基本情況
宋化燦（Hua-Can Song），男，博士、教授，有機化學專業博士生導師。
國籍:中國
出生地:山東
出生日期:1959年4月
職業:教師
畢業院校:山東大學（本科）、中山大學（博士）
代表作品：《物理有機化學》
人物介紹
教育經歷
·1978年2月-1982年1月，山東大學化學系有機化學專業，本科；
·1993年9月-1996年7月，中山大學化學系有機化學專業，博士；
工作閱歷
1996年6月中山大學有機化學專業博士畢業留校任教至今，先後任講師、副教授、教授。先後於1998和1999年赴美國Brigham Young University和2001-2002年赴台灣大學做博士後研究各一年。主講過《有機化學》、《有機分析》、《有機化學實驗》、《物理有機化學》等課程。公開發表研究論文60餘篇。
·1982年1月-1993年8月，鄭州輕工業學院化工系任教；
·1996年7月-1998年8月，中山大學化學系，副教授；
·1998年9月-1999年8月，美國Brigham Young University，博士後；
·1999年8月-2001年9月，中山大學化學院，副教授；
·2001年9月-2002年8月，台灣大學化學系，博士後；
·2002年8月-2004年3月，中山大學化學院，副教授；
·2004年4月至今，中山大學化學院，教授，博士生導師。
2016年2月—至今，中山大學化學工程與技術學院，教授，博士生導師。
科研方向
藥物設計與合成，有機發光材料，物理有機化學（冠醚與發光材料）。
工作方向
承擔課題：
1. 教育部留學回國人員啟動基金；
2. 廣東省科技廳(974077)；
3. 廣州市科技局重點套用基礎研究項目(98-J-013-01)；
4. 廣州市科技局(01-J-015-01)；
5. 廣東省科技廳重點攻關項目(2003C103006)；
6. 含多聚、寡聚和單氨基葡萄糖新型抗癌藥物的研發；
7. 頭孢唑蘭的合成工藝；
8. 頭孢卡品酯的合成工藝；
9. 廣東省科技廳重點引導項目(2004B30101007)。
10、順德科技局產學研結合項目“水基噴柒產品技術的研究與套用”，2007-2009；
11、廣東省教育部產學研結合項目“高性能氯化聚丙烯改性樹脂的研發” 2009-2010；
12、廣東省教育部產學研結合項目“低硫低碳製革工藝和助劑的研究開發”， 2010-2011；
13、廣東中煙公司項目“主要煙用香料轉移行為對捲菸品質的影響及其套用研究” 2009-2011
14、廣東省科技計畫重點項目“廣東涼茶的數位化質量控制技術研究”，2011-2012；
15、長江生命科技國際有限公司項目（香港）“用於抗癌藥物活性測試的化合物的合成”，2010-2012
16、惠州大亞灣科技局重點項目“高效、環保新型光引發劑推廣套用關鍵技術的研發”，2012-2015。
17、廣東省科技計畫重點項目“環保型有機矽表面活性劑關鍵技術開發及產業化”，2013-2016；
論著一覽
《物理有機化學》英柏寧、宋化燦，化學工業出版社，2010年
講授課程
《物理有機化學》（本科生，36學時），《物理有機化學》（研究生，60學時）。
主要論文
1. Ning Su, Jerald S. Bradshaw, Xian Xin Zhang, Hua-Can Song, Paul B. Savage, Guaoping Xue, Krzysztof, Krakowiak, and Reed M. Izatt, Synthesis and metal ion complexation of novel 8-Hydroxyquinoline-containing diaza-18-crown-6 ligands and analogs, J. Org. Chem. 1999, 64, 8855
2, Jerald S. Bradshaw, Hua-can Song, Guoping Xue, R. Todd Bronson, Joseph A. Chiara, and Reed, M. Izatt, Synthesis of diazadi(and tri)thiacrown ethers containing two 5-substituent(or 2-methyl)-8-hydroxyquinoline side arms, Supramol. Chem. 2001, 13, 499
3, Hua-Can, Song, Yi-Wen Chen, Xiang-Li Zheng, Bai-Ning Ying, Study on second harmonic generation of 10-hydrocarbylacridiones, Spectrochimica Acta Part A, 2001, 57 , 1717
4, Guo-ping Xue, Jerald S. Bradshaw, Hua-can Song, R. Todd, Bronson, Paul B. Savage, Reed, M. Izatt, A convenient synthesis and preliminary photophysical study of novel fluoroionophores: macrocyclic polyamines containing two dansylaminoethyl side arms. Tetrahedron, 2001, 57, 87
5, Hua-Can Song, Rui Jiang Jin, Xiang Li Zheng, Bai Ning Ying. Study on second harmonic generation of 9-(substituted-benzylidene-10-methyl)-9,10-dihydroacridines, Spectrochimica Acta Part A, 2001, 57, 2729
6, Hua-Can Song, Jearld S. Bradshaw, Yi-Wen Chen, et al. Synthesis of diazadithiacrwn ethers containing two 8-hydroxyquinoline side arms, ARKIVOC, 2001 ISSUE in Honor of Prof. Miha Tisler. 2001, 2, Part3, ms 0116.
