人物簡介
PLoS ONE 和Cancer Investigation期刊審稿人,捷克共和國(Czech Republic)國家自然科學基金特邀評審。
1980年至1988年在武漢大學醫學院(原湖北醫科大學)醫學系和病原生物學專業學習,先後獲醫學學士和碩士學位。1993年至1995年獲中英科技合作項目資助在英國倫敦大學倫敦衛生和熱帶醫學學院(London School of Hygiene and Tropical Medicine)進修血清流行病學和分子生物學。1996年-1999年第二軍醫大學病原生物學博士畢業獲醫學博士學位。2000年6月至2005年3月在美國國家衛生研究院(NIH)從事博士後研究,主要研究斑馬魚發育基因組學。隨後應聘美國賓夕法尼亞大學醫學院(University of Pennsylvania School of Medicine )助理研究員(Research Associate),從事白血病和抑癌基因表觀遺傳學和信號轉導研究。2009年3月回國就職於上海海洋大學水產與生命學院。
科研方向
幹細胞和再生,發育基因組學,信號轉導。
研究興趣
1)組織完全再生的細胞轉分化及其分子機制;2)幹細胞遷移和巢居;3)環境因素對生殖幹細胞性別分化的影響。
發表論文
1.Jizhou Yan, Shawn Burgess. Using a yeast inverse one-hybrid system to identify functional binding sites of transcription factors. Methods Mol Biol. 2012:786:275-290
2.He H, Hua X, Yan J*. Epigenetic regulations in hematopoietic Hox code. Oncogene, 2011;30:379-388
3.Austin T. Thiel, Peter Blessington, Tao Zou, Danielle Feather, Xinjiang Wu, Jizhou Yan, Hui Zhang, Zuguo Liu, Patricia Ernst, Gary A. Koretzky, and Xianxin Hua. MLL-AF9-Induced Leukemogenesis Requires Co-Expression of the Wild Type Mll Allele. Cancer Cell, 2010;17(2):148- 59
4.J Yan, Y Yang, H Zhang, C King, H-M Kan, C-X Yuan, GS Bloom and X Hua. Menin interacts with IQGAP1 to enhance intercellular adhesion of beta cells. Oncogene. 2009;28 (7):973.
5.Jizhou. Yan*,XIANG YANG, Mark A. Martin*, Mohammed Shahabuddin.malariasporozoite antigen-directed genome-wide responses in transgenic Drosophila. Genesis, 2009,47(3):196.
6.Jue Zeng, Jizhou Yan, Ting Wang, et al. Genome wide screens in yeast to identify potential binding sites and target genes of DNA binding proteins. Nuclei Acid Research 2008, 36, 1,e8, 共第一作者
7.Jizhou Yan, Ya-Xiong Chen, Angela Desmond, Albert Silvia, Yuqing Yang, Haoren Wang, Xianxin Hua. Cdx4 and menin co-regulate Hoxa9 expression in hematopoietic cells. PLoS ONE 2006; 1(1): e47
8.Chen Ya-Xiong, Jizhou Yan, Keeshan K, et al. The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Proc Natl Acad Sci USA. 2006; 103: 1018共第一作者
9.Jizhou Yan, Lisha Xu, Gregory Crawford, and Shawn M. Burgess. The forkhead transcription factor Foxi1 remains bound to condensed mitotic chromosomes and stably remodelschromatinstructure. Mol Cell Biol, 2006, 26 (1): 155.
10.Robert M. Nissen, Jizhou Yan, Adam Amsterdam, Nancy Hopkins, and Shawn M. Burgess. Zebrafish foxi one modulates cellular responses of Fgf signalling required for the integrity of ear and jaw patterning. Development 2003, 130 (11):2543