王澤峰[計算生物學研究所成員]

王澤峰，計算生物學研究所研究人員。

簡歷：

工作經歷： 2014/9-至今,中國，中國科學院上海生命科學研究院，計算生物學研究所，研究員、所長 2013/5-2014/9,美國，北卡羅來納大學（教堂山），醫學院藥理系，副教授（終身教職） 2007/1-2013/4,美國，北卡羅來納大學（教堂山）醫學院藥理系，助理教授 2002/9-2006/12,美國，麻省理工學院，生物系，博士後研究員 教育經歷： 1997/09-2002/06,美國，約翰霍普金斯醫學院，生化博士 1994/09-1997/06,中國，中科院生物物理所，分子生物學碩士 1991/09-1994/06,中國，清華大學,計算機工程與技術，工學學士 1989/09-1994/06,中國，清華大學,生物科學與技術，理學學士

研究方向：

1）RNA可變剪接的機理 2）RNA結合蛋白的合成生物學 3）RNA功能基因組學

職稱：

研究員

職務：

計算生物學研究所所長、研究組長、博士生導師

獲獎及榮譽：

2012-2016 傑弗遜基礎醫學獎（Jefferson-Pilot Fellowships in Academic Medicine Award） 2009-2011 Kimmel學者獎(Kimmel Scholar Award,) 2008-2011 貝克曼青年學者獎(Beckman Young Investigator Award ) 2008-2010 斯隆研究獎(Alfred Sloan Research Fellow) 2007 RNA 學會青年學者獎(RNA Society/Scaringe Young Scientist Award) 2003-2006 Damon Runyon博士後研究獎 2002Paul Ehrlich青年學者獎(Paul Ehrlich Research,Johns Hopkins University) 1999Burroughs Wellcome獎學金(Burroughs Wellcome Fellowship) 1996-1997中科院地奧獎學金 1994清華大學優秀畢業生（生物系94年唯一優秀畢業生） 1993-1994清華大學光華獎學金 1990-1993清華大學優秀生獎學金

代表論著：

1. Tsai YS, Dominguez D, Gomez SM, and Wang Z*. Cancer-specific splicing events acrossmultiple tumors are closely associated with cell cycle regulation (2015) Oncotarget 6 (9), 6825-6839 2. Wang Z*Not just a sponge: new functions of circular RNAs discovered (2015) Sci China Life Sci. 2015 Feb 14. [Epub ahead of print] 3. Wang Y, Wang Z*. Efficient backsplicing produces translatable circular mRNAs. (2015)RNA Feb;21(2):172-9. doi: 10.1261/rna.048272.114. Epub 2014 Dec 1. PubMed PMID:25449546. 4. Wang Y, Chen D, Qian H, Tsai YS, Shao S, Dominguez D and Wang Z*. RBM4 specifically controls alternative splicing to suppress tumor progression (2014) Cancer Cell 26(3):374-389.doi: 10.1016/j.ccr.2014.07.010. Highlighted by Research Watch article “RBM4-regulated alternative splicing suppresses tumorigenesis” Cancer Discovery 2014 Nov;4(11):1253. doi: 10.1158. 5. Choudhury R and Wang Z*Manipulation of RNA using engineered proteins with customized specificity (2014) In: GW Yeo (ed.) System Biology of RNA Binding Proteins. Adv Exp Med Biol., 2014;825:199-225. doi: 10.1007/978-1-4939-1221-6_6. 6. Tsai YS, Gomez SM, and Wang Z*. Prevalent RNA recognition motif duplication in the human genome. RNA (2014) May;20(5):702-12. doi: 10.1261/rna.044081.113. 7. Choudhury R, Ghose Roy S, Tsai YS, Tripathy A , Graves LM and Wang Z*. The splicing activator DAZAP1 integrates splicing control into MEK/Erk regulated cell proliferation and migration. Nature Communications (2014); 5:3078. doi: 10.1038/ncomms4078. 8. Matera AG and Wang Z*. Ribonucleoprotein assembly and dynamics: A day in the life of the spliceosome. Nature Review Molecular Cell Biology (2014) Apr;15(4):294 9. Zhang W, Wang Y, Dong S, Choudhury R, Jin Y, and Wang Z*Treatment of type 1 Myotonic Dystrophy by engineering site-specific RNA endonucleases that target (CUG)n repeats. Molecular Therapy 2013 Oct 23. doi: 10.1038/mt.2013.251. [Epub ahead of print] 10. Wang Y and Wang Z*Systematical identification of splicing regulatory cis-elements and cognate trans-factors (2013), Methods. Aug 22. doi:pii: S1046-2023(13)00326-5. 11. Wang Y, Wang Z* and Hall TM* (co-corresponding author). Engineered proteins with PUF scaffold to manipulate RNA metabolism (2013). FEBS J. Jun 3. doi: 10.1111/febs.12367 invited review 12. Wang Y, Xiao X, Zhang J, Choudhury R, Robertson A, Li K, Ma M, Burge CB and Wang Z*. A complex network of factors with overlapping affinities control splicing repression by intronic elements. (2013) Nature Structure Molecular Biology Jan;20(1):36-45. doi: 10.1038/nsmb.2459. Epub 2012 Dec 16. 13. Choudhury R, Dominguez D, Wang Y and Wang Z*. Engineering RNA endonucleases with customized sequence specificities (2012). Nature Communications Oct 23;3:1147. doi: 10.1038/ncomms2154. 14. Wang Y, Ma M, Xiao XS and Wang Z*. Intronic splicing enhancers, cognate splicing factors and context dependent regulation rules. (2012) Nature Structure Molecular Biology,19(10):1044-52. doi: 10.1038/nsmb.2377. Epub 2012 Sep 16 15. Dong S, Wang Y, Cassidy-Amstutz C, Lu G, Bigler R, Li C, Jezyk MR, Hall TM , Wang Z*. A specific and modular binding code for cytosine recognition in PUF domains. (2011) J Biol Chem. 2011 Jul 29;286(30):26732-42. Epub 2011 Jun 8. Selected as the paper of the week by J Bio. Chem. Recommended by an editorial comment in Chem Biol. 2011 Jul 29;18 (7):821-3. 16. Abbas AI, Urban DJ, Jensen NH, Farrell MS, Kroeze WK, Mieczkowski P, Wang Z, Roth BL. Assessing serotonin receptor mRNA editing frequency by a novel ultra high-throughput sequencing method. (2010) Nucleic Acids Res. 38(10):e118. Epub 2010 Feb 25. 17. Burd CE, Jeck WR, Liu Y, Sanoff HK, Wang Z, Sharpless NE. Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk. (2010) PloS Genet, 6(12):e1001233.