![孫鐵民[中國瀋陽藥科大學藥物化學專業教授]](/img/1/102/nBnauM3XwUDN5kTN2kDO2kTO0UTMyITNykTO0EDMwAjMwUzL5gzLxQzLt92YucmbvRWdo5Cd0FmL0E2LvoDc0RHa.jpg "孫鐵民[中國瀋陽藥科大學藥物化學專業教授]")
基本信息
孫鐵民教授1981年於瀋陽藥科大學畢業，同年考入瀋陽藥科大學藥物化學專業碩士研究生，師從於沈建民教授，於1984年獲理學碩士並留校任教，從事藥物化學的教學和科研工作。先後主持國家“八五”攻關、國家醫藥局局控項目和國家醫藥局青年新藥基金的研究項目。
工作經歷
1977年考入瀋陽藥學院化學製藥專業，1981年畢業獲學士學位
1981考入本校藥物化學專業研究生，1984年畢業獲碩士學位，
1993年考入本校藥物化學專業研究生，1999年畢業獲博士學位。
1987晉升為講師，1994年晉升副教授，1999年晉升為教授。
教學情況：
1995年任藥物化學教研室主任，負責教學和科研工作，本教研室承擔全校的藥物化學課和製藥工程專業的數門專業課程，經過多年建設，已經取得較好的成績，受到同行的關注， 每年都有許多院校特別是製藥工專業的同仁前來訪問和交流。起到了專業示範作用。主要負責理科基地的藥物化學課程、藥學專業的藥物化學課程，研究生的藥物化學專論等教學。
人才培養
招收藥物化學和製藥工程專業博士和碩士研究生，已經畢業博士碩士20餘名，現有碩士和博士研究生20餘名。
已經培養大量本科生。
科研方向
主要從事複雜藥物的合成工藝研究，特別是手性藥物的製備工藝的研究
天然產物的合成和半合成研究
抗腫瘤藥物、抗愛滋病藥物和心血管藥物的設計研究
曾主持的科研工作有
1.“十五” 重大專項創新藥物和中藥現代化研究中抗愛滋病藥物恩曲他濱（Emtricitabine）的研究，課題編號：2004AA2Z3752，科技部，2004~2005,
2. 2004年自然科學基金 麥芽炮製前後抗乳腺增生成分變化及其構效關係研究課題編號：30472190，自然基金委
3. 鹽酸坦羅新的研究，企業合作，1999-2004，
4. 奧斯內特和吉莫斯特的研究，企業合作，2003-2005，
5. 美斯鈉和異環磷醯胺的新合成工藝研究，企業合作，2003-2005，
6. 鹽酸氯雷他定的研究，企業合作，1999-2004，
7. 聚甲酚磺醛的研究，企業合作，1999-2004
8. 獲得新藥證書2個，
已經獲得各種科研經費數百萬元，
部分論文
A Class of Amide Ligands Enable Cu-Catalyzed Coupling of (Hetero) aryl Halides with Sulfinic Acid Salts under Mild Conditions[J]. The Journal of organic chemistry, 2018.
Theoretical studies on the mechanism of sugammadex for the reversal of aminosteroid-induced neuromuscular blockade[J]. Journal of Molecular Liquids, 2018 .
Conformational and characterization of benidipine hydrochloride polymorphs: Spectroscopic and computational modeling investigations[J]. Journal of Molecular Structure, 2018, 1164: 493-500.
Design, Synthesis, Configuration Research, and In Vitro Antituberculosis Activities of two Chiral Naphthylamine Substituted Analogs of Bedaquiline[J]. Journal of Heterocyclic Chemistry, 2017, 54(2): 1024-1030.
Conformations and interactions in pasiniazid: a spectroscopic and computational characterization[J]. Journal of Molecular Structure, 2017, 1133: 179-186.
Effectively enhancing the enantioseparation ability of β-cyclodextrin derivatives by de novo design and molecular modeling[J]. Analyst, 2017, 142(19): 3699-3706.
Determination of absolute configuration of an isopimarane-type diterpenoid by experimental and theoretical electronic circular dichroism and vibrational circular dichroism[J]. Journal of Molecular Structure, 2017, 1146: 484-489.
Design and Stereochemical Research (DFT, ECD and Crystal Structure) of Novel Bedaquiline Analogs as Potent Antituberculosis Agents[J]. Molecules, 2016, 21(7): 875.
The stereochemistry of baishouwubenzophenone, a unique atropisomer from C. wilfordii[J]. Journal of Molecular Structure, 2016, 1125: 370-373.
Detailed structural study of β-artemether: density functional theory (DFT) calculations of infrared, Raman spectroscopy, and vibrational circular dichroism[J]. Journal of Molecular Structure, 2015, 1097: 61-68.
An Electronic Circular Dichroism Study for the Structure–Chiroptical Relationship of Chiral Proton Pump Inhibitors[J]. Chemistry Letters, 2015, 45(2): 110-112.
