講授主要課程:
主要承擔研究生《食品安全科學》、《食品安全新型檢測技術》、《食品加工與安全領域專題討論》、《食品安全檢測新技術進展》、《食品質量安全與管理》及本科生《食品安全科學》、《食品安全科學概論》等課程的教學工作。
科研方向:
1.食品中有毒有害殘留物高靈敏快速檢測技術研究(色譜、毛細管電泳、化學發光);
2.化學及仿生感測器分析方法研究;
3.仿生免疫分析方法與理論研究;
4.食品加工過程中有毒有害物質的產生機理、安全控制理論與技術研究;
5.分子印跡仿生吸附在食品活性成分提取、分離中的套用研究。
主持的國家及省部級項目
(1)2014年國家自然科學基金面上項目:基於量子點標記有機磷農藥多殘留仿生免疫分析研究,編號:31471649,2015.1-2018.12,主持;
(2)2011年國家自然科學基金面上項目:農藥多殘留仿生吸附檢測方法及機理研究,編號:31171699,2012.1-2015.12,主持;
(3)2010年國家自然科學基金面上項目:親水性分子印跡膜仿生免疫吸附檢測食品中痕量丙烯醯胺,編號:31071543,2011.1-2013.12,主持;
(4)2013年國家農業科技成果轉化項目:有機磷農藥新型檢測技術套用與示範,編號:2013GB2C60027,2013.9-2015.8,主持。
(5)2014年山東省科技計畫項目:食品高溫加工過程中丙烯醯胺最佳化控制關鍵技術研究,編號:2014GSF120010,2014.07-2017.06,主持;
(6)2010年國家博士後特別資助項目:親水性印跡膜仿生免疫吸附檢測食品中痕量喹乙醇,編號:201003645,2010.12-2013.12,主持;
(7)2009年山東省科技攻關:基於分子識別的農產品中有機磷農藥痕量殘留檢測技術研究,編號:2009GG10009058,2009.7-2012.7,主持。
論文成果
(1) Zhixiang Xu, Guozhen Fang, Shuo Wang*. Molecularly imprinted solid phase extraction coupled to high-performance liquid chromatography for determination of trace dichlorvos residues in vegetables. Food Chemistry, 2010, 119: 845-850. (IF 4.052)
(2)Jie Li, Juxiu Lu#, Xuguang Qiao*, Zhixiang Xu*. A study on biomimetic immunoassay-capillary electrophoresis method based on molecularly imprinted polymer for determination of trace trichlorfon residue in vegetables. Food Chemistry, 2017, 221: 1285-1290. (IF 4.052)
(3)Qinghua Tang, Xiujuan Shi#, Xiaolin Hou, Jie Zhou and Zhixiang Xu*. Development of molecularly imprinted electrochemical sensors based on FeO@MWNTs-COOH/CS nanocomposite layers for detecting traces of acephate and trichlorfon. Analyst, 2014, 139: 6406-6413. (IF 4.033)
(4) Zhixiang Xu, Shuang Chen, Wei Huang, Guozhen Fang, Shuo wang*. Study on an on-line molecularly imprinted solid-phase extraction coupled with high-performance liquid chromatography for the determination of trace estrone in environment. Analytical and Bioanalytical Chemistry, 2008, 393: 1273-1279. (IF 3.125)
(5)Ling Meng, Xuguang Qiao, Jiaming Song, Zhixiang Xu*, Junhong Xin, Yue Zhang. Study of an online molecularly imprinted solid phase extraction coupled to chemiluminescence sensor for the determination of trichlorfon in vegetables. Journal of Agricultural and Food Chemistry, 2011, 59: 12745-12751. (IF 2.857)
(6)Xilong Wang, Xuguang Qiao, Yue Ma, Tao Zhao, Zhixiang Xu*. Simultaneous determination of nine trace organophosphorous pesticide residues in fruit samples using molecularly imprinted matrix solid-phase dispersion followed by gas chromatography. Journal of Agricultural and Food Chemistry, 2013, 61: 3821-3827. (IF 2.857)
(7) Zhixiang Xu, Jing Zhang, Li Cong, Ling Meng, Jiaming Song, Jie Zhou, Xuguang Qiao*. Preparation and characterization of magnetic chitosan microsphere sorbent for separation and determination of environmental estrogens through SPE coupled with HPLC. Journal of Separation Science, 2011, 34: 46-52. (IF 2.741)
(8)Junhong Xin, Xuguang Qiao, Yue Ma, Zhixiang Xu*. Simultaneous separation and determination of 8 organophosphorous pesticide residues in vegetables through molecularly imprinted solid-phase extraction coupled to gas chromatography. Journal of Separation Science, 2012, 35: 3501-3508. (IF 2.741)
