人物簡介
1994年本科畢業於西北農業大學農學系
1997年碩士研究生畢業於西北農業大學基礎科學系
2005年在中科院微生物所獲微生物學博士學位
2005-2008年為美國普度大學生物科學系博士後
2008-2010年被聘為中科院武漢病毒所病毒學國家重點實驗室副研究員
現為西北農林科技大學生命科學學院教授，博士生導師。
研究方向
主要研究方向為微生物分子生理學和生物化學，以谷氨菌棒桿菌、嗜肺軍團菌、假結核耶爾森氏菌等重要的模式微生物為模型，利用生物化學、分子生物學、遺傳學和功能基因組學技術進行微生物重要代謝途徑、致病因子的分子生理學研究，並在此基礎上發現重要的藥物作用靶標，以及設計新的代謝工程策略，通過對微生物進行系統生物技術改造，從而利用微生物技術進行污染物的降解和生物質源大宗化學品的合成，以及為病原微生物的防治提供理論指導和技術支持。在PLoS Pathogens, Cellular Microbiology, Applied and Environmental Microbiology等國際著名期刊發表研究論文10餘篇，是國際期刊Archives of Microbiology的審稿人。
研究成果
部分發表文章： Li Xu*, Xihui shen*, Andrew Bryan, Simran Banga, Michele S. Swanson, Zhao-Qing Luo. Inhibition of Host Vacuolar H -ATPase Activity by a Legionella pneumophila effector. PLos Pathogens. 2010，19;6(3):e1000822.（* Co-first Author）
Xihui Shen, Simran Banga, Yancheng Liu, Li Xu, Ping Gao, Ilya Shamovsky, Evgeny Nudler, Zhao-Qing Luo. Targeting eEF1A by a Legionella pneumophila effector leads to inhibition of protein synthesis and induction of host stress response. Cellular Microbiology. 2009, 11(6):911-26.
Banga S, Gao P, Shen XH, Fiscus V, Zong WX, Chen L, Luo ZQ. Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 family. PNAS 2007，104(12):5121-6.
Yan Huang, Kexin Zhao, Xihui Shen, Chengying Jiang, and shuang-Jiang Liu. Genetic and biochemical characterization of a 4-hydroxybenzoate hydroxylase from Corynebacterium glutamicum. Applied Microbiology and Biotechnology 2008, 78(1):75-83.
Chaudhry MT, Huang Y, Shen XH, Poetsch A, Jiang CY, Liu SJ. Genome-wide investigation of aromatic acid transporters in Corynebacterium glutamicum. Microbiology. 2007，153(3):857-65.
Huang Y, Zhao KX, Shen XH, et al. Genetic characterization of the resorcinol catabolic pathway in Corynebacterium glutamicum. Applied and Environmental Microbiology 2006，72(11):7238-45.
Jie Feng, Yongsheng Che, Johanna Milse, Ya-Jie Yin, Lei Liu, Christian, Rückert, Xi-Hui Shen, Su-Wei Qi, Jörn Kalinowski, and Shuang-Jiang Liu. The gene ncgl2918 encodes a novel maleylpyruvate isomerase that needs mycothiol as cofactor and links mycothiol biosynthesis and gentisate assimilation in Corynebacterium glutamicum. Journal of Biological Chemistry. 2006， 281(16):10778-85.
Xihui Shen, Chengying Jiang, Yan Huang, Zhipei Liu, and Shuang-Jiang Liu. Functional identification of novel genes involved in the glutathione-independent gentisate pathway in Corynebacterium glutamicum. Applied and Environmental Microbiology 2005，71(7):3442-52.
Xi-Hui Shen, Yan Huang，Shuang-Jiang Liu Genomic analysis and identification of catabolic pathways for aromatic compounds in Corynebacterium glutamicum. Microbes and Environments. 2005. 20(3):160-167.
Xihui Shen, Shuang-Jiang Liu. Molecular basis of the protocatechuate branch of the β-ketoadipate pathway for aromatic degradation in Corynebacterium glutamicum. Science in China 2005, 48: 241-249.
Xihui Shen, Zhipei Liu, and Shuang-Jiang Liu. Functional identification of the gene locus (ncg12319) and characterization of catechol 1,2-dioxygenase in Corynebacterium glutamicum. Biotechnology Letters 2004, 26:575-580.
