梁德生
2004年至今，主持國家“973”和“863”計畫課題各1項，主持或參加國家和部級重大科研計畫課題5項；獲2005年度國家科技進步獎二等獎1項，省部級科技進步獎各4項；發表論文40餘篇，其中SCI收錄論文20篇。2004年參加完成“角膜環狀皮樣瘤”致病基因的克隆；2005年發現了一個新的近端三體12p綜合徵並闡明染色體畸變的來源和發生機制；2006年參加完成國際合作研究項目“人類耳垢性狀基因的克隆”，論文在Nature Genetics上發表；2007年1月“人源基因載體在血友病A基因治療的套用研究”取得重要進展；2007年4月在國際上率先定位“人類4型並指/趾”致病位點。
主要科研項目
· 遺傳病的基因治療
· 中國人類染色體異常核型遺傳資源的收集、保藏和利用
· 中國人類遺傳疾病資源信息整理整合共享平台，教育部重大項目資助計畫
· 染色體畸變發生機制及其遺傳學效應，國家科技攻關計畫
· 遺傳病家系和腫瘤樣本資源的收集及其資料庫建設，國家高技術發展計畫
· 遺傳病家系收集、基因定位、基因克隆、基因功能研究和基因治療，“長江學者”科學創新團隊計畫，· 人類染色體異常核型資源的收集、保藏與利用，中南大學科學研究基金項目主要成果/獎勵
· 世界首報中國人染色體異常核型遺傳資源保藏及其B/S共享模式，2005年，中華人民共和國科學技術進步獎二等獎
· 脆性X綜合徵的遺傳學研究，2003年，廣東省科學技術進步獎三等獎
· 顯微切割、探針池和FISH技術對染色體異常來源的研究，1996年，廣東省科學技術進步獎三等獎
· 4500名兒童青少年動脈粥樣硬化危險因子調查研究，1995年，廣東省科學技術進步獎三等獎
· 中國南方人A型行為類型常模調查研究，1994年，全國愛衛會、衛生部科學技術進步獎三等獎
主要論文
Peer review publications (since 2004):
1. Sato D*, liang D*, Wu L, Pan Q, Xia K, Dai H, Wang H, Nishimura G, Yoshiura KI, Xia J, Niikawa N. A syndactyly type IV locus maps to 7q36. J Hum Genet. 2007 May 3; [Epub ahead of print] (*co-author)
2. Hu H, Wu L, Feng Y, Pan Q, Long Z, Li J, Dai H, Xia K, Liang D , Niikawa N, Xia J. Molecular analysis of hearing loss associated with enlarged vestibular aqueduct in the mainland Chinese: a unique SLC26A4 mutation spectrum. J Hum Genet. 2007 Apr 19; [Epub ahead of print] (correspondent)
3. Liang Z, Luo H, Yang YF, Liu XH, Xie L, Xue ZG, Hu DX, Liang DS, Xia K, Xia JH. Targeted expression of vascular endothelial growth factor 165 in the hrDNA locus mediated by hrDNA targeting vector. Chin Med J (Engl). 2007 Mar 5; 120(5): 355-358.
4. Liu X, Liu M, Xue Z, Pan Q, Wu L, Long Z, Xia K, Liang D , Xia J. Non-viral ex vivo transduction of human hepatocyte cells to express factor VIII using a human ribosomal DNA-targeting vector. J Thromb Haemost. 2007 Feb;5(2):347-51. (correspondent)
5. Wang Lina, Xue Zhigang, Li Zhuo, Xue Jinfeng, Liu Xionghao, Pan Qian, Long Zhigao, Cai Fang, Wu Lingqian, Dai heping, Xia Kun, Liang Desheng and Xia Jiahui. Investigation of hrDNA targeting vector-mediated tumor-specific suicide gene therapy for hepatocellular carcinoma. Chinese Science Bulletin 2006 Oct 5; 51(19): 2342-2350.
6. Zhu HY, Wu LQ, Pan Q, Liang DS, Long ZG, Dai HP, Xia K, Xia JH. Analysis of PAX6 gene in a Chinese aniridia family. Chin Med J (Engl). 2006 Aug 20; 119(16): 1400-2.
7. Zhu HY, Wu LQ, Pan Q, Tang BS, Liang DS, Long ZG, Dai HP, Xia K, Xia JH. Rapid genetic diagnosis and prenatal diagnosis of spinal muscular atrophy by denaturing high-performance liquid chromatography. Chin Med J (Engl). 2006 Jul 20; 119(14): 1222-5.
8. Xie ZG, Hu ZM, Pan Q, Zhang RF, Liang DS , Wu LQ, Long ZG, Dai HP, Xia K, Xia JH. A mutation 1633-26(C-->A) in EXT1 gene causes multiple exostoses. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006 Apr;23(2):147-50. Chinese. (correspondent)
9. Yoshiura K, Kinoshita A, Ishida T, Ninokata A, Ishikawa T, kaname T, Bannai M, Tokunaga K, Sonoda S, Komaki R, Ihara M, Saenko VA, Alipov GK, Sekine I, Komatsu K, Takahashi H, Nakashima M, Sosonkina N, Mapendano CK, Ghadami M, Nomura M, Liang DS, Miwa N, Kim DK, Garidkhuu A, Natsume N, Ohta T, Tomita H, Kaneko A, Kikuchi M, Russomando G, Hirayama K, Ishibashi M, Takahashi A, Saitou N, Murray JC, Saito S, Nakamura Y, Niikawa N. A SNP in the ABCC11 gene is the determinant of human earwax type. Nat Genet. 2006 Mar;38(3):324-30. Epub 2006 Jan 29.