7, Hua-Can Song, Yi-Wen Chen, Ji-Guo Song, Paul B. Sarage, Guo-Ping Xue, Jeseph A. Chiara, Krzysztof E. Krakowoak, Reed M. Izatt and Jerald S. Bradshaw. New diazdi (and tri) thia-21-crown-7 ethers containing 8-hydroxyquinoline side arms, J. Heterocyclic Chem. 2001, 38, 1369
8, Hua-Can Song, Jerald S. Bradshaw, Yi-Wen Chen, Guo-Ping Xue, Wei-Ming Li, Krzysztof E. Krakowoak, Paul B. Sarage, Zun-le Xu and Reed M. Izatt. Synthesis of new crown ethers containing appended pyridine, 10-hydroxybenzoquinoline, 8-hydroxyquinoline and 2-amino-1-hydroxybiphenyl sidearms, Supramol. Chem. 2002, 14, 263
9, Chin-Fa Lee, Liu Chin-Yuan, Hua-Can Song, et al, Bidirectional iterative synthesis of alternating benzene-furan oligomers towards molecular wires, Chem. Commun. 2002, 2824
10, Hua-Can Song, Ping Huan, Bai-Ning Ying, Molecular complexes of antipsychotic pharmaceutical parent molecule phenothiazine and unsaturated acid anhydrides. Spectrochimica Acta Part A, 2003, 59, 1509
11, Hua-Can Song, Wei-Ming Li, Guang-Rong Liu, Zun-Le Xu. Study on the optical properties of 4,4’-bis-(2-(substituted-styryl))-biphenyl and 1,4-bis-(2-(substituted-styryl)) benzene Spectrochimica Acta Part A, 2003, 59, 2041
12, Hua-Can Song, Yi-Wen Chen, Jun-Hua Yao, Zun-Le Xu, Jeaald S. Bradshaw and Reed M. Izatt. Syntheses of diazadithiacrown ethers containing appended coumarin or 1-aminonaphthene as sidearms J. Heterocyclic Chem. 2003, 40, 475
13, Huang, Z.-L.; Li, N.; Sun, Y.-F.; Wang, H.-Z.; Song, H.-C.; Xu, Z.-L. Synthesis and photophysical characterization of two new coumarinyl-based organic molecules with two-photon induced fluorescent emission, J. Mol. Structure, 2003, 657, 343
14, Hua-Can Song, Huan Wen, Wei-Ming Li, Study on the second-order optical behavior of 4-(substituted-benzylidene)-2-phenyl-4H-oxazol-5-one, Spectrochimica Acta Part A. 2004, 60, 1587
近期主要論文
1. 1-(1-Arylethylidene)Thiosemicarbazide derivatives: A new class of tyrosinase inhibitors, Bioorganic and Medicinal Chemistry, 2008, 1096;
2. Synthesis and cytotoxic activities of 1-benzylidine substituted β-carboline derivatives, Bioorganic & Medicinal Chemistry Letters, 2008, 6558;
3. Synthesis and in vitro cytotoxic evaluation of novel 3,4,5-trimethoxyphenyl substituted β-carboline derivatives, European Journal Medicinal Chemistry,2008, 533;
4. Synthesis and biological evaluation of helicid analoguesas novel acetylcholinester as einhibitors, European Journal Medicinal Chemistry, 2008, 166;
5. The synthesis and preliminary optical study of 1-alkyl-2,4,5-triphenylimidazole derivatives, Dyes and Pigments, 2008, 17;
6. Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors, Bioorganic & Medicinal Chemistry Letters, 2008, 6490;
7. A class of potent tyrosinase inhibitors: Alkylidenethiosemicarbazide compounds, European Journal Medicinal Chemistry, 2009, 1773;
8. Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl β-aldehyde ketone derivatives, European Journal Medicinal Chemistry, 2009, 1737;
9. Discovery of 4-functionalized phenyl-O-β-d-glycosides as a new class of mushroom tyrosinase inhibitors, Bioorganic & Medicinal Chemistry Letters, 2009, 6157;
10.Synthesis and biological evaluation of novel4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors, European Journal of Medicinal Chemistry, 2009, 1737;
11. Synthesis and evaluation of 5-benzylidene(thio)barbiturate-β-d-glycosides as mushroom tyrosinase inhibitors, Bioorganic & Medicinal Chemistry Letters, 2009, 4055;
12. Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities, European Journal of Medicinal Chemistry, 2009, 4235;
13. Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl β-aldehyde ketone derivatives, European Journal of Medicinal Chemistry, 2009, 1737;
14. Synthesis and optical behaviors of 2-(9-phenanthrenyl)-, 2-(9-anthryl)-, and 2-(1-pyrenyl)-1-alkylimidazole homologues, Spectrochimica Acta Part A, 2009, 233;
