蔣序林

蔣序林,出生於1967年3月,教授、博士生導師

基本信息

簡介

職稱職務:教授、博士生導師

學科專業:高分子化學與物理

研究方向

1. 可控高分子的合成、改性及共軛技術的研究,

2. 基因藥物用新型可降解高分子載體的研究,

3. 熱敏性兩親性可降解高分子藥物靶向載體的研究(抗腫瘤藥物、多肽、蛋白質藥物),

4. HPLC分離與表征高分子。

主要主持科研項目

1 國家自然科學基金項目21174109 長循環-靶向-逃逸-示蹤-多功能高分子膠束藥物載體及其細胞相互作用的研究(資助時間2012.01-2015.12, 60萬)

2 國家自然科學基金項目21074100 穩定化熱敏腫瘤靶向高分子納米膠束載藥系統的研究(資助時間 2011.01-2013.12, 37萬)

3 國家自然科學基金項目20774068點擊化學合成降解梳形聚合物及用於基因載體的研究(資助時間 2008.01-2010.12, 29萬)

4 20744002 HPLC用於新型生物醫用高分子的分離與表征

5 博士點基金新教師項目 點擊化學可控合成基因載體用新型可降解星形陽離子高分子

學習及工作簡歷

1985,9-1989,7 成都科技大學優秀生試點班, 高分子材料系, 學士

1989,9-1992,6 成都科技大學高分子材料工程國家重點實驗室,碩士 (導師:徐僖院士,鄭邦乾教授)

1992,7-2000,9 上海交通大學化學化工學院高分子材料系 助教,講師,副教授

2000,9-2004,5 荷蘭阿姆斯特丹大學高分子分析組, 博士 (導師: Prof. Dr. P. J. Schoenmakers)

2004,6-2006,10荷蘭烏特勒支大學藥學院藥劑系博士後 (導師: Prof. Dr. W.E. Hennink)

2006,11-至今:武漢大學化學學院生物醫用高分子材料教育部重點實驗室(教授,博導)

近期代表性研究論文

29 Xulin Jiang, Yan-feng Chu,Jia Liu, Guang-yan Zhang and Renxi Zhuo(2011) Aueous SEC Ananlysis of Cationic Polymers as Gene Carries,Chines Journal of Polymer Science 29(4),421-426.

28 Jiang, X. L., Liu, J., Xu, L., and Zhuo, R. X. (2011) Disulfide-Containing Hyperbranched Polyethylenimine Derivatives via Click Chemistry for Nonviral Gene Delivery. Macromolecular Chemistry and Physics 212, 64-71.

27 Liu, J., Jiang, X. L., Xu, L., Wang, X. M., Hennink, W. E., and Zhuo, R. X. (2010) Novel Reduction-Responsive Cross-Linked Polyethylenimine Derivatives by Click Chemistry for Nonviral Gene Delivery. Bioconjugate Chemistry 21, 1827-1835.

26 L.-H. LI; X.-L. Jiang*; R.-X. Zhuo. Synthesis and Characterization of Thermoresponsive Polymers Containing Reduction-Sensitive Disulfide Linkage, J Polym Sci Part A: Polym Chem 2009, 47(22): 5989–5997

25 Wan, H.; Chen, Y.; Chen, L.; Zhu, X.; Yan, D.; Li, B.; Liu, T.; Zhao, L.; Jiang, X.; Zhang, G. Supramolecular Control of the Branched Topology of Poly(sulfone-amine) from Divinylsulfone and Hexamethylenediamine, Macromolecules, 2008, 41(2), 465-470

24 Jie Xue, Li Zhou, Peng He, Xinyuan Zhu, Deyue Yan and Xulin Jiang, Supramolecular end-group separation of linear polymers with different terminals through host-guest interaction,Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2008, 61, 83-88

23 C. Lin, Z.-Y. Zhong, M. C. Lok, X..-L. Jiang, W. E. Hennink, J. Feijen, J. F. J. Engbersen, “Novel Bioreducible Poly(amido amine)s for Highly Efficient Gene Delivery”, Bioconjugate Chem., 2007, 18(1), 138 – 145.

22 X.-L, Jiang, M. C. Lok, C. F. van Nostrum, W. E. Hennink, “Degradable-Brushed pHEMA-pDMAEMA Synthesized via ATRP and Click Chemistry for Gene Delivery”, Bioconjugate Chem., 2007, 18(6), 2077-2084

21 Lin, C.; Zhong, Z.; Lok, M. C.; Jiang, X.; Hennink, W. E.; Feijen, J.; Engbersen, J. F. J., Random and block copolymers of bioreducible poly(amido amine)s with high- and low-basicity amino groups: study of DNA condensation and buffer capacity on gene transfection, J Controlled Release, 2007, 123, 67-75

20 K. D. F. Vlugt-Wensink, X.-L.Jiang, G. Schotman, G. Kruijtzer, A. Vredenberg, J.T. Chung, Z. Zhang, C. Versluis, D. Ramos, R. Verrijk, W. Jiskoot, D. J. A. Crommelin, W. E. Hennink, “In Vitro Degradation Behavior of Microspheres Based on Cross-Linked Dextran”, Biomacromolecules, 2006, 7(11), 2983-2990.

18 X. Jiang, A. van der Horst, M.J. van Steenbergen, N. Akeroyd, C.F. van Nostrum, P.J. Schoenmakers and W.E. Hennink, “Aqueous size-exclusion chromatography of cationic polymers for gene delivery”, J. Controlled Release, 2006, 116(2), e69-e71.

