![李曉萌[博士生導師]](/img/4/a5c/nBnauM3XyEDM5ADMwIDO3AjMzUTM4kDM0IDMxADMwAzMwIzLygzLyIzLt92YucmbvRWdo5Cd0FmLzE2LvoDc0RHa.jpg "李曉萌[博士生導師]")
個人履歷
2011年12月東北師範大學生命科學學院教授
2008年9月東北師範大學生命科學學院博士生導師
2006年1月-2008年9月東北師範大學生命科學學院副教授
2003年1月-2005年12月美國史丹福大學醫學院遺傳學泌尿外科學博士後
2001年6月-2002年6月日本東北大學醫學部JICA研究員
2001年9月-2003年1月吉林大學基礎醫學院病理生理學教研室講師
1999年7月-2001年9月白求恩醫科大學基礎醫學院助教
1999年9月-2002年7月博士，吉林大學病理學與病理生理學
1996年9月-1999年7月碩士，白求恩醫科大學病理學與病理生理學
1990年9月-1996年7月學士，白求恩醫科大學日語醫學系
科研方向
（1）腫瘤信號轉導
（2）甾體類激素受體轉錄調控與腫瘤發生
（3）轉錄因子的SUMO化修飾與腫瘤發生
（4）阿爾茲海默症藥物研發
科研成果
論文
(1)XiaowanWang,RunminSong,WenliangLu,ZiyuLiu,LichunWang,XiaojuanZhu,YanjunLiu,ZijieSun,JiangLi*,XiaomengLi*.YXQNReducesAlzheimer'sDisease-LikePathologyandCognitiveDeclineinAPPswePS1dE9TransgenicMice.FrontAgingNeurosci.9:157:1-15.,2017
(2)HuiQin,AzharRasual,XinLi,MuqaddasMasood,GuangYang,NaWang,WeiWei,XiHe,NobumotoWatanabe,JiangLi*,XiaomengLi*.CD147-inducedcellproliferationisassociatedwithSmad4signalinhibition.ExpCellRes.358(2):279-289.2017
(3)ChunwaJiang,MuqaddasMasood,AzharRasul,WeiWei,YaWang,MuhammadAli,MuhammadMustaqeem,JiangLi*,XiaomengLi*.AltholactoneInhibitsNF-κBandSTAT3ActivationandInducesReactiveOxygenSpecies-MediatedApoptosisinProstateCancerDU145Cells.Molecules.22(2):1-13.,2017
(4)ChunwaJiang,JuanjingWang,ChenDong,WeiWei,JiangLi*,XiaomengLi*.Membranoustypematrixmetalloproteinase16induceshumanprostatecancermetastasis.OncolLett.14(3):3096-3102.,2017
(5)MoussaIdeNasser,MuqaddasMasood,WeiWei,XiaochunLi,YifaZhou,BaoLiu,JiangLi*,XiaomengLi*.CordycepininducesapoptosisinSGC 7901cellsthroughmitochondrialextrinsicphosphorylationofPI3K/AktbygeneratingROS.IntJOncol.50(3):911-919.,2017
(6)FayaM.Millimouno,JiaDong,LiuYang,JiangLi*,XiaomengLi*.TargetingapoptosispathwaysincancerandperspectiveswithnaturalcompoundsfromMotherNature.CancerPrevRes.7(11):1081-1107.,2014
(7)NYang,BZhao,ARasul,HQin,JLi*,XLi*.PIAS1-modulatedSmad2/4complexactivationisinvolvedinzinc-inducedcancercellapoptosis.CellDeathDis.4:e811:1-16.,2013
(8)BingZhao,XiaomengLi*.Altholactoneinducesreactiveoxygenspecies-mediatedapoptosisinbladdercancerT24cellsthroughmitochondrialdysfunction,MAPK-p38activationandAktsuppression.OncolRep.31(6):2769-2775.,2014
(9)LiuHe,TingtingWang,JipingA,XiaomengLi*,LingyuZhang,LuLi,GuangzheLi,XiaotongWu,ZhongminSu*,ChungangWan*.Carbonnanodots@zeoliticimidazolateframework-8nanoparticlesforsimultaneouspH-responsivedrugdeliveryandfluorescenceimaging.CrystEngComm.16:3259-3263.,2014
(10)AzharRasul,Bin-JiZhao,JunLiu,BaoLiu,Jia-XinSun,JiangLi*,Xiao-MengLi*.MolecularMechanismsofCasticinAction:anUpdateonitsAntitumorFunctions.AsianPacJCancerPrev.15(21):9049-9058.,2014
