人物履歷
吳蓓麗,研究員。 中科院上海藥物所研究員、研究組組長,入選中科院百人計畫,承擔多項國家、科學院及地方的科研項目。
研究方向
主要從事G蛋白偶聯受體(GPCR)的結構生物學研究,研究工作集中在以下幾個方面:1、GPCR高解析度晶體結構解析;2、GPCR三維結構與功能關係的研究;3、基於GPCR結構的藥物設計與研發。
任免信息
2017年12月27日,被選舉為上海市第十五屆人民代表大會代表。
人物榮譽
2018年5月30日,吳蓓麗獲陳嘉庚青年科學獎生命科學獎。
2018年8月3日,國家自然科學基金委員會公布2018年度國家傑出青年科學基金建議資助項目申請人名單,其中吳蓓麗在2018年度國家傑出青年科學基金建議資助項目申請人名單內。
2018年11月,獲頒何梁何利基金科學與技術獎“青年創新獎”。
代表論著
Li P, Shu C, Wu B, Ding Y, Shen B and Rao Z. Crystallization and preliminary X-ray diffraction analysis of FKBP52 N-terminal domain. ActaCryst. D.
Li P, Wang L, Ding Y, Wu B, Shu C, Nie A, Li S, Shen B and Rao Z. Crystallization and preliminary X-ray diffraction analysis of FKBP12 complexed with a novel neurotrophic ligand. Protein and Peptide Letters
Wu B, Li P, Shu C, Shen B and Rao Z. Crystallization and preliminary crystallographic studies on the C-terminal Domain of human FKBP52. ActaCryst. D
Li P, Ding Y, Wu B, Shu C, Shen B and Rao Z. Crystal Structure of the N-terminal domain of human FKBP52. ActaCryst. D
Li P, Zhu J, Wu B, Gao F, Tien P, Rao Z and Gao GF. Crystallization and preliminary X-ray diffraction analysis of post-fusion six-helix bundle core structure from Newcastle disease virus F protein. ActaCryst. D
Li P, Wang L, Wu B, Shu C, Nie A, Shen B, Li S and Rao Z. Crystallization and preliminary X-ray diffraction analysis of FKBP12 complexed with a new neurotrophic ligand. Progress in Natural Science.
Wu B, Li P, Liu Y, Lou Z, Ding Y, Shu C, Ye S, Bartlam M, Shen B &Rao Z. 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilinheterocomplex. Proc Natl Acad Sci USA
Sun Y, Li X, Wu B, Sun P and Rao Z. Crystallization and Preliminary Crystallographic Analysis of Human eukaryotic translation initiation factor 5A (eIF-5A). Protein and Peptide Letters
Wu B, Liu Y, Zhao Q, Liao S, Zhang J, Bartlam M, Chen W &Rao Z. Crystal Structure of RS21-C6, involved in nucleoside triphosphate pyrophosphohydrolysis. Journal of Molecular Biology
Zhao Q, Oin L, Jiang F, Wu B, Yue W, Xu F, Rong Z, Yuan H, Xie X, Gao Y, Bai C, Bartlam M, Pei X &Rao Z. Structure of human Spindlin1: Tandem TUDOR-like domains for cell cycle regulation. Journal of Biological Chemistry.
Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel TM, Cherezov V & Stevens RC. Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science.