10. Liang D, Wu L, Pan Q, Harada N, Long Z, Xia K, Yoshiura K, Dai H, Niikawa N, Cai F, Xia J. A father and son with mental retardation, a characteristic face, inv(12), and insertion trisomy 12p12.3-p11.2. Am J Med Genet A. 2006 Feb 1; 140 (3):238-44.
11. XUE Zhigang*, LIANG Desheng*, LONG Zhigao, PAN Qian, LIU Xionghao, WU Lingqian, CAI Fang, DAI Heping, XIA Kun & XIA Jiahui. Silica nanoparticle is a possible safe carrier for gene therapy. Chinese Science Bulletin. 2005, 50 (1): 1-5. (*co-author)
12. Hu H, Wu LQ, Liang DS, Feng Y, Cai F, Xia K, Pan Q, Long ZG, Dai HP, Xia JH. Prenatal diagnosis of prelingual deafness by determination of SLC26A4 gene mutation. Zhonghua Fu Chan Ke Za Zhi. 2005 Sep;40(9):591-4.
13. Liang Y, Liang D, Xue Z, Long Z, Wu L, Pan Q, Hu Y, Dai H, Xia K, Xia J. A minidystrophin-EGFP fusion gene expressed in Cos-7 cells mediated by human source vector. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005 Oct 10;22(5):493-496.
14. Liu XH, Liu MJ, She H, Wen L, Xue ZG, Liang DS, Cai F, Pan Q, Long ZG, Wu LQ, Dai HP, Xia K, Xia JH. Targeted Expression of the Modified FVIII Using Targeting Vector of Human Ribosomal RNA Gene. Chinese Science Bulletin. 2005, 50(18):1972-1977.
15. He LQ, Liu Y, Cai F, Tan ZP, Pan Q, Liang DS, Long ZG, Wu LQ, Huang LQ, Dai HP, Xia K, Xia JH, Zhang ZH. Intracellular distribution, assembly and effect of disease-associated connexin 31 mutants in HeLa cells. Acta Biochim Biophys Sin (Shanghai). 2005 Aug;37(8):547-54.
16. Hu H, Liang D , Wu L, Feng Y, Cai F, Xia K, Pan Q, Long Z, Dai H, Xia J. Molecular analysis of SLC26A4 gene in a Chinese deafness family. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005 Aug;22(4):376-9. Chinese. (correspondent)
17. Zhang R, Zhu Z, Zhu H, Nguyen T, Yao F, Xia K, Liang D, Liu C. SNP Cutter: a comprehensive tool for SNP PCR-RFLP assay design. Nucleic Acids Res. 2005 Jul 1;33 (Web Server issue):W489-92.
18. He LQ, Cai F, Liu Y, Liu MJ, Tan ZP, Pan Q, Fang FY, Liang de S, Wu LQ, Long ZG, Dai HP, Xia K, Xia JH, Zhang ZH. Cx31 is assembled and trafficked to cell surface by ER-Golgi pathway and degraded by proteasomal or lysosomal pathways. Cell Res. 2005 Jun; 15(6): 455-64.
19. Deng XY, Cai F, Xia K, Pan Q, Long ZG, Wu LQ, Liang DS, et al. Identification of the Alternative Promoters of the KChIP4 Subfamily. Acta Biochim Biophys Sin (Shanghai). 2005 Apr;37(4):241-7.
20. Lyu QF, Wu LQ, Li YP, Pan Q, Liu DE, Xia K, Liang DS, Cai F, Long ZG, Dai HP, Xia JH. An improved mechanical technique for assisted hatching. Hum Reprod. 2005 Jun; 20(6):1619-23.
21. De-sheng Liang, et al. Phenotype Location on Chromosomes in a Patient With the Syndrome of Partial Trisomy 7p21.2→pter. Acta Genetica Sinica. 2005 Feb; 32(2):124-9.
22. Kun Xia, Desheng Liang, et al. A Novel Fusion Suicide Gene Yeast CDglyTK plays a Role in Radio-genetherapy of Nasopharyngeal Carcinoma. Cancer Gene Therapy. 2004 Dec;11(12):790-6.
23. Xia K, Wu LQ,Xi XH,Liu XP,Liang DS, Zheng D, Cai F, Pan Q, Long ZG, Dai HP,Hu ZM, Tang BS,Zang ZH, Xia JH. Mutation in PITX2 is associated with Ring Dermoid of the cornea. Journal of Medical Genetics. 2004 Dec;41(12):e129.
24. Baorong Zhang, Kun Xia, Meiping Ding, Desheng Liang, et al. Confirmation and refinement of a genetic locus of congenital motor nystagmus in Xq26.3-q27. 1 in a Chinese family. Human Genetics. 2005 Jan;116(1-2):128-31.
25. Jiahui Xia, Kun Xia, Yong Feng,Aifa Tang, Yaoyun Tang, Linqiang Wu, Desheng Liang, Fang Cai,Qian Pan, Zhigao Long, Heping Dai, Yunyi Zhang, Suping Zhao, Zhuchu Chen.Combination of Suicide gene therapy and radiation enhances the killing of nasopharyngeal carcinoma xenographs. Journal of Radiation Research. 2004,45(2): 281-289.
26. De-sheng Liang, et al. Analysis of chromosomes and its phenotype location on a patient with the karyotype of 45,XX,-13/46,XX,r(13)/46,XX,r(13;13)/47,XX,2r(13)(p13q32.3). Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004 Aug; Vol21,No.4:392-394
著作:
 《醫學遺傳學》
