Trichosanthin

Root of Chinese trichosanthes, fruit of the Cucurbitaceae plant is root, is a traditional Chinese medicine, and fire - purging drugs.Efficacy is the specific heat and purging fire and helping produce saliva and slake thirst, the effects of evacuating pus for detumescence.Indications to treat fever and thirst, thirst, jaundice, hemoptysis lung dryness, carbuncles, hemorrhoids and fistula.For the treatment of diabetes, which is used for common with nourishing Yin to solve the problem of the role.It was an irregular cylindrical, spindle - shaped or flap or long 8 ~ 16cm, diameter 1. 5 ~ 5. 5 cm.Surface yellowish white or pale brown with longitudinal wrinkles, fine roots mark and is slightly recessed in the long transverse lenticels, and some have brown skin residue.It's solid, white or pale yellow, a rich silt, finer.The xylem yellow, slightly positive longitudinal section visible yellow longitudinal stripes in the xylem.Odorless, slightly bitter taste.Autumn, winter is collected in autumn, washed, peeled, cut into segments or longitudinal flap is cut and dried.

Overview

Trichosanthin "-" The God of Thunder who concocted the "Trichosanthin "-" The God of Thunder who concocted the "." of the Tang Dynasty ": this is not the same as that of the powder with Mongolian snakegourd root, such as arrowroot starch, white and beautiful " of the Tang Dynasty ": this is not the same as that of the powder with Mongolian snakegourd root, such as arrowroot starch, white and beautiful .
" Bencao justice ": four of the so - called root of Chinese trichosannthes, i. e. wilting root slice with which, in the name of a powder, a powder - free cover for the pursuit of its in fine powder or the right," Qian Jinyaofang "has to say in fine powder or the right," Qian Jinyaofang "has to say .
Now I quite fond of Marie Claire, loaded to take the city, regarded as one of the native method to mine the Dongyue Now I quite fond of Marie Claire, loaded to take the city, regarded as one of the native method to mine the Dongyue . clematis root, which turns brown and its outer skin, grinding with water, went to shoes - polishing shop for her clarification, several changes of water, then exposed to dry, pure white, no mote, boiling soup have fallen into the hands of the clothes, although the thick smooth paste without you becoming viscous, clear, limpid water of the jade, and other city spirit which had crept into those impurities, clematis root, which turns brown and its outer skin, grinding with water, went to shoes - polishing shop for her clarification, several changes of water, then exposed to dry, pure white, no mote, boiling soup have fallen into the hands of the clothes, although the thick smooth paste without you becoming viscous, clear, limpid water of the jade, and other city spirit which had crept into those impurities,.
is never the same stomach, pushing the works of wonderful works, is the most conducive to the sick and the infirm, stood in the way of a non - sticky sensation in the is never the same stomach, pushing the works of wonderful works, is the most conducive to the sick and the infirm, stood in the way of a non - sticky sensation in the . though this clematis root, seven times, all the dross, bitter and cold nature, have been eliminated, more does not allow its cold in the deficient. It can be changed, particularly the full advantage of it and to its non - raw may be the same as that of Japanese!
Maxim climbers, up to 10m long Maxim climbers, up to 10m long . Caudex terete, fleshy, rich in starch Caudex terete, fleshy, rich in starch .
stems are strong, much branched, longitudinally angular and grooved stretching is white pilose stems are strong, much branched, longitudinally angular and grooved stretching is white pilose . Leaves alternate;Petiole 3 - 10 cm long, with longitudinal stripes, the stripe is pubescent;tendrils 3 - 7, pilose;blade grade, contour subrounded or subcordate, and the width are about 5 - 20 cm, 3 - (5 - 7) - lobed to middle fissure, dilute deep crack or split have not only such large coarse teeth, lobe rhombic - obovate, oblong, apex obtuse, acute, margin often lobed again, base cordate, sinus 3 - 4cm deep, dark green surface, scabrous, abaxially pale green, pilose along veins on both sides of the bristle - like, palmately veined 5 basal veins, veinlets reticulate Leaves alternate;Petiole 3 - 10 cm long, with longitudinal stripes, the stripe is pubescent;tendrils 3 - 7, pilose;blade grade, contour subrounded or subcordate, and the width are about 5 - 20 cm, 3 - (5 - 7) - lobed to middle fissure, dilute deep crack or split have not only such large coarse teeth, lobe rhombic - obovate, oblong, apex obtuse, acute, margin often lobed again, base cordate, sinus 3 - 4cm deep, dark green surface, scabrous, abaxially pale green, pilose along veins on both sides of the bristle - like, palmately veined 5 basal veins, veinlets reticulate .
dioecious;Racemes solitary or with a male flower and green, solitary or in the upper branches, total 10 - 20cm too long of inflorescence, stout, longitudinally angular and sulcate, puberulent, apex 5 - 8 flowers, florets about 15cm long pedicels, small about 3mm long pedicels, bracteoles broadly ovate or obovate, long 1. 5 - 2. (5 - 3) cm, 1 cm wide, in the upper portion of the coarsely dentate basally, petiolate, abaxially pubescent;Calyx tubular cylinder, 2 - 4 cm long, apex expanded, diameter approximately 10 mm, lower diameter about 5 mm, pubescent, lobes lanceolate, 10 - 15 cm long, 3 - 5 mm wide, margin entire;Corolla white, lobes obovoid, ca. 20 mm, a width of about 18 mm, apex with a central pointed green 1, both sides fringed with filiform, pubescent, glabrescent;anthers connivent, ca. 2 mm, a diameter of about 4mm, Separated filament, stout, pilose;Female flowers solitary, pedicels ca. 7 cm, glabrous;Calyx tube length: 2 cm, diameter 1. 2cm, and male flowers with corolla lobes;Ovary ellipsoid, Green, 2 cm long, styles 2 cm long, the stigmas 3 Fruit oval, flat with a length of 11 - 16mm, 7 - 12 mm wide, pale yellowish brown, the proximal edge at a ridgeline with Fruit oval, flat with a length of 11 - 16mm, 7 - 12 mm wide, pale yellowish brown, the proximal edge at a ridgeline with .
5 - 8, fr. Aug - Oct 1

Drug Description

and so on: TCS (Pinyin: tian hua Fen in English: The Mongolian Root, Root pterodonta DC.: Trichosanthes. T. Harms efficiency classes: Chinese traditional medicine;promoting the production of medicine efficiency classes: Chinese traditional medicine;promoting the production of medicine .
Division belong to classification: Cucurbitaceae Division belong to classification: Cucurbitaceae . alias: Trichosanthes Root, Yunnan Baiyao, Ruixue, guar powder, pollen, root, fruit powder, betel powder alias: Trichosanthes Root, Yunnan Baiyao, Ruixue, guar powder, pollen, root, fruit powder, betel powder .
flavor: taste sweet;Slightly bitter; flavor: taste sweet;Slightly bitter;. viscerastate and slightly cold: lung meridian;Stomach via viscerastate and slightly cold: lung meridian;Stomach via .
Function: Clearing heat and promoting salivation.moistening lung and resolving phlegm;detumescence and apocenosis concentrated Indications: fever and thirst;Thirst and polydipsia.Hyperactivity dry cough;pyogenic
Usage and Dosage: Oral: decocted in water, 9 - 15g;or into pill, powder and Usage and Dosage: Oral: decocted in water, 9 - 15g;or into pill, powder and . topical: the amount, which are ground and sprinkled or mixed topical: the amount, which are ground and sprinkled or mixed .
eco: (Vacant) data resource distribution: most of the country have eco: (Vacant) data resource distribution: most of the country have . produced mainly in Henan, Guangxi, Shandong, Jiangsu, Guizhou, Henan and Anhui to produced mainly in Henan, Guangxi, Shandong, Jiangsu, Guizhou, Henan and Anhui to .
which has the advantages of high yield, high quality, and are often called the Anyang which has the advantages of high yield, high quality, and are often called the Anyang . Artemisia pollen source: is the Chinese root of Trichosanthes kirilowii Maxim and Artemisia pollen source: is the Chinese root of Trichosanthes kirilowii Maxim and .
harvest storage: Spring, autumn can be dug, the autumn harvest. The best one is . after, washing dirt, scrape off rough skin, cut into 10 - 20 cm long, white or yellow can be cut off in the sun
. Yo with Huang Bai preparatin process: pick the impurities, the size of the block separately, with about 60 percent permeable blisters,and pulling it out to a uniform moistening and outside humidity, slicing, drying in the sun, or by washing with water, and pulling it out. It's extremely sun - dried, the grinded into small block

Contraindication

1, spleen deficiency diarrhea stool who hates 1, spleen deficiency diarrhea stool who hates . 2, "I need to get some herbal": stomach damp phlegm, yan is thirsty for, in cases of disabled 2, "I need to get some herbal": stomach damp phlegm, yan is thirsty for, in cases of disabled .
3, "Herbal Classic": for pressure relief of the person do not suit 3, "Herbal Classic": for pressure relief of the person do not suit . 4, the "Collected Works of Materia Medica: Khan, after the liquid is made to appear to die thirsty he shall not vote.yin fire moving body cannot be made on the bearing while the thirsty, not almost Shi
5, "Mu Jing Feng Yuan": Where a phlegm - colored white, runny, ji yong 5, "Mu Jing Feng Yuan": Where a phlegm - colored white, runny, ji yong . 6 not applicable because of Aconitum L. species with the handle
7, adverse reactions and treatment: the Cinese trichosanthes root protein showed solid antigenicity, measured in 188 cases 1 - 6 years with Trichosanthin protein abortion of serum antibody, which is displayed in 6 years, the titer of filmmaking "had a tendency to decrease 7, adverse reactions and treatment: the Cinese trichosanthes root protein showed solid antigenicity, measured in 188 cases 1 - 6 years with Trichosanthin protein abortion of serum antibody, which is displayed in 6 years, the titer of filmmaking "had a tendency to decrease . trichosanthin common side effects are fever, headache, rash, sore throat, neck and occasionally in neurological adverse events such as trichosanthin common side effects are fever, headache, rash, sore throat, neck and occasionally in neurological adverse events such as .
angioedema, hypotension,Abnormal heart rhythms and splenomegaly in bleeding amount and the like angioedema, hypotension,Abnormal heart rhythms and splenomegaly in bleeding amount and the like ., who reported that trichosanthin induced anaphylactic shock (VCHP) and brachial artery thrombosis and 1 oral trichosanthin induce facial extremities as rash, itching, and the report of the machining process in the TCS in the treatment of 2 anaphylactic cases, and of mid - trimester of pregnancy - induced disseminated intravascular coagulation and 1 died of oral facial extremities , who reported that trichosanthin induced anaphylactic shock (VCHP) and brachial artery thrombosis and 1 oral trichosanthin induce facial extremities as rash, itching, and the report of the machining process in the TCS in the treatment of 2 anaphylactic cases, and of mid - trimester of pregnancy - induced disseminated intravascular coagulation and 1 died of oral facial extremities .
trichosanthin induce itching rash is not the same as that of Example 2, there is another report that trichosanthin machining process in the treatment of 2 anaphylactic cases of mid - trimester pregnancy and diffuse intravascular coagulation - induced death cases trichosanthin induce itching rash is not the same as that of Example 2, there is another report that trichosanthin machining process in the treatment of 2 anaphylactic cases of mid - trimester pregnancy and diffuse intravascular coagulation - induced death cases . 1 1.

Main Component

1, amino acids protein containing trichosanthes protein, 19 kinds of amino acids, amino acid residues 234 is composed of a single polypeptide chain of a basic protein 1, amino acids protein containing trichosanthes protein, 19 kinds of amino acids, amino acid residues 234 is composed of a single polypeptide chain of a basic protein . also contains 13 kinds of amino acids, such as citrulline, arginine, glutamic acid, aspartic acid and the like also contains 13 kinds of amino acids, such as citrulline, arginine, glutamic acid, aspartic acid and the like .
2, sterol containing delta - 7 - stigmasterol, alpha - spinasterol 2, sterol containing delta - 7 - stigmasterol, alpha - spinasterol . 3, a polysaccharide, a polysaccharide, a polysaccharide, a starch, glucopyranoside 3, a polysaccharide, a polysaccharide, a polysaccharide, a starch, glucopyranoside .
4, organic acids in the expressed oil containing linoleic acid, linolenic acid, palmitic acid and the like 4, organic acids in the expressed oil containing linoleic acid, linolenic acid, palmitic acid and the like . 5, enzyme inhibitors comprising a polypeptide, a tryptase inhibitor, a carboxypeptidase inhibitor 5, enzyme inhibitors comprising a polypeptide, a tryptase inhibitor, a carboxypeptidase inhibitor .
6, also containing lectin,peroxidase, saponins, 6, also containing lectin,peroxidase, saponins, .

