簡歷:
1979-1984北京醫科大學本科高曉明 |
1984-1987衛生部長春生物製品研究所實習研究員
1987-1989英國Wellcome研究所博士
1990-1993英國牛津大學分子醫學研究所博士後研究員
1994-1998英國帝國理工醫學院WellcomeSeniorFellow
1997-2010北京大學醫學部免疫學系教授,博導,系主任
2010-今蘇州大學生物醫學研究院教授,博導,PI
2010-今蘇州大學基礎醫學與生物科學學院教授,博導,院長
主要研究方向:
1、糖免疫生物學2、免疫調節與免疫耐受的分子與細胞機制
3、自身免疫病的發病機制及免疫治療
4、抗感染免疫應答的分子與細胞機制。
教學專著:
獨自撰寫長學制免疫學教材兩部《免疫學教程》,2006年,高等教育出版社出版,北京大學長學制本科生教材
《醫學免疫學基礎》,2001年,北京大學醫學出版社,“十一五”規劃教材,面向21世紀課程教材,北京市高等教育精品教材
主編或共同主編教材五部
“十一五”規劃教材《醫學免疫學》第二版(主編),2010年,高等教育出版社
“十一五”規劃教材《醫學免疫學》(主編),2006年,高等教育出版社
“十一五”規劃教材《醫學免疫學》(主編),2004年,北京大學醫學出版社
“十一五”規劃教材《醫學免疫學》第二版(副主編),2009年,人衛出版社
“十一五”規劃教材《醫學免疫學》(副主編),2005年,人民衛生出版社
代表性論文目錄:
1Hong,C.,X.Qiu,Y.Li,Q.Huang,Z.Zhong,Y.Zhang,X.Liu,L.Sun,P.Lv,andX.M.Gao.Functionalanalysisofrecombinantcalreticulinfragment39-272:implicationsforimmunobiologicalactivitiesofcalreticulininhealthanddisease.JImmunol.2010.185:4561-4569.2DaiH,ZGLi,YZhang,PLv,XMGao:ElevatedlevelsofserumAbsagainstSaccharomycescerevisiaeMANNANinpatientswithsystemiclupuserythematosus.2009.Lupus18(12):1087-90
3BoH,XQWei,HLDong,YZhang,PLv,XMGao:ElevatedexpressionoftransmembraneIL-15inimmunecellscorrelateswiththedevelopmentofmurinelupus:apotentialtargetforimmunotherapyagainstsystemiclupuserythematosus.ScanJImmunol.2009,69(2):119-29.
4ZhaoJC,QRHuang,WWang,YZhang,PLv,XMGao:IdentificationandcharacterizationofhelperTcellepitopesinthenucleocapsidproteinofSARS-CoV.JVirology2007,81(11):6079-88.
5ZhaoJ,WWang,WLWang,ZZhao1,YZhang,PLv,FRen,XMGao:ComparisonofIgGresponsesagainstthespikeandnucleocapsidproteinsofSARS-coronavirusinpatientswithsevereacuterespiratorysyndrome.Clin.VaccineVirology2007,14(7):839-846.
6YangP,BLi,PLv,YZhang,XMGao:InteractionbetweenautoreactiveTcellsandantigenpresentingcells.CellRes2007,17:556-564.
7ZhaoJC,WWang,RJJia,ZHYuan,ZDZhao,XJXu,PLv,YZhang,XMGao:Astudyonantigenicityandreceptor-bindingabilityoffragment450-650ofthespikeproteinofSARS-coronavirus.Virology2007,359:362-370.
8LuY,WXu,ZYe,PLvandXMGao:RegulatoryactivityofactivatedmurineperipheralCD4+CD25-Tcells:Apossiblemechanismoffeedbackregulationonadaptiveimmunity.ScandinavianJImmunol.2006,64:501-506.
9LiZG,RMu,ZPDai,XMGao:TcellvaccinationinsystemiclupuserythematosuswithautologousactivatedTcells.Lupus2005,14:884-889.
