人物介紹
李志剛畢業於內蒙古醫學院;在日本京都大學腫瘤外科碩博連讀;在美國休斯敦貝勒醫學院讀博士後;美國休斯敦安德森癌症中心學習。在內蒙古第二醫院工作十年,擔任美國休斯敦安德森癌症中心講師、天津醫科大學總醫院腫瘤外科教授、博士生導師,天津市肺癌研究所肺癌轉移實驗室負責人(PI),天津市中西醫結合醫院南開醫院腫瘤中心主任。2015年至今任海南省腫瘤醫院國際醫學部主任、中西醫結合科主任、氬氦刀治療中心主任。
李志剛擁有十餘年的國外留學背景及二十餘年的國際臨床經歷,擅長使用國際先進的腫瘤微創治療技術,例如各種腔鏡(胸腔鏡、腹腔鏡、氣管鏡、胃鏡和腸鏡等),例如各種腫瘤消融技術(氫氦刀冷凍消融、射頻消融、微波消融、光動力消融和放射性粒子植入技術)和腫瘤血管介入技術。治療患者超過七千餘例。
李志剛在國外流行的“五師查房”模式基礎上加以改善,形成一套具有中國特色的“五師查房”,即西醫臨床醫師、中醫師、營養師、疼痛醫師和心理醫師,五類專科醫生常規在患者床旁共同診治,體現了腫瘤綜合治療的科學性、精準性、時效性、連續性和有效性。
個人榮譽
1、2005年10月獲得美國國防部醫學研究基金
2、DepartmentofDefense(DOD)FiscalYear2005(FY05)
3、ProstateCancerResearchProgram(PCRP).
4、FundingNumber:PC05-POSTDOC(PC050182)
學術研究
主持或參與的研究課題
1、主持國家自然科學基金(NSFC)面上項目。項目名稱:雄性激素水平低下誘發前列腺癌的分子機制2、指導國家自然科學基金青年課題
項目名稱:DNA甲基化、組蛋白修飾調控非小細胞肺癌lncRNAMALAT1表達的分子機制研究
3、主持國家中醫藥管理局全國名老中醫藥專家傳承工作室建設項目
項目名稱:中藥核桃青皮活性因子抗食管癌分子機制研究
已發表的醫學論文
1、Ze-HanLiu,QiZhang,Yi-JieDing,Ying-HuiRen,Hui-PengYang,QingXi,Ying-NanCheng,Guo-LinMiao,Hong-KunLiu,Cai-XiaLi,Wen-QiangYan,YanLi,ZhenyiXue,Li-juanZhang,Xin-YeLi,Chen-LongZhao,YurongDa,Xian-ZhongWu,Jun-QiangChen,RongxinZhang,Zhi-GangLi(李志剛,通訊),OverexpressionofCHD1LisAssociatedwithPoorSurvivalandAggressiveTumorBiologyinEsophagealCarcinoma.Oncotarget.2017Jun29,Doi:10.18632/Oncotarget18830(IF:5.168).
2、GuoF,JiaoF,SongZ,LiS,LiuB,YangH,ZhouQ,LiZ(李志剛,通訊)RegulationofMALAT1expressionbyTDP43controlsthemigrationandinvasionofnon-smallcelllungcancercellsinvitro.BiochemBiophysResCommun,2015,465(2):293-298.(IF:2.371;Cited:3)
3、GuoF,GuoL,LiY,ZhouQ,LiZ(李志剛,通訊),MALAT1isanoncogeniclongnon-codingRNAassociatedwithtumorinvasioninnon-smallcelllungcancerregulatedbyDNAmethylation.IntJClinExpPathol,2015,8(12):15903-15910.(IF:1.581;Cited:2)
4、YanS,TianS,KangQ,XiaY,LiC,ChenQ,ZhangS,LiZ(李志剛,通訊),RhizomaParidisSaponinsSuppressesTumorGrowthinaRatModelofN-Nitrosomethylbenzylamine-InducedEsophagealCancerbyInhibitingCyclooxygenases-2Pathway.PLoSOne.2015Jul6;10(7):(IF:3.75,cited:0)
5、WangDB1,LuXK,ZhangX,LiZG(李志剛),LiCX.Carbonicanhydrase1isapromisingbiomarkerforearlydetectionofnon-smallcelllungcancer.TumourBiol.2015Aug1.(IF:3.6,cited:2)
6、LiS,LiZ(李志剛,並列),GuoF,QinX,LiuB,LeiZ,SongZ,SunL,ZhangHT,YouJ,ZhouQ.miR-223regulatesmigrationandinvasionbytargetingArtemininhumanesophagealcarcinoma.JBiomedSci.2011Mar31;18:24(IF:2.4,cited:77)