(11)AzharRasul,JunD,FayaMartinMillimouno,MahadevMalhi,IchiroTsuji,MuhammadAli,JiangLi*,XiaomengLi*.ReactiveoxygenspeciesmediateIsoalantolactone-inducedapoptosisinhumanprostatecancercells.Molecules.18:9382-9396.,2013
(12)AzharRasul,RuiBao,MahadevMalhi,BingZhao,IchiroTsuji,JiangLi*,XiaomengLi*.InductionofapoptosisbyCostunolideinbladdercancercellsismediatedthroughROSgenerationandmitochondrialdysfunction.Molecules.18:1418-1433.,2013
(13)WUJing,LIUShu,SHENXiao-yan,YANGNan-yang,LIUYing,TSUJIIchiro,YAMAMURATakaki,LIJiang*,LIXiao-meng*.PhytoestrogensInhibitingAndrogenReceptorSignalandProstateCancerCellProliferation.ChemResChinUni.29(5):911-916.,2013
(14)WUJing,WEIWei,YANGNan-yang,SHENXiao-yan,TSUJIIchiro,YAMAMURATakaki,LIJiang*,LIXiao-meng*.Xeno-oestrogensBisphenolAandDiethylstilbestrolSelectivelyActivatingAndrogenReceptorMediatedAREs-TATAReporterSystem.ChemResChinUni.29(3):512-518.,2013
(15)ZhenyuChen,AzharRasul,ChaoyueZhao,FayaMartinMillimouno,IchiroTsuji,TakakiYamamura,RehanaIqbal,MahadevMalhi,JiangLi*,XiaomengLi*.DracorhodinperchlorateinducesapoptosisinbladdercancercellsthroughBcl-2,Bcl-XL,survivindown-regulationandcaspase-3activation.BJPharmacol.8:276-282.,2013
(16)WeiWei,JunDi,AzharRasul,ChaoyueZhao,FayaMartinMillimouno,IchiroTsuji,FurhanIqal,MahadevMalhi,XiaomengLi*,JiangLi*.Antipro-liferativeandapoptoticeffectsofpinocembrininhumanprostatecancercells.BJPharmacol.8:255-262.,2013
(17)AzharRasul,JinmeiLiu,YingLiu,FayaMartinMillimouno,XiaowanWang,IchiroTsuji,TakakiYamamura,JiangLi*,XiaomengLi*.EriocalyxinBinhibitsproliferationandinducesapoptosisthroughdownregulationofBcl-2andactivationofcaspase-3inhumanbladdercancercells.BJPharmacol.8:116-123.,2013
(18)AzharRasul,MuhammadKhan,MuhammadAli,JiangLi*,XiaomengLi*.TargetingApoptosisPathwaysinCancerwithAlantolactoneandIsoalantolactone.ScientifiWorldJ,248532:1-9.,2013
(19)AzharRasul,FayaMartinMillimouno,WafaAliEltayb,MuhammadAli,JiangLi*,XiaomengLi*.Pinocembrin:anovelnaturalcompoundwithversatilepharmacologicalandbiologicalactivities.BioMedResearchInternational.2013:379850:1-9.,2013
(20)HaoWang,JiangLi*,YangGao,YingXu,YingPan,IchiroTsuji,Zi-JieSun,XiaomengLi*.Xeno-oestrogensandphyto-oestrogensarealternativeligandsfortheandrogenreceptor.AsianJAndrol.12(4):535-547.,2013
(21)AzharRasul,ChuanDing,XiaomengLi,MuhammadKhan,FeiYi,MuhammadAli,TonghuiMa*.DracorhodinperchlorateinhibitsPI3K/AktandNF-κBactivation,up-regulatestheexpressionofp53,andenhances apoptosis.Apoptosis.17(10):1104-19.,2012
(22)XiaomengLi*,ChunfangZhu,WilliamH.Tu,NanyangYang,HuiQin,ZijieSun*.ZMIZ1preferablyenhancesthetranscriptionalactivityofandrogenreceptorwithshortpolyglutaminetract.PLoSOne,6(9):e25040.1-12.,2011
