簡介:
宋學軍,教授,中國科學院上海腦研究所(現中科院神經科學研究所前身)博士(1995),美國耶魯大學博士後(1995-1998)。現任美國德克薩斯州帕克學院教授、帕克(醫學)研究所副所長、神經生物學研究室主任、高級研究員。2006年起擔任江蘇省麻醉學重點實驗室主任、徐州醫學院麻醉學院副院長,第四軍醫大學博士研究生導師。併兼任浙江省溫州醫學院疼痛醫學研究所(外方)所長;近年來,主要研究神經損傷(疾病)、修復和保護及其機制;神經病理性痛的感覺神經元和脊髓機制及其治療;以及B類維生素的神經保護和鎮痛作用等。獲得美國以及中國國家基金委員會傑出青年基金等多項重要科研資助。研究論文主要發表在神經科學、疼痛醫學、麻醉學以及相關領域的國際權威性期刊上。研究成果曾獲得美國生理學會的表彰及其官方網站以及美國和國際主流媒體如美國國家電視新聞網等的專題報導;國際神經正骨聯盟和國際神經正骨教育和研究基金會最高研究獎―Scott Haldeman 獎;美國國際ACTIVATOR有限公司年度最佳研究員獎;以及中國教育部、中國科學院院長、中國生理學會等的嘉獎。現為美國神經科學學會 (SFN),美國生理學會 (APS), 國際疼痛研究會 (IASP), 國際腦研究會 (IBRO), 美國科學發展學會 (AAAS) 以及紐約科學院等會員;“疼痛基礎研究與臨床治療國際年會(ICP)”的發起人和組織委員會常任主席(美方);若干國際英文核心學術期刊的約定審稿人以及美國、英國、西班牙國家疼痛研究基金評審人。研究興趣和方向
1.神經病理性痛的細胞和分子水平的機制;2.B族維生素的鎮痛機制國內活動:
1.共同發起“疼痛研究與臨床調控國際研討會”,分別於2006~2009年在溫州、西安、武漢 、徐州召開了四屆,會議堅持基礎與臨床相結合、邀請國內外知名專家與會演講的原則,取得了良好的學術效應和社會效應,是本領域水平最高的學術會議之一。2.任第四軍醫大學博士生導師,以疼痛研究與治療為方向在麻醉學和神經生物學兩個學科同時招生。
部分發表文章
Liu WT, Li HC, Song XS, Huang ZJ, Song XJ. EphB Receptor Signaling in Mouse Spinal Cord Contributes to Physical Dependence on morphine. FASEB J 2009 Jan; 23(1):90-98. Epub 2008 September 4.Song XS, Huang ZJ, Song XJ. thiamine may suppress thermal hyperalgesia by inhibiting hyperexcitability and regulating altered sodium channel of the injured dorsal root ganglion neurons in rats. Anesthesiology 2009 February; 110:387-400.
Han Y, Song XS, Liu WT, Henkemeyer M, Song XJ. Targeted Mutation of EphB1 Receptor Prevents Development of Neuropathic Hyperalgesia and Physical Dependence on Morphine in Mice. Mol Pain 2008 November 21;4(1):60.
Huang ZJ and Song XJ: Differential alteration of sodium currents in nociceptive dorsal root ganglion neurons following injuries to the somata and peripheral branches of axons. Mol Pain 2008 May 4:20,
Song XJ, Zheng JH, Cao JL, Li HC, Liu WT, Song XS Huang ZJ: Ephrin-EphB receptor signaling contributes to neuropathic pain by regulating neural excitability and spinal plasticity in rats. PAIN 2008; 139:168-180, April 28. [Epub ahead of print]
Song XJ, Cao JL, Li HC, Song XS, Xiong LZ: Upregulation and redistribution of ephrin1B-EphB1 receptor signaling in dorsal root ganglion and spinal dorsal horn after nerve injury and dorsal rhizotomy. Eur J Pain 2008 Mar; 12(8): 1031-1039
Cao JL, Ruan JP, Ling DY, Guan XH, Bao Q, Yuan Y, Zhang LC, Song XJ, Zeng YM. Activation of peripheral ephrinBs/EphBs signaling induces hyperalgesia through a MAPKs-mediated mechanism in mice. Pain 2008, 139: 617-631. [Aug Epub ahead of print]
Zheng JH, Walters ET, and Song XJ: Dissociation of dorsal root ganglion neurons induces hyperexcitability that is maintained by increases responsiveness to cAMP and cGMP. J Neurophysiol 2007; 97:15-25. Editorial Focus in 2007; 97:1-2
Song XJ, Wang ZB, Gan Q, and Walters ET: cAMP and cGMP Pathways contribute to expression of hyperalgesia and sensory neuron hyperexcitability following dorsal root ganglion compression in the rat. J Neurophysiol 2006; 95:479-492.
Song XJ, Gan Q, Cao JL, Wang ZB, Rupert RL: Spinal Manipulation Reduces Pain and Hyperalgesia Produced by lumbar Intervertebral Foramen Inflammation in the Rat. J manipulative Physiol Ther 2006;29:1-9.
Liu YB, Shi J, Lu CC, Wang ZB, Song XJ, Zou YM: Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract. Nature Neuroscience 2005; 8(9):1151-9.
Wang ZB, Gan Q, Rupert RL, and Song XJ: Thiamine, pyridoxine, cyanocobalamin and their combination inhibit thermal but not mechanical hyperalgesia in rats with primary sensory neuron injury. Pain 2005;114(1-2):266-77
Zheng JH, Song XJ: Aβ-Afferents Activate NK-1 Receptor in Dorsal Horn Neurons after Nerve Injury. NeuroReport 2005;16(7):715-9
Song XJ (textbook chapter): Central projections of spinal receptors. In Haldeman S: Principle and Practice of chiropractic, 3rd ed, McGraw-Hill, New York. 2004
Song, XJ, Vizcarra C, Xu DS, Rupert RL, Wong ZN: Hyperalgesia and neural excitability following injuries to the peripheral and central branches of axon and somata of dorsal root ganglion neurons. J Neurophysiol 2003;89:2185-2193
Song XJ, Zhang JM and LaMotte RH: Somata of nerve-injured sensory neurons exhibit enhanced responses to inflammatory mediators. Pain 2003;104(3):701-709
Song XJ, Xu DS, Vizcarra C, Rupert RL: Onset and recovery of hyperalgesia and hyperexcitability of sensory neurons following intervertebral foramen volume reduction and restoration. J Manipulative Physiol Ther 2003;26(7):426-436