學習經歷
2008/09-2013/06，武漢大學，博士
2004/09-2008/06，武漢大學，學士
主要工作經歷與任職情況：
2015/03-至今：武漢大學生命科學學院；副研究員
2013/09-2015/01：美國辛辛那提兒童醫院醫學中心
研究領域
真核細胞發育和分化過程中，功能基因組的表達受到精細而廣泛的調控，主要通過相應的調控元件如啟動子增強子等實現。近年來的研究發現，真核細胞內染色體組蛋白的特定修飾與基因調控元件密切相關，如H3K4me3特異性標記啟動子，H3K4me特異性標記增強子，而H3K27ac標記活化的調控原件。通過組蛋白特定修飾相對應的抗體進行高通量的Chip-seq實驗，在全基因組範圍內揭示功能基因組的調控元件，並結合生物信息學的方法統計分析與調控元件相結合的轉錄因子，從而確定真核細胞發育和分化的關鍵基因及其調控網路。系統性的研究生命過程中功能基因組表達和相互之間的調控關係，從而繪製基因調控迴路，全面解析生命過程。
代表性論文
1.HepingXu,VirendraKChaudhri,ZhiguoWu,KonstantinosBiliouris,KristaDienger-Stambaugh,YrinaRochmanandHarinderSingh*.(2015).RegulationofbifurcatingBcelltrajectoriesbymutualantagonismbetweentranscriptionfactorsIRF4andIRF8.NatureImmunology(doi:10.1038/ni.3287).
2.XiaomingLu,ErinE.Zoller,MatthewT.Weirauch,ZhiguoWu,BahramNamjou,AdrienneH.Williams,JulieT.Ziegler,MaryE.Comeau,MirandaC.Marion,StuartB.Glenn,AdamAdler,NanShen,SwapanK.Nath,AnneM.Stevens,BarryI.Freedman,BettyP.Tsao,ChaimO.Jacob,DianeL.Kamen,ElizabethE.Brown,GaryS.Gilkeson,GracielaS.Alarcón,JohnD.Reveille,Juan-ManuelAnaya,JudithA.James,KathyL.Sivils,LindseyA.Criswell,LuisM.Vilá,MartaE.Alarcón-Riquelme,MichellePetri,RHalScofield,RobertP.Kimberly,RosalindRamsey-Goldman,YoungBinJoo,JeongimChoi,Sang-CheolBae,SusanA.Boackle,DeborahCunninghameGraham,TimothyJ.Vyse,JoelM.Guthridge,PatrickM.Gaffney,CarlD.Langefeld,JenniferA.Kelly,KennethD.Greis,KennethM.Kaufman,JohnB.Harley,*LeahC.Kottyan*.(2015).Lupusrisk-variantincreasespSTAT1bindinganddecreasesETS1expression.AmericanJournalofHumanGenetics5:731-739.
3.ZhiguoWu,XiaoXie,PuzhenLi,JiayiZhao,LiliHuang,XiangZhou*.(2013).EquilibriousstrandexchangepromotedbyDNAconformationalswitching.ScientificReports3:1121
4.ZhiguoWu,TianTian,JunpingYu,XiaochengWeng,YiLiu,XiangZhou*.(2011).Formationofsequence-independentZ-DNAinducedbyarutheniumcomplexatlowsaltconcentrations.AngewChemIntEdEngl.50:11962-11967.
5.ZhiguoWu,MingliangTang,TianTian,JianguoWu,YuanlinDeng,XiaohuDong,ZhengTan,XiaochengWeng,ZhihongLiu,ChunjiangWang,XiangZhou*.(2011).Aspecificprobefortwo-photonfluorescencelysosomalimaging.Talanta87:216-221
6.JingHuang,GuoruiLi,ZhiguoWu(co-firstauthor),ZhibinSong,YangyangZhou,LiangShuai,XiaochengWeng,XiangZhou*,GuangFuYang.(2009).Bisbenzimidazoletobenzobisimidazole:frombindingB-formduplexDNAtorecognizingdifferentmodesoftelomereG-quadruplex.ChemCommun8:902-904.
7.XunLiu,ZhiguoWu,TianyouPeng*,PingCai,HongjinLv,WenlongLian.(2009).Fabricationofaluminananofibersbyprecipitationreactioncombinedwithheterogeneousazeotropicdistillationprocess.MaterialsResearchBulletin44:160-167.