Studies On The Chemical Constituents Of Traditional Chinese Medicine

From the fresh root juice separated trichosanthin (-) From the fresh root juice separated trichosanthin (-) . also obtained a variety of amino acids: alpha - hydroxymethyl - serine - aspartic acid, citrulline (), the serine (serine), glutamate (glutamic acid), (Thr), glycine, glycine, valine, tyrosine (tyrosine),(-) - phenylalanine, histidine, and lysine (lysine), arginine (Arg), ornithine () and peptides (peptide), ribose (pol), xylose, arabinose), glucose (dextrose), galactose (-) and the like;root - containing polysaccharide having Long for Blood Sugar;Trichosanthes root polysaccharide (A), B, C, D, E;rhizome containing anticancer and immune activity of polysaccharides from glucose, galactose, fructose, mannose, mannose, xylose and a small amount of the protein composition of the fresh root also obtained a variety of amino acids: alpha - hydroxymethyl - serine - aspartic acid, citrulline (), the serine (serine), glutamate (glutamic acid), (Thr), glycine, glycine, valine, tyrosine (tyrosine),(-) - phenylalanine, histidine, and lysine (lysine), arginine (Arg), ornithine () and peptides (peptide), ribose (pol), xylose, arabinose), glucose (dextrose), galactose (-) and the like;root - containing polysaccharide having Long for Blood Sugar;Trichosanthes root polysaccharide (A), B, C, D, E;rhizome containing anticancer and immune activity of polysaccharides from glucose, galactose, fructose, mannose, mannose, xylose and a small amount of the protein composition of the fresh root .
also containing 7 - - en - 3 beta - alcohol (- 7 - en - 3 beta - ol - 3 - O - beta - D - glucopyranoside (- 7 - en - 3 beta - 3 - O - beta - D - glucopyranoside), bryony alkyd (acid),Cucurbitacin (-) B and D, 23, 24) - cucurbitacins (23, 24) - B.

