姜志宏 教授
澳門科技大學澳門藥物與健康套用研究所所長
中藥質量研究國家重點實驗室(澳門科技大學)副主任
姜志宏教授於1987年畢業於中國藥科大學，1990年於同校取得碩士學位。1994年獲日本國費獎學金資助留學日本，1998在長崎大學獲得藥學博士學位。1999年至2001年間在美國哈佛醫學院生物化學與分子藥理學系進行博士後研究工作,從事抗腫瘤抗生素與小RNA形成共價鍵附加物的研究。2001年姜志宏博士受聘於香港浸會大學中醫藥學院任助理教授，2005年提升為副教授， 2008年任教授。曾擔任教學部副主任和中藥學碩士課程主任。2011年7月任澳門科技大學澳門藥物與健康套用研究所所長，兼任中藥質量研究國家重點實驗室副主任。
姜教授的研究方向包括天然藥物化學，代謝組學，中藥質量標準研究，與生物大分子 (DNA, RNA，peptide)相互作用的藥理活性物質的分子機理的研究。姜教授在國際學術刊物上共發表了130餘篇SCI論文，於2006年獲香港浸會大學校長獎（學術研究），2007年榮獲「國家傑出青年科學基金．海外及香港、澳門青年學者合作研究基金獎」, 2008年獲得Elsevier出版社刊物Bioorganic & Medicinal Chemistry的“「被引用次數最多論文獎」。”他的研究得到香港研究資助局，香港衛生署，國家自然科學基金，美國國立衛生研究院和製藥企業的資助。
學歷:
1987年7月，中國藥科大學 理學學士學位
1990年7月，中國藥科大學 理學碩士學位
1998年3月，日本長崎大學 藥學博士學位
工作經歷:
1990年7月-1994年3月，中國藥科大學助教，講師
1996年10月-2001年9月，日本長崎大學 藥學部 助手（文部教官）
1999年11月-2001年9月，哈佛醫學院生物化學與分子藥理學系 博士後
2001年10月-2005年6月，香港浸會大學中醫藥學院 助理教授
2005年7月-2008年8月，香港浸會大學中醫藥學院 副教授
2008年9月-2011年6月，香港浸會大學中醫藥學院 教授
2011年7月-今，澳門科技大學 教授
授課科目: 中藥化學選論；中藥學研究進展
研究領域: 天然藥物化學，代謝組學，生物有機化學，中藥質量標準
專業會員: 美國化學會；日本藥學會；香港質譜學會
獲獎：香港浸會大學學術研究校長獎（2006年），國家傑出青年科學基金．海外及香港、澳門青年學者合作
研究基金獎（2007年）, Elsevier出版社刊物Bioorganic & Medicinal Chemistry“被引用次數最多論文
獎”（2008年）”
研究論文:
1) Y. Liu, Ke,K. Y. Wu,S. Liu,W.-H. Chen,S. jiang,Z.-H. Jiang. An Amphiphilic conjugate Approach toward the Design and Synthesis of Betulinic Acid-Polyphenol Conjugates as Inhibitors of the HIV-1 gp41 Fusion Core Formation. ChemMedChem, 6, 1654-1664, 2011.
2) D. S-H Chan,B. Y.-W. Man,H. Yang,M. H.-T. Kwan, L.-P. Bai, Z.-H. Jiang, D.-L. Ma, C.-H. Leung. Structure-based optimization of FDA-approved drug methylene blue as a c-MYC G-Quadruplex DNA stabilizer. Biochimie, 93, 1055-1064, 2011.
3) J. Wang, C. Y. Leung, H. M. Ho, S. Chai, L. F. Yau, Z. Zhao, Z.-H. Jiang. Quantitative Comparison of Ginsenosides and Polyacetylenes in Wild and Cultivated American Ginseng. Chem. & Biodivers., 7, 975-983, 2010.
4) X.-Y. Wen, S.-Y. Wu, Z.-Q. Li, Z. Liu, J.-J. Zhang, G.-F. Wang, Z.-H. Jiang, S.-G. Wu. An Anti-proliferative Natural Polyphenol Compound can Regulate the Expression of MicroRNAs in HepG2 Cancer Cells. Phytotherapy Research, 23, 778-784, 2009.
