黃健[武漢大學生命科學學院教授]

黃健，女，職位是武漢大學生命科學學院教授。主要研究領域與興趣:激素防治Alzheimer病的機制研究 ;新型ERβ選擇性雌激素受體調節劑的篩選和研究.

人物經歷

學習簡歷
1986-1990年 武漢大學生命科學學院 生物化學專業　獲學士學位。
1993-1996年 武漢大學生命科學學院 生物化學專業　獲碩士學位。
1996-1999年 武漢大學生命科學學院 微生物學專業　獲博士學位。
研究工作簡歷
講　師　1999-2001年　武漢大學生命科學學院。
助　研　1999-2000年　香港理工大學套用生物及化學學系。
博士後　2001-2003年　美國肯塔基大學生物化學學系。
副教授　2001-2009年　武漢大學生命科學學院。
教　授　2009-現　在　武漢大學生命科學學院。

主講課程

1.主講《生物化學技術原理極其套用》(本科生)。
2.主講《專業文獻研讀》（本科生）。
3.主講《神經生物學》(研究生)。

研究方向

研究方向：神經生物化學和分子生物學 。

主要貢獻

教育科研

主要研究領域與興趣。
激素防治Alzheimer病的機制研究 。
新型ERβ選擇性雌激素受體調節劑的篩選和研究。

主持科研項目
教育部留學回國人員科研啟動基金 。
國家自然科學基金面上項目 。
國家自然科學基金二個基地項目 。
國家自然科學基金面上項目 。
湖北省自然科學基金（2006ABA219）。
湖北省科技攻關計畫項目（2006AA301B31）。
湖北省高等學校教學研究項目（20062022）。
湖北省自然科學基金（2007ABA115）。

教材《生物化學技術原理極其套用》第四版，副主編，2008年，科學出版社。

代表性論文

1. Zhimin Xiao, Can Huang, Jun Wu, Li Sun, Wei Hao, Lai K. Leung, Jian Huang*. The neuroprotective effects of ipriflavone against H2O2 and amyloid beta induced toxicity on human neuroblastoma SH-SY5Y cells. Eur J Pharmacol. (2013)

2. Caihua Wang, Changhao Li, Haibing Zhou and Jian Huang*. High-Throughput Screening Assays for Estrogen Receptor by Using Coumestrol, a Natural Fluorescence Compound. J Biomol Screen. (2013).

3. Wenjuan Tan, Tsz Yan Wong, Yanfei Wang, Jian Huang, Lai K. Leung*. CYP19 expression is induced by 2,3,7,8-tetrachloro-dibenzo-para-dioxin in human glioma cells. Mol Cell Endocrinol. 15;375(1-2):106-12. (2013).

4. Nelson L. S. Chan, Jinzhen Guo, Tianyi Zhang, Guogen Mao, Caixia Hou, Fenghua Yuan, Jian Huang, Yanbin Zhang, Jianxin Wu, Liya Gu, and Guo-Min Li*. Coordinated processing of 3' slipped (CAG)n/(CTG)n hairpins by DNA polymerases β and δ preferentially induces repeat expansions. J Biol Chem. 288(21): 15015–15022, (2013).

5. Xinlong Zhang, Ziqing Zuo, Juan Tang, Kai Wang, Caihua Wang, Weiyan Chen, Changhao Li, Wen Xu, Xiaolin Xiong, Kangxiang Yuntai, Jian Huang, Xiaoli Lan, Hai-Bing Zhou*. Design, synthesis and biological evaluation of novel estrogen-derived steroid metal complexes. Bioorg Med Chem Lett. 1;23(13):3793-7. (2013).

6. Feng Li, Guogen Mao, Dan Tong, Jian Huang, Liya Gu, Wei Yang and Guo-Min Li*. The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSα. Cell. 153(3):590-600. (2013).

7. Yangfan Zheng, Caihua Wang, Changhao Li, Jinxia Qiao, Feng Zhang, Minjian Huang, Wenming Ren, Chune Dong, Jian Huang* and Hai-Bing Zhou*. Discovery of novel SERMs with a ferrocenyl entity based on the oxabicyclo[2.2.1]heptene scaffold and evaluation of their antiproliferative effects in breast cancer cells. Org. Biomol. Chem., 10: 9689. (2012).