Pharmacological Action

Experiments with mature females during mating days to Experiments with mature females during mating days to . as on Day 1 of pregnancy as on Day 1 of pregnancy .
pregnancy day 10, rats were anesthetized with sodium pentobarbital, the abdominal incision will be connected to a thin plastic tube type emulsion water bag (volume about 1 ml) into the uterine cavity pregnancy day 10, rats were anesthetized with sodium pentobarbital, the abdominal incision will be connected to a thin plastic tube type emulsion water bag (volume about 1 ml) into the uterine cavity . thin plastic tube via the abdomen and back, from the neck of the extraction slit thin plastic tube via the abdomen and back, from the neck of the extraction slit .
. the abdominal wound the next day at the complex recorded via surgery in rabbits of intrauterine pressure change the abdominal wound the next day at the complex recorded via surgery in rabbits of intrauterine pressure change .
uterine activity tracings, a thin plastic tube, and this capsule to water filling, the plastic pipe and pressure transducer, is connected to the recorder trace is a uterine contraction activity curve uterine activity tracings, a thin plastic tube, and this capsule to water filling, the plastic pipe and pressure transducer, is connected to the recorder trace is a uterine contraction activity curve . all the experimental rabbits before administration and trying to be the first to record spontaneous uterine activity, oxytocin,i.e. by the rabbits' ears which injected the synthetic oxytocin (tenth Shanghai Pharmaceutical products) is 0. 1 unit, observe uterine reaction
24, 48, 72 hours, re - recorded uterine spontaneous activity and oxytocin 24, 48, 72 hours, re - recorded uterine spontaneous activity and oxytocin . test rats were divided into 4 groups with 4 rabbits in the control group - only test rats were divided into 4 groups with 4 rabbits in the control group - only .
5: do not give any drug, only intramuscularly injected with normal saline 0. 5ml / rabbit;Trichosanthin group: pregnancy on sept. 11, the intramuscular injection of radix trichosanthis pro injectione (Shanghai Biochemistry Pharmaceuticals Factory product, trichosanthes protein crude extracts of sterile freeze dried preparation, each ampoule containing 2 mg), 2 mg / kg;Megestrol Acetate 10 on Trichosanthin group: injection of trichosanthin 1 hour before intramuscular megestrol acetate suspension by Shanghai Pharmaceutical Company (twelfth) 10 mg / kg;Indomethacin plus trichosanthin group: in addition to intramuscular Trichosanthin (2mg / kg), also from Day 11, l2, l3 when daily intramuscular injections of indomethacin (such as sesame oil), twice daily at a dose of 5 mg / kg experiment showed that the rabbit uterus of early pregnancy is completely in the resting state of a substance to stimulate spawning and the lack of reaction, but the injection of a sufficient amount of TCS (after 24 or 48 hours, you've seen it. Spontaneous activity is gradually strengthening the uterus, uterine oxytocin on the substance of an obvious improvement in the
In addition, the above - described experiments also prove that, at a certain dose,The protrusion also has obvious effect of In addition, the above - described experiments also prove that, at a certain dose,The protrusion also has obvious effect of . it led to the formation of the blastocyst necrosis, liquefaction, and finally completely absorbed it led to the formation of the blastocyst necrosis, liquefaction, and finally completely absorbed .
Trichosanthin on rabbit uterine muscle activation, although may be supplemented with exogenous progestin or a prostaglandin synthesis inhibition by prevented, but the root of Chinese trichosannthes, the effect is not expected to do against Trichosanthin on rabbit uterine muscle activation, although may be supplemented with exogenous progestin or a prostaglandin synthesis inhibition by prevented, but the root of Chinese trichosannthes, the effect is not expected to do against . The trichosanthin for termination of pregnancy, and not secondary to inhibition of hormone secretion, or prostaglandin synthesis and release, so as to directly act on the support of trichosanthin for termination of gestation in placental trophoblastic cells of The trichosanthin for termination of pregnancy, and not secondary to inhibition of hormone secretion, or prostaglandin synthesis and release, so as to directly act on the support of trichosanthin for termination of gestation in placental trophoblastic cells of .
results were also reported, taking the rabbit uterine horn, 1. 5 cm to the right and to the ventilation hook on Mars in the baths, of which 50 ml of nutrient solution,pass a 95% O2 and 5% CO2 mixture gas, a water bath at 37.d egree. C., uterine activity tracings lever fixed to the rotating drum on first recorded uterine spontaneous activity in 30 minutes, followed by the addition of 15 - methyl prostaglandin F2a (15 - methyl PGF2a), the determination of the tension or contraction frequency and amplitude increases of 15 - methyl - PGF2d minimum threshold concentration first recorded uterine spontaneous activity in 30 minutes, followed by the addition of 15 - methyl prostaglandin F2a (15 - methyl PGF2a), the determination of the tension or contraction frequency and amplitude increases of 15 - methyl - PGF2d minimum threshold concentration .
control animals were only 6 was, in addition to a spontaneous rhythmic contraction of uterine, The remaining 5 no spontaneous uterine contraction, adding 15 - methyl PGF2a induced tension increases the minimum threshold concentration is 10 - 1000 mg / ml,Trichosanthin group performed ex vivo experiments 6 only in the uterus in 5 spontaneous rhythmic contraction of uterus have the obviously, only one spontaneous contraction of the uterus without, addition of 15 - methyl PGF2a excitement of the minimum threshold concentration is the l - 10 mg / ml control animals were only 6 was, in addition to a spontaneous rhythmic contraction of uterine, The remaining 5 no spontaneous uterine contraction, adding 15 - methyl PGF2a induced tension increases the minimum threshold concentration is 10 - 1000 mg / ml,Trichosanthin group performed ex vivo experiments 6 only in the uterus in 5 spontaneous rhythmic contraction of uterus have the obviously, only one spontaneous contraction of the uterus without, addition of 15 - methyl PGF2a excitement of the minimum threshold concentration is the l - 10 mg / ml . experiment shows that Radix Trichosanthis can make the pseudopregnant rabbits after 24 hours of spontaneous contraction increases experiment shows that Radix Trichosanthis can make the pseudopregnant rabbits after 24 hours of spontaneous contraction increases .
Radix trichosanthis injection of pseudopregnant rabbit uterine progesterone - receptor (P R) and estradiol receptors (E - R): healthy mature rabbits, weight 2.3 - 2.5kg, with more than 5 kg, intravenous injection of human chorionic gonadotropin (HCG) 500 units to produce a pseudopregnancy, pseudocyesis as during the day of the Nov. 1,Then the animals were divided into 2 groups of 7 - 8 to pseudopregnancy on 6, 7, to the root of Chinese trichosanthes root of Chinese trichosannthes daily intramuscular injection group (Shanghai Biochemistry Pharmaceutical Factory, Before using dissolved in physiological saline to 5 mg / ml) mg / to pseudopregnancy on 6, 7, to the root of Chinese trichosanthes root of Chinese trichosannthes daily intramuscular injection group (Shanghai Biochemistry Pharmaceutical Factory, Before using dissolved in physiological saline to 5 mg / ml) mg / .
times was given to control injection of normal saline 0. 8ml / times 8 was injected through ear edge venous blood 2ml medium containing heparin (about 0. 5 mg) of the centrifuge tube, centrifuged for plasma, for progesterone with
then the rabbits were sacrificed by exsanguinations, immediately taking out the lower uterus, clipping a uterus into a nutrient solution supply is performed in vitro by experiment,the remainder of the ice saline 3 times and mincing with a buffer in a ratio of 1: 3 (W / V) are mixed, and placed in homogenization tube, at a low temperature and homogenized, for receptor assay with the then the rabbits were sacrificed by exsanguinations, immediately taking out the lower uterus, clipping a uterus into a nutrient solution supply is performed in vitro by experiment,the remainder of the ice saline 3 times and mincing with a buffer in a ratio of 1: 3 (W / V) are mixed, and placed in homogenization tube, at a low temperature and homogenized, for receptor assay with the . P - R - E - R, and the measurement of the value of KA obtained using radioreceptor assay, reference etc etc and combined with the method of this experiment condition according to a modified version of P - R - E - R, and the measurement of the value of KA obtained using radioreceptor assay, reference etc etc and combined with the method of this experiment condition according to a modified version of .
Determination of uterine cytosol protein content, diphenylamine) were measured cancer DNA content of the nucleus, cytosol receptor fmol / mg protein,nuclear receptor that is expressed as fmol / mg DNA of Determination of uterine cytosol protein content, diphenylamine) were measured cancer DNA content of the nucleus, cytosol receptor fmol / mg protein,nuclear receptor that is expressed as fmol / mg DNA of . obtained for progesterone and estradiol and P - R - E - R - KA and the value of obtained for progesterone and estradiol and P - R - E - R - KA and the value of .
plasma progesterone concentration determination method according to the report, to 11a hydroxyprogesterone succinic anhydride - bovine serum albumin as antigen, to immunize rabbits, the titer of the antiserum is 1: more than 2000 plasma progesterone concentration determination method according to the report, to 11a hydroxyprogesterone succinic anhydride - bovine serum albumin as antigen, to immunize rabbits, the titer of the antiserum is 1: more than 2000 Experimental results show that, on the eighth day of pseudopregnancy uterine cytosol and the nucleus of the P - R content via t - test, there was a statistically significant difference, indicating that injection of trichosanthin,Can the rabbit uterine of pseudopregnant P - R to reduce the content of the obtained as
progesterone and the cytoplasm liquid of P - R - KA: KA = control group 1. 08x10 (9) M - 1, trichosanthin group KA = 0. obtained in (9) M with Trichosanthin and progesterone so that the P - R significantly decreased the affinity on the eighth day of pseudopregnancy uterine cytosol and the nucleus of the E - R, by t - test, no clear difference between these two groups, the estradiol and E - R - KA values: a value KA = 1. (9) to 0,01 M - 1, trichosanthin group KA = (1 x 10 9 M - 1),also no significant difference between groups, indicating that the root of Chinese trichosannthes group of pseudopregnant rabbits showed no influence on the E - R
pseudopregnant rabbits after 8, the plasma progesterone concentrations in control group with no significant differences were observed between the root of Chinese trichosannthes pseudopregnant rabbits after 8, the plasma progesterone concentrations in control group with no significant differences were observed between the root of Chinese trichosannthes . uterine activity is generally considered to be regulated by hormones, et al. reported that a pregnant uterus is in the resting state, with an in - vivo plasma progesterone concentration is higher, the pregnant rabbit uterine activity may be stimulated by progesterone and oxytocin and prostaglandins are not sensitive to the beam like
. Huaide, who reported that TCS enables pregnant rabbit uterine contraction activity, possibly by trichosanthin damage embryos,causes the in - vivo progesterone level in decidua and promote the prostaglandin release relevant experimental rabbit Huaide, who reported that TCS enables pregnant rabbit uterine contraction activity, possibly by trichosanthin damage embryos,causes the in - vivo progesterone level in decidua and promote the prostaglandin release relevant experimental rabbit .
pseudopregnancy, measured after 8, the plasma progesterone concentrations, and the like, is reported in the same period of the plasma progesterone concentrations of pregnant rabbits was similar to that of the injection of trichosanthin after progesterone concentration did not decline, with similar controls, but can make the uterus contracted at a rate of increase of trichosanthin on Embryo and Decidua of injury and secondary to progesterone, may not be the root of Chinese trichosannthes uterus contracted at a rate of increase of the main mechanism of the rat's pseudopregnancy, measured after 8, the plasma progesterone concentrations, and the like, is reported in the same period of the plasma progesterone concentrations of pregnant rabbits was similar to that of the injection of trichosanthin after progesterone concentration did not decline, with similar controls, but can make the uterus contracted at a rate of increase of trichosanthin on Embryo and Decidua of injury and secondary to progesterone, may not be the root of Chinese trichosannthes uterus contracted at a rate of increase of the main mechanism of the rat's . Hai et al. reported in pre - clinical P - R in uterine nuclei decreased,It is thought that this increase is due to uterine uterine activity within the P - R the content of the reduction in the
experiments have observed 15 - methyl PGF2a of pseudopregnant rabbit - luteolytic effect, the concentration of plasma progesterone injection 15 - methyl PGF2a after 24 hours drops to very low levels, at which point the uterus P - R receptor content increases, no spontaneous contraction of the uterus and is at a resting state experiments have observed 15 - methyl PGF2a of pseudopregnant rabbit - luteolytic effect, the concentration of plasma progesterone injection 15 - methyl PGF2a after 24 hours drops to very low levels, at which point the uterus P - R receptor content increases, no spontaneous contraction of the uterus and is at a resting state . TCS does not change the pseudopregnant rabbit plasma progesterone concentrations, but the uterus (endometrium) P - R content is decreased and the progesterone - P and R of the affinity, while spontaneous uterine contraction of activity in TCS does not change the pseudopregnant rabbit plasma progesterone concentrations, but the uterus (endometrium) P - R content is decreased and the progesterone - P and R of the affinity, while spontaneous uterine contraction of activity in .
therefore envisaged,Trichosanthin, the uterus (endometrium) and reduce the content of P - R - P - R to make progesterone and a reduced affinity, root of Chinese trichosanthes is likely to cause spontaneous uterine contraction increases of important mechanism, P - R might be correlated with activities associated with the setting of the therefore envisaged,Trichosanthin, the uterus (endometrium) and reduce the content of P - R - P - R to make progesterone and a reduced affinity, root of Chinese trichosanthes is likely to cause spontaneous uterine contraction increases of important mechanism, P - R might be correlated with activities associated with the setting of the .: taking a mature male and female mice to 2: 1), the daily morning check the vagina, to find vaginal plug was noted as : taking a mature male and female mice to 2: 1), the daily morning check the vagina, to find vaginal plug was noted as .
1 pregnancy in 4 to 5 days, once daily subcutaneous injection of trichosanthin per 10 g body weight injection of 0. 1ml, on day 8 of pregnancy, the pregnancy of animals TCS (at a dose of 10, 5, 2.5, 1.25, 0.625 mg / kg, the pregnancy rate of inhibition of 100%,81. 17%, 47. 16%, 47. 16% and 12. 69%, with a simplified probability unit calculated by the method of root of Chinese trichosannthes, the effect of ED _ 1. + -. 78 0. 28mg / kg
reported in the literature, the separate administration of trichosanthin 0.4 mg intramuscular injection, the mice early pregnancy of the effect of the above experiments no ideal also observedRadix Trichosanthis can be terminated early pregnancy in mice, the effect increased with the dosage increase, however, the pregnancy rate reached above 80% of the dose, the mice lost weight dramatically, the harm caused by certain toxic also observedRadix Trichosanthis can be terminated early pregnancy in mice, the effect increased with the dosage increase, however, the pregnancy rate reached above 80% of the dose, the mice lost weight dramatically, the harm caused by certain toxic .
this description may be clinically affected due to drug toxicity is restrained by increasing the dose of root of Chinese trichosannthes. It improves the curative effect and shorten the time for the purpose of abortion exogenous megestrol and chorionic gonadotropin have, the effect of affect in the same way as the above: pregnancy (4, 5, daily subcutaneous injection of trichosanthin 10 mg / kg while subcutaneous injection of an aqueous suspension of megestrol acetate 50mg / kg,or intraperitoneal injection of human chorionic gonadotropin (HCG) 10I. U, 8 anatomy of pregnancy, the pregnancy of animals the results are shown in Table 3
. combined injection of two groups decreased pregnancy rates were all combined injection of two groups decreased pregnancy rates were all .
and the embryos were smaller, some of which are equipped with separate endometrial, uterine cavity and the embryos were smaller, some of which are equipped with separate endometrial, uterine cavity . pollen with 15 - methyl PGF2a on mice, the effect of: The method with the pollen with 15 - methyl PGF2a on mice, the effect of: The method with the .
pregnancy (4, 5, daily subcutaneous injection of trichosanthin was 0. 625mg / kg while subcutaneously l5 - - PGF2a0. 0125mg / kg, daily,Morning and afternoon known dose 15 - methyl PGF2a of the diagnosis of early pregnancy in mice; the inhibition rate of 20% known dose 15 - methyl PGF2a of the diagnosis of early pregnancy in mice; the inhibition rate of 20% .
8 on anatomy to the pregnancy, the pregnancy of animals the results are shown in Table 3 8 on anatomy to the pregnancy, the pregnancy of animals the results are shown in Table 3 . .
Trichosanthin with 15 - methyl PGF2a group, all 12 mice in the not pregnancy Trichosanthin with 15 - methyl PGF2a group, all 12 mice in the not pregnancy . Combination In the resulting mice; the inhibition rate of 100% (ED100) Combination In the resulting mice; the inhibition rate of 100% (ED100) .
i.e. This indicates that the 15 - methyl - PGF0. 0125mg / kg + and co 2 + 0. 625mg / kg, the effects are not additive, but rather increases the | object.Check the 6 - 8 weeks old, body weight 20 - 22g Jian Lian females. Males and 2:1), the vaginal plug is first
would see the bolt of the females, were randomized to groups of 10 - 15 would see the bolt of the females, were randomized to groups of 10 - 15 . only took place in the sixth day in the following experimental design team in each group: Group 1 crystallized snakegourd proteoliposome (a liposome, TL), the dose per mouse injected TL2ug, 4ug sclectivity and group 2 were injected with TCS, 160ug / ml;Article 3 blank liposome were injected with 0.5 ml;Section 4 were injected with saline 0. 5ml normal
d5 after injection, the mice were dissected to observe the uterus the embryos fetation d5 after injection, the mice were dissected to observe the uterus the embryos fetation . results, TL antiearly pregnancy at a dose of 2 ug / mouse, while the dose of 40ug / Trichosanthin only, each rate was 66. 7% and 70%
explained TL dose were obvious pregnancy terminating activity in aminal explained TL dose were obvious pregnancy terminating activity in aminal . TL of the in vitro release test confirmed that the 6 hours of its release rate was 4. 6%, up to 72 hours 68. 2%
prompt stomach drug liposome in the section on contraception and Research of the Application of prompt stomach drug liposome in the section on contraception and Research of the Application of . gravid from 6 mice injected intraperitoneally with different doses of TL solution,can selectively make the placenta villous syncytiotrophoblast cells degeneration and necrosis, disintegration of the cell debris left in it, caused by clotting, circulatory disorder and further a large amount of tissue necrosis gravid from 6 mice injected intraperitoneally with different doses of TL solution,can selectively make the placenta villous syncytiotrophoblast cells degeneration and necrosis, disintegration of the cell debris left in it, caused by clotting, circulatory disorder and further a large amount of tissue necrosis .
placenta villi damage is reflected in the function aspect, i.e. chorionic gonadotrophin (HCG) and steroid hormone concentrations declined rapidly to below the critical level of abortion due to placental morphological and functional injury as a result of the severe, damaging the mother and the relationship between endocrine and metabolite exchange, and perhaps less clear mechanism: prostaglandin synthesis is increased, the contraction of uterus leading to abortion due to placental morphological and functional injury as a result of the severe, damaging the mother and the relationship between endocrine and metabolite exchange, and perhaps less clear mechanism: prostaglandin synthesis is increased, the contraction of uterus leading to abortion .
Further, trichosanthin in mice can be isolated uterus,In the contraction in uterus, and uterus can be improved on the chemotherapeutic sensitivity, effects on uterine smooth muscle of direct stimulatory effect, may have also contributed to the abortion of the one of the factors Further, trichosanthin in mice can be isolated uterus,In the contraction in uterus, and uterus can be improved on the chemotherapeutic sensitivity, effects on uterine smooth muscle of direct stimulatory effect, may have also contributed to the abortion of the one of the factors . 2 and anticancer action: Vaccination of mice with early - stage hepatic action: 18 - 22g Healthy mice were subcutaneously injected tumor cell suspension (the original times, or 1: 1) 0.2 ml / mouse, in 24 hours and weighed after random grouping
treatment group were subcutaneously injected with TCS (0. 2ml / only (5 mg / kg), the interval 4 - 6 days and then press the original dose by subcutaneous injection of trichosanthin 1 saline and control mice 0.5 - times,05 (see Table 5)
treatment group the majority of ascites and the last to have died from toxic reaction, and occasionally in individual mice with ascites, the ascites in pathological examinations showed that the total number of cells is small, the vast majority of lymphocytes, and lymphocytes surround the cancer cells of the so - called satellite phenomenon, neutrophils and macrophages treatment group the majority of ascites and the last to have died from toxic reaction, and occasionally in individual mice with ascites, the ascites in pathological examinations showed that the total number of cells is small, the vast majority of lymphocytes, and lymphocytes surround the cancer cells of the so - called satellite phenomenon, neutrophils and macrophages . was the last large amount of ascites due to liver cancer and 1 case was died, the total number of the cells in the ascites, the vast majority of cancer cells is was the last large amount of ascites due to liver cancer and 1 case was died, the total number of the cells in the ascites, the vast majority of cancer cells is .
3 batches of experimental treatment, instead of cells 24 hours after subcutaneous injection of trichosanthin 0. 2ml / only once, no further treatment,Experimental therapy to prolong the survival rate was 85. 6% in the control group, mice ascites too long, eventually died of liver cancer in mice advanced hepatic transplantation, therapeutic effects on selected 18 - 22g of the mice were injected subcutaneously with tumor cell suspension (1: 1), 24 hour weighing the random packet interval from 6 ascites has grown after weighing in the treatment group were subcutaneously injected with TCS (0. 2ml / only, spacing on 4 weighing after subcutaneous injection of trichosanthin 0.4 or 0.2 ml / mouse, subcutaneously in the control group and normal saline (2m1 / only, the interval is the same with treatment group
Results Trichosanthin Injection after abdominal Reduction,the content of streptomycin in previous Results Trichosanthin Injection after abdominal Reduction,the content of streptomycin in previous . more than three cells displayed monolayer growth and more than three cells displayed monolayer growth and .
37 according to the literature method 37 according to the literature method . experiment. Experimental results show that, the crystalline trichosanthin on human choriocarcinoma cell line Jar markedly inhibited the proliferation of, and incubated for 48 hours after intradermal injection of 50 is 3. 3ug / ml, while Hela human cervical cancer cells and normal cells of the intradermal injection of 50 were 13. 0 and 16. 0 ug / ml
Furthermore, Crystal trichosanthin for Jar cells inhibition after 48 hour incubation, the inhibition of 50%,cells at a concentration of 1. 3ug / ml Another report, in the immersion, the freeze - dried agent and flooding agent, an uterine cancer U - 14 were inhibited by 40. 4% and 30. 9%, while on the expression of the uterus U - 14 no effect
post stimulation Trichosanthin could inhibit Ehrlich ascites cancer growth and prolong survival time of mice post stimulation Trichosanthin could inhibit Ehrlich ascites cancer growth and prolong survival time of mice .: Healthy Kunming male mice 2 - 3 months of age, body weight 21. + -. 3 4. 6g, root of Chinese trichosannthes group and a group of mice were inoculated with tumor cells, tumor cell suspension,the activity of C3b receptor was significantly impaired, trichosanthes root, after treatment, can be restored to normal level;Group 2 was the control group, received subcutaneous l times 0. 5ml saline
8 days, the mice were sacrificed, their salivary glands, and then stained with HE staining and other 8 days, the mice were sacrificed, their salivary glands, and then stained with HE staining and other . The results show that the mice submandibular gland within the PNA, PBA receptors significantly increased, IgG increased obviously, and also higher than that in control group, suggesting that the root of Chinese trichosanthes and promote the salivary glands of the ethylamine synthesis of galactose and galactose and increase immune function related to the root of Chinese trichosannthes The results show that the mice submandibular gland within the PNA, PBA receptors significantly increased, IgG increased obviously, and also higher than that in control group, suggesting that the root of Chinese trichosanthes and promote the salivary glands of the ethylamine synthesis of galactose and galactose and increase immune function related to the root of Chinese trichosannthes .
Decoction in vitro hemolytic streptococcus, diplococcus pneumoniae, bacillus diphtheria, and the inhibitory effect on Salmonella typhi, Pseudomonas aeruginosa, Shigella spp.Proteus and Staphylococcus aureus are weaker used cytopathic effect inhibition method and 125I radioimmunoassay (RIA) in three cell culture system of Trichosanthes kirilwii was carried out on the antiviral activitis of a purified protein inhibition used cytopathic effect inhibition method and 125I radioimmunoassay (RIA) in three cell culture system of Trichosanthes kirilwii was carried out on the antiviral activitis of a purified protein inhibition .
The trichosanthes protein concentration 10ug / ml or less, with no evident toxic effects, in an amount of from about 0.001 to about 10 ug / ml of encephalitis B, Coxsackie B2, measles, adenovirus type 3, type I herpes simplex virus, vesicular stomatitis virus and hepatitis B virus and the like,and this inhibitory protein powder days of concentration increased with a higher concentration in 0. 01ug / ml could be suppressed by 100TC intradermal injection 50 resulting from the 50 per cent, prompting, root of Chinese trichosanthes is likely to be the interferon after another broad - spectrum anti - poison protein
: experiment in vitro indicated that TCS inhibits AIDS virus (HIV) infection in immune cell replication, reduced immune cells that are infected with viable cell number,The effective inhibition concentration is 0. 05 - 10ug / ml capable of inhibiting HIV infection and replication of the egg mass is referred to as anti - HIVTA29 capable of inhibiting HIV infection and replication of the egg mass is referred to as anti - HIVTA29 .
clinical data also showed the certain therapeutic efficacy clinical data also showed the certain therapeutic efficacy .