5) L.-P. Bai, M. Hagihara, Z.-H. Jiang, K. Nakatani. Ligand Binding to Tandem G-quadruplexes from Human Telomeric DNA. ChemBioChem, 9, 2583-2587, 2008.
6) L.-P. Bai, Z. Cai, Z. Zhao, K. Nakatani, Z.-H. Jiang. Site-Specific Binding of Chelerythrine and Sanguinarine to Single Pyrimidine Bulge in hairpin DNA. Analytical Bioanalytical Chemistry, 392, 709-716, 2008.
7) Z.-H. Jiang, Q. Yang, T. Tanaka, I. Kouno. Bicyclic Polyketide Lactones from Chinese Medicinal Ants Polyrhacis lamellidens.J. Nat. Prod., 71, 724-727, 2008.
8) Z.-H. Jiang, X.-Y. Wen, T. Tanaka, S.-Y. Wu, Z. Liu, H. iwata, Y. Hirose, S. Wu, I. Kouno. Cytotoxic Hydrolyzable Tannins from Balanophora japonica. J. Nat. Prod., 71, 719-723, 2008.
9) J. Liu, C. S. Lee, K.-M. Leung, Z. Yan, B. Shen, Z. Zhao, Z.-H. Jiang. Quantification of Two Polyacetylenes in Radix Ginseng and Related Panax Herbs Using a Gas Chromatography-Mass Spectrometric Method. J. of Agricultural and Food Chemistry, 55, 8830-8835, 2007.
10) G.-S. Qian, Q. Wang, kelvin S.-Y. Leung, Y. Qin, Z. Zhao, Z.-H. Jiang. Quality Assessment of Rhizoma et Radix Notopterygii by HPTLC, HPLC Fingerprinting and HPLC Quantitative Analysis. J. of Pharmaceutical and Biomedical Analysis, 44, 812-817, 2007.
Curriculum Vitae of Zhi-Hong JIANG
Professor, PhD
Director of Macau Institute for Applied Research in Medicine and Health
Deputy Director of State Key Laboratory for Quality Research in Chinese Medicines
Macau University of Science and Technology
Prof. Jiang’s research fields include natural products chemistry, quality control of Chinese medicinal herbs, metabolomics, interaction of pharmacologically-active natural products with biomacromolecules (DNA, RNA, peptides). He has published more than 130 papers in SCI journals. He received a number of awards, including “HKBU Presidential Award for Outstanding Performance in scholarly Work” in 2006, “National Outstanding Young Scientists Award (Overseas)” by the National Science Foundation of China (NSFC) in 2007, and "Most Cited Paper 2005-2008 Award" presented by the Elsevier. His research was financially supported by Research Grants Council of University Grants Committee of Hong Kong and Department of Health of HKSAR, National Natural Science Foundation of China, National Institutes of Health of U.S.A. and some pharmaceutical industries.
Education:
July, 1987, B. Sc. (China Pharmaceutical University, Nanjing, China)
July, 1990, M. Sc. (China Pharmaceutical University, Nanjing, China)
March, 1998, Ph. D. (Nagasaki University, Japan)
Professional chronology:
Jul., 1990- Mar., 1994 Research Associate, Lecturer, China Pharmaceutical University, Nanjing, China
Oct., 1996-Sept., 2001 Research Assistant Professor, School of Pharmaceutical Sciences, Nagasaki University, Japan
Nov., 1999-Sept., 2001 (sabbatical leave) Postdoctoral Research Fellow, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, U.S.A.
