向嵩

coen ction reaction

研究領域：
利用結構生物學、生物化學等手段來研究蛋白質等生物大分子的結構與功能的聯繫，理解它們功能的分子機理。目前的研究方向包括：1)對核受體等重要的轉錄因子的結構與功能的研究；2)對在DNA的損傷反應過程中起重要作用的蛋白的結構與功能的研究。
近期論文：
1. Xiang S, Callaghan MM, Watson KG, Tong L. A different mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by tepraloxydim. Proc Natl Acad Sci U S A. 2009 Dec; 106 (49): 20723-27.
2. Sinturel F, Pellegrini O, Xiang S, Tong L, Condon C, Bénard L, Real-time fluorescence detection of exoribonucleases. RNA. 2009 Nov; 15(11): 2057-62.
3. Yu LP, Xiang S, Lasso G, Gil D, Valle M, Tong L, A symmetrical tetramer for S. aureus pyruvate carboxylase in complex with coenzyme A. Structure. 2009 Jun 10; 17(6): 823-32.
4. Xiang S, Cooper-Morgan A, Jiao X, Kiledjian M, Manley JL, Tong L, Structure and function of the 5’®3’ exoribonuclease Rat1 and its activating partner Rai1. Nature. 2009 Apr 9; 458(7239): 784-8.
5. Xiang S, Usunow G, Lange G, Busch M, Tong L. 1-deoxy-D-xylulose 5-phosphate synthase (DXS), a crucial enzyme for isoprenoids biosynthesis. Book chapter, T.J. Bach Ed. (in press)
6. Xiang S, Tong L. Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction. Nat Struct Mol Biol. 2008 Mar; 15(3): 295-302.
7. Khan JA*, Xiang S*, Tong L. Crystal structure of human nicotinamide riboside kinase. Structure. 2007 Aug; 15(8): 1005-13. (*-equal contribution authors)
8.Xiang S, Usunow G, Lange G, Busch M, Tong L. Crystal structure of 1-deoxy-D-xylulose 5-phosphate synthase, a crucial enzyme for isoprenoids biosynthesis. J Biol Chem. 2007 Jan 26; 282(4): 2676-82.
9. Nichols JD, Xiang S, Schindelin H, Rajagopalan KV. Mutational analysis of Escherichia coli MoeA: two functional activities map to the active site cleft. Biochemistry. 2007 Jan 9; 46(1): 78-86.
10. Xiang S, Kim EY, Connelly JJ, Nassar N, Kirsch J, Winking J, Schwarz G, Schindelin H. The crystal structure of Cdc42 in complex with collybistin II, a gephyrin-interacting guanine nucleotide exchange factor. J Mol Biol. 2006 May 26; 359(1): 35-46.
11. Tian G, Xiang S, Noiva R, Lennarz WJ, Schindelin H. The crystal structure of yeast protein disulfide isomerase suggests cooperativity between its active sites. Cell. 2006 Jan; 124(1): 61-73.
12. Karakas E, Wilson HL, Graf TN, Xiang S, Jaramillo-Busquets S, Rajagopalan KV, Kisker C. Structural insights into sulfite oxidase deficiency. J Biol Chem. 2005 Sep 30; 280(39): 33506-15.
13. Xiang S, Nicolas J, Rajagopalan KV, Schindelin H. The crystal structure of Escherichia coli MoeA and its relationship to the multifunctional protein gephyrin. Structure. 2001 Apr 4; 9(4): 299-310.
14. Sato S, Xiang S, Raleigh D. On the relationship between protein stability and folding kinetics: a comparative study of the N-terminal domains of RNase HI, E. coli and Bacillus stearothermophilus L9. J Mol Biol. 2001 Sep 21; 312(3): 569-77.