(Science)

Side Effects and Toxicity: female dog muscle injection of radix trichosanthis pro injectione exhibit a general malaise, loss of appetite, feeding, at a dose of 0.2 - 2mg / kg, as well as the side by 3 - 5 days of recovery, but 3 - 4mg / kg for the most part 1 - 2 weeks after the death;drug dog of leukocytes increased up to 3 million - 4 million / mm3;neutrophil percentage may be increased to 90%, generally over a 1 week later returned to normal;The changes of electrocardiogram, 0.2 -2 mg / kg group had transient ST segment reduction after 2 - 3 day recovery, 3 - 4 mg / kg group decreased gradually along with the course of the ST segment, T wave was inverted, when premature phenomenon;liver, renal function, giving the dog a 3 - 4 mg / kg dose, the SGPT increased significantly, which can grow up to 200 mg / kg, at the same time, serum sodium, serum chlorine and serum decreased, blood potassium increased, which made the abiding strength and CO2, metabolic acidosis;Pathological examination, 0.2 -2 mg / kg group and the systemic capillaries, and venule dilation, congestion, liver, renal parenchymal cells mild degeneration, 3 - 4mg / kg were still present a variety of organ haemorrhage and necrosis of renal proximal convoluted tubules, hepatic parenchyma cells of the small areas of necrosis;drug antigenicity, mice were injected subcutaneously with different degree of allergic reaction, skin test and serum antibody determinations, can cause the body to produce specific antibodies, the allergic skin test for prevention of root of Chinese trichosannthes Definite Meaning;Mice subcutaneously injected, were observed for 10 days, which was 0. 6mg / mouse;labor - inducing side - reactions, typically fever 38. 5 C, and aching limbs, sore throat, headache, neck, injection - site pain and adherent placenta such as elevated body temperature, and is generally considered to be the organism's proteins that exist in the protective response, i.e., the recovery after the abortion, placenta adhesions caused by inflammation is considered to be overweight, so drugs should be closely observed dogs given different doses of Radix Trichosanthis protein formulations, low - dose group (human induction dose of 3 - 6 times) may appear listlessness, loss of appetite that antifeedants,2 - 5 day gradually restored dogs given different doses of Radix Trichosanthis protein formulations, low - dose group (human induction dose of 3 - 6 times) may appear listlessness, loss of appetite that antifeedants,2 - 5 day gradually restored .
has a transient ST - segment reduction has a transient ST - segment reduction . minority of canine liver function ALT increased slightly, and the body appears to capillaries and venules with extension and blood stasis, liver, renal parenchymal cells mild degeneration and minority of canine liver function ALT increased slightly, and the body appears to capillaries and venules with extension and blood stasis, liver, renal parenchymal cells mild degeneration and .
high - dose group (human induction doses of 9 - 12 times), most of the dogs in the 1 - 2 weeks after a serious failure and death, electrocardiogram ST segment along with the course of the stepwise lowered, T wave became obvious and inverted, when multiple premature beats high - dose group (human induction doses of 9 - 12 times), most of the dogs in the 1 - 2 weeks after a serious failure and death, electrocardiogram ST segment along with the course of the stepwise lowered, T wave became obvious and inverted, when multiple premature beats . phenomenon occur substantially simultaneously and kidney cell necrosis and a metabolic acidosis and the cytotoxicity of trichosanthin protein purity is relation to phenomenon occur substantially simultaneously and kidney cell necrosis and a metabolic acidosis and the cytotoxicity of trichosanthin protein purity is relation to .
mouse LD50 Determination of Trichosanthin 2. 26mg / only,Trichosanthin crude preparation by using 0. 6mg / only, dialysis trichosanthin 0.29mg / only, Trichosanthin protein 0. 236 mg / only

Pharmacokinetics

10 minutes after intramuscular Trichosanthin protein in the serum appear, after 4 hours of local content was of 3 / 5, 24 hours after the dose of only 3 / 10 l 10 minutes after intramuscular Trichosanthin protein in the serum appear, after 4 hours of local content was of 3 / 5, 24 hours after the dose of only 3 / 10 l . hours after intramuscular injection to the cortex and the colon contents is the highest, that of placental tissues and the liver, spleen, lung and low levels in hours after intramuscular injection to the cortex and the colon contents is the highest, that of placental tissues and the liver, spleen, lung and low levels in .
uterine muscle, fetal liver, and the like can be detected in the root of Chinese trichosanthes protein, but free of serum and amniotic fluid uterine muscle, fetal liver, and the like can be detected in the root of Chinese trichosanthes protein, but free of serum and amniotic fluid . in the intramuscular Trichosanthin in 4 hours and reached the peak, at which time the circulation occurs in the instantaneous maximum amount approximate to that of the intramuscular injection of 50% has been decremented to half h8, 24 hours when the peak amount of approximately 1 / 7,16 hours after intramuscular injection, in addition to the renal cortex, other tissue, were rarely in the intramuscular Trichosanthin in 4 hours and reached the peak, at which time the circulation occurs in the instantaneous maximum amount approximate to that of the intramuscular injection of 50% has been decremented to half h8, 24 hours when the peak amount of approximately 1 / 7,16 hours after intramuscular injection, in addition to the renal cortex, other tissue, were rarely .
excreted by urine and blood. The peak time is similar to, and are not degraded and intravenous administration, the blood in the disappearance of half of the required time is about 1 hour, to the highest liver concentration, 24 hour urinary excretion rate reached 67%, the amniotic cavity injection, the levels of maternal serum was not detected in the root of Chinese trichosanthes protein, urine, cell proliferation, mostly retained within the cavity, until when the abortion with amniotic fluid excreted intravenous administration, the blood in the disappearance of half of the required time is about 1 hour, to the highest liver concentration, 24 hour urinary excretion rate reached 67%, the amniotic cavity injection, the levels of maternal serum was not detected in the root of Chinese trichosanthes protein, urine, cell proliferation, mostly retained within the cavity, until when the abortion with amniotic fluid excreted .
abortion after determination of amniotic fluid, amniotic membrane, chorion and placenta in trichosanthin - - - - - - - - - - - - -,depending on the anatomical location from the inside to the outside of the abortion after determination of amniotic fluid, amniotic membrane, chorion and placenta in trichosanthin - - - - - - - - - - - - -,depending on the anatomical location from the inside to the outside of the . content decreases gradually from the above results suggest that the root of Chinese trichosanthes protein administered by different routes, it dissimilarity content decreases gradually from the above results suggest that the root of Chinese trichosanthes protein administered by different routes, it dissimilarity .

Application Compatibility

1, fever and polydipsia 1, fever and polydipsia . product with sweet, both of that action of clearing stomach - heat, thirst, commonly used to treat fever and polydipsia, reed rhizome, ophiopogon root, etc.;or with rehmannia root, schisandra fruit, such as smallpox ("Fang (effective prescription from Renzhai House);Prepare thirst. The work, straight ladybell root, ophiopogon root, fragrant solomonseal rhizome, etc., which may be used to treat stomach dryness damage lung, pharynx doing is thirsty, as Shashen Maidong Tang (from Treatise)
2, Hyperactivity dry cough 2, Hyperactivity dry cough . The product either as purging fire and clear away lung heat, while the secretion of saliva and moistening lung to relieve dryness, moistenes the lung and for its hot, dry cough with little phlegm, the phlegm in the lung - heat and blood dryness syndrome, asparagus root, ophiopogon root, rehmannia root, etc, as Dryness - Moistening Drink ("Origin of rhino candle and miscellaneous diseases");Take the product as well as moistening dryness and relieving uneasiness of body, ginseng is combine with heat scorching the lung qi and yin of cough and hemoptysis, such as ginseng flower (Wan Bing Hui Chun) The product either as purging fire and clear away lung heat, while the secretion of saliva and moistening lung to relieve dryness, moistenes the lung and for its hot, dry cough with little phlegm, the phlegm in the lung - heat and blood dryness syndrome, asparagus root, ophiopogon root, rehmannia root, etc, as Dryness - Moistening Drink ("Origin of rhino candle and miscellaneous diseases");Take the product as well as moistening dryness and relieving uneasiness of body, ginseng is combine with heat scorching the lung qi and yin of cough and hemoptysis, such as ginseng flower (Wan Bing Hui Chun) .
3, inner heat and 3, inner heat and . product good clearing lung and stomachs hotness, and helping produce saliva and slake thirst, they are indicated for the product and heat, and dryness of thirst and are usually served with ophiopogon root, reed rhizome, cogongrass rhizome medicinal (");If the ginseng, and cure inner heat, deficiency of both Qi and Yin, such as horse - pill ("Fang (effective prescription from Renzhai House) product good clearing lung and stomachs hotness, and helping produce saliva and slake thirst, they are indicated for the product and heat, and dryness of thirst and are usually served with ophiopogon root, reed rhizome, cogongrass rhizome medicinal (");If the ginseng, and cure inner heat, deficiency of both Qi and Yin, such as horse - pill ("Fang (effective prescription from Renzhai House) .
4, sore swollen poison 4, sore swollen poison . product either energy while detoxication, detumescence and pus drainage to sore, and for the early stage of skin, and excessive heat toxin, without abscess may have dissipated, pus may become sore and discharging pus, often with honeysuckle, angelica dahurica, pangolin scales, such as Xian Fang Huo Ming Yin (Furen Daquan Liangfang");Take the product of heat, effect, or the like is divided into a mint, watermelon juice, which may be used to treat wind - heat abscess of throat, such as silver and kept under lock and key ("Waike Baixiao Quanshu") product either energy while detoxication, detumescence and pus drainage to sore, and for the early stage of skin, and excessive heat toxin, without abscess may have dissipated, pus may become sore and discharging pus, often with honeysuckle, angelica dahurica, pangolin scales, such as Xian Fang Huo Ming Yin (Furen Daquan Liangfang");Take the product of heat, effect, or the like is divided into a mint, watermelon juice, which may be used to treat wind - heat abscess of throat, such as silver and kept under lock and key ("Waike Baixiao Quanshu") .
5, trichosanthes root, anemarrhena rhizome, blending, 15ml / kg, of body fluid to quench thirst, cure the pyreticosis of thirst and lung - stomach heat damage of diabetes 5, trichosanthes root, anemarrhena rhizome, blending, 15ml / kg, of body fluid to quench thirst, cure the pyreticosis of thirst and lung - stomach heat damage of diabetes . 6, reed rhizome, the functions of clearing lung, eliminating phlegm, and for heat in the lung and phlegm cough, difficult;7, Fritillaria, transforming phlegm, dryness - heat for humanized lung or lung yin deficiency cough, phlegm and discomforting symptom;8, with oysters, is used for the treatment of depression of phlegm - fire, gallae with phlegm and lily disease thirst not difference;9, radix asparagi, governance Hyperactivity dry cough, and hemoptysis;with honeysuckle, treating sore swollen toxin 6, reed rhizome, the functions of clearing lung, eliminating phlegm, and for heat in the lung and phlegm cough, difficult;7, Fritillaria, transforming phlegm, dryness - heat for humanized lung or lung yin deficiency cough, phlegm and discomforting symptom;8, with oysters, is used for the treatment of depression of phlegm - fire, gallae with phlegm and lily disease thirst not difference;9, radix asparagi, governance Hyperactivity dry cough, and hemoptysis;with honeysuckle, treating sore swollen toxin .

