人物簡介
湖南師範大學特聘教授。2001年被教育部批准為“長江學者獎勵計畫”特聘教授，並獲得國家傑出青年科學基金課題。在美留學期間他以複雜性狀與疾病為研究對象，以遺傳與突變為研究的核心問題，從事了進化生物學、分子進化遺傳學、群體及數量遺傳學、生態遺傳學、骨醫學、骨質分子遺傳學、計算和統計遺傳學等跨學科和交叉學科的研究，並取得了傑出成就。2003年分獲第二屆HOMA獎“傑出青年學者獎”和湖南省科技進步二等獎，2004年獲國際骨質疏鬆基金“IOF-Servier 青年學者研究獎”，2004年教育部提名國家科學技術獎自然科學二等獎，共申請國內外專利7項。
科研成就
1)發展了“鄧-林奇”(Deng-Lynch)法來測定基因突變的突變率、突變對機體的危害及其遺傳效應。有關這項工作的一系列文章發表在美國遺傳學報(Genetics)上。主要因為這項工作，他於1997年獲得美國自然科學家協會的優秀青年科學獎；
2)第一次發現並證實維生素-D的受體基因和雌性激素的受體在一定程度上決定人類骨質密度的自然變化及藥理調控。這項工作發表在Human Genetics及國際骨質研究學刊(Osteoporosis International)上。他為此於1999年4月獲美國骨學研究會第一次有命名的(John Haddad)優秀青年科學家獎；
3)第一次發現並證實人類的手腕骨折有其重要的遺傳原理及機制。這項工作為尋找人類骨折基因打下了堅實的基礎。鄧紅文博士在Nature、Genetics、Human Genetics、J Bone and Mineral Res、 Evolution、Molecular Biology and Evolution、 Heredity、Genetical Research、Genetica和American J Human Genetics等國際權威刊物上共發表了70餘篇論文。其中第一作者和獨著或通訊作者的論文60餘篇,全部文章被SCI收錄,論文總引用達500餘次。
鄧紅文博士承擔和主持過國家級重大課題7項,獲得國際和美國各種傑出青年科學家獎9項，7次應邀在國際重要學術會議上作專題報告,為13個國際一流雜誌和美國NSF等基金組織擔任評審。
目前鄧紅文博士在美國Creighton大學醫學院主持一個遺傳學研究室，在研課題6項，經費323.35萬美元；在湖南師範大學生命科學學院主持一個分子與統計遺傳學研究室，主要開展人類複雜多基因遺傳疾病(如骨質疏鬆、高血壓、心臟病、癌症等)基因的分子遺傳分析與鑑定。
課題研究
國家自然科學基金重點項目1項(160萬元),國家傑出青年科學基金課題1項(80萬)、國家自然科學基金面上項目1項(21萬)、湖南省特聘教授基金課題1項(300萬)、霍英東教育基金第八屆青年教師基金1項(2萬美金),教育部留學回國人員啟動基金課題1項(5萬)，課題經費達600萬元人民幣。該研究室已具規模，目前指導有碩士生、博士生10餘名。與國內外同行已建立起了廣泛的聯繫，各項研究工作已全面展開並取得了良好的進展。
論文論著
1. Deng,H.-W.,Population Admixture May Appear to mask, change or Rererse Genetic Effects of Genes Underlying Complex Traits. Genetics，2001,159：1319-1323。
2..Tan,Y.,D.and H.-W.Deng, An Amplified Fragment length Polxmorphism Nap of the Silkworm. Genetics 2001，157：1277-1284。
3.Deng,H.-W.,J. Li,The effect of polygenes on transmission disquilibrium test of a QTL in nuclear families with multiple children. Genet Epodemiology.2001,21,243-265.
4. Deng,H.-W.,Biased tests of association:comparison of allele frequencies when departing from Hardy-Weinberg proportions 2000 Am.Jepidemiology,151:335-357.
5. Deng,H.-W.,Determination of BND at hip and spine by genetic and life-style factors. Gemetics Epidemiology,2000:19:160-177.
6. Deng,H.-W.,Characterizing deleterious genomic mutations in partial seltfing/outcrossing populations and in nonequilium Popuations.2000 Genetics 154:1839-1906.(*Deng is the corresponding author).
