholipids in Hexane: Nano-self-assemblies Studied by Synchrotron Small-Angle X-ray Scattering. (2006) Langmuir, 22, 7994-8000.

13. Liu, W., Wang, H.J., Wang, L.P., Liu, S.L., Wang, J.Y. Formation of High-molecular-weight Protein Adducts by Methyl Docosahexaenoate Peroxidation Products. (2007) Biochim. Biophys. Acta, 1774, 258-266.

*14. Wang, H.J., Gong, S.J., Lin, Z.X., Fu, J.X., Xue, S.T., Huang, J.C., Wang, J.Y. In Vivo Biocompatibility and Mechanical Properties of Porous Zein Scaffolds. (2007) Biomaterials, 28, 3952-3964.

15. Wang, J.Y., Wang, L.P., Ren, Q.S. Atomic Force Microscope Observation on Biomembrance Before and After Peroxidation. (2007) Biophys. Chem. 131, 105-110.

16. Wang, H.J., Ji, L.W., Li, D.F., Wang, J.Y. Characterization of Nanostructure and Cell Compatibility of Polyaniline Films with Different Dopant Acids. (2008) J. Phys. Chem. B, in press.

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