7、WanX,LiZG(李志剛),YinglingJM,YangJ,StarbuckMW,RavooriMK,KundraV,VazquezE,NavoneNM.Effectoftransforminggrowthfactorbeta(TGF-β)receptorIkinaseinhibitoronprostatecancerbonegrowth.Bone.2012Mar;50(3):695-703.(IF:4.09,cited:29)
8、MohamedaliKA,LiZG(李志剛),StarbuckMW,WanX,YangJ,KimS,ZhangW,RosenblumMG,NavoneNM.InhibitionofprostatecancerosteoblasticprogressionwithVEGF121/rGel,asingleagenttargetingosteoblasts,osteoclasts,andtumorneovasculature.ClinCancerRes.2011Apr15;17(8):2328-38.Epub2011Feb22.(IF:6.5,cited:22)
9、LiZG(李志剛),MathewP,YangJ,StarbuckMW,ZuritaAJ,LiuJ,SikesC,MultaniAS,EfstathiouE,LopezA,WangJ,FanningTV,PrietoVG,KundraV,VazquezES,TroncosoP,RaymondAK,LogothetisCJ,LinSH,MaityS,NavoneNM.Androgenreceptor-negativehumanprostatecancercellsinduceosteogenesisinmicethroughFGF9-mediatedmechanisms.JClinInvest.2008Aug;118(8):2697-710.(IF:16.915,cited:104)
10、LiZG(李志剛),JYang,ESVazquez,DRose,FVakar-Lopez,PMathew,ALopez,CJLogothetis,S-HLinandNMNavone.Low-densitylipoproteinreceptor-relatedprotein5(LRP5)mediatestheprostatecancer-inducedformationofnewbone.Oncogene.2008Jan24;27(5):596-60(IF:6.872,cited:53).
11、LiZG(李志剛),HeidiYShiandMingZhang.Targetedexpressionofmaspinintumorvasculaturesinducesendothelialcellapoptosis.Oncogene.2005Mar17;24(12):2008-19(IF:6.872,cited:132)
12、LiZG(李志剛),HongT,ShimadaY,KomotoI,KawabeA,DingY,KaganoiJ,HashimotoY,ImamuraM.SuppressionofN-nitrosomethylbenzylamine(NMBA)-inducedesophagealtumorigenesisinF344ratsbyresveratrol.Carcinogenesis.2002Sep;23(9):1531-6(IF:5.406,cited:260).
13、LiZG(李志剛),ShimadaY,KawabeA,SatoF,MaedaM,KomotoI,HongT,DingY,KaganoiJ,ImamuraM.SuppressionofN-nitrosomethylbenzylamine(NMBA)-inducedesophagealtumorigenesisinF344ratsbyJTE-522,aselectiveCOX-2inhibitor.Carcinogenesis.2001Apr;22(4):547-51.(IF:5.406,cited:238).
14、LiZG(李志剛),SchemC,ShiYH,MedinaD,ZhangM.IncreasedCOX2expressionenhancestumor-inducedosteoclasticlesionsinbreastcancerbonemetastasis.ClinExpMetastasis.2008;25(4):389-400.(IF:2.514,cited:114).
15、LiZG(李志剛),ShimadaY,UchidaS,MaedaM,KawabeA,MoriA,ItamiA,KanoM,WatanabeG,ImamuraM.TGF-alphaaswellasVEGF,PD-ECGFandbFGFcontributetoangiogenesisofesophagealsquamouscellcarcinoma.IntJOncol.2000Sep;17(3):453-60.(IF:2.931,cited:92).
16、LiZG(李志剛),ShimadaY,SatoF,MaedaM,ItamiA,KaganoiJ,KomotoI,KawabeA,ImamuraM.Inhibitoryeffectsofepigallocatechin-3-gallateonN-nitrosomethylbenzylamine-inducedesophagealtumorigenesisinF344rats.IntJOncol.2002Dec;21(6):1275-83(IF:2.931,cited:79).