18 C. Hiemstra, Z.Y. Zhong, X. Jiang, W.E. Hennink, P.J. Dijkstra and J. Feijen, “PEG–PLLA and PEG–PDLA multiblock copolymers: Synthesis and in situ hydrogel formation by stereocomplexation”, J. Controlled Release, 2006, 116(2), e17-e19.

17. Chao Lin, Zhiyuan Zhong, Martin C. Lok, Xulin Jiang, Wim E. Hennink, Jan Feijen and Johan F.J. Engbersen,“Linear poly(amido amine)s with secondary and tertiary amino groups and variable amounts of disulfide linkages: Synthesis and in vitro gene transfer properties”, J. Controlled Release, 2006, 116(2), 130-137.

16. X.-L, Jiang, A. van der Horst, M. J. van Steenbergen, C. F. van Nostrum, P. J. Schoenmakers, W. E. Hennink, “molar-Mass Characterization of Cationic Polymers for Gene Delivery by Aqueous SEC with Online Multi-Angle Light Scattering Detection”, Pharmaceut. Res., 2006,23(3), 595-603.

15 X.-L, Jiang, A. van der Horst, V. Lima, P. J. Schoenmakers, “Comprehesive Two-Dimentional Liquid Chromatography for the Characterization of Functional Acrylate Polymers”, J. Chromatogr. A, 2005, 1076(1-2), 51-61.

14. V. Lima V, X.-L. Jiang, J. Brokken-Zijp, P. J. Schoenmakers, B. Klumperman, R. Van Der Linde, “Synthesis and characterization of telechelic polymethacrylates via RAFT polymerization”m, J. Polym. Sci.: Polym. Chem., 2005, 43(5), 959-973.

13. X.-L. Jiang, P. J. Schoenmakers, X.-W. Lou, V. Lima, J. L. J. van Dongen, and J. Brokken-Zijp, “Separation and Characterization of Functional Poly(n-Butyl Acrylate) by Critical Liquid Chromatography”, J. Chromatogr. A, 2004, 1055(1-2), 123-133.

12 H.-Q. Zhang, X.-L. Jiang, R. van der Linde, “Synthesis ofhydroxylEnd-Capped Telechelic Polymers with Poly(Methyl Methacrylate)-block-Poly(n-Butyl Acrylate) Backbones via Atom-Transfer Radical Polymerisation”, Polymer, 2004, 45 (5), 1445-1466.

11. X.-L. Jiang, P. J. Schoenmakers, J. L.M van Dongen, X.W. Lou, V. Lima, J. Brokken-Zijp, “Mass-Spectrometric Characterization of Functional Poly(Methyl Methacrylate) in Combination with Critical Liquid Chromatography”, Anal. Chem., 2003, 75(20), 5517-5524.

10 X.-L. Jiang, V. Lima, P. J. Schoenmakers, “Robust Isocratic Liquid Chromatography Separation of Functional Poly(Methyl Methacrylate)”, J. Chromatogr. A, 2003, 1018(1), 19-27.

09 X.-L. Jang, A. van der Horst, P. J. Schoenmakers, “breakthroughof Polymers in Interactive Liquid Chromatography”, J. Chromatogr. A, 2002, 982 (1), 55-68.

08 J.-Y. Li, D.-Y. Yan, X.-L. Jiang, Q. Chen, “Formation of the Crystalline Inclusion Complex between Gamma-Cyclodextrin and Poly(N-acetylethylenimine)”, Polymer, 2002, 43, 2625-2629.

07 夏平 蔣序林 顏德岳, “耐熱性星型甲基丙烯酸甲酯基共聚物的合成”,高等學校化學學報,2002. 23(2), 336-338.

06 W.-X. Wang, D.-Y. Yan, X.-L. Jiang, C. Detrembleur, P. Lecomte, R. Jér?me, “Reverse Atom-Transfer Radical Polymerization at Room Temperature”, Macromol. Rapid Commun. 2001, 22, 439-443.

05 P. Xia, Q.-S. Hu, X.-L. Qian, X.-L. Jiang, D.-Y. Yan, “Simultaneous Measurement of Free Rdical Decay in Polymerization of MMA Initiated byAIBNUsing ESR and Its Kinetic Model”, Chinese J. Polym. Sci. 2001, 19 (1), 33-38.

04 X.-L. Jiang, P. Xia, D.-Y. Yan, W.-L. Liu, “Atom Transfer Radical Copolymerization of Styrene and N-cyclohexylmaleimide”, J. Polym. Sci.: Polym. Chem., 2000, 38(8), 1203.

03 X.-L. Jiang, D.-Y. Yan, Y.-L. Zhong, W.-L. Liu, and Q.-X. Chen. “Atom Transfer Radical Copolymerization of MMA and N-cyclohexylmaleimide”, Polym. Int., 2000, 49, 893-897.

02 X.-L. Jiang, Y.-L. Zhong, D.-Y. Yan, and H. Yu, “Hyperbranched Copolymers of p-(Chloromethyl)styrene and N-Cyclohexylmaleimide Synthesized by ATRP”, J. Appl. Polym. Sci., 2000, 78(11), 1992-1997.

01 蔣序林 顏德岳劉萬里, “原子轉移自由基聚合(ATRP)合成耐熱性共聚物”,高等學校化學學報,2000. 21(10), 1613-1615.

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