Agastache

1, Dryness - Moistening Drink ("Zunsheng Shen's book": trichosanthes root, asparagus root, ophiopogon root, dried rehmannia root, root of herbaceous peony, large - leaf gentian root, treating lung dryness cough, thirsty2. (of Yuye Tang's Medical Studies: Chinese yam, anemarrhena rhizome, kudzu vine root, schisandra fruit, Chinese yam, astragalus, gizzard lining, in the treatment of diabetes;3, Qingshu Tang ("Full set of surgery": trichosanthis, capsule of weeping forsythia, honeysuckle, radix paeoniae rubrathe, root of lophatherum gracile, rhizoma alismatis, talcum, plantain seeds, liquorice, pemphigus vulgaris, miliaria 4, Surgical Formula of Miraculous Decoction, External golden paste is also observed in the root of Chinese trichosannthes, treating sores and furuncles 4, Surgical Formula of Miraculous Decoction, External golden paste is also observed in the root of Chinese trichosannthes, treating sores and furuncles .

Clinical Application

1, for induction of labor: the medium - term pregnancy, stillbirth, miscarriage induced with high efficacy; the method is simple, and no hemorrhage 1, for induction of labor: the medium - term pregnancy, stillbirth, miscarriage induced with high efficacy; the method is simple, and no hemorrhage . preparation and usage of: (i) Radix trichosanthis injection: pre - injection with normal saline to trichosanthin were diluted to 2 micrograms per milliliter concentration, 0.05 ml was injected into the skin on the flexor side of forearm, within 20 minutes after the test findings, in the case of a negative can be deep intramuscular injection of 0. 2 mg of TCS as the probe test, observed 2 hours such as no reaction for a deep intramuscular injection of 5 ~ 8 mg
2000 according to number around mid - pregnancy, stillbirth, miscarriage of induced labor observation;A success rate of 95 per cent of labor stillbirth effect 2000 according to number around mid - pregnancy, stillbirth, miscarriage of induced labor observation;A success rate of 95 per cent of labor stillbirth effect . average labor time: mid - term pregnancy generally in 6 days; the stillbirth in 3 ~ 5 days after injection, usually in average labor time: mid - term pregnancy generally in 6 days; the stillbirth in 3 ~ 5 days after injection, usually in .
6 ~ 8 hours developed fever, headache, sore throat, joint aches, neck activities adverse side effects such as local pain and erythema.handful of rashes, nausea and vomiting;individual urticaria, angioneurotic edema), chest pain, abdominal distension, hepatomegaly and splenomegaly, and even anaphylactic shock reaction that weigh shall be timely rescued, in order to avoid adverse consequences;the reaction may be generally mild in 2 ~ 3 days after and it disappeared spontaneously after treatment with promethazine can mitigate shall be timely rescued, in order to avoid adverse consequences;the reaction may be generally mild in 2 ~ 3 days after and it disappeared spontaneously after treatment with promethazine can mitigate .
on the heart, liver and kidney diseases and dysfunction, severe anemia and psychiatric patients and care given to the on the heart, liver and kidney diseases and dysfunction, severe anemia and psychiatric patients and care given to the . ii taken 1 g of Radix Trichosanthis, Fructus Gleditsiae Abnormalis powder 0. 5 g of water and the paste is wrapped with gauze, misoprostol vaginally. After the 24 hours that urges the second trimester of pregnancy, stillbirth, miscarriage, fetal block or the like until naturally excreted
general bleeding, pain, and successful application of general bleeding, pain, and successful application of . 147 cases, the success rate was 93. 2%
iii of pollen of 70 ~ 80 mg,40 mg of saponin dental mixing and loading the capsule iii of pollen of 70 ~ 80 mg,40 mg of saponin dental mixing and loading the capsule . bark 1 placed in the vagina for bark 1 placed in the vagina for .
general 12 - 24 hours by chilly, fever, joint pain and other side effects, for a period of around 2 days general 12 - 24 hours by chilly, fever, joint pain and other side effects, for a period of around 2 days . medicine after 4 hours of their temperature, pulse, blood pressure, such as temperature over 38. 5 C or blood pressure below 90 / 60, should be considered that the desensitization treatment, lest the medication are advised to drink as much water as possible during accidental
. in the order of 3 ~ 6 days may be observed spontaneous delivery in the order of 3 ~ 6 days may be observed spontaneous delivery .
1046 cases;1 973 success rate was 93% 1046 cases;1 973 success rate was 93% . ii iii - Dot - ELISA, but serious side effects, while the use of ii iii - Dot - ELISA, but serious side effects, while the use of .
2, trichosanthin - 5g, intramuscular injection, in the treatment of 129 cases of hydatidiform mole, a natural evacuation of 55 cases (42. 6% (Yunnan medicine, 1978, 3: 1);3 days with a soap mixture, vaginal suppositories, for the treatment of malignant trophoblastic tumor 7 cases with malignant hydatidiform mole and 5 cases were cured, 2 cases were ineffective (fluff Jiangsu Medical Journal, 1978, 6: 5);4. Further, also with Trichosanthin clinical treatment of diabetes mellitus, acute bronchitis, pneumonia, mastitis, and mumps infections and for the medium - term pregnancy, induced abortion, missed abortion, stillbirth, ectopic pregnancy, intestinal gland metaplastic etc.

Common Formula

1, to treat Baihe diease thirsty: Trichosanthes Kirilowi Root, oysters (cooked) 1, to treat Baihe diease thirsty: Trichosanthes Kirilowi Root, oysters (cooked) . is dispersive, low in Fangcun is dispersive, low in Fangcun .
dagger ("Yong - Qian Fang") 2, extreme thirst: Trichosanthes Kirilowi Root digging deep into the large, thick peel to white at the stop, inches of J.M., flooding, 1 night, easily passes through the water 5, removed rotten pestle, chess, calligraphy and painting to silk bag filter, such as a dry powder method of clothes water unfatherly dagger, on three, four, also act as powder porridge, in cheese - eating, with no limit on how much, and then, stopping the unfatherly dagger, on three, four, also act as powder porridge, in cheese - eating, with no limit on how much, and then, stopping the .
("Qian Jinyaofang") 3, is used for the treatment of diabetes, in addition to the intestines and stomach real: Trichosanthes root, fresh ginger each pennyweights, ophiopogon root, raw (with juice), reed (cut) in each of the two - litre, couchgrass root (cut) in a three liter. Gomi on fine - cut, water to a funnel.Cook picks up three liter, three times ( "Qian Jinyaofang") 4, is used for the treatment of critical illness: a kilo of trichosanthes root, Dao, Liuhe, a reduction of the yellow water from a young age to be out there with, if not out, and to wait for the "Qian Jinyaofang") 4, is used for the treatment of critical illness: a kilo of trichosanthes root, Dao, Liuhe, a reduction of the yellow water from a young age to be out there with, if not out, and to wait for the .
("simple") 5, the child suddenly yellowing, face flesh and Huang: Trichosanthes Kirilowi Root pound takes juice to oil, one tablespoon of honey, two warm - up phase and, for an additional minute ("simple") 5, the child suddenly yellowing, face flesh and Huang: Trichosanthes Kirilowi Root pound takes juice to oil, one tablespoon of honey, two warm - up phase and, for an additional minute . ("Techenergy") 6, and treating deficiency - heat cough:, ginsenosides with ("Techenergy") 6, and treating deficiency - heat cough:, ginsenosides with .
for money at the end of each serving a money, rice soup ( for money at the end of each serving a money, rice soup (. lower "set, on the south, Lake Jian Fang") 7, and cure abscess without ulcerated change: Trichosanthes Root, etc lower "set, on the south, Lake Jian Fang") 7, and cure abscess without ulcerated change: Trichosanthes Root, etc .
the medicine to powder, applying with the People's Republic of China; the medicine to powder, applying with the People's Republic of China; . ("Classified Materia Medica") 8, stomach and duodenal ulcer:root of Chinese trichosannthes, Fritillaria, must weigh ten eggshell ("Classified Materia Medica") 8, stomach and duodenal ulcer:root of Chinese trichosannthes, Fritillaria, must weigh ten eggshell .
research side, each serving money, plain water under research side, each serving money, plain water under . ("Liaoning common Chinese medicinal herbal manuals") 9, is used for the treatment of carbuncle: Trichosanthes Kirilowi Root, Bitter boiled dry, the neutralisation of the screen 18 ("Liaoning common Chinese medicinal herbal manuals") 9, is used for the treatment of carbuncle: Trichosanthes Kirilowi Root, Bitter boiled dry, the neutralisation of the screen 18 .
Bitters, coated paper sticking out on the Bitters, coated paper sticking out on the . (" dietetic materia medica ") 10, is used for the treatment of ulcer of nipple: noodles, which are ground, dressing in Inner Mongolia ( (" dietetic materia medica ") 10, is used for the treatment of ulcer of nipple: noodles, which are ground, dressing in Inner Mongolia (.
ovum gallus Domesticus album" of the new health - care Chinese herbal medicine and Selected Documents") 11, post - natal mammary nodules, hard swelling and pain that if light, galactostasis, and at worst as breast carbuncle: Trichosanthes Kirilowi Root, frankincense a ovum gallus Domesticus album" of the new health - care Chinese herbal medicine and Selected Documents") 11, post - natal mammary nodules, hard swelling and pain that if light, galactostasis, and at worst as breast carbuncle: Trichosanthes Kirilowi Root, frankincense a . money is at the end of the warm tone, each serving money money is at the end of the warm tone, each serving money .
("Yong - Qian Fang") 12, is used for the treatment of epidemic blisters: root of Chinese trichosannthes, talc, etc ("Yong - Qian Fang") 12, is used for the treatment of epidemic blisters: root of Chinese trichosannthes, talc, etc . the medicine to powder,water dispatching liniment ( the medicine to powder,water dispatching liniment (.
"by Ji - Fang") 13, waxberry soaked days: Radix Trichosanthis, Rhizoma Ligustici Chuanxiong, each flower two "by Ji - Fang") 13, waxberry soaked days: Radix Trichosanthis, Rhizoma Ligustici Chuanxiong, each flower two . to powder and rice paste pill, to powder and rice paste pill, .
large galls per hollow weak ginger soup under seven, eighty pills large galls per hollow weak ginger soup under seven, eighty pills . ("simple") 14, traumatic injury, chest pain, cough more than years: regardless of how much of each serving money, with the gypsum tofu was boiled ("simple") 14, traumatic injury, chest pain, cough more than years: regardless of how much of each serving money, with the gypsum tofu was boiled .
halogen (Materia Medica of Yunnan ") 15, cure sore eyes into a nebula: Trichosanthes Kirilowi Root BAN, snakeskin money halogen (Materia Medica of Yunnan ") 15, cure sore eyes into a nebula: Trichosanthes Kirilowi Root BAN, snakeskin money . on the same root, sheep liver one, open, end of two used in the form of money, linen wrapping, the rice is cooked, frequency with feed and food of liver failure on the part of on the same root, sheep liver one, open, end of two used in the form of money, linen wrapping, the rice is cooked, frequency with feed and food of liver failure on the part of .
, , . nannie polyphagia (" child Fang Yan's On ") nannie polyphagia (" child Fang Yan's On ").

