![徐國良[中國科學院院士]](/img/3/349/nBnauM3XxgzMzkzNwQDM2kTO0UTMyITNykTO0EDMwAjMwUzL0AzLyAzLt92YucmbvRWdo5Cd0FmLwE2LvoDc0RHa.jpg "徐國良[中國科學院院士]")
個人簡介
![徐國良[中國科學院院士]](/img/9/980/wZwpmL2cTNyYTMyADO0kTO0UTMyITNykTO0EDMwAjMwUzLwgzLzQzLt92YucmbvRWdo5Cd0FmLwE2LvoDc0RHa.jpg)
徐國良[中國科學院院士]1981.9-1985.7：浙江大學生物系，學士；1985.9-1989.8：中國科學院遺傳所，碩士；1989.9-1993.3：德國馬普分子遺傳學研究所，博士；1993.3-1994.7：德國馬普分子遺傳學研究所，博士後；1994.8-1995.9：新加坡國立大學生命科學中心，實驗室主任；1995.1-2000.3：美國哥倫比亞大學遺傳發育系，博士後；2000.4-2001.7：美國哥倫比亞大學醫學系，Associate Research Scientist；2001.8-至今任中國科學院與德國馬普學會國際合作青年科學家小組組長。2015年12月7日，當選中國科學院院士 。
研究方向
DNA甲基化與發育調控
發表論文
Jing-Yu Li, Min-Tie Pu, Ryutaro Hirasawa, Bin-Zhong Li, Yan-Nv Huang, Rong Zeng, Nai-He Jing, Taiping Chen, En Li, Hiroyuki Sasaki and Xu G.-L. (2007) Synergistic Function of DNA Methyltransferases Dnmt3a and Dnmt3b in the Methylation of Oct4 and Nanog. Mol. Cell. Biol., 27, 8748-8759.
Ya-Qiang Li, Ping-Zhu Zhou, Xiu-Dan Zheng, Colum P. Walsh and Xu G.-L. (2007) Association of Dnmt3a and Thymine DNA Glycosylase Links DNA Methylation with Base Excision Repair. Nucleic Acids Research, 35, 390-400.
Xie Z.-H., Huang Y.-N., Chen Z.-X., Riggs A.D., Ding J.-P., Gowher H., Jeltsch A., Sasaki H., Hata K. and Xu G.-L*. (2006) Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L. Human Molecular Genetics 15, 1375-1385.
Yuki O., Feng Q., Lin Y., Jiang Q., Li Y., Coffield V.M., Su L., Xu G.-L* and Zhang Y*. (2005) hDOT1L Links Histone Methylation to Leukemogenesis. Cell 121,167-178 (Erratum in Cell 121, 809; * corresponding authors).
Ge, Y-Z, Pu, M.-T., Gowher, H., Ding J.-P., Jeltsch, A. and Xu G-L. (2004) Chromatin-targeting of de novo DNA methyltransferases by PWWP domain. J. Biol. Chem. 279, 25447-25454.
Cheng J.C., Weisenberger D.J., Gonzales F.A., Liang G., Xu G.-L., Hu Y.-G., Marquez V.E. and Jones P. A. (2004) Continuous Zebularine treatment effectively sustains demethylation in human bladder cancer cells. Mol. Cell. Biol. 24, 1270-1278.
Bourc´his D., Xu, G.-L., C.-S. Lin, B. Bollman and T. H. Bestor. (2001) Dnmt3L and the establishment of maternal genomic imprints. Science 294, 2536-2539.
Xu, G.-L., T. H. Bestor, D. Bourc´his, C.L. Hsieh, N. Tommerup, M., Bugge, X., Qu, J. J. Russo and E. Viegas-Péquignot. (1999) Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature 402, 187-191.
Xu, G.-L. and T. H. Bestor. (1997) Cytosine methylation targeted to predetermined sequences. Nature Genetics 17, 376-378.
Chuang, L.S.H., Ian H.-I., Hoh H.-H., Ng H.-H., Xu G.-L. and Li B.F.L. (1997) Human DNA-(Cytosine-5) methyltransferase –PCNA complex as a target for p21 WAF1. Science 277, 1996-2000.
院士候選
2015年7月31日，入選中國科學院院士增選初步候選人名單。