(23)ZHANGAi-li,LIJiang,WANGYan-qing,ZAKNROUZohra,MATong-hui,LIXiao-meng*.Aquaporin1FacilitatedHepatocellularCarcinomaSMMC7221CellMigrationAssociatedwithWaterPermeability.ChemResChinUni.27(1):99-103.,2011
(24)TingtingWang,XuliZhang,YingPan,XiuminMiao,ZhongminSu,ChungangWang*,XiaomengLi*.Fabricationofdoxorubicinfunctionalizedgoldnanorodprobesforcombinedcancerimaginganddrugdelivery.DaltonTrans,40(38):9789-9794.,2011
(25)LIJiang,ZHANGAi-li,TONGQian,ZHANGJun-fang,LIHai-jing,ZHAOBing,MATong-hui,LIXiao-meng1*.ExpressionandEmmprinRegulatedFunctionofAquaporin1inSMMC7221Cells.ChemResChinUni.26(4):578-582.,2010
(26)LIJiang*,YANGNan-yang,GUANXin-gang,ZHANGShu-zhi,ZHANGYan,QINMei-ling,MATong-hui,LIXiao-meng*.GSTFusionProteinBasedSpecificPolyclonalAntibodyPreparationofMouseAquaporin1.ChemResChinUni.25(4):500-505.,2009
(27)Xiao-MengLi*,JiangLi,IchiroTsuji,NaokiNakaya,YoshikazuNishino,Xue-JianZhao*.Massscreening-basedcase-controlstudyofdietandprostatecancerinChangchun,China.AsianJAndrol.10(4):551-60.,2008
(28)XiaomengLi,GregoryThyssen,JasonBeliakoffandZijieSun*.ThenovelPIAS-likeproteinHZIMP10enhancesSmadtranscriptionalactivity.JBiolChem,281(33):23748-23756.,2006
(29)Xiao-MengLi,LingZhang,JiangLi,YangLi,Hong-LiangWang,Guo-YiJi,MasaakiKuwaharaandXue-JianZhao*.MeasurementofserumzincimprovesprostatecancerdetectionefficiencyinpatientswithPSAlevelsbetween4ng/mLand10ng/mL.AsianJAndrol.7(3):323-328.,2005
(30)Chun-YinHuang,JasonBeliakoff,XiaoyuLi,JaneLee,XiaomengLi,ManjuSharma,BingLim,ZijieSun*.hZimp7,anovelPIAS-likeprotein,enhancesandrogenreceptor-mediatedtranscriptionandinteractswithSWI/SNF-likeBAFcomplexes.MolEndocrinol.19(12):2915-2929.,2005
(31)XiaomengLi*,ItiroTsuji,MasaakiKuwahara,HaifengZhang,HongliangWang,LingZhang,GuoyiJi,XuejianZhao.MassscreeningofprostatecancerinChangchunCityofChina.IntUrolNephrol.36(4):541-548.,2004
(32)MeletiosVerras,JeffreyBrown,XiaomengLi,RoelNusseandZijieSun*.Wnt3agrowthfactorinducesandrogenreceptor-mediatedtranscriptionandenhancescellgrowthinhumanprostatecancercells.CancerRes.64(24):8860-8866.,2004
(33)MasaakiKuwahara*,TatsuoTochigi,SadafumiKawamura,YukihikoOgata,NingXu,HongliangWang,HaifengZhang,ShengwenLi,XiaomengLi,XuejianZhao.Massscreeningforprostatecancer:acomparativestudyinNatori,JapanandChangchun,China.Urology.61(1):137-141.,2003
論著
參編國際專著：“SoybeanandProstateCancer”inSoybean-Bio-ActiveCompounds,ISBN978-953-51-0977-8,Croatia，2013
參編教材：細胞生物學簡明教程，高等教育出版社，2010年4月
學術獎勵
2012年吉林省科學技術進步獎二等獎：hZimp10在前列腺癌相關信號通路中的作用機制研究
2011年吉林省科技進步二等獎：前列腺癌篩查中日比較及相關研究
2009年吉林省科技進步三等獎：恢復前列腺癌TGFβ-Smad信號通路的新型分子靶向研究
代表科研項目
國家重點研發計畫（政府間國際科技創新合作專項）：
SUMO化修飾與前列腺癌關係的機制研究（2016YFE0128500）（2017-2019），項目負責人。
科技部國際合作項目：
環境雌激素與前列腺癌的關係及植物雌激素的抑癌機制研究（2010DFA31430）（2010-2013），項目負責人。
