![李紀文[副教授]](/img/3/27d/nBnauM3XzADOwEzNzMDO2kTO0UTMyITNykTO0EDMwAjMwUzLzgzL2IzLt92YucmbvRWdo5Cd0FmLwE2LvoDc0RHa.jpg "李紀文[副教授]")
簡介
李紀文，華東師範大學生命科學學院生命醫學研究所生物化學與分子生物學學科組副教授級高級研究助理。碩士導師。
簡歷
學習經歷
1986-1990: 學士學位，生物化學專業，復旦大學
1995-1997: 碩士學位，生物化學專業，Hood College, Frederick, Maryland, USA，
工作經歷
1990-1994：研究助理，中國科學院上海有機生化所生物化學系。
1997-2003：研究技術員，Department of Cell Biology, Baylor College of Medicine, USA.
2003-2007：高級研究助理，Department of Cell Biology, Baylor College of Medicine, USA.
2007-至今：副教授，華東師範大學生命科學學院生命醫學研究所
研究方向
1) 雄性激素受體基因表達調控與前列腺癌
2) 蛋白SUMO修飾
科研項目
1、2008年至今參與一項973課題，“染色質解碼的基礎與臨床研究”。
2、參與上海市科委細胞信號傳導平台建設研究。
代表性的論文
1.Chen, H.-B., Li, J., and Yang, J. 1992. Expression of a chemically synthesized gene for the mature rbcS from tobacco in E. coli.. In”Research in Photosynthesis” (Murata, n., ed), vol. III, 645-648.
2.Stolow, M.A; Bauzon, D.D; Li, J; Sedgwick, T; Liang, V.C-T; Sang, Q.A; and Shi, Y-B. (1996). Identification and characterization of a novel collagenase in Xenopus laevis: possible roles during frog development. Molecular Biology of the Cell, Vol. 7, 1471-1483.
3. Li, J; Liang, V.C-T; Sedgwick, T; Wong, J; and Shi, Y-B. 1998. Unique organization and involvement of GAGA factors in transcriptional regulation of the Xenopus stromelysin-3 gene. Nucleic Acids Res. 26(12): 3018-3025
4. Li, J., O’Malley B.W and Wong J. 2000. p300 requires its HAT activity and SRC-1 interaction motif to facilitate TR activation in chromatin. Mol. Cell. Biol. 20: 2031-2042.
5. Li, J,. Wang, J; Wang, J; Nawaz, Z; Liu, J., Jun, Q., and Wong J. 2000. Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. EMBO J. 19(16): 4342-4350.
6. Huang, Z., Li, J. and Wong J. 2002. Androgen receptor possesses an intrinsic-hormone-independent trans-activation activity. Molecular Endocrinology. 16: 924-937.
7. Li, J; Lin, Q; Wade, P., Wang, W and Wong J. 2002. Specific targeting and constitutive association of histone deacetylase complexes during transcriptional repression. Genes & Development 16: 687-692.
8. Li, J., Lin, Q., Yoon, H-G., Huang, Z., Strahl, B.D., Allis, C.D., and Wong J. 2002. Involvement of histone methylation and phosphorylation in regulation of transcription by thyroid hormone receptor. Mol Cell Biol 22 (16): 5688-5697.
9.Yoon HG, Chan DW, Huang ZQ, Li, J, Fondell JD, Qin J and Wong J. 2003. Purification and Functional Characterization of the Human N-CoR Complex: the Roles of HDAC3 and two WD-40 Repeat Subunits TBL1 and TBLR1. EMBO J 22(6):1336-1346.
10. Lee KC#, Li, J#, Cole PA, Wong J * and Kraus L*. 2003. Transcriptional activation by thyroid hormone receptor involves chromatin remodeling, histone acetylation, and cooperative stimulation by p300 and SRC coactivators. Molecular Endocrinology, 17(5):908-22. (#equal contribution and co-corresponding authors.)
11.Huang ZQ, Li, J, Sachs LM, Cole PA and Wong J. 2003. A Role for Cofactor-Cofactor and Cofactor-Histone Interaction in Targeting of CBP/p300, SWI/SNF and Mediator for transcription. EMBO J 22(9):2146-2155.
12.Stewart MD, Li J and Wong J. 2005 Relationship between H3 lysine 9 methylation, transcription repression and heterochromatin protein 1 recruitment. Mol Cell Biol;25(7):2525-38.
13.Burd CJ, Petre CE, Morey LM, Wang Y, Revelo MP, Haiman CA, Lu S, Fenoglio-Preiser CM, Li J, Knudsen ES, Wong J and Knudsen KE. 2006 Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation. Proc Natl Acad Sci U S A; 103:2190-5.
14. Li, J., Fu J, Toumazou C, Yoon HG, and Wong J. 2006. A role of the amino-terminal (N) and carboxyl-terminal (C) interaction in binding of androgen receptor to chromatin. Mol Endocrinol 20:776-85.