Discuss Literature

1, Cheng - gong: Kuolou root, moistening and then boring also 1, Cheng - gong: Kuolou root, moistening and then boring also . body fluid passage, is also suited for thirsty body fluid passage, is also suited for thirsty .
deficiency but is thirsty, bitter to Caine, Trichosanthes Root, to promoting saliva deficiency but is thirsty, bitter to Caine, Trichosanthes Root, to promoting saliva . 2, "Compendium: Trichosanthes Root, sweet and slight bitter taste of an acid, an acid, so as to be capable of moistening thirsty and dry, slightly bitter, not sweet, I only say what you do and bitter, like 2, "Compendium: Trichosanthes Root, sweet and slight bitter taste of an acid, an acid, so as to be capable of moistening thirsty and dry, slightly bitter, not sweet, I only say what you do and bitter, like .
Richard non deep 3," Collected Works of Materia Medica: root of Chinese trichosannthes, stagnation of the viscera, such as Sheng Firelight while dry tongue and mouth, the lung with fire from the throat while the throat due to swollen spleen, swollen tongue with fire from the teeth, while the phlegm - fire cough Sheng Ning Richard non deep 3," Collected Works of Materia Medica: root of Chinese trichosannthes, stagnation of the viscera, such as Sheng Firelight while dry tongue and mouth, the lung with fire from the throat while the throat due to swollen spleen, swollen tongue with fire from the teeth, while the phlegm - fire cough Sheng Ning . if not anger hypochondriac distention, a walk in two lines, the fire in kidney of osteopyrexia and dysphoria, or an ulcer or ulcer has not collapsed, while heat - toxicity does not come loose,Five or jaundice humungous. Huang Ju, but small and the water sprinkling if astringent, stagnation is all hot, but this agent was able to open, drop of phlegm - fire, and can cure of
again its sexual sweet cold, good cure thirst, from tonic while treating thirsty, thirsty from answering for cure by fire, drugs to treat Yu from gas - thirsty, but from blood thirst, thirst, Naizhi to turn all too again its sexual sweet cold, good cure thirst, from tonic while treating thirsty, thirsty from answering for cure by fire, drugs to treat Yu from gas - thirsty, but from blood thirst, thirst, Naizhi to turn all too . 4, Ben Jing Feng Yuan ": Kuolou root, descending of superior heat - phlegm, nourish the heart and the hearts of polydipsia, except when illness fanaticism, dispelling wine wet Dan Huang, the disintoxicating drainage treating large carbuncle 4, Ben Jing Feng Yuan ": Kuolou root, descending of superior heat - phlegm, nourish the heart and the hearts of polydipsia, except when illness fanaticism, dispelling wine wet Dan Huang, the disintoxicating drainage treating large carbuncle .
" with tonifying deficiency, calming in adiabatic continued to hurt, to have its QingWeiQuShi thermal masses, or the fire is in the air, body fluid is blood and the complex injury continued " with tonifying deficiency, calming in adiabatic continued to hurt, to have its QingWeiQuShi thermal masses, or the fire is in the air, body fluid is blood and the complex injury continued . would die and is cold - natured and drop, which is derived from the stomach to vomit,yin deficiency cough Lao misuse, anti - stomach gas, diarrhea, asthma and cough a long time will, head ache the more solid 5 would die and is cold - natured and drop, which is derived from the stomach to vomit,yin deficiency cough Lao misuse, anti - stomach gas, diarrhea, asthma and cough a long time will, head ache the more solid 5 .
Goldberg), "Materia Medica of Truth: The root of Chinese trichosannthes, Trichosanthes kirilowii, which was found to be slightly flat, and does not appear to be improved urgently, while the push wall when the wall falls, plainreliable Goldberg), "Materia Medica of Truth: The root of Chinese trichosannthes, Trichosanthes kirilowii, which was found to be slightly flat, and does not appear to be improved urgently, while the push wall when the wall falls, plainreliable . to the" by "in Yanan Xu Jue, like non - orthodox interpretations, but cloud its heat removal from the group consisting of An meaning to the" by "in Yanan Xu Jue, like non - orthodox interpretations, but cloud its heat removal from the group consisting of An meaning .
6" to 7 "Sequel": Where two certificates are thirsty, annoying, thirsty gypsum as King, but thirsty Trichosanthes Root master of 6" to 7 "Sequel": Where two certificates are thirsty, annoying, thirsty gypsum as King, but thirsty Trichosanthes Root master of . 7 "s Medical Studies: The, such that it can produce saliva and slake thirst, moistening lung, lung dryness in the sputum, lung, stop cough, pulmonary tuberculosis, and traffic channels, all home heat toxin, sore, furuncle and carbuncle did at the beginning, with the capsule of weeping forsythia,pangolin scales with that elimination;Sore suppurated or with astragalus root, liquorice root (previously shall be for the living) and, more capable of promoting tissue regeneration and discharging pus, fester to deep, next to the string he shall be sentenced to fixed - term imprisonment of not more than, no dressing, and it is also possible that the self - growth of muscle, will slowly discharge pus 7 "s Medical Studies: The, such that it can produce saliva and slake thirst, moistening lung, lung dryness in the sputum, lung, stop cough, pulmonary tuberculosis, and traffic channels, all home heat toxin, sore, furuncle and carbuncle did at the beginning, with the capsule of weeping forsythia,pangolin scales with that elimination;Sore suppurated or with astragalus root, liquorice root (previously shall be for the living) and, more capable of promoting tissue regeneration and discharging pus, fester to deep, next to the string he shall be sentenced to fixed - term imprisonment of not more than, no dressing, and it is also possible that the self - growth of muscle, will slowly discharge pus .
8 "This after": the thirst, body heat, dysphoria, large hot, tonifying deficiency, calming, Xu Jue hurt 8 "This after": the thirst, body heat, dysphoria, large hot, tonifying deficiency, calming, Xu Jue hurt . 9, "Bielu": in addition to the heat in the intestines and stomach diseases, jaundice eight body being yellowish, dry lips, mouth, 9, "Bielu": in addition to the heat in the intestines and stomach diseases, jaundice eight body being yellowish, dry lips, mouth, .
month pass water, small convenience month pass water, small convenience . 10, "Materia Medica" records: pass the small intestine, drainage of pus, detumescence, promoting granulation, eliminating blood stasis and cure 10, "Materia Medica" records: pass the small intestine, drainage of pus, detumescence, promoting granulation, eliminating blood stasis and cure .
pounced on a loss when the fever, breast carbuncle, carbuncle, furunculosis hemorrhoid fistula pounced on a loss when the fever, breast carbuncle, carbuncle, furunculosis hemorrhoid fistula . 11, Materia Medica of Yunnan ": to treat boils and bunacles,and stopping coughing up blood - - 11, Materia Medica of Yunnan ": to treat boils and bunacles,and stopping coughing up blood - - .
12, Ben Cao Meng Quan ": Migraine treating hernia 12, Ben Cao Meng Quan ": Migraine treating hernia . 13," Materia Medica ": cool cardiopulmonary, anti - pyretic thirst 13," Materia Medica ": cool cardiopulmonary, anti - pyretic thirst .
diaphragmatic drops on the retention of heat, eliminating carbuncle swollen poison milk diaphragmatic drops on the retention of heat, eliminating carbuncle swollen poison milk . 14," Rock - a - Lin on the Outline: Bufei, astringe qi, lowering fire, calming heart, Liver and Purging, by relaxing the liver, bladder clearing heat, stopping heat stranguria urinary short number, except for the damp - heat in the yangming 14," Rock - a - Lin on the Outline: Bufei, astringe qi, lowering fire, calming heart, Liver and Purging, by relaxing the liver, bladder clearing heat, stopping heat stranguria urinary short number, except for the damp - heat in the yangming .
15, "Practical Modern Chinese medicine": as a spreading agent, is used for the treatment of skin eczema, tinea versicolor, galling 15, "Practical Modern Chinese medicine": as a spreading agent, is used for the treatment of skin eczema, tinea versicolor, galling . 16, Shen Nong Ben Cao Jing ":" the thirst, body heat, dysphoria, tonifying deficiency, Ann, 16, Shen Nong Ben Cao Jing ":" the thirst, body heat, dysphoria, tonifying deficiency, Ann, .
never hurt "17," Materia Medica ": decreasing internal heat and moistening dryness, sputum, thirstMultipurpose medical prescriptions to cure diabetes (i.e., diabetes) row water dredging the meridian passage, stomach - heat and jaundice yellow, talk one's tongue weary, carbuncle swollen poison, milk carbuncle sore row water dredging the meridian passage, stomach - heat and jaundice yellow, talk one's tongue weary, carbuncle swollen poison, milk carbuncle sore .
Hemorrhoid Hemorrhoid.

Trichosanthin Porridge

TCS feedstock 20 grams, rice 100 grams TCS feedstock 20 grams, rice 100 grams . practices take root of Chinese trichosannthes immersed for 15 minutes, and simmer 20 minutes, to remove residue and filtrate, join rice to boil congee practices take root of Chinese trichosannthes immersed for 15 minutes, and simmer 20 minutes, to remove residue and filtrate, join rice to boil congee .
usage in 2 separate morning and evening is taken with usage in 2 separate morning and evening is taken with . action of clearing lung to relieve cough, thirst and action of clearing lung to relieve cough, thirst and .
applicable to diabetes and lung heat cough applicable to diabetes and lung heat cough . commentary, root of Chinese trichosannthes can hypoglycemic, now used primarily to treat diabetic commentary, root of Chinese trichosannthes can hypoglycemic, now used primarily to treat diabetic .
trichosanthin cause of induction of lobor in mid pregnancy, and pregnant women.

Identification Of Crude Drug

The hammer - shaped or flap or long 8 - 40 cm, diameter 2 - 5 cm The hammer - shaped or flap or long 8 - 40 cm, diameter 2 - 5 cm . skin color yellow crown, with longitudinal wrinkles and long transverse lenticels;Scrape the skin after a relatively smooth, yellowish white, with transverse wrinkles and residual campestre spot welding, in longitudinal section a visible yellow longitudinal stripes skin color yellow crown, with longitudinal wrinkles and long transverse lenticels;Scrape the skin after a relatively smooth, yellowish white, with transverse wrinkles and residual campestre spot welding, in longitudinal section a visible yellow longitudinal stripes .
It's solid, yellowish white, powdery, the catheter bore, is slightly radially arranged from It's solid, yellowish white, powdery, the catheter bore, is slightly radially arranged from . gas micro, taste bitter gas micro, taste bitter .
Chinese Trichosanthes Root peeling those common color brown to grayish yellow, grayish yellow section, the powder is higher.with the distinctly gray - brown, reticulate wrinkles transverse section: 1. the phellem of Trichosanthes kirilowii. Its DNA sequence is 14 - 20 rows of cork cells,
yellow cortex 1 - 4 column stone cells intermittently arranged in a ring, a tricyclic, stone cells can be rectangular, oval or polygonal, as long as 180 mu m and a diameter of 140. m u.m to the phloem, cambium narrower .
. the xylem is significantly wide, 3 - (5 - 10), or single, with a diameter of up to 360 mum, secondary xylem bundle 1 is usually arranged in dichasial, some are the xylem neighbourhood interxylary phloem parenchyma cells in starch granule product the xylem is significantly wide, 3 - (5 - 10), or single, with a diameter of up to 360 mum, secondary xylem bundle 1 is usually arranged in dichasial, some are the xylem neighbourhood interxylary phloem parenchyma cells in starch granule product .
. 2,Chinese trichosanthes kirilowii maxim Stone cell is square or irregular shape, the edges of the often short horns or branched, up to 250 mu m and a diameter of up to 100. m u.m;the diameter of the catheter to 465 m
: 1, Trichosanthes kirilowii yellowish white : 1, Trichosanthes kirilowii yellowish white . 1 single starch grains, such as oval, having a diameter of 5 to 35 - 45 (. mu.m), the cord - like dots, short slit shape or a herringbone shape, obvious grain layer;compound grain, by 2 - 14 - (18) consists of particles, usually 1 - 3 a large classification and small classification, which are the plurality composite 10
2 stone cells take nearly square shape, rectangular, triangular or round, a few with a short blunt protuberance or branches, the diameter is 40 - 140 m, as long as 180. m u.m and a wall thickness of 4 - (15 - 20) m z, there is a relatively thin side walls, pits, holes and fine grooves, many are not obvious ③ bordered pit vessel much broken; if intact, and 400. m u.m in diameter, the diameter of the pits on 6 - 9. m u.m, and closely - arranged multi -
④ wood fiber is fiber tracheid, often broken, the diameter of 30 to 50. mu. m,the wall thickness of 4 - 8 mu m In addition, there are xylem parenchyma cells and phloem fibers In addition, there are xylem parenchyma cells and phloem fibers .
2, Chinese Trichosanthes starch grains with a diameter of 2 to 50. mu. m;compound grain by 2 - 9 division composed of Stone cell square or irregular, margin often short horns or branched, up to 250. m u.m to 100. m u.m diameter
2g of powdered notopterygium, adding 20 ml of 50% alcohol, ultrasonic treatment for 30 min, filtered, the filtrate as the test solution into another piece of 2g of powdered notopterygium, adding 20 ml of 50% alcohol, ultrasonic treatment for 30 min, filtered, the filtrate as the test solution into another piece of . citrulline is Zhaopin, plus 50% alcohol has been dissolved, to prepare 1mg / ml of the solution, acting as the control solution citrulline is Zhaopin, plus 50% alcohol has been dissolved, to prepare 1mg / ml of the solution, acting as the control solution .
of the test sample 6, unique to the point of any one of the silica gel G plate and on a butanol - anhydrous alcohol / acetic acid / water (8: 2: 2: 3),taken out and dried, sprayed with ninhydrin solution, drying at 105.d egree. C. to spot clear in the chromatogram obtained with the corresponding position in the chromatogram are color spots same commodity class in the chromatogram obtained with the corresponding position in the chromatogram are color spots same commodity class .
. There are three classes: long, 15 cm or more, the diameter of the middle 3. 5cm;- class: more than 15 cm long, the middle diameter 2. 5cm;Third: twisted, not straight, having a middle diameter not less than 1 cm

