簡介
龔芸，醫學博士（Yun Gong, M. D.）
病理學和細胞病理學副教授 (Associate Professor)
美國德克薩斯大學M. D.安德森癌症中心（The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA）
學習及工作經歷
1979年至1984 年就讀於浙江醫科大學 (現浙江大學醫學院) 醫療系, 畢業後留校在組胚教研組任教兩年。
1986年考取該校病理專業徐英含教授的研究生，並於1989年獲碩士學位。
1991年前往荷蘭, 在Department of Molecular and Developmental Genetics, Catholic University of Nijmegen 從事分子遺傳學研究。
自1994起, 先後在美國加州大學聖地亞哥分校的醫學中心以及The Scripps Research Institute從事蛋白受體與心血管疾病發病機理的研究。
1998年至2002年，在芝加哥西北大學(Northwestern University) 接受解剖病理和臨床病理住院醫訓練。繼而在美國著名的德克薩斯大學M. D. Anderson癌症中心接受細胞病理學專業培訓(Fellowship)。
2003年起受聘於該中心。
科研情況
主要研究領域是改良細針穿刺的診斷標準, 提高其診斷的準確率和探索乳腺癌愈後及預測新指標。迄今，已發表學術論文和特邀綜述五十餘篇，參與編寫專著Plasminogen: Structure, Activation and Regulation, Kluwer Academic/Plenum Publishers; cytology For Oncology;並參與乳腺癌基礎研究和臨床試驗課題二十餘項。
社會兼職
· 美國細胞病理學協會(American Society of Cytopathology) 的Editorial Review Board七位成員之一
· 全美華人病理學會教育學術委員會（Committee member of the Educational Committee, Chinese American Pathologists Association, CAPA）成員
· 國立癌症研究所(NCI)/國立衛生院(NIH) 科研基金評審委員會成員（study section for RFP SBIR Topic 257）
· M. D.安得森癌症中心科研基金評審委員會成員
· 為多個病理學及腫瘤學雜誌審稿：Modern Pathology; Cancer (Cytopathology); Diagnostic Cytopathology; Histology and Histopathology; Archives of Pathology & Laboratory Medicine; Lancet Oncology; British Journal of Cancer; Gynecologic Oncology; Clinical Biochemistry
· 訪問教授：湖北腫瘤醫院， 2005 年10月至2008 年10月
獲獎情況
· 1991-1992年，德國政府科研獎學金 (Deusche Forschungsgemeinshaft）
· 1997 年, Travel Award, American Society of Hematology 39thAnnual Meeting
· 2000年, Award of Alumni Relations and Graduate Medical Education, Northwestern University, Chicago
· 多項獲獎乳腺癌科題的重要合作人， 包括兩項Susan G.Komen 基金($7.5 millions each)
· Who’s Who in America, 2009
Selected peer-reviewed publications (in chronological order).
1. Parmer RJ, Mahata SK, Jiang Q, Taupenot L,Gong Y,Mahata M, O’Connor DT, Miles LA. Tissue plasminogen activator and chromaffin cell function. Adv Exp Med Biol 482:179-92, 2000.
2. Parmer RJ, Mahata M,Gong Y,Mahata SK, Jiang Q, O’Connor DT, Xi XP, Miles LA. Processing of chromogranin A by plasmin provides a novel mechanism for regulating catecholamine secretion. J Clin Invest 106:907-15, 2000.
3. Gong Y,Kim SO, Grella, DK, Castellino FJ, Miles LA. Conversion of glu-plasminogen to lys-plasminogen is necessary for optimal stimulation of plasmingen activation on the endothelial cell surface. J Biol Chem 276:19078-83, 2001.
4. Sun X,Gong Y,Rao S. Loss of CD44s expression is associated with metastatic potential of carcinoid tumor. Mod Pathol 15:1333-38, 2002.
