![袁正宏[復旦大學黨委副書記、紀委書記]](/img/0/801/nBnauM3XyYzM2AzMzkTN2MTO1UTMxQTNzQjM0QTNwAzMwIzL5UzL3UzLt92YucmbvRWdo5Cd0FmLxE2LvoDc0RHa.jpg "袁正宏[復旦大學黨委副書記、紀委書記]")
人物履歷
1985年畢業於江蘇南通醫學院醫療系本科，1988年獲南通醫學院微生物與免疫學碩士學位，1993年獲上海醫科大學醫學博士學位。1995－1996年獲歐共體居里獎學金在英國帝國理工學院聖瑪麗醫院進修C型肝炎病毒分子生物學；1999，2002年作為高級訪問學者分別在美國WashingtonUniversity（StLouis）及RockefellerUniversity進行HCV分子生物學及RNA-蛋白相互作用的研究工作。
2001年7月，任部醫學分子病毒學教育部/衛生重點實驗室主任；
2001年7月至2008年4月任復旦大學上海醫學院副院長；
2005年1月起兼任上海市（復旦大學附屬）公共衛生臨床中心副主任；
2006年7月起兼任生物醫學研究院副院長；
2008年4月-2012年10月任上海市（復旦大學附屬）公共衛生臨床中心黨委書記兼副主任；2012年9月起任復旦大學上海醫學院（大醫口）副院長；
2013年9月，任復旦大學委員會常委、副書記兼紀委書記 。
任免信息
2019年5月，擬任市管高校正職 。
社會兼職
主要學術兼職有中華醫學會病毒專業學會主任委員、中國微生物學會理事、上海病毒學會名譽主任委員等。
人物榮譽
曾獲“973”計畫先進個人、全國高等學校優秀骨幹教師、政府特殊津貼、教育部首屆“青年教師獎”等榮譽，入選上海市優秀學科帶頭人、上海市醫學領軍人才和國家“新世紀百千萬人才工程“。
曾獲得國家自然科學三等獎、上海醫學科技獎、上海市科技進步獎、教育部高校技術發明一等獎、中華醫學獎一等獎、衛生部科技進步二等獎等。獲國際和國內專利多項。
人物著作
近年代表性學術論文*通訊作者
1.Exosomesmediatethecell-to-celltransmissionofIFN-a-inducedantiviralactivity.JianhuaLi,KuanchengLiu,YangLiu,YanXu,FeiZhang,HuijuanYang,JiangxiaLiu,TingtingPan,JieliangChen,MinWu,XiaohuiZhouandZhenghongYuan*.NatureImmunology,2013,onlineDOI:10.1038/ni.2647.
2.AssociationbetweenadverseclinicaloutcomeinhumandiseasecausedbynovelinfluenzaAH7N9virusandsustainedviralsheddingandemergenceofantiviralresistance.YunwenHu,ShuihuaLu,ZhigangSong,WeiWang,PeiHao,JianhuaLi,XiaonanZhang,Hui-LingYen,BishengShi,TaoLi,WencaiGuan,LeiXu,YiLiu,SenWang,XiaolingZhang,DiTian,ZhaoqinZhu,JingHe,HuangKai,HuijieChen,LuluZheng,XuanLi,JiePing,BinKang,XiuhongXi,LijunZha,YixueLi,ZhiyongZhang,MalikPeiris,ZhenghongYuan*.Lancet,PublishedOnlineMay28,20136736(13)61125-3.
3.Humaninfectionwithanovelavian-origininfluenzaA(H7N9)virus.RongbaoGao,BinCao,YunwenHu,ZijianFeng,DayanWang,WanfuHu,JianChen,---GuizhenWu,YuWang,ZhenghongYuan*,andYuelongShu.NEnglJMed2013.DOI:10.1056.
4.HepatitisBVirusSurfaceAntigenSelectivelyInhibitsTLR2Ligand-InducedIL-12ProductioninMonocytes/MacrophagesbyInterferingwithJNKActivation.WangS,ChenZ,HuC,QianF,ChengY,WuM,ShiB,ChenJ,HuY,YuanZ*.JImmunol.2013May15;190(10):5142-51.
5.HepatitisBviruspolymeraseimpairsinterferon-α-inducedSTATsactivationthroughnhibitionofimportin-α5andproteinkinaseC-δ.JieliangChen,MinWu,XiaonanZhang,WenZhang,ZhanqingZhang,LixiangChen,JingHe,YeZheng,CuncunChen,FanWang,YunwenHu,XiaohuiZhou,CongWang,YangXu,MengjiLu,ZhenghongYuan*Hepatology.2013，57：2：470–482.
6.NewinsightsintohowHBVmanipulatestheinnateimmuneresponsetoestablishacuteandpersistentinfection.ZhenghongYuan*.AntiviralTherapy.2013;18:1-15.
7.Rupintrivirisapromisingcandidatefortreatingseverecasesofenterovirus-71infection:EvaluationofantiviralefficacyinamurineinfectionmodelXiaonanZhang,ZhigangSong,BoyinQin,XiaolingZhang,LixiangChen,YunwenHu,ZhenghongYuan*.AntivralTherapy,2013,97:3:264–269.