False Identification

Trichosanthes truncata, aka root, snakegourd root, is the root of Trichosanthes kirilowii Trichosanthes truncata, aka root, snakegourd root, is the root of Trichosanthes kirilowii . annually in the spring and autumn can be dug, the autumn harvest. The best one is
. after, washing dirt, scrape off rough skin, cut into segments or yellow - grey, and then dividing it into two halves, on the side of the street after being dried in the appearance of the yellow layer, so that it can be used in the form of a white its cool nature, sweet bitter taste and an acid, into the lung and stomach, promoting secretion of saliva or body fluid, quenching thirst, lowering fire, moistening dryness, discharge pus, swelling effect, for the treatment of fever and thirst, thirst, jaundice, hemoptysis, lung carbuncle, abscess and fistula etc its cool nature, sweet bitter taste and an acid, into the lung and stomach, promoting secretion of saliva or body fluid, quenching thirst, lowering fire, moistening dryness, discharge pus, swelling effect, for the treatment of fever and thirst, thirst, jaundice, hemoptysis, lung carbuncle, abscess and fistula etc .
market to plants in the same family Solena amplexicaulis dried root tuber of trichosanthes impersonation, market to plants in the same family Solena amplexicaulis dried root tuber of trichosanthes impersonation,. is used when the need to differentiate the authentic root of Chinese trichosannthes root dried irregular cylindrical shape, a length of 5 to 10 cm, diameter 2 ~ 6 cm, the surface of the yellowish white to light brown, uneven shrinkage, has a slight concave on the fine root and the marks of long transverse lenticels, with the remaining brown skin;qualitative firm and heavy, silty, easily broken, vertical cross - sectional view of the white, with yellow stripes on top of the bundle;of a cross - sectional view of the white, scattered with pale brown streaks catheter group;smell gas micro, taste a little dilute on the palaten turns austhere and slightly bitter is used when the need to differentiate the authentic root of Chinese trichosannthes root dried irregular cylindrical shape, a length of 5 to 10 cm, diameter 2 ~ 6 cm, the surface of the yellowish white to light brown, uneven shrinkage, has a slight concave on the fine root and the marks of long transverse lenticels, with the remaining brown skin;qualitative firm and heavy, silty, easily broken, vertical cross - sectional view of the white, with yellow stripes on top of the bundle;of a cross - sectional view of the white, scattered with pale brown streaks catheter group;smell gas micro, taste a little dilute on the palaten turns austhere and slightly bitter .
counterfeit Solena amplexicaulis dry root mass was oval or nearly cylindrical shape with a diameter of 1. 5 ~ 3 cm, the surface is brownish, flour, with conspicuous veins, tendons and vessels, often exposing partially in longitudinal section;Wen is also slightly bitter, but the taste is slightly bitter counterfeit Solena amplexicaulis is corresponding to the root of Chinese trichosanthes is plants in the same family, but does not have its effect should not be used in place of root of Chinese trichosannthes counterfeit Solena amplexicaulis is corresponding to the root of Chinese trichosanthes is plants in the same family, but does not have its effect should not be used in place of root of Chinese trichosannthes .
3 3.

The Cultivation

Soil Preparation

TCS and the original plant in warm and moist environment with plenty of sunshine, not suffering from drought, poor soil of fear of waterlogging, growed better in winter is low, in the mountainous TCS and the original plant in warm and moist environment with plenty of sunshine, not suffering from drought, poor soil of fear of waterlogging, growed better in winter is low, in the mountainous . 20 C in annual average, the warmest month 28. degree. C., Jan. 6, when a more suitable to the growth and
lax to edaphic requirement, but due to plants with taproots deep into the soil in the 1 - 1. 5m below the selected soil deep, loose and fecund, good drainage, no pollutant around the sandy loam with a plain or 15 ~ 40 degree of Xiangyang Hill as a planting to the head in front of land tillage, leveling the soil, press 1. 5m,,: digging ditch depth of 80 cm, 50 cm wide, out of the soil should be dried thoroughly, and then covered with successive layers into the ditch, make the soil fully ripe
combined sun - weathered soil earthfill, ha) was rotten manure, manure, cake fertilizer, calcium superphosphate, mixed compound fertilizer of heap and had a total of 3000 kg fertilizer was applied, after application to surface soil with the fertilizer mix well, and then a lid with a thin layer of soil for planting combined sun - weathered soil earthfill, ha) was rotten manure, manure, cake fertilizer, calcium superphosphate, mixed compound fertilizer of heap and had a total of 3000 kg fertilizer was applied, after application to surface soil with the fertilizer mix well, and then a lid with a thin layer of soil for planting .

Seedling Breeding

trichosanthes seeds are produced by this method and the main trichosanthes seeds are produced by this method and the main . from seed in only a handful are female, the male plants planted unworthy if not results, conducive to root formation and high - yield seed propagation from seed in only a handful are female, the male plants planted unworthy if not results, conducive to root formation and high - yield seed propagation .
Direct Seeding and seedling can be planted moves in two ways: first, the live broadcast is directly planting the seeds to the folds of a large area of planting them on without passing through the nursery seedling transplanting stage Direct Seeding and seedling can be planted moves in two ways: first, the live broadcast is directly planting the seeds to the folds of a large area of planting them on without passing through the nursery seedling transplanting stage . 2 seedling transplant may be the originally selected and planted special gardens or on the ground, and a row spacing of 15 cm or 9 cm x 18cm x 8cm ditching 2 seedling transplant may be the originally selected and planted special gardens or on the ground, and a row spacing of 15 cm or 9 cm x 18cm x 8cm ditching .
sowing should be first and middle ten days of March to early sowing should be first and middle ten days of March to early . under the pre - seed melon wilt will shell out at least the seed,selecting particles are large and full of particles put in the 40 - 50 DEG C in water for 24 hours, and in the middle of the water being changed 2 - 3 times, and then removed with wet sand mixing box 25 to 30 degrees C under the condition that the accelerating germination, when most of the breach could be sown seeds per mu were 0. 5 ~ 1 kg
when seedlings or pieces of leaves and a height of about 30 cm and can distinguish the sex at the time, and then transplanted to the field to tear down when seedlings or pieces of leaves and a height of about 30 cm and can distinguish the sex at the time, and then transplanted to the field to tear down . sowing seeds and collecting, and 3 ~ 5cm soil surface mulch film to cover the thermal insulation and moisturizing, anti - cold attacking sowing seeds and collecting, and 3 ~ 5cm soil surface mulch film to cover the thermal insulation and moisturizing, anti - cold attacking .
generally over 13 ~ 18 days and the emergence of generally over 13 ~ 18 days and the emergence of . The Act has, to stay, convenient for sowing,during spreading characteristics in winter or spring The Act has, to stay, convenient for sowing,during spreading characteristics in winter or spring .
annually harvested root of Chinese trichosanthes root, according to different requirements of cultivation objects, different gender selection scooping tubers of plants is not the same as that of the seedling to harvest tubers; root of Chinese trichosannthes. The aim is to select the female or male plants root with the purpose of propagation material Seed selection requirements that have been grown or result 3 ~ 5 years seeds of Trichosanthes kirilowii tubers of plants of the species as a winter harvest Seed selection requirements that have been grown or result 3 ~ 5 years seeds of Trichosanthes kirilowii tubers of plants of the species as a winter harvest .
in conjunction with the root of Chinese trichosannthes, specially selected diameter and its width is 3 ~ 5cm, the white section of the plant diseases and insect pests of fresh tuber seed, seed root were admixed with a hierarchical set of indoor storage, until the next field planted and in conjunction with the root of Chinese trichosannthes, specially selected diameter and its width is 3 ~ 5cm, the white section of the plant diseases and insect pests of fresh tuber seed, seed root were admixed with a hierarchical set of indoor storage, until the next field planted and . As spring again dug out of the outdoor wintering place for seeds,in middle furrow culture soil thickness of ground cover or grass to proof As spring again dug out of the outdoor wintering place for seeds,in middle furrow culture soil thickness of ground cover or grass to proof .
which are propagated by having a well - bred characters, with fast investment characteristics of which are propagated by having a well - bred characters, with fast investment characteristics of . plant adapted to calculate the spring drought in April by plant adapted to calculate the spring drought in April by .
consider climate differences and in the south of the vernal equinox to the Qingming, the North may be in the Qingming to Guyu consider climate differences and in the south of the vernal equinox to the Qingming, the North may be in the Qingming to Guyu . planting density of 1. 5m x 0. 5m or 1. 3m x 0. 5m, hole diameter and depth of each 30cm, applying sufficient base fertilizer, and is connected with the soil are mixed uniformly and filled with fine soil in 8 ~ 10 cm thick, are planted and has good seedlings, tubers or seeds
seeds may be soaked in warm water to the germination of seeds in threadbare just when seeding, each hole sowing 4 ~ 6 capsules,Then 4 ~ 5cm soil covering, cover and appropriate watering grass mulch or soil retention pockets seeds may be soaked in warm water to the germination of seeds in threadbare just when seeding, each hole sowing 4 ~ 6 capsules,Then 4 ~ 5cm soil covering, cover and appropriate watering grass mulch or soil retention pockets . moist tubers planting is indoor or outdoor in - situ from the root of the seeds removed, cut in a length of 5 cm in length, the incision is dipped in the ash, which he held indoor at a dry, airing to dry and incision healing after planting to subterranean species, each species of root pockets lying 1 - 2, 8 ~ 10 cm soil covering, cover or on the same grass mulching, about 20 days after emergence of the moist tubers planting is indoor or outdoor in - situ from the root of the seeds removed, cut in a length of 5 cm in length, the incision is dipped in the ash, which he held indoor at a dry, airing to dry and incision healing after planting to subterranean species, each species of root pockets lying 1 - 2, 8 ~ 10 cm soil covering, cover or on the same grass mulching, about 20 days after emergence of the .