Synthesis, Crystal Structure, Absolute Configuration and Antitumor Activity of the Enantiomers of 5-Bromo-2-chloro-N-(1-phenylethyl) pyridine-3-sulfonamide[J]. Molecules, 2015, 20(11): 20926-20938.
Stereochemical Investigation of a Novel Biological Active Substance from the Secondary Metabolites of Marine Fungus Penicillium chrysogenum SYP-F-2720[J]. Journal of the Mexican Chemical Society, 2015, 59(1): 53-58.
Density functional theory (DFT) and natural bond orbital (NBO) study of vibrational spectra and intramolecular hydrogen bond interaction of l-ornithine–l-aspartate[J].Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2015, 136: 338-346
The stereochemistry of two monoterpenoid diastereomers from Ferula dissecta[J]. RSC Advances, 2014, 4(28): 14373-14377.
Determination of Absolute Configurations of Bedaquiline Analogs by Quantum Chemical Electronic Circular Dichroism Calculations and an X‐ray Diffraction Study[J]. European Journal of Organic Chemistry, 2014, 18(6):3814–3821.
Selective Substitution of 31/42–OH in Rapamycin Guided by an in Situ IR Technique[J]. Molecules, 2014, 19(6): 7770-7784.
Design and optimization of novel 4-(2-fluorophenoxy) quinoline derivatives bearing a hydrazone moiety as c-Met kinase inhibitors[J]. European journal of medicinal chemistry, 2014, 87: 508-518.
Study on molecular structure, spectroscopic investigation (IR, Raman and NMR), vibrational assignments and HOMO–LUMO analysis of L-sodium folinate using DFT: A combined experimental and quantum chemical approach[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014, 120: 106-118.
Phenolic Esters of O-Desmethylvenlafaxine with Improved Oral Bioavailability and Brain Uptake[J]. Molecules, 2013, 18(12): 14920-14934.
1.A Class of Amide Ligands Enable Cu-Catalyzed Coupling of (Hetero) aryl Halides with Sulfinic Acid Salts under Mild Conditions[J]. The Journal of organic chemistry, 2018.
2.Theoretical studies on the mechanism of sugammadex for the reversal of aminosteroid-induced neuromuscular blockade[J]. Journal of Molecular Liquids, 2018 .
3.Conformational and characterization of benidipine hydrochloride polymorphs: Spectroscopic and computational modeling investigations[J]. Journal of Molecular Structure, 2018, 1164: 493-500.
4.Journal of Heterocyclic Chemistry
5.Conformations and interactions in pasiniazid: a spectroscopic and computational characterization[J]. Journal of Molecular Structure, 2017, 1133: 179-186.
6.Effectively enhancing the enantioseparation ability of β-cyclodextrin derivatives by de novo design and molecular modeling[J]. Analyst, 2017, 142(19): 3699-3706.
7.Determination of absolute configuration of an isopimarane-type diterpenoid by experimental and theoretical electronic circular dichroism and vibrational circular dichroism[J]. Journal of Molecular Structure, 2017, 1146: 484-489.
8.Molecules
9.Journal of Molecular Structure
10.Journal of Molecular Structure
11.Chemistry Letters
12.Molecules
13.Stereochemical Investigation of a Novel Biological Active Substance from the Secondary Metabolites of Marine Fungus Penicillium chrysogenum SYP-F-2720[J]. Journal of the Mexican Chemical Society, 2015, 59(1): 53-58.
14.Density functional theory (DFT) and natural bond orbital (NBO) study of vibrational spectra and intramolecular hydrogen bond interaction of l-ornithine–l-aspartate[J].Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2015, 136: 338-346
15.The stereochemistry of two monoterpenoid diastereomers from Ferula dissecta[J]. RSC Advances, 2014, 4(28): 14373-14377.
16.Determination of Absolute Configurations of Bedaquiline Analogs by Quantum Chemical Electronic Circular Dichroism Calculations and an X‐ray Diffraction Study[J]. European Journal of Organic Chemistry, 2014, 18(6):3814–3821.
17.Selective Substitution of 31/42–OH in Rapamycin Guided by an in Situ IR Technique[J]. Molecules, 2014, 19(6): 7770-7784.
18.Design and optimization of novel 4-(2-fluorophenoxy) quinoline derivatives bearing a hydrazone moiety as c-Met kinase inhibitors[J]. European journal of medicinal chemistry, 2014, 87: 508-518.
19.Study on molecular structure, spectroscopic investigation (IR, Raman and NMR), vibrational assignments and HOMO–LUMO analysis of L-sodium folinate using DFT: A combined experimental and quantum chemical approach[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014, 120: 106-118.
20.Phenolic Esters of O-Desmethylvenlafaxine with Improved Oral Bioavailability and Brain Uptake[J]. Molecules, 2013, 18(12): 14920-14934.