8. Nelson L. S. Chan, Caixia Hou, Tianyi Zhang, Fenghua Yuan, Amrita Machwe, Jian Huang, David K. Orren,Liya Gu, and Guo-Min Li?. The Werner syndrome protein promotes CAG/CTG repeat stability by resolving large (CAG)(n)/(CTG)(n) hairpins. J Biol Chem. 287(36):30151-6. (2012).

9. Hsiang-Tsui Wang, YuHu, Dan Tong, Jian Huang, Liya Gu, Xue-Ru Wu, Fung-Lung Chung, Guo-Min Li,and Moon-shong Tang?. Effect of Carcinogenic Acrolein on DNA Repair and Mutagenic Susceptibility. J Biol Chem. 287(15): 12379–86. (2012).

10. Tianyi Zhang, Jian Huang*, Liya Gu, Guo-Min Li?. In vitro repair of DNA hairpins containing various numbers of CAG/CTG trinucleotide repeats. DNA Repair, 11: 201–209. (2012).

11. Peng Yuan, Kaiwei Liang, Buyong Ma, Nan Zheng, Ruth Nussinov, and Jian Huang*. Multiple-Targeting and Conformational Selection in the Estrogen Receptor: Computation and Experiment. Chem Biol Drug Des, 78: 137–149. (2011).

12. Caixia Hou, Tianyi Zhang, Lei Tian, Jian Huang, Liya Gu, Guo-Min Li*. The Role of XPG in Processing (CAG)n/(CTG)n DNA Hairpins. Cell & Bioscience, 1:11-17. (2011).

13. Kaiwei Liang, Liuqing Yang, Chen Yin, Zhimin Xiao, Junjian Zhang, Yumin Liu and Jian Huang*, Estrogen stimulates degradation of {beta}-amyloid peptide by upregulating neprilysin. J Biol Chem. 285(2):935-42. (2010). doi:10.1074/jbc.M109.051664

14. Zhi-Min Xiao; Li Sun; Yu-Min Liu; Jun-Jian Zhang; Jian Huang*, Estrogen Regulation of the Neprilysin Gene Through A Hormone-Responsive Element. Journal of Molecular Neuroscience, 39:22-6. (2009). doi:10.1007/s12031-008-9168-1

15. Kaiwei Liang, Liuqing Yang, Zhimin Xiao and Jian Huang*, A Bipartite Recombinant Yeast System for the Identification of Subtype-Selective Estrogen Receptor Ligands. Molecular Biotechnology, 41:53–62, (2009). doi:10.1007/s12033-008-9097-9

16. Li-Juan Deng, Yan Xu, Jian Huang*, Developing a double-antigen sandwich ELISA for effective detection of human hepatitis B core antibody. Comp Immunnol Microb, 31: 515-26. (2008).doi:10.1016/j.cimid.2007.09.001

17. Guogen Mao, Xiaoyu Pan, Bei-Bei Zhu, Yanbin Zhang, Fenghua Yuan, Jian Huang, Mark A. Lovell, Maxwell P. Lee, William R. Markesbery, and Guo-Min Li, Liya Gu. Identification and characterization of OGG1 mutations in patients with Alzheimer’s disease. Nucleic Acids Research, 35(8):2759-66. (2007). doi:10.1093/nar/gkm189

18. Huang, J., Guan, H., Booze, R. M., Eckman, C. B., Hersh, L.B. Estrogen regulates neprilysin activity in rat brain. Neurosci Lett. 367(1):85-7. (2004)．doi:10.1016/j.neulet.2004.05.085

19. Deming Gou, Jun Wang, Li Gao, Yan Sun, Xiao Peng, Jian Huang, Wenxin Li. Identification and functional analysis of a novel Human KRAB/C2H2 zinc finger gene ZNF300. Biochimica et biophysica acta, 2004 ,1676 (3):203-209. doi:10.1016/j.bbaexp.2003.11.011

20. Huang, J., Gou, D. M., Zhen, C. Y., Jiang, D. H., Mao, X., Li, W. X. Protection of xenogeneic cells from human complement-mediated lysis by expression of human DAF, CD 59 and MCP. FEMS Immunology and Medical Microbiology, 31(3):203-9. (2001).

21. Gou DM; Sun Y; Gao L; Chow LM; Huang J; Feng YD; Jiang DH; Li WX. Cloning and characterization of a novel Kruppel-like zinc finger gene, ZNF268, expressed in early human embryo. Biochimica et biophysica acta, 2001 ,1518(3):306-10.