(9)Qinghua Tang, Xilong Wang#, Fan Yu, Xuguang Qiao, Zhixiang Xu*. Simultaneous determination of ten organophosphate pesticide residues in fruits by gas chromatography coupled with magnetic separation. Journal of Separation Science, 2014, 37: 820-827. (IF 2.741)
(10)Ling Meng, Xuguang Qiao, Zhixiang Xu*, Junhong Xin and Lei Wang. Development of a direct competitive biomimetic enzyme-linked immunosorbent assay based on a hydrophilic molecularly imprinted membrane for the determination of trichlorfon residues in vegetables. Food Analytical Methods, 2012, 5: 1229-1236. (IF 2.167)
(11)Junhong Xin, Xuguang Qiao, Zhixiang Xu*, Jie Zhou. Molecularly imprinted polymer as sorbent for solid-phase extraction coupling to gas chromatography for the simultaneous determination of trichlorfon and monocrotophos residues in vegetables. Food Analytical Methods, 2013, 6: 274-281. (IF 2.167)
(12)Longhua Xu, Xuguang Qiao, Yue Ma, Xin Zhang, Zhixiang Xu*. Preparation of a hydrophilic molecularly imprinted polymer and its application in solid-phase extraction to determine of trace acrylamide in foods coupled with high-performance liquid chromatography. Food Analytical Methods, 2013, 6: 838-844. (IF 2.167)
(13)Hongyan Zhang, Yuwei Wei, Jianhua Zhou, Zhixiang Xu*, Shuo Tian, Hua Huang, Jinxing He. Preparation and application of a molecular imprinting matrix solid phase dispersion extraction for the determination of olaquindox in chicken by high performance liquid chromatography. Food Analytical Methods, 2013, 6: 915-921. (IF 2.167)
(14)Tao Zhao, Huiju Gao, Xilong Wang, Limin Zhang, Xuguang Qiao, Zhixiang Xu*. Study on a molecularly imprinted solid-phase extraction coupled to capillary electrophoresis method for the determination of trace trichlorfon in vegetables. Food Analytical Methods, 2014, 7: 1159-1165. (IF 2.167)
(15)Handong Zhao, Ningyang Li, Jinwang Li, Xuguang Qiao & Zhixiang Xu. Preparation and Application of Chitosan-Grafted Multiwalled Carbon Nanotubes in Matrix Solid-Phase Dispersion Extraction for Determination of Trace Acrylamide in Foods through High-Performance Liquid Chromatography. Food Analytical Methods, 2015, 8: 1363-1371. (IF 2.167)
(16)Qingqing Wang, Xin Zhang,# Zhixiang Xu, Huiju Gao*. Simultaneous determination of three trace organophosphorus pesticide residues in vegetables using molecularly imprinted solid-phase extraction coupled with high performance liquid chromatography. Food Analytical Methods, 2015, 8: 2044-2051. (IF 2.167)
(17)Chen Shi, Xueyan Liu, Lingyu Song, Xuguang Qiao, Zhixiang Xu*. Biomimetic enzyme-linked immunosorbent assay using a hydrophilic molecularly imprinted membrane for recognition and fast determination of trichlorfon and acephate residues in vegetables. Food Analytical Methods, 2015, 8: 2496-2503. (IF 2.167)
(18)Xiujuan Shi, Juxiu Lu, Hongzong Yin, Xuguang Qiao, Zhixiang Xu*. A biomimetic sensor with signal enhancement of ferriferrous oxide-reduced graphene oxide nanocomposites for ultratrace levels quantification of methamidophos or omethoate in vegetables. Food Analytical Methods, 2016. DOI 10.1007/s12161-016-0641-0. (IF 2.167)
(19)Deqing Li, Xin Zhang#, Feifan Kong, Xuguang Qiao*, Zhixiang Xu*. Molecularly imprinted solid-phase extraction coupled with high-performance liquid chromatography for the determination of trace trichlorfon and monocrotophos residues in fruits. Food Analytical Methods, 2016. DOI 10.1007/s12161-016-0687-z. (IF 2.167)
