個人經歷
1982.09-1986.07:中國藥科大學藥學系,獲學士學位;
1986.07-1988.08:武漢第四製藥廠,任助理工程師;
1988.09-1993.06:中國藥科大學藥劑學專業,獲博士學位;
1993.06-1994.08:南京國科公司,任高級工程師;
1994.09-1996.08:軍事醫學科學院,博士後;
1996.08-2000.11:復旦大學生命科學學院遺傳所生物技術中心,副教授;
2000.12- 復旦大學生命科學學院教授,博士生導師。
主要研究方向
(1)生物大分子藥物與新型給藥系統研究;
(2)納米載體材料與分子藥劑學研究;
(3)新藥及藥物新劑型的研究與開發。
主持在研科研項目
(1)國家自然科學基金面上項目,30772656,載藥納米粒與靶點細胞相互作用的機制研究,2008.01-2010.12;
(2)國家自然科學基金面上項目,30873204,可改善藥物功效的新型藥用材料亞油酸和聚蘋果酸修飾的殼聚糖類衍生物研究,2009.01-2011.12;
作為研究負責人和主要研究者,已獲國家批准的新藥證書20餘項;申請中國發明專利19項,獲授權的中國發明專利8項;
主要著作
1 Lichen Yin, Jieying Ding, Likun Fei, Miao He, Fuying Cui, Cui Tang, Chunhua Yin*. Beneficial properties for insulin absorption using superporous hydrogel containing interpenetrating polymer network as oral delivery vehicles. Int J Pharm, 2008; 350:220-229
2 Lichen Yin, Ziming Zhao, Yizhe Hu, Jieying Ding, Fuying Cui, Cui Tang, Chunhua Yin*. Polymer-protein interaction, water retention, and biocompatibility of a stimuli-sensitive superporous hydrogel containing interpenetrating polymer networks. J App Polym Sci, 2008; 108(2):1238-1248
3 Fuying Cui, Chunbai He, Miao He, Cui Tang, Lichen Yin, Feng Qian, Chunhua Yin*. Preparation and evaluation of chitosan-ethylenediamineteraacetic acid hydrogel films for the mucoadhesive transbuccal delivery of insulin. J Biomed Mater Res A, 2008; Published Online: May 13 2008 11:26AM DOI: 10.1002/jbm.a.32071
4 Yu Zhang, Siyu Zhu, Lichen Yin, Feng Qian, Cui Tang, Chunhua Yin*. Preparation, characterization and biocompatibility of poly(ethylene glycol)-poly(n-butyl cyanoacrylate) nanocapsules with oil core via miniemulsion polymerization. Eur Polymer J, 2008; 44(6):1654-1661
5 Chunbai He, Fuying Cui, Lichen Yin, Feng Qian, Cui Tang, Chunhua Yin*. A Polymeric Composite Carrier for Oral Delivery of Peptide Drugs: Bilaminated Hydrogel Film Loaded with Nanoparticles. Eur Polymer J, 2008; Available online 12 November 2008 doi: 10.1016/j.eurpolymj.2008.11.004
6 Lichen Yin, Likun Fei, Fuying Cui, Cui Tang, Chunhua Yin*. Superporous hydrogels containing poly(acrylic acid-co-acrylamide)/ O-carboxymethyl chitosan interpenetrating polymer networks. Biomaterials, 2007; 28: 1258-1266
7 Fuying Cui, Chunbai He, Lichen Yin, Feng Qian, Miao He, Cui Tang, Chunhua Yin*. Nanoparticles Incorporated in Bilaminated Films: A Smart Drug Delivery System for Oral Formulations. Biomacromolecules, 2007; 8:2845-2850
8 Lei Jiang, Feng Qian, Xiaowen He, Fang Wang, Ding Ren, Ying He, Ka Li, Shuhan Sun, Chunhua Yin*. Novel chitosan derivative nanoparticles enhance the immunogenicity of a DNA vaccine encoding hepatitis B virus core antigen in mice. J Gene Med, 2007; 9:253-264
9 Siyu Zhu, Feng Qian, Yu Zhang, Cui Tang Chunhua Yin*. Synthesis and characterization of PEG modified N-trimethylaminoethylmethacrylate chitosan nanoparticles. Eur Polymer J, 2007; 43(6):2244-2253
10 Huaizhi Dou, Min Zhang, Yu Zhang, Chunhua Yin*. Synthesis and Purification of Mono-PEGylated Insulin. Chem Biol Drug Des, 2007; 69:132-138
11 Lichen Yin, Likun Fei, Cui Tang, Chunhua Yin*. Synthesis, characterization, mechanical properties and biocompatibility of interpenetrating polymer network-super-porous hydrogel containing sodium alginate. Polym Int, 2007; 56(12):1563-1571
12 Lei Song, Jieying Ding, Cui Tang, Chunhua Yin*. Compositions and Biological Activities of Essential Oils of Kadsura longepedunculata and Schisandra sphenanthera. Am J Chinese Med, 2007;35(2):353-364
13 Cui Tang, Jing Yu, Lichen Yin, Chunhua Yin*, Yuanying Pei. Transport of Insulin in Modified Valia-Chien Chambers and Caco-2 Cell Monolayers. Drug Dev Ind Pharm, 2007; 33(4):449-456 14 Min Zhang,Yu Zhang,Siyu Zhu,Lifang Wu,Huaizhi Dou, Chunhua Yin*. Synthesis and Chromatographic Separation of Monomethoxypolyethylene Glycol Modified Insulin. Sep Sci Technol, 2007;42(4):789-801
15 Cui Tang, Lichen Yin, Jing Yu, Chunhua Yin*, Yuanying Pei. Swelling behavior and biocompatibility of Carbopol-containing superporous hydrogel composites. J Appl Polym Sci, 2007; 104(5):2785-2791
16 Feng Qian, Fuying Cui, Jieying Ding, Cui Tang, Chunhua Yin*. Chitosan Graft Copolymer Nanoparticles for Oral Protein Drug Delivery: Preparation and Characterization. Biomacromolecules, 2006; 7:2722-2727
17 Fuying Cui, Feng Qian, Chunhua Yin*. Preparation and characterization of mucoadhesive polymer-coated nanoparticles. Int J Pharm, 2006; 316:154-161
18 Feng Qian, Fuying Cui, Chunhua Yin*. Preparation, characterization and enzyme inhibition of methylmethacrylate copolymer nanoparticles with different hydrophilic polymeric chains. Eur Polymer J, 2006; 42( 7):1653-1661
成就榮譽
(1)獲2003年教育部科學技術獎(發明)一等獎(第一完成人);
(2)獲2003年上海市科學技術獎(發明)二等獎(第一完成人);
(3)獲2003年上海市優秀髮明選拔賽一等獎(第一完成人)。