10ZhaoJC,WWang,GFWang,ZHYuan,RJJia,XXu,FRRen,ZDZhao,XMGao:Developmentandevaluationofanenzyme-linkedimmunosorbentassayfordetectionofantibodiesagainstthespikeproteinofSARS-coronavirus.JClinVirol.2005,33(1):12-18.
11HanSH.,B.Li,YT.ChenandXMGao:IsolationandfunctionalanalysisofautoreactiveTcellsfromBXSBmicewithmurinelupus.J.Autoimmunity2002.19(1-2):45-54.
12ZhaoY.,ZPDai,PLu&XMGao:PhenotypeandfunctionalanalysisofhumanTlymphocytesinearlysecondandthirdtrimestertofetuses.Clin.Exp.Immunol.2002.129(2):302-8.
13ChilversMM.,P.Wordsworth,A.StubbsandXM.Gao:Tcellreceptorusagebyhomocysteine-specifichumanCTL.J.Immunol.,1998,160:3737-42.
14Gao,XM.,MM.ChilversandP.Wordsworth:Astudyonhomocysteine-specificCTLfrompatientswithankylosingspondylitisandreactivearthritis.InProceedingsofthe10thInternationalCongressofImmunology,1998,Vol.2:785-92.
15Gao,XM.andA.McMichael:Collagen-specificCTLdonotcausearthritisinB10mice.Clin.Exp.Immunol.,1996,103:89-93.
16Gao,XM.,J.Bell,C.QuinnandA.McMichael:ExpressionandfunctionofHLA-B27inlipid-linkedform:implicationsforCTL-inducedapoptosis.Eur.J.Immunol.,1993,23:653-8.
17Hill,AVS.,J.Elvin,AC.Willis,CEM.Allsopp,XM.Gao,M.Takiguchi,BM.greenwood,ARM.Townsend,AMcMichaelandHC.whittle:MolecularanalysisofanHLA-diseaseassociation:HLA-B53andresistancetoseveremalaria.Nature,1992,360:434-9.
18Gao,XM.,JP.Tite,M.Lipscombe,S.Rowland-JonesandA.McMichael:RecombinantSalmonellatyphimuriuminvadingnon-phagocyticcellsareresistanttorecognitionbyantigen-specificcytotoxicTlymphocytes.Infect.&Immunity,1992,60(9):3780-90.
19Gao,XM.,FY.Liew,K.Bottomly,A.meagerandJP.Tite:ClonalanalysisoftherelationshipbetweenclassIIMHC-restrictedcytolysisandlymphokinesecretioninmurineL3T4+Tcells.Immunology,1991,72:256-60.
20Gao,XM.,B.Zheng,FY.Liew,S.BrettandJP.Tite:PrimingofinfluenzavirusspecificCTLinvivobyshortsyntheticpeptides.J.Immunol.,1991,147(10):3268-73.
<,SPANstyle="mso-list:Ignore">21Gao,XM.,andJ.Rhodes:Chemicaleventsinimmuneinduction:pre-formationofSchiff-basesonaccessorycellsinhibitsantigen-dependentT-cellactivation.J.Immunol.,1990,144(8):2883-90.
22Gao,XM.,FY.LiewandJP.Tite:AdominantThepitopeininfluenzanucleoprotein:analysisofthefinespecificityandfunctionalrepertoireofT-cellsrecognisingasingledeterminant.J.Immunol.,1990,144(7):2730-7.
23Gao,XM.,FY.LiewandJ.P.Tite:IdentificationandcharacterisationofThepitopesinnucleoproteinofinfluenzaAvirus.J.Immunol.,1989,143(9):3007-14.
24Gao,XM.,JA.SchmidtandF.Y.Liew:SuppressivesubstanceproducedbyT-cellsfrommicechronicallyinfectedwithTrypanosomacruzi,IIIGeneticrestrictionandfurthercharacterisation.J.Immunol.,1988,141(3):989-95.