5. Sun X,Gong Y,Rao S, Badve S. Loss of BRCA1 expression in sporadic male breast carcinoma. Breast Cancer Res Treat 71:1-7, 2002.
6. Gong Y,Chao J, Bauer B, Sun X, Chou PM. Primary cutaneous alveolar rhabdomyosarcoma of perineum. Arch Pathol Lab Med 126:982-84, 2002.
7. Zhang L,Gong Y,Grella DK, Castellino FJ, Miles LA. Endogenous plasmin converts Glu-plasminogen to Lys-plasminogen on the monocytoid cell surface. J Thromb Haemost 1:1264-70, 2003.
8. Sun X,Gong Y,Pins M. Paratesticular mass in a 55-year-old man.Arch Pathol Lab Med 127:e111-2, 2003.
9. Gong Y,Sun X, Haines K, Pins M. Renal cell carcinoma, chromophobe type, with collecting duct carcinoma and sarcomatoid components. Arch Pathol Lab Med 127:e38-40, 2003.
10. Gong Y,DeFrias DV, S, Nayar R. Pitfalls in fine needle aspiration cytology of extra-adrenal paraganglioma. Acta Cytol 47:1082-6, 2003.
11. Miles LA, Castellino FJ,Gong Y.Critical role for conversion of glu-glasminogen to lys-plasminogen for optimal stimulation of plasminogen activation on cell surfaces. Trends Cardiovasc Med 13:21-30, 2003.
12. Gong Y,Sun X, Attal S, Wiliamson B, Bedrossian cwm. Immunocytochemistry on serouseffusion specimens: a comparison of ThinPrep versus cell block. Diagn Cytopathol 28:1-5, 2003.
13. Gong Y,caraway N, Gu J, Zaidi T, Fernandez R, Sun X, Katz RL. Evaluation of interface fluorescence in situ hybridization for the t(14;18)(q32;q21) translocation in the diagnosis of follicular lymphoma on fine needle aspirates. Cancer 99:385-93, 2003.
14. Kidwai N,Gong Y,Sun X, Deshpande CG, Yeldandi A, Rao MS, Badve S. Expression of androgen receptor and prostate-specific antigen in male breast carcinoma. Breast Cancer Res 6:R18-23. 2004.
15. Gong Y,Symmans FW, Krishnamurthy S, Patel S, Sneige N. Optimal fixation conditions for immunocytochemical analysis of estrogen receptor in cytology specimens of breast carcinoma. Cancer 102:34-40, 2004.
16. Sun X, LoAnn P,Gong Y,Traynor AE, Nelson BP. Post-transplant plasma cell myeloma and polymorphic post-transplant lymphoid proliferation with features of Waldenstrom’s macroglobulinemia occurring in solid organ recipients. Mod Pathol 17:389-94, 2004.
17. Gong Y(corresponding author),Sun X, Huo L, Wiley EL, Rao MS. Expression of cell adhesion molecules, CD44s and E-cadherin, and microvessel density in invasive micropapillary carcinoma of the breast. Histopathology 46:24-30, 2005.
18. Gong Y(corresponding author),Jalali M, Staerkel G. Fine needle aspiration cytology of a thyroid metastasis of metaplastic breast carcinoma. Acta Cytol 49:327-30, 2005.
19. Ren R, Sun X, Staerkel G, Sneige N,Gong Y. (corresponding author)Fine-needle aspiration cytology of a liver metastasis of follicular dendritic cell sarcoma. Diagn Cytopathol 32:38-43, 2005.
20. Gong Y (corresponding author),Ren R, Ordonez N, Sun X, Sneige N. Fine-needle aspiration cytology of well-differentiated papillary mesothelioma. Acta Cytol 49:537-542, 2005.
21. Gong Y,Krishnamurthy S. Diagnostic challenge of poorly differentiated insular carcinoma of the thyroid by fine needle aspiration – one case report. Diagn Cytopathol 32:103-7, 2005.