(20)Jiaming Song, Xuguang Qiao, Haihua Chen, Dongyan Zhao, Yue Zhang, Zhixiang Xu*. Molecularly imprinted solid-phase extraction combined with high performance liquid chromatography for analysis of trace olaquindox residues in chick feeds. Journal of the Science of Food and Agriculture, 2011, 91: 2378-2385. (IF 2.076) 他引5次
(21) Zhixiang Xu, Jiaming Song, Liqing Li, Xuguang Qiao and Haihua Chen. Development of an on-line molecularly imprinted chemiluminescence sensor for determination of trace olaquindox in chick feeds. Journal of the Science of Food and Agriculture, 2012, 92: 2696-2702. (IF 2.076)
(22)Qing Sun, Longhua Xu, Yue Ma, Xuguang Qiao, Zhixiang Xu*. Study on a biomimetic enzyme-linked immunosorbent assay method for fast determination of trace acrylamide in French fries and cracker samples. Journal of the Science of Food and Agriculture, 2014, 94:102-108. (IF 2.076)
(23)Xilong Wang, Qinghua Tang, Qingqing Wang, Xuguang Qiao, Zhixiang Xu*. Study of a molecularly imprinted solid-phase extraction coupled with high-performance liquid chromatography for simultaneous determination of trace trichlorfon and monocrotophos residues in vegetables. Journal of the Science of Food and Agriculture, 2014, 94: 1409-1415. (IF 2.076)
(24)Handong Zhao, Bingye Dai, Longhua Xu, Xilong Wang, Xuguang Qiao, Zhixiang Xu*. Preparation and application of immobilized ionic liquid in solid-phase extraction for determination of trace acrylamide in food samples coupled with high-performance liquid chromatography. Journal of the Science of Food and Agriculture, 2014, 94: 1787-1793. (IF 2.076)
(25)Tao Zhao, Qingqing Wang, Jie Li, Xuguang Qiao, Zhixiang Xu*. Study on an electrochromatography method based on organic-inorganic hybrid molecularly imprinted monolith for determination of trace trichlorfon in vegetables. Journal of the Science of Food and Agriculture, 2014, 94: 1974-1980. (IF 2.076)
(26)Jinwang Li, Jie Zuo, Xuguang Qiao, Yongju Zhang and Zhixiang Xu*. Effect of garlic powder on acrylamide formation in a low-moisture model system and bread baking. Journal of the Science of Food and Agriculture, 2016, 96: 893-899. (IF 2.076)
(27) Zhixiang Xu, Jie Zhou, Dongyan Zhao, Xuguang Qiao, Jianmei Yang. Determination of trace Para Red residues in foods through on-line molecularly imprinted solid phase extraction coupled with high-performance liquid chromatography. Journal of Food Science, 2010, 75: C49-C55. (IF 1.649)
(28) Zhixiang Xu, Huiju Gao, Limin Zhang, Xueqing Chen, Xuguang Qiao*. The biomimetic immunoassay based on molecularly imprinted polymer: A comprehensive review of recent progress and future prospects. Journal of Food Science, 2011, 77: R69-R75. (IF 1.649)
(29) Xu Zhixiang, Wang Shuo, Fang Guozhen, Song Jiajia, Zhang Yan. On-line SPE coupled with LC for analysis of traces of Sudan dyes in foods. Chromatographia, 2010, 71: 397-403. (IF 1.332)
(30)Xin Junhong, Zhao Dongyan, Zhang Limin, Xu Zhixiang*, Zhou Jie, Qu Dejing. Determination of trace Sudan IV residues in foods through molecularly imprinted SPE coupled with LC. Chromatographia, 2011, 73: 235-242. (IF 1.332)