Oct., 2001-Jun., 2005 Assistant Professor, School of Chinese Medicine, Hong Kong Baptist University
Jul., 2005-Aug., 2008 Associate Professor, School of Chinese Medicine, Hong Kong Baptist University
Sept., 2008-June, 2011 Professor, School of Chinese Medicine, Hong Kong Baptist University
Jul., 2011-present Professor and Director, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology
Teaching Subjects:
1) Advanced Natural Products Chemistry
2) Prospect and Progress in Chinese Medicine Research
Research Fields:
1) Natural Products Chemistry
2) Metabolomics
3) Bioorganic Chemistry
4) Chemical Analysis of Chinese Herbs
Memberships:
1) American Chemical Society
2) Pharmaceutical Society of Japan
3) Hong Kong Society of Mass Spectrometry
Awards:
1) HKBU Presidential Award for Outstanding Performance in Scholarly Work, 2006
2) National Outstanding Young Scholar Award (Oversea Scholar), NSFC, 2007
3) Most Cited Paper Award (2005-2008) by “Bioorganic & Medicinal Chemistry”
Selected Publications:
1) Y. Liu, Ke,K. Y. Wu,S. Liu,W.-H. Chen,S. Jiang,Z.-H. Jiang. An Amphiphilic Conjugate Approach toward the Design and Synthesis of Betulinic Acid-Polyphenol Conjugates as Inhibitors of the HIV-1 gp41 Fusion Core Formation. ChemMedChem, 6, 1654-1664, 2011.
2) D. S-H Chan,B. Y.-W. Man,H. Yang,M. H.-T. Kwan, L.-P. Bai, Z.-H. Jiang, D.-L. Ma, C.-H. Leung. Structure-based optimization of FDA-approved drug methylene blue as a c-myc G-Quadruplex DNA stabilizer. Biochimie, 93, 1055-1064, 2011.
3) J. Wang, C. Y. Leung, H. M. Ho, S. Chai, L. F. Yau, Z. Zhao, Z.-H. Jiang. Quantitative Comparison of Ginsenosides and Polyacetylenes in Wild and Cultivated American Ginseng. Chem. & Biodivers., 7, 975-983, 2010.
4) X.-Y. Wen, S.-Y. Wu, Z.-Q. Li, Z. Liu, J.-J. Zhang, G.-F. Wang, Z.-H. Jiang, S.-G. Wu. An Anti-proliferative Natural Polyphenol Compound can Regulate the Expression of MicroRNAs in HepG2 Cancer Cells. Phytotherapy Research, 23, 778-784, 2009.
5) L.-P. Bai, M. Hagihara, Z.-H. Jiang, K. Nakatani. Ligand Binding to Tandem G-quadruplexes from Human Telomeric DNA. ChemBioChem, 9, 2583-2587, 2008.
6) L.-P. Bai, Z. Cai, Z. Zhao, K. Nakatani, Z.-H. Jiang. Site-Specific Binding of Chelerythrine and Sanguinarine to Single Pyrimidine Bulge in Hairpin DNA. Analytical Bioanalytical Chemistry, 392, 709-716, 2008.
7) Z.-H. Jiang, Q. Yang, T. Tanaka, I. Kouno. Bicyclic Polyketide Lactones from Chinese Medicinal Ants Polyrhacis lamellidens.J. Nat. Prod., 71, 724-727, 2008.
8) Z.-H. Jiang, X.-Y. Wen, T. Tanaka, S.-Y. Wu, Z. Liu, H. Iwata, Y. Hirose, S. Wu, I. Kouno. Cytotoxic Hydrolyzable Tannins from Balanophora japonica. J. Nat. Prod., 71, 719-723, 2008.
9) J. Liu, C. S. Lee, K.-M. Leung, Z. Yan, B. Shen, Z. Zhao, Z.-H. Jiang. Quantification of Two Polyacetylenes in Radix Ginseng and Related Panax Herbs Using a Gas Chromatography-Mass Spectrometric Method. J. of Agricultural and Food Chemistry, 55, 8830-8835, 2007.
10) G.-S. Qian, Q. Wang, Kelvin S.-Y. Leung, Y. Qin, Z. Zhao, Z.-H. Jiang. Quality Assessment of Rhizoma et Radix Notopterygii by HPTLC, HPLC Fingerprinting and HPLC Quantitative Analysis. J. of Pharmaceutical and Biomedical Analysis, 44, 812-817, 2007.