22. Gong Y,Booser DJ, Sneige N. Comparison of HER-2 status determined by Fluorescence in Situ Hybridization in primary and metastatic breast cancer. Cancer 103:1763-69, 2005.
23. Gong Y(corresponding author),Sun X. Fine-needle aspiration of a presacral myelolipoma. Diagn Cytopathol 34:29-30, 2006.
24. Gong Y(corresponding author),Joseph T, Sneige N. Validation of commonly used immunostains on cell-transferred cytologic specimens. Cancer105:158-64, 2005.
25. Gong Y,Gilcrease M, Sneige N. Chromogenic in situ hybridization (CISH) in the evaluation of HER-2 status – interobserver reproducibility and comparison with fluorescence in situ hybridization (FISH). Mod Pathol 18:1015-21, 2005.
26. Anderson K, Hess KR, Kapoor M, Tirrell S, Courtemanche J, Wang B, Wu Y,Gong Y,Hortobagyi GN, Symmans WF, Pusztai L. Reproducibility of gene expression signature based predictions in replicate experiments.Clin Cancer Res 12:1721-27, 2006.
27. Gong Y (corresponding author),Sneige N., Guo M, Hicks M, Moran C. Transthoracic fine needle aspiration versus concurrent core needle biopsy in diagnosis of intrthoracic lesions: a retrospective comparison of diagnostic accuracy. Am J Clin Pathol 125:438-44, 2006.
28. Gong Y(corresponding author),Joseph T, Sneige N. Author reply to immunohistochemistry performed on cell-transferred cytologic specimens. Cancer 108:135-136, 2006.
29. Alrahwan D, Staerkel G,Gong Y.(corresponding author)Fine needle aspiration cytology of a metastatic ductal adenocarcinoma of the prostate.Acta Cytol 50:469-72, 2006.
30. Huang P, Sneige N, Staerkel G,Gong Y. (corresponding author)Fine-Needle aspiration of pancreatic serous cystadenoma: cytologic features and diagnostic pitfalls.Cancer 108:239-49, 2006.
31. Sneige N, Liu B, Yin G,Gong Y,Arun B. Correlation of cyologic findings and chromosomal instability detected by fluorescence in situ hybridization in breast fine-needle aspiration specimens from women at high risk for breast cancer. Mod Pathol 19:622-629, 2006.
32. Gong Y(corresponding author),Caraway N, Stewart J, Staerkel G. Metastatic ductal adenocarcinoma of the prostate: cytologic features and clinical findings. Am J Clin Pathol 126:302-9, 2006.
33. Ren R, Guo M, Sneige N, Moran C,Gong Y.(corresponding author)Fine-needle aspiration of adrenal cortical carcinoma: cytologic spectrum and diagnostic challenges. Am J Clin Pathol 126:389-398, 2006.
34. Ganzalez-Angulo, A, Guarneri, V,Gong, Y,Cristofanilli, M, Morales-Vasquez, F, Sneige, N, Hortobagyi, G, Esteva, F. Downregulation of the cyclin-dependant kinase inhibitor p27kip1might correlate with poor disease-free and overall survival in inflammatory breast cancer. Clin Breast Cancer 7:326-30, 2006.
35. Cabioglu N,Gong Y (co-first author),Broglio K, Islam R, Sneige N, Sahin A., Gonzalez-Angulo AM, Marandi P, Bucana C, Hortobagyi G, Cristofanilli M. Expression of growth factors and chemokine receptors: New insights in the biology of inflammatory breast cancer. Ann Oncol 18:1021-9, 2007.
36. Gong Y (corresponding author),Yan K, Lin F, Anderson K, Sotiriou C, Andre F, Holmes FA, Valero V, Booser D, Pippen JE, Vukelja, S, Gomez H, Mejia J, Barajas LJ, Hess KR, Sneige N, Hortobagyi GN, Pusztai L, Symmans, WF. Determination of estrogen receptor and HER-2 status of breast carcinoma using mRNA measurements from Affymetrix gene expression profiling. Lancet Oncol 8:203-11, 2007.
