研究方向
用蛋白質組學和代謝組學技術尋找精神分裂症
分子診斷方法;構建維生素A缺乏及N-甲基-D-天門冬酸受體拮抗劑注射等精神分裂症動物模型研究精神分裂症疾病機制。
發表論文
1. Yang J, Chen T, Sun L, Zhao Z, Qi X, Zhou K, Cao Y, Wang X, Qiu Y, Su M, Zhao A, Wang P, Yang P, Wu J, Feng G, He L, Jia W, Wan C*. Potential metabolite markers of schizophrenia. Mol Psychiatry. 2011. [Epub ahead of print]
2. Zhou K, Yang Y, Gao L, He G, Li W, Tang K, Ji B, Zhang M, Li Y, Yang J, Sun L, Zhang Z, Zhu H, He L, Wan C*. NMDA receptor hypofunction induces dysfunctions of energy metabolism and semaphorin signaling in rats: A synaptic proteome study. Schizophr Bull. 2010. [Epub ahead of print]
3. Zhang M, Huang K, Zhang Z, Ji B, Zhu H, Zhou K, Li Y, Yang J, Sun L, Wei Z, He G, Gao L, He L*, Wan C*. Proteome alterations of cortex and hippocampus tissues in mice subjected to Vitamin A depletion. J Nutr Biochem. 2011;22(11):1003-8.
4. Ji B, La Y, Gao L, Zhu H, Tian N, Zhang M, Yang Y, Zhao X, Tang R, Ma G, Zhou J, Meng J, Ma J, Zhang Z, Li H, Feng G, Wang Y, He L*, Wan C*. A Comparative Proteomics Analysis of Rat Mitochondria from the Cerebral Cortex and Hippocampus in Response to Antipsychotic Medications. J Proteome Res. 2009; 8(7): 3633-3641.
5. Ji B, Zhang Z, Zhang M, Zhu H, Zhou K, Yang J, Li Y, Sun L, Feng G, Wang Y, He L*, Wan C*. Differential expression profiling of the synaptosome proteome in a rat model of antipsychotic resistance. Brain Res. 2009; 1295:170-178.
6. Wan C#, Yang Y#, Li H, La Y, Zhu H, Feng G and He L*. Dysregulation of Retinoid Transporters Expression in Body Fluids in Schizophrenia Patients. J. Proteome Res. 2006; 5: 3213-3216