人物履歷
1987 年國防科技大學材料系本科畢業後進入國家航天局 165 廠工作， 1995 年西安交通大學電子系碩士畢業，
1998 年復旦大學物理系博士畢業，
2000 年中科院上海藥物所博士後流動站出站後留所工作至今，從事新藥設計研究工作。
研究方向
目前主要從事糖尿病與心血管新藥藥學研究，具體課題包括：抗糖尿病和抗動脈粥樣硬化症天然活性化合物的結構最佳化；基於靶標結構的抗代謝綜合症藥物先導化合物的設計與合成；治療多囊腎藥物先導化合物的臨床前研究；中藥複方的深度開發。
專家類別
研究員
現任職務
中科院上海藥物所研究員、博士生導師、研究組長
科研項目
承擔了自然科學基金項目、科技部生物和信息領域 863 項目、 973 計畫 SARS 防治專項、上海市基礎重點研究項目等
所獲榮譽
2007年國家自然科學二等獎；
2003年上海市科技進步一等獎；
代表論著
1. Antitumor activity of a novel series of alpha-aryloxy-alpha-methylhydrocinnamic acid derivatives as PPAR gamma agonists against a panel of human cancer cell lines.Invest New Drugs.
2. Structure-based virtual screening for identification of novel 11beta-HSD1 inhibitors. Eur J Med Chem. 2009 Mar;
3. Design, synthesis and biological evaluation and molecular modelingof α-Aryloxy-α-methylhydrocinnamic Acids as PPARγ agonists and 11β-HSD1 inhibitors with antihyperglycemia and lipid modulating activity. Bioorg Med Chem
4. (Phenylsulfonamidomethyl)benzamides as Potent and Selective Inhibitors of the 11β-Hydroxysteroid Dehydrogenase Type1 with Efficacy in diabetic ob/ob mice. Bioorg Med Chem
5. 4-(Phenylsulfonamidomethyl)benzamides as Potent and Selective Inhibitors of the 11β-Hydroxysteroid Dehydrogenase Type 1 with Efficacy in diabetic ob/ob mice. Acta Pharmacol Sin
6. Discovery of novel inhibitors of 11b-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling. Bioorganic & Medicinal Chemistry Letters
7. Conformational transition of amyloid beta –peptide.PNAS
8. How Does Huperzine A Enter and Exit the Active Site of Acetylcholinesterase? Steered Molecular Dynamics Simulations. J. Am. Chem. Soc
9. Virtual Screening on Natural Products for Discovering Active Compounds and Target Clues. Curr. Med. Chem
10. Steered Molecular Dynamics Simulation on the Binding of NNRTI to HIV-1 RT. Biophys. J.
