研究方向：
化學生物感測技術; 新型分子探針設計與套用; 核酸分子砌合器件; 納米生物技術
主要簡歷
1975年出生。2008年從湖南大學化學生物感測與計量學國家重點實驗室畢業,獲分析化學博士學位。從事碩博連讀研究期間,於2006年破格加盟湖南大學化學化工學院。在影響因子高於5的期刊上發表學術論文10多篇；博士論文被推薦參與2011年全國優秀博士論文評選。主持國家自然科學基金一項；主研國家自然科學基金兩項；曾獲教育部自然科學一等獎、湖南省第十一屆青年化學化工獎等獎項。2010年開始從事麥克馬斯特大學博士後研究,是獲得Michael G. DeGroote基金的第一位中國學者，2011年頭條新聞該校生物學院對此做了專題報導 。目前研究領域主要涉及核酸與適體信號探針�核酸分子砌合器件�納米生物技術與靈敏信號核酸操縱技術等方面（材料截止2011年5月）。
Selected Publications:
1. Li-Ping Qiu, zai-Sheng Wu*, Guo-Li Shen, and Ru-Qin Yu*, Highly Sensitive and Selective Bifunctional Oligonucleotide Probe for Homogeneous Parallel Fluorescence Detection of Protein and Nucleotide Sequence, Analytical Chemistry, 2011, 83, 3050�3057
2. Zai-Sheng Wu,* Hui Zhou, Songbai Zhang, Guoli Shen,* and Ruqin Yu. Electrochemical Aptameric Recognition System for a Sensitive Protein Assay Based on Specific Target Binding-Induced Rolling Circle Amplification. Analytical Chemistry, 2010, 82 (6), 2282�2289
3. Zai-Sheng Wu, Songbai Zhang, Hui Zhou, Guo-Li Shen,* and Ruqin Yu.* Universal Aptameric System for Highly Sensitive Detection of Protein Based on Structure-Switching-Triggered Rolling Circle Amplification. Analytical Chemistry, 2010, 82 (6), 2221�2227.
4. Zai-Sheng Wu, * Haixia Lu, Xueping Liu, Rong Hu, Hui Zhou, Guoli Shen, * and Ru-Qin Yu. Inhibitory Effect of Target Binding on hairpin Aptamer Sticky-End Pairing-Induced Gold Nanoparticle Assembly for Light-up Colorimetric Protein Assay. Analytical Chemistry, 2010, 82, 3890�3898
5. Jing-Lin He, Zai-Sheng Wu,* Hui Zhou, Hong-Qi Wang, Jian-Hui Jiang, Guo-Li Shen, and Ru-Qin Yu*. Fluorescence Aptameric Sensor for Strand Displacement Amplification Detection of cocaine. Analytical Chemistry, 2010, 82, 1358�1364
6. Songbai Zhang, Rong Hu, Peng Hu, Zai-Sheng Wu,* Guo-Li Shen,* and Ru-Qin Yu, Background current-free electrochemical aptameric sensing platform for ultrasensitive signal-on detection of small molecule. Nucleic Acids Research, 2010, 38 (20), e185
7. Zaisheng Wu,* Hui Zhou, Songbai Zhang, Xiaobing Zhang, Guoli Shen* and Ruqin Yu, Pendulum-type optical DNA nanodevice. Chemical Communications, 2010, 46, 2232�2234.
8. Zai-Sheng Wu, Fan Zheng, Guo-Li Shen,* Ru-Qin Yu, A hairpin aptamer-based electrochemical biosensing platform for the sensitive detection of proteins. Biomaterials, 2009, 30, 2950-2955
9. Zai-Sheng Wu, Meng-Meng Guo, Song-Bai Zhang, Chen-Rui Chen, Jian-Hui Jiang, Guo-Li Shen* and Ru-Qin Yu,* Reusable electrochemical sensing platform for highly sensitive detection of small molecules based on structure-switching signaling Aptamers, Analytical Chemistry, 2007, 79(7), 2933-2939
10. Zai-Sheng Wu, Jian-Hui Jiang, Guo-Li Shen,* and Ru-Qin Yu, Highly sensitive DNA detection and point mutation identification: an electrochemical approach based on the combined use of ligase and reverse molecular beacon, Human Mutation, 2007, 28(6): 630-637