37. Arun B, Logan C, Broglio K, Yin C, Valero V, Kuerer H, Meric-Bernstam F,Gong Y,Browne D, Hortobagyi GN, Sneige N. Comparison of ductal lavage and random periaroelar fine-needle aspiration as tissue acquisition methods in early breast cancer prevention trials. Clin Cancer Res 13:4943-48, 2007.
38. Gong Y (corresponding author),Symmans, WF, Pusztai, L. Gene expression microarrays provide new prognostic and predictive tests for breast cancer(Review).Pharmacogenomics 8: 1359-1368, 2007.
39. Dawood S, Broglio K,Gong Y,Yang, WT, Cristofanilli, M, Kau SW, Meric FB, Buchholz TA, Hortobaghy GN, Ganzalez-Angulo A. Prognostic significance of HER2 status in women with inflammatory breast cancer. Cancer 112:1905-1911, 2008.
40. Piao Y, Guo M,Gong Y (corresponding author).Fine-needle aspiration cytology of metastatic spindle cell melanoma: a study of 81 cases. Cancer 114:94-101, 2008.
41. Guo, M,Gong Y. Evaluation of a commercialized in situ hybridization assay for detecting human papillomavirus DNA in cervical intraepithelial neoplasia and cervical carcinoma. J Clin Microbiology 46:274-80, 2008
42. Guo M, Lin CY,Gong Y, Cogdell DF, Zhang W, Lin E, Sneige N. Human papillomavirus genotyping for the eight oncogenic types can improve specificity of HPV testing in women with mildlyabnormal Pap results. Mod Pathol. 21:1037-43, 2008.
43. Gong Y (corresponding author).Pathology aspect of inflammatory breast cancer: Biologic insights of its aggressive phenotype (Review). Semin Oncol, 35;33-40, 2008.
44. Uzquiano MC, Prieto, VG, Nash, JW, Ivan, DS,Gong Y, Lazar AJ, Diwan AH. Metastatic basal cell carcinoma. Mod Pathol, 21:540-43, 2008.
45. Angeles R,Gong Y (corresponding author)Fine needle aspiration of a subcutaneous gouty tophus. Diagn Cytopathol, 36:494-95, 2008.
46. Payne M, Staerkel G andGong Y (corresponding author)indeterminate diagnosis in fine-needle aspiration of the pancreas: reasons and clinical implications. Diagn Cytopthol 37:21-9, 2009
47. Gong Y (corresponding author),Sweet W, Duh YJ, Greenfield L, Fang Y, Zhao J, Tarco E, Symmans WF, Isola J, Sneige. Chromogenic in situ hybridization (CISH) is a reliable method for detecting HER2 gene status in breast cancer: A multicenter study using conventional scoring criteria and the new ASCO/CAP recommendations. Am J Clin Pathol 131: 490-97, 2009.
48. Ge Y, Sneige N, Eltorky MA, Wang Z, Lin E,Gong Y, Guo M Immunohistochemical characterization of subtypes of male breast carcinoma Breast Cancer Res. 2009 May 14;11(3):R28.
49.Gong Y (corresponding author),Sweet W, Duh YJ, Greenfield L, Trivedi S, Symmans WF, Isola J, Sneige N. Performance of chromogenicin situhybridization on testing HER2 status in breast carcinomas with chromosome 17 polysomy and equivocal (2+) HercepTest: a study of two institutions using conventional and the new ASCO/CAP scoring criteria. Am J Clin Pathol 132: 228-36, 2009.
50. Pusztai L, Jeong J,Gong Y, Ross J, Kim C, Hortobagyi GN, Paik S, Symmans, WF, Evaluation of microtubule associated protein Tau expression as prognostic and predictive maker in the NSABP-B 28 randomized clinical trial. Accepted and In Press 3.2009 Journal of Clinical Oncology
