Ｒ因子

reason often often

存在不同R因子的細菌可具有抗氯黴素、鏈黴素、四環素和磺胺類藥物等多種抗性.由承擔抗藥性轉移功能的抗性轉移因子和含有抗藥基因、能賦予宿主菌以抗藥特性的抗性決定因子組成.以上兩種因子可獨立存在，也可結合在一起.只有抗性決定因子而無轉移因子的R因子，不能以接合方式轉移.R因子使細菌具有多種抗藥性的原因，主要是：（1）R因子編碼的鈍化酶使化學藥劑的化學結構發生變化，使之失效.（2）控制了菌細胞膜的通透性，使藥物不能進入細胞內.（3）阻止藥物與細胞內的作用部位結合.R因子常以接合或轉導方式在同一種屬或不同種屬的細菌中廣泛傳遞，使耐藥菌株不斷增多，常給臨床治療帶來很大困難.
GOOGLE英文翻譯:
Also known as the resistance factor. And anti-chemical agents (mainly antibiotics) of a class of plasmids. It carries one or several resistance genes. There are different R factors in bacteria resistant to chloramphenicol, streptomycin , tetracycline and sulfa drugs and other resistance. by a commitment to drug resistance transfer factor resistance transfer of functions and products containing resistant genes, will provide the host bacteria resistant to drug-resistant properties of the composition of the decision factors. These two factors may independent existence, but also together. only without the transfer factor resistance determinants of R factors can not be otherwise transfer bonding. R factor to make bacteria resistant to a variety of reasons, mainly: (1) R factor encoded passivation enzyme so that the chemical structure of chemicals to change to make it ineffective. (2) control of the bacterial cell membrane permeability, so that drugs can not enter the cells. (3) to prevent drugs and the role of intracellular binding site. R factor often means bonding or transduction in the same or different species of a genus of bacteria in the wide range of transmission of drug-resistant strains growing, and often caused great difficulties for clinical treatment.