7. Deng,H.-W.,Pooduct difference of multiplex and singleplex PCR and its practical for human genctic studies.BioTechniques.2000,29:298-308
8. Deng,H.-W.,QTL fine mapping in extreme samples of finite populations for complex traits with familial correlation due to polygenes “Am.J Himan Genet”(2000,67:259-261)
9. Deng,H.-W Association of Estrogen Receptor-alpha(ER)Genotypes with Body Mass Index in Normal Healthy Postmenopausal Caucsisn Women. J Clincical Endocrinology and Mrtabolism.2000,85:2748-2751.
10. Deng, H .-W., J. Li , and J.- Li. Recovery of mutations of different size from a population sample of DNA sequences under variable mutation rates across sites.Moleclar Biology and Evolution,1999,618:1098-1104.
11. H. -W., Deng,V.Haynatzka, Spitze,K.and G.Haynatzki.On the determination of genetic covariances and prediction of evolutionary trajectories based on genetic correlations matrix. Evolution. 1999,53(5):1592-1599.
12. Deng,HW,J.Li,J.L.Li,M.Johnson,M.Davies and RR Recker. Change of bone mass in postmenopausal Caucasian women with and without hormone replacement therapy is associated with Vitamin D receptor and estrogen receptor genotypes. Human Genetics.1998,103:576-585.
13. Li , J.- L ., J. Li and H .- W. Deng . The effects of overdominance on characterizing deleterious genomic mutations in large natural populations. Genetics. 1999,151:895-913.
14. Deng,H.W. Estimation of deleterious-mutation rate and efficts in outcrossing populations. Genetics. 1998,150: 945-956.
15. Deng,H.-W.,J.Li, and J.-L.Li On the experimental designs and data analyses of mutation accumulation experiments.Genetical Research. 1999,73:147-194.
16. Deng,H.-W,J.L.Li,J.Li,M.K.Davies,and R.R. Recker. Heterogeneity of bone mass density across skeletal sites and its clnical implications. J Clinical Densitometry.1998, 1:339-353.
17. Deng, H.-W. Estimating coefficient of (over)dominance from inbreeding data and discriminating dominance and overdominance hypothesis for heterosis. Genetics .1998,148:1333-1340.
18. Deng, H.- W. and Y.- X. Fu. On the three different approaches to estimating deleterious genomic mutation parameters. Genetical Research .1998,71 (3): 223-236.
19.Deng ,H.-W.,D.B. Kimel, T. Conway, K. M.Davies, R. R. Recker High narrow-sense heritability for peak bone mass in humans. J Bone Miner Res.1997, 12:S563.
20.Deng, H.- W. and M. Lynch. Inbreeding depression and the inferred genomic mutation parameters in Daphnia species. Genetics, 1997,147:147-155.
21.Deng, H. - W. Increase of dvelopmental instability upon inbreeding in Daphnia. Heredity,1997,78: 182-189.
22 .Deng, H-W.and Y.-X. Fu. The effects of variable mutation rate across sites on the phylogenetic estimation of population size or mutation rate of DNA sequences. Genetics, 1996,144: 1271-1281.
23.Deng, H.-W. and M. Lynch. Estimation of deleterious- mutation parameters in nature populations. Genetics, 1996, 144:349-360.
24.Deng,H.- W. and M.Lynch. Change of genetic architecture in response to sex. Genetics, 1996,143:203-212.
25.Deng, H. - W. Environmental and genetic control of sexual reproduction in Daphnia. Heredity,1996,76:449-458.
26.Deng,H.-W.Sexual reproduction in Daphnia: its control and genetieconsequences..Ph.D.Thesis. University of Oregon(Advisor-Dr.Michael Lynch). 1995
27.Deng, H.-W. and T. Kibota, The importance of environmental variance and covariance structure in predicting evolutionary response. Evolution.1995, 49: 572-574.
28.Butcher, D. and H.-W.Deng. Hypothetical“Sister Killer”. Nature. 1994, 369: 26.
29.Lynch,M. and H.-W. Deng. Genetic slippage in response to sex.American Naturalist. 1994, 144:242-261.