17、LiZG(李志剛),ShimadaY,SatoF,MaedaM,ItamiA,KaganoiJ,KomotoI,KawabeA,ImamuraM.PromotioneffectsofhotwateronN-nitrosomethylbenzylamine-inducedesophagealtumorigenesisinF344rats.OncolRep.2003Mar-Apr;10(2):421-6(IF:1.597,cited:88).
18、LiZG(李志剛),ShimadaY,SatoF,MaedaM,ItamiA,KaganoiJ,KomotoI,KawabeA,ImamuraM.PromotioneffectsofhotwateronN-nitrosomethylbenzylamine-inducedesophagealtumorigenesisinF344rats.OncolRep.2003Mar-Apr;10(2):421-6(IF:1.597).
19、NagataniS,ShimadaY,LiZG(李志剛),KaganoiJ,KanT,MaedaM,WatanabeG,ImamuraM.Validationofintra-operativedetectionofparatracheallymphnodemetastasisusingreal-timeRT-PCRtargetingesophagealsquamouscellcarcinoma.JpnJClinOncol.2003Nov;33(11):549-55.(IF:0.967).
20、ShimadaY,SatoF,MaedaM,WatanabeG,NagataniS,KaganoiJ,HashimotoY,KanT,LiZG(李志剛),ImamuraM.Validityofintraoperativepathologicaldiagnosisofparatracheallymphnodeasastrategyforselectionofpatientsforcervicallymphnodedissectionduringesophagectomy.DisEsophagus.2003;16(3):246-51.(IF:0.797).
21、DingY,ShimadaY,Gorrin-RivasMJ,ItamiA,LiZG(李志剛),HongT,MaedaM,KomotoI,KawabeA,KaganoiJ,ImamuraM.Clinicopathologicalsignificanceofhumanmacrophagemetalloelastaseexpressioninesophagealsquamouscellcarcinoma.Oncology.2002;63(4):378-84(IF:2.114).
22、ShimadaY,ImamuraM,SatoF,MaedaM,KaganoiJ,HashimotoY,KanT,NagataniS,LiZG(李志剛).Indicationsforabdominalpara-aorticlymphnodedissectioninpatientswithesophagealsquamouscellcarcinoma.Surgery.2002Jul;132(1):93-9.(IF:2.355).
23、SatoF,ShimadaY,LiZG(李志剛),KanoM,WatanabeG,MaedaM,KawabeA,KaganoiJ,ItamiA,NagataniS,ImamuraM.Paratracheallymphnodemetastasisisassociatedwithcervicallymphnodemetastasisinpatientswiththoracicesophagealsquamouscellcarcinoma.AnnSurgOncol.2002,Jan-Feb;9(1):65-70.(IF:4.035).
24、HongT,ShimadaY,UchidaS,ItamiA,LiZG(李志剛),DingY,KaganoiJ,KomotoI,SakuraiT,ImamuraM.Expressionofangiogenicfactorsandapoptoticfactorsinleiomyosarcomaandleiomyoma.IntJMolMed.2001Aug;8(2):141-8.(IF:3.190).
25、SatoF,ShimadaY,LiZG(李志剛),WatanabeG,MaedaM,ImamuraM.Lymphnodemicrometastasisandprognosisinpatientswithoesophagealsquamouscellcarcinoma.BrJSurg.2001Mar;88(3):426-32.(IF3.580).
26、DingY,ShimadaY,KanoM,ItamiA,KawabeA,MaedaM,LiZG(李志剛),HongT,SatoF,KaganoiJ,ImamuraM.PTEN/MMAC1expressioninesophagealsquamouscellcarcinomas.IntJOncol.2000,Oct;17(4):695-9.(IF:2.295).
27、KanoM,ShimadaY,KaganoiJ,SakuraiT,LiZG(李志剛),SatoF,WatanabeG,ImamuraM.DetectionoflymphnodemetastasisofoesophagealcancerbyRT-nestedPCRforSCCantigengenemRNA,BrJCancer.2000Jan;82(2):429-35.(IF:3.580).
28、UchidaS,ShimadaY,WatanabeG,LiZG(李志剛),HongT,MiyakeM,ImamuraM.Motility-relatedprotein(MRP-1/CD9)andKAI1/CD82expressioninverselycorrelatewithlymphnodemetastasisinoesophagealsquamouscellcarcinoma,BrJCancer.1999Mar;79(7-8):1168-73.(IF:3.742)