8.FlavivirusreplicationcomplexassemblyrevealedbyDNAJC14functionalmapping.YiZ,YuanZ,RiceCM,MacdonaldMR.JVirol.2012,86(21):11815-11832.
9.HBsAgInhibitsIFN-aProductioninPlasmacytoidDendriticCellsthroughTNF-aandIL-10InductioninMonocytes.BishengShi,GuangxuRen,YunwenHu,SenWang,ZhanqingZhang,ZhenghongYuan*PLOSONE.September2012|Volume7|Issue9|e44900.
10.PlasmamicroRNAprofileasapredictorofearlyvirologicalresponsetointerferontreatmentinchronichepatitisBpatients.XiaonanZhang,CuncunChen,MinWu,LiangChen,JimingZhang,XinxinZhang,ZhanqinZhang,JingdiWu,JiefeiWang,XiaorongChen,TaoHuang，LixiangChen,ZhenghongYuan*.AntiviralTherapy.2012.;17(7):1243-53.
11.ViperininhibitsHepatitisCVirusreplication3byinterferingwiththebindingofNS5AtohostproteinhVAP-33ShanshanWang,XianfangWu,TingtingPan,WuhuiSong,YaohuiWang,FeiZhang,ZhenghongYuan*.JournalofGeneralVirology(2012),93,83–92.
12.InhibitionofhepatitisBvirusreplicationbycIAP2involvesacceleratingtheubiquitin-proteasome-mediateddestructionofpolymerase.ZekunWang,JinjingNi,JianhuaLi,BishengShi,YangXu,andZhenghongYuan*.J.Virol.published24August2011,10.1128/JVI.00879-11.
13.HepatitisCvirusNS5BdelaysS-phaseprogressioninhumanhepatocyte-derivedcellsbyrelocalizingthecyclin-dependentkinase2-interactingprotein(CINP).YaohuiWang,YuchanWang,YanXu,WenyanTong,TingTingPan,JianhuaLi,ShuhuiSun,JunjieShao,HuanpingDing,ZhenghongYuan*.JBC.2011286:26603-26615.
14.HepatitisCVirusCo-OptsRas-GTPase-ActivatingProtein-BindingProtein1forItsenomeReplicationZhigangYi,TingtingPan,XianfangWu,WuhuiSong,ShanshanWang,YanXu,CharlesM.Rice,MargaretR.MacDonald,*andZhenghongYuan*.JournalofVirology.July2011,p.6996–7004.
15.SubversionofCellularAutophagyMachinerybyHepatitisBVirusforViralEnvelopmentJianhuaLi,YinghuiLiu,ZekunWang,KuanchengLiu,YaohuiWang,JiangxiaLiu,HuanpingDing,andZhenghongYuan*.JournalofVirology,July2011,p.6319–6333.
16.IdentificationandCharacterizationoftheHostProteinDNAJC14asaBroadlyActiveFlavivirusReplicationModulator.ZhigangYi1,LindseySperzel1,CindyNurnberger1,PeterJ.Bredenbeek1,KirkJ.Lubick,SonjaM.Best,CristinaT.Stoyanov1,LokManJ.Law1,ZhenghongYuan,CharlesM.Rice,MargaretR.MacDonald1*PLoSPathogens.January2011|Volume7|Issue1|e1001255.
17.InhibitionofhepatitisBvirusreplicationbyMyD88involvesaccelerateddegradationofpregenomicRNAandnuclearretentionofpreS/SRNAs，JianhuaLi,ShanshanLin,QiyingChen,LuPeng,JianweiZhaiYinghuiLiu,ZhenghongYuan*.JournalofVirology,July2010,p.6387–6399.
18.HCVNS5AActivatestheMammalianTargetofRapamycin(mTOR)PathwayandContributestoCellSurvivalbyDisruptingtheInteractionbetweenFK506-bindingProtein38(FKBP38)andmTOR.LuPeng,DongyuLiang,WenyanTong,JianhuaLi,andZhenghongYuan*TheJournalofBiologicalChemistry.July2,2010.285,NO.27,pp.20870–20881.
19.HepatitisBviruspolymeraseinhibitsRIG-IandToll-likereceptor3-mediatedinterferon-binductioninhumanhepatocytesthroughinterferencewithinterferonregulatoryfactor3activationanddampeningoftheinteractionbetweenTBK1/IKKeandDDX3.，ShiyanYu，JieliangChen,MinWu,HuiChenandYuanZ*.JournalofGeneralVirology(2010),91,2080-2090.
20.WholerecombinantHansenulapolymorphaexpressinghepatitisBvirussurfaceantigen(yeast-HBsAg)inducespotentHBsAg-specificTh1andTh2immuneresponses.GuanglinBian,YumingCheng,ZekunWang,YunwenHu,XiaonanZhang,MinWu,ZhiaoChen,BishengShi,ShuhuiSun,YanShen,ErjiaChen,XinYao,YumeiWen,ZhenghongYuan*Vaccine28(2010)187–194.