(31)Xu Longhua, Zhang Limin, Qiao Xuguang, Xu Zhixiang*, Song Jiaming. Determination of trace acrylamide in potato chip and bread crust based on SPE and HPLC. Chromatographia, 2012, 75: 269-274. (IF 1.332)
(32) Zhixiang Xu, Jiaming Song, Dongyan Zhao, Jie Zhou, and Xuguang Qiao. Preparation and characterization of hydrophilic olaquindox molecularly imprinted polymer in aqueous environment. International Journal of Polymer Analysis and Characterization, 2011, 16: 67-77. (IF 1.515)
(33)Longhua Xu, Dongyan Zhao, Jiaming Song, Zhixiang Xu*, Jie Zhou. Preparation of an epichlorohydrine modified chitosan microsphere functionalized materials and adsorption characterization toward olaquindox. International Journal of Polymer Analysis and Characterization, 2011, 16: 118-126. (IF 1.515)
(34)Zhang Jing, Xie L. Chao, Cong Li, Xu Z. Xiang*, Qiao X. Guang & Song J. Ming. Separation and determination of trace environmental estrogen through molecularly imprinted solid phase extraction coupled to high performance liquid chromatography. Journal of Environmental Science and Health, Part A, 2012, 47: 1889-1896. (IF 1.276)
(35)Xilong Wang, Limin Zhang, Mingxiao Li, Zhixiang Xu*. Synthesis of a novel imprinted polymeric material for simultaneous recognition of the methamidophos and acephate. Advances in Polymer Technology, 2013, 32 (3). (IF 1.114)
(36)Qingqing Wang, Xin Zhang#, Jie Li, Zhixiang Xu*. Synthesis and evaluation of organic-inorganic hybrid molecularly imprinted monolith column for selective recognition of acephate and phosphamidon in vegetables. Advances in Polymer Technology. 2015, DOI 10.1002/adv. 21620. (IF 1.114)
(37)Deqing Li, Xuguang Qiao#, Juxiu Lu, Zhixiang Xu*. Synthesis and Evaluation of a Magnetic Molecularly Imprinted Polymer Sorbent for Determination of Trace Trichlorfon Residue in Vegetables by Capillary Electrophoresis. Advances in Polymer Technology. 2016, DOI 10.1002/adv. 21745. (IF 1.114)
申請和授權專利
(1)徐志祥,宋佳明,徐龍華.喹乙醇流動注射分子印跡-化學發光線上聯用檢測方法,專利號:ZL201110265788.5.(已授權)
(2)徐志祥,孟玲,喬旭光.敵百蟲仿生酶聯免疫吸附檢測方法,專利號:ZL201110213929.9.(已授權)
(3)徐志祥,辛軍紅,喬旭光.一種同時檢測敵百蟲和久效磷的方法,專利號:ZL201110316910.7.(已授權)
(4)徐志祥,王璽龍,趙濤.一種同時檢測九種有機磷農藥的方法.專利號:ZL201310352371.1.(已授權)
(5)王碩,徐志祥,方國臻.蘇丹紅I號吸附功能材料的合成方法,專利號:CN200710057147.4.(已授權)
(6)王碩,徐志祥,方國臻,張燕,徐蓓.痕量蘇丹紅III號的快速檢測方法,專利號:CN200710059342.0.(已授權)
(7)方國臻,徐志祥,王碩,劉冰.一種敵敵畏選擇性分離功能材料的合成方法,專利號:CN200810151244.4.(已授權)
(8)徐志祥,孫卿,徐龍華.一種丙烯醯胺酶標記仿生免疫分析方法.申請號:201310352244.1.
(9)徐志祥,唐清華,王璽龍.一種磁分離-氣相色譜檢測十種有機磷農藥方法.申請號:201410128462.1.
(10)徐志祥,李金旺,張璐,張永菊.一種低丙烯醯胺保健薯條及其製備方法.申請號:201410606225.1.
(11)徐志祥,時辰,高繪菊.一種酶標記仿生免疫分析檢測敵百蟲和乙醯甲胺磷的方法.申請號:201410669510.8.
(12)徐志祥,王情情,張昕.一種同時檢測三種有機磷農藥的方法.申請號:201410668930.4.
鑑定成果
(1) 徐志祥,李麗清,等. 基於分子識別的優勢出口農產品中喹乙醇痕量殘留檢測技術研究,2011.11.19通過泰安市科技局組織的專家鑑定,達到 國際領先水平。
(2) 徐志祥,張麗敏,等. 基於分子識別的農產品中有機磷農藥痕量殘留檢測技術研究,2012.10.13通過山東省教育廳組織的專家鑑定,達到 國際領先水平。
(3) 徐志祥,趙冬艷,等. 基於水相分子印跡技術的喹乙醇痕量殘留檢測,2013.11.9通過山東省教育廳組織的專家鑑定,達到 國內領先水平。
(4)張麗敏,戴炳業, 徐志祥,等. 有機磷農藥新型檢測方法研究及其在葡萄酒檢測中的套用,2013.11.9通過山東省教育廳組織的專家鑑定,達到 國內領先水平。
(5)陳麗,徐強, 徐志祥,等. 山東省食品衛生檢驗機構現狀及發展對策研究,2014年12月通過山東省軟科學辦公室驗收, 評為優秀。
(6) 徐志祥,等. 有機磷農藥新型檢測技術套用與示範,2015年10月12日通過專家驗收, 評為優秀。
(7)王碩,王俊平,鄧啟良,方國臻,潘明飛, 徐志祥,等. 食品與農產品中有害物痕量檢測的新型材料製備與套用,2016年4月22日通過專家鑑定,達到 國際領先水平。
獲得獎勵
研究成果先後獲得山東省科技進步三等獎、山東省高等學校優秀成果二等獎、泰安市科技進步三等獎等科技獎勵8項。
編著專著、教材
(1)高等學校“十二五”規劃教材:《食品安全學》,科學出版社,副主編,2012;
(2)專著:《酶聯免疫吸附分析方法》,科學出版社,參編,2011.