Yield Management

water drenching and singling seedling in field transplanting in the event of the Climate drought should normally be sprayed with water retention pockets moist soil, promote seedling quick water drenching and singling seedling in field transplanting in the event of the Climate drought should normally be sprayed with water retention pockets moist soil, promote seedling quick . unearthed by seed and root of seedling height to live longer than 10 cm, i.e. on the uniform thinning seedlings per hole and seedling selection, seedling 2 ~ 3, remaining weak and the Chinese - Miao purpose plucking
intertill topdressing, adjusting the ratio of root to shoot: Trichosanthes, usually growing to Qin Shi Shi who mainly livestock manure, fertilizer and water at a ratio of 15: 100, after appropriate concentration increase, due in August before the temperatures are high, well - lit, Trichosanthes kirilowii will quickly mature leaves, stem stout, Liqiu topdressing nitrogenous fertilizer in a timely manner before the above - mentioned water,can increase the "crown" of the destination intertill topdressing, adjusting the ratio of root to shoot: Trichosanthes, usually growing to Qin Shi Shi who mainly livestock manure, fertilizer and water at a ratio of 15: 100, after appropriate concentration increase, due in August before the temperatures are high, well - lit, Trichosanthes kirilowii will quickly mature leaves, stem stout, Liqiu topdressing nitrogenous fertilizer in a timely manner before the above - mentioned water,can increase the "crown" of the destination . in August after the mid - and late growth stage, moderately control the moisture, while modified by nitrogen fertilizer is more phosphate and potash fertilizers;At this time also can be used as the temperature gradually lower diurnal temperature difference is great, the harvest of the root of Chinese trichosannthes of Trichosanthes kirilowii "crown" is controlled, so that the roots grew and developed into in August after the mid - and late growth stage, moderately control the moisture, while modified by nitrogen fertilizer is more phosphate and potash fertilizers;At this time also can be used as the temperature gradually lower diurnal temperature difference is great, the harvest of the root of Chinese trichosannthes of Trichosanthes kirilowii "crown" is controlled, so that the roots grew and developed into .
Liqiu turn cold temperatures, T. truncata "crown" has been substantially closed with a patch of soil, reduce the sunlight irradiates the ground, the soil temperature is advantageous, in that case, application of phosphorus and potassium appeared with a large amount of carbohydrates to the roots of Trichosanthes kirilowii. Its DNA transport can not promote the growth, with the growth rate of the "crown" the proportion of the increase in the effectively enlarged by the ratio of root to shoot ", such as the root of Chinese trichosanthes root and form a foundation cited Teng topping,Control of vegetative and reproductive allocation of Trichosanthes kirilowii. Its DNA sequence is a target of vines, on axil of tendril climber it grows
so that when the spring and the stem and grow up to 30cm when scaffolding or stent insertion rod, high 1. 5m, and the artificial auxiliary lead rattan shelves;At the same time to perform picking buds per tree, the only strong bud keeps 2 ~ 3 for the main stem for the shed, the rest of the buds should be removed in a timely manner, to control the aerial part of excessive consumption of nutrients to the roots of the vegetative on the shed after the main stem as long as 2 ~ 3m. Timely correct the topping, to promoting the growth of the stem and rattan vine (early)
Feng Peng Feng Peng after they should be followed in the cultivation and growth condition was reasonably with topping, thinning, picking buds or bud picking, facilitating ventilation pervious to light, increase photosynthesis, reduce plant diseases and insect pests occurrence and regulation of vegetative and reproductive body of target allocation to Feng Peng Feng Peng after they should be followed in the cultivation and growth condition was reasonably with topping, thinning, picking buds or bud picking, facilitating ventilation pervious to light, increase photosynthesis, reduce plant diseases and insect pests occurrence and regulation of vegetative and reproductive body of target allocation to . harvest for the purpose of trichosanthes root,7 ~ 8 month plants budding early in time the reproductive body of a small inflorescence bud removal, to prevent or reduce the reproductive body flowering nutrient consumption, so as to promote the root tubers of vegetative growth, increase the yield of trichosanthin harvest for the purpose of trichosanthes root,7 ~ 8 month plants budding early in time the reproductive body of a small inflorescence bud removal, to prevent or reduce the reproductive body flowering nutrient consumption, so as to promote the root tubers of vegetative growth, increase the yield of trichosanthin .
newly discovered in Anyang of Henan ProvinceThousands of Trichosanthes kirilowii. Its development planting demonstration bases, the rare giant trichosanthes root of Trichosanthes kirilowii in Anyang of Henan local planter development demonstration base staff digging of root of Chinese trichosannthes, gouging out a crocodilian, with a length of about 4.1 meters, weighing about 150 kilograms of trichosanthin king according to the base of Trichosanthes kirilowii. Its DNA sequence has a wealth of experience of Yang Baocheng, root of Chinese trichosanthes is a traditional Chinese medicine, is mainly produced in Henan, Hebei, Shandong and other places,currently in the country has now been found that it is not so much to whether in the shape of the root of Chinese trichosanthes root of Chinese trichosannthes
- - on the surface of the weight on all the amazing - - on the surface of the weight on all the amazing . pest, a pest control agent for controlling root knot nematode: prophase lowerrate of main, side, all the raw roots of various sizes and Meloidogyne javanica (gall), the taproot is the largest diameter is 2 cm or more, cut - knot after visible white female nematodes;the late leading to root rot, as well as lowerrate of short stature, slow growth, smaller leaves, green - yellow, and finally the whole plant and the stem and wither pest, a pest control agent for controlling root knot nematode: prophase lowerrate of main, side, all the raw roots of various sizes and Meloidogyne javanica (gall), the taproot is the largest diameter is 2 cm or more, cut - knot after visible white female nematodes;the late leading to root rot, as well as lowerrate of short stature, slow growth, smaller leaves, green - yellow, and finally the whole plant and the stem and wither .
Prevention is recommended in the physical and biological synthesis: in autumn and early spring when soil tillage land, soil solarization, killing pest and disease management;The selection of disease - free seed tubers and fruits seeding, reducing pathogens of artificially propagated;The rainy season field drainage, reduce soil moisture, as well as lowerrate of earth for the discovery and timely checks, excision of diseased or infected, the disease and a sprinkling of lime powder at covering soil compaction, to prevent the spread of;The necessary when available and low - toxicity fungicide polyoxin or anti - mycotic characteristics of 100 ~ 150 ppm in the chemical plant at an early stage and Watering Roots on Prevention is recommended in the physical and biological synthesis: in autumn and early spring when soil tillage land, soil solarization, killing pest and disease management;The selection of disease - free seed tubers and fruits seeding, reducing pathogens of artificially propagated;The rainy season field drainage, reduce soil moisture, as well as lowerrate of earth for the discovery and timely checks, excision of diseased or infected, the disease and a sprinkling of lime powder at covering soil compaction, to prevent the spread of;The necessary when available and low - toxicity fungicide polyoxin or anti - mycotic characteristics of 100 ~ 150 ppm in the chemical plant at an early stage and Watering Roots on . Aulacophora femoralis chinensis imago in flocks of biting of the blade;half - born larvae in the soil in the root, that bite, even bored into roots, the plants are dying Aulacophora femoralis chinensis imago in flocks of biting of the blade;half - born larvae in the soil in the root, that bite, even bored into roots, the plants are dying .
prevention methods are as follows: 1. in the morning by artificial killing adult In order to increase the insect trapping efficiency during seedling stage and anthesis stage, and may utilize the adults of suspended animation, with one containing a batter of ground beneath the washbasin in the stems and leaves, then pat or stem and leaf, imagoes fall one after another in the basin, for example a paste suffocated In order to increase the insect trapping efficiency during seedling stage and anthesis stage, and may utilize the adults of suspended animation, with one containing a batter of ground beneath the washbasin in the stems and leaves, then pat or stem and leaf, imagoes fall one after another in the basin, for example a paste suffocated .
. biologics derris extract 400 ~ 600 times dilution method to spray the Control biologics derris extract 400 ~ 600 times dilution method to spray the Control .
2 2.

Directions

Alias: Trichosanthes Root, Yunnan Baiyao, guar powder, pollen, fructus Trichosanthis powder, betel powder used: Oral: decocted in water, 9 g / l to 15 g; or into pill, powder and Alias: Trichosanthes Root, Yunnan Baiyao, guar powder, pollen, fructus Trichosanthis powder, betel powder used: Oral: decocted in water, 9 g / l to 15 g; or into pill, powder and . topical: the amount, which are ground and sprinkled with, or mixed topical: the amount, which are ground and sprinkled with, or mixed .
TCS knowledge introduction: Definition: Cochinchina Momordica Seed is the Chinese root of Trichosanthes kirilowii Maxim or TCS knowledge introduction: Definition: Cochinchina Momordica Seed is the Chinese root of Trichosanthes kirilowii Maxim or . .
distribution) parts of the country in autumn and winter are dug out and clean the dirt, scrape off rough skin, cut into segments, and then for those longitudinal incision in the sun distribution) parts of the country in autumn and winter are dug out and clean the dirt, scrape off rough skin, cut into segments, and then for those longitudinal incision in the sun . when water infiltration, slice or knock down into small pieces, dried root of Trichosanthes kirilowii when water infiltration, slice or knock down into small pieces, dried root of Trichosanthes kirilowii .
irregularly cylindrical, spindle - shaped or block - shaped flap has a length of from 8 to 30 cm and a diameter of 1.5 to 5 cm, the surface or yellowish brown, with longitudinal wrinkles,fine root and the composite recess of the long transverse lenticels, with residual brown skins It's solid, yellowish or white, rich silt It's solid, yellowish or white, rich silt .
xylem duct also has an essentially radiation arranged xylem duct also has an essentially radiation arranged . gas micro, taste bitter gas micro, taste bitter .
Chinese Trichosanthes Root with distinctly gray - brown, reticulate wrinkles, peeling those beige, pale - yellow powder is a little less Chinese Trichosanthes Root with distinctly gray - brown, reticulate wrinkles, peeling those beige, pale - yellow powder is a little less . color to white, solid, powder - Foot is color to white, solid, powder - Foot is .
minority patient can appear allergic minority patient can appear allergic . TCS supplementary information: Processed: taking the herbs, removing impurities, dipped to 3 to 4 into a permeable, spooning, moistening, and drying after dry storage container, a well - ventilated and dry place,mothproof TCS supplementary information: Processed: taking the herbs, removing impurities, dipped to 3 to 4 into a permeable, spooning, moistening, and drying after dry storage container, a well - ventilated and dry place,mothproof .
TCS crowd: cold phlegm of yan is thirsty for stomach; spleen - stomach, loose stools were forbidden for TCS crowd: cold phlegm of yan is thirsty for stomach; spleen - stomach, loose stools were forbidden for . TCS function: taste sweet, slightly bitter and slightly cold TCS function: taste sweet, slightly bitter and slightly cold .
in lung, and stomach gas real in lung, and stomach gas real . body and, may be raised or lowered body and, may be raised or lowered .
1. Clearing Heat Producing Fluid for febrile diseases, thirsty, is also used to treat lung and stomachs hotness: shicheng for febrile diseases, thirsty, is also used to treat lung and stomachs hotness: shicheng .
Chang; the radix rehmanniae, rhizoma anemarrhenae, rhizoma phragmitis equivalent with Chang; the radix rehmanniae, rhizoma anemarrhenae, rhizoma phragmitis equivalent with . 2. The treatment of Qingfei Huatan
Hyperactivity dry cough, cough, sputum less hard, dry throat, short fur or greasy fur ctious Hyperactivity dry cough, cough, sputum less hard, dry throat, short fur or greasy fur ctious . This product can dispel phlegm and moistening lung, relieving cough, dry phlegm within the knot to the lung is particularly suitable for people with This product can dispel phlegm and moistening lung, relieving cough, dry phlegm within the knot to the lung is particularly suitable for people with .
3. detoxifcation and with honeysuckle, radix paeoniae rubrathe,The dryness of noxious sore with honeysuckle, radix paeoniae rubrathe,The dryness of noxious sore .
4. termination of pregnancy can cause miscarriage in .
product moist with sweet, good clearing stomach heat and moistening dryness, Where the injury - lung - stomach heat syndrome of the root are all frequently - used product moist with sweet, good clearing stomach heat and moistening dryness, Where the injury - lung - stomach heat syndrome of the root are all frequently - used . Furthermore, detumescence and pus drainage to sore carbuncle Furthermore, detumescence and pus drainage to sore carbuncle .
TCS Foods: unfavorable with the root of Aconitum L. species with the handle TCS practice guidance: 1. for Hyperactivity dry cough, febrile diseases, thirsty, etc
the product can nourish the lung, the product can nourish the lung, . clinic for Hyperactivity dry cough, may be the root of straight ladybell, radix ophiopogonis and the like; compatibility for febrile diseases, and diabetes, etc, and dwarf lilyturf tuber, anemarrhena rhizome, etc. used to carbuncle sore
XIEHE DEGENERATIONS who have sores and detumescenceFestering has a partially non patent tubes have drainage effect, but the above syndrome is often associated with forsythia, dandelion, Bulbus Fritillariae Thunbergii combine with the XIEHE DEGENERATIONS who have sores and detumescenceFestering has a partially non patent tubes have drainage effect, but the above syndrome is often associated with forsythia, dandelion, Bulbus Fritillariae Thunbergii combine with the .