翟琦巍

"2000年畢業於中國科學院上海生物化學研究所獲博士學位。 2003年至今在中國科學院上海生命科學研究院營養科學研究所工作。 Z

個人簡介：

中科院營養與慢性代謝疾病研究組組長

1995年畢業於南京大學生物化學系獲學士學位。2000年畢業於中國科學院上海生物化學研究所獲博士學位。2000年至2003年先後在哈佛大學醫學院病理系、哈佛大學兒童醫院神經生物學系進行博士後研究。2003年至今在中國科學院上海生命科學研究院營養科學研究所工作。2004年入選中國科學院“百人計畫”，2005年入選“上海市青年科技啟明星”，2008年入選上海市青年科技啟明星跟蹤計畫，2008年獲“上海市科教黨委系統十佳青年科技創新人才”稱號，2008年獲“國家傑出青年科學基金”，2009年“百人計畫”終期評估獲得優秀，並獲“賽諾菲-安萬特—中科院上海生命科學研究院優秀青年人才獎”。2010年獲得“中國科學院上海分院第2屆傑出青年科技創新人才獎”和“第五屆上海青年科技英才”稱號。2011年入選“上海市優秀學術帶頭人計畫”。

研究領域：

從分子、細胞和動物水平研究各種營養因素對於肥胖、糖尿病、腫瘤和長壽的影響。目前重點研究乙醯化酶和去乙醯化酶及其調控因子對肥胖、糖尿病和腫瘤的影響；並通過高通量測序、高通量液質聯用分析、蛋白質組學、以及一些最新篩選方法尋找能緩解肥胖、糖尿病和腫瘤或延長壽命的基因和藥物。

近期論文：

Zhang F, Xu X, Zhou B, He Z, Zhai Q*.(2011) Gene Expression Profile Change and Associated Physiological and Pathological Effects in Mouse Liver Induced by Fasting and Refeeding. PLoS One. In press.
Wu J, Zhang F, Yan M, Wu D, Yu Q, Zhang Y, Zhou B, McBurney MW, Zhai Q*. (2011) WldS Enhances Insulin Transcription and Secretion via a SIRT1-Dependent Pathway and Improves Glucose Homeostasis. Diabetes. Oct 13. [Epub ahead of print] doi: 10.2337/db11-0232
Yu Q, Wang T, Zhou X, Wu J, Chen X, Liu Y, Wu D, Zhai Q*. Wld Reduces paraquat-Induced Cytotoxicity via SIRT1 in Non-Neuronal Cells by Attenuating the Depletion of NAD. PLoS One. 2011. 6(7): e21770. Epub 2011 Jul 5.
Wu D, Qiu Y, Gao X, Yuan XB, Zhai Q*. Overexpression of SIRT1 in Mouse Forebrain Impairs Lipid/Glucose Metabolism and Motor Function. PLoS One. 2011. 6(6): e21759. Epub 2011 Jun 30.
Wang P, Xu T, Guan Y, Tian W, Viollet B, Rui Y, Zhai Q, Su D, Miao C. Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway. Ann Neurol. 2011; 69(2): 360-74. Epub 2011 Jan 19.
Hong Y, Chen Z, Zhang B, Zhai Q*. Isolation of Photobacterium sp. LUB-1 and its application in rapid assays for chemical toxicants in water. Lett Appl Microbiol. 2010 Sep; 51(3): 308-12.
Feng Y, Yan T, Zheng J, Ge X, Mu Yu, Zhang Y, Wu D, Du J, Zhai Q*. Overexpression of WldS or Nmnat2 in Mauthner cell by single-cell electroporation delays axon degeneration in live zebrafish. J Neurosci Res. 2010 Nov. 88(15): 3319-27.
Yan T, Feng Y, Zhai Q. Axon degeneration: Mechanisms and implications of a distinct program from cell death. Neurochem Int. 2010 Mar; 56(4):529-34. (Invited review)
Feng Y, Yan T, He Z, Zhai Q*. WldS, Nmnats and Axon degeneration -progress in the past two decades. Protein & Cell. 2010 Mar; 1(3): 237-45. (Invited review)
Zheng J, Yan T, Feng Y, Zhai Q*. Involvement of lysosomes in the early stages of axon degeneration. Neurochem. Int. 2010 Feb; 56(3): 516-21.
Jin Q*, Zhang F*, Yan T, Liu Z, Wang C, Ge X, Zhai Q*. C/EBPα Regulates SIRT1 Expression during Adipogenesis. Cell Res. 2010 Apr;20(4):470-9. Epub 2010 Feb 16.
Yan T, Feng Y, Zheng J, Ge X, Zhang Y, Wu D, Zhao J, Zhai Q*. Nmnat2 delays axon degeneration in superior cervical Ganglia dependent on its NAD synthesis activity. Neurochem Int. 2010 Jan;56(1):101-6.
Xia YL, Zhai Q*. IL-1β enhances the antibacterial activity of astrocytes by activation of NF-κB. Glia. 2010 Jan 15;58(2):244-52.
Wang F, Gao Y, Zhang L, Bai B, Hu Y, Dong Z, Zhai Q, Zhu H, Liu J. A pair of WINDMILL-shaped enantiomers from Lindera aggregata with activity toward improvement of insulin sensitivity. Org Lett. 2010 Jul 16; 12(14): 3196-9.
Liu Z, Liu Y, Wang H, Ge X, Jin Q, Ding G, Hu Y, Zhou B, Chen Z, Ge X, Zhang B, Man X, Zhai Q*. Patt1, a novel protein acetyltransferase that is highly expressed in liver and downregulated in hepatocellular carcinoma, enhances apoptosis of hepatoma cells. Int J Biochem Cell Biol. 2009 Dec;41(12):2528-37. Epub 2009 Aug 18.
Hu H, He L, Gong Z, Li N, Lu Y, Zhai Q, Liu H, Jiang H, Zhu W, Wang H. A novel class of antagonists for the FFAs receptor GPR40. Biochem Biophys Res Commun. 2009; 390(3): 557-63. Epub 2009 Oct 8.
Ge X, Jin Q, Zhang F, Yan T, Zhai Q*. PCAF Acetylates β-Catenin and Improves its Stability. Mol Biol Cell. 2009 Jan;20(1):419-27. Epub 2008 Nov 5.
Ge X, Liu Z, Qi W, Shi X, Zhai Q*. Chromium(VI) Induces Insulin Resistance in 3T3-L1 adipocytes Through Elevated Reactive Oxygen Species Generation. Free Radical Res. 2008; 42(6):554-563.
Ge X, Yu Q, Qi W, Shi X, Zhai Q*. Chronic Insulin Treatment Causes Insulin Resistance in 3T3-L1 Adipocytes through Oxidative Stress. Free Radical Res. 2008; 42(6):582-591.
Zhang F, Sun C, Wu J, He C, Ge X, Huang W, Zou Y, Chen X, Qi W, Zhai Q*. Combretastatin A-4 activates AMP-activated protein kinase and improves glucose metabolism in db/db mice. Pharmacol Res. 2008; 57(4): 318-323.
Sun C, Zhang F, Ge X, Yan T, Chen X, Shi X, Zhai Q*. SIRT1 Improves Insulin Sensitivity under Insulin-Resistant Conditions by Repressing PTP1B. Cell Metab. 2007; 6(4):307-19.
Featured Article. Highlighted by Featured Preview: Zabolotny J, Kim Y. Silencing insulin resistance through SIRT1. Cell Metab. 2007; 6(4):247-9.