15. Biological evaluations of novel vitamin C esters as mushroom tyrosinase inhibitors and antioxidants, Food Chemistry, 2009, 381;
16. Synthesis of 4-[(diethylamino)methyl]phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyryl cholinesterase, Bioorganic & Medicinal Chemistry Letters,2010, 3254;
17. Synthesisandcytotoxicevaluationof N-benzylatedquaternary b-carboline amino acid ester conjugates, European Journal of Medicinal Chemistry, 2010, 1515;
18. Synthesis and preliminary optical study of 1,3,4-oxadiazole derivatives containing imidazole units, Dyes and Pigments, 2010, 249;
19. Synthesis of novel β-carbolines with efficient DNA-binding capacity and potent cytotoxicity, Bioorganic & Medicinal Chemistry Letters, 2010, 3876;
20. Design, synthesis and 3D-QSAR of β-carboline derivatives as potent antitumor agents, European Journal of Medicinal Chemistry, 2010,2503;
21. Synthesis, cytotoxic activities and DNA binding properties of β-carboline derivatives, European Journal of Medicinal Chemistry, 2010, 4740;
22. Synthesis and cytotoxic evaluation of 1-carboxamide and 1-amino side chain substituted β-carbolines, European Journal of Medicinal Chemistry, 2010, 5513;
23.Synthesis and biological evaluation of novel4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors, European Journal of Medicinal Chemistry, 2010, 639;
24. α-Glucosidase and α-amylase inhibitory activities of guava leaves, Food Chemistry, 2010, 6;
25. Design, synthesis and biological evaluation of 3-(4-halophenyl)-3-oxopropanal and their derivatives as novel antibacterial agents, Chem. Pharm. Bull. 2010, 1127;
26. Rational design and synthesis of 4-O-substituted phenylmethylene thiosemi- carbazones as novel tyrosinase inhibitors, Chem. Pharm. Bull. 2010, 752;
27, Design, synthesis and evaluation of difunctionalized 4-hydroxybenzaldehyde derivatives as novel cholinesterase inhibitors, Chem. Pharm. Bull. 2010, 1216;
28.Synthesis and biological evaluation of novelB-Carbolines as potent cytotoxic and DNA intercalatingagents, Chem. Pharm. Bull. 2010, 901.
29. Synthesis and cytotoxicity of A-homo-lactam derivatives of cholic acid and 7-deoxycholic acid, Steriods, 2011, 76,690;
30. Synthesis and cytotoxicity of 17a-aza-D-homo-androster-17-one derivatives, Bioorganic & Medicinal Chemistry Letters, 2011, 21,3641;
31. Refinement of arylthiosemicarbazone pharmacophore in inhibition of mushroom tyrosinase, European Journal of Medicinal Chemistry, 2011, 46, 4330;
32. Synthesis and biological evaluation of 1,9-disubstituted b-carbolines as potent DNA intercalating and cytotoxic agents, European Journal of Medicinal Chemistry, 2011, 46, 5127;
33. Design, synthesis and in vitro and in vivo antitumor activities of novel bivalent β-carbolines, European Journal of Medicinal Chemistry, 2013, 60, 10;
34. Synthesis and Neuroprotective Action of Xyloketal Derivatives in Parkinson’s Disease Models, Marine Drugs 2013, 11, 5159;
35. Design, Synthesis and Evaluation of N13-SubstitutedEvodiamine Derivatives against Human Cancer Cell Lines, Molecules 2013, 18, 15750;
36. Rational design, synthesis and structure–activity relationships of 4-alkoxy- and 4-acyloxy-phenylethylenethiosemicarbazone analogues as novel tyrosinase inhibitors, Bioorganic & Medicinal Chemistry, 2015, 23, 924;
37. Structure-based modification of 3-/4-aminoacetophenones giving a profound change of activity on tyrosinase: From potent activators to highly efficient inhibitors, European Journal of Medicinal Chemistry, 2015, 93, 255;
38. Rh(III)-catalyzed and alcohol-involved carbenoid C–H insertion into N-phenoxyacetamides using a-diazomalonates, Chemcal Communication, 2015, 51, 5868;
39. A new and efficient ZnCl2-catalyzed synthesis and biological evaluation of novel 2-amino-3,5-dicyano-4-aryl-6-arylaminopyridines as potent antibacterial agents against Helicobacter pylori (HP), Tetrahedron, 2015, 71, 8628.
