研究興趣
1.生物活性多肽及小分子蛋白的設計、合成及構效關係研究。
2.生物活性多肽及以天然活性產物結構為模板的有機小分子的組合化學庫的構建及藥理活性篩選。
3.以1.2.為基礎的抗病毒，抗腫瘤等相關藥物研究。
主持項目
1．抑制CXCR4的SDF-1a重組多肽庫的構建及其生理意義，教育部重點科技項目，2005年
2．基質細胞衍生因子衍生多肽的抗腫瘤轉移作用研究，廣東省自然科學基金，2006
3．還原型谷胱甘肽的化學合成工藝研究，廣州白雲山天心藥業有限公司，2005
4．中山大學醫學科學處主任基金，2005年
5．中山大學百人計畫引進人才“行動計畫”基金，2003年
6．免疫活性多肽的合成研究，橫向合作項目，2004年
代表性成果
論文：
1.Shen YD, Bu XZ*, et al. Novel synthesis of o-naphthothiophenequinone derivatives via regioselective Diels-Alder reaction TETRAHEDRON 61 (38): 9097-9101 SEP 19 2005
2.Shen YD, Bu XZ*, et al. Unexpected synthesis of 2,2 -[1-(4-methoxyphenoxy)propane-2, 2-diyl]bis(5-methoxy-3-methylbenzofuran) CHINESE CHEMICAL LETTERS 16 (12): 1581-1583 DEC 2005
3.LX Pei, SL Huang, YD Shen, LQ An, ZS Huang, YM Li, LQ Gu, XZ Bu*, and Albert S. C.C. Synthesis of novel dihydrofuro -pyridinone derivatives: oxidation coupling of 3-hydroxy-4(1H)-pyridinone with b-dicarbonyl compounds TETRAHEDRON LETTERS 46 (30): 5085-5088 25 July 2005
4.Bu XZ, Wu XM, Ng NLJ, et al. Synthesis of gramicidin S and its analogues via an on-resin macrolactamization assisted by a predisposed conformation of the linear precursors JOURNAL OF ORGANIC CHEMISTRY 69 (8): 2681-2685 APR 16 2004
5.Bu XZ, Wu XM, Xie GY, et al. Synthesis of tyrocidine A and its analogues by spontaneous cyclization in aqueous solution ORGANIC LETTERS 4 (17): 2893-2895 AUG 22 2002
6.Bu XZ, Xie GY, Law CW, et al. An improved deblocking agent for direct Fmoc solid-phase synthesis of peptide thioesters TETRAHEDRON LETTERS 43 (13): 2419-2422 MAR 25 2002
7.Bu XZ, Huang ZS, Zhang M, et al. Synthesis of new 1,1-dimethyl-1,2,3,4- tetrahydrophenanthrene derivatives, TETRAHEDRON LETTERS 42 (33): 5737-5740 AUG 13 2001
8.Shen YD, Wu HQ, Bu XZ*, et al. 2-Amino-7-chloro-1,8-naphthyridine, ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE 60: O1641-O1642 Part 9 SEP 2004
9.Qin CG, Bu XZ, Zhong XF, et al. Optimization of antibacterial cyclic decapeptides JOURNAL OF COMBINATORIAL CHEMISTRY 6 (3): 398-406 MAY-JUN 2004
10.Qin CG, Bu XZ, Wu XM, et al. A chemical approach to generate molecular diversity based on the scaffold of cyclic decapeptide antibiotic tyrocidine A JOURNAL OF COMBINATORIAL CHEMISTRY 5 (4): 353-355 JUL-AUG 2003
11.Wu XM, Bu XZ, Wong KM, et al. Biomimetic synthesis of gramicidin S and analogues by enzymatic cyclization of linear precursors on solid support ORGANIC LETTERS 5 (10): 1749-1752 MAY 15 2003
12.A n LK, Bu XZ, Wu HQ, et al. Reaction of tanshinones with biogenic amine metabolites in vitro TETRAHEDRON 58 (52): 10315-10321 DEC 23 2002
13.Qin CG, Zhong XF, Bu XZ, et al. Dissociation of antibacterial and hemolytic activities of an amphipathic peptide antibiotic JOURNAL OF MEDICINAL CHEMISTRY 46 (23): 4830-4833 NOV 6 2003
發明專利：
1.一種合成多肽及其套用,申請號: 200410077777.4, 申請日期2004.12.30；第一發明人
2.一種化合物萊克多巴胺的製備方法,申請號: 200410077776.X,申請日期：2004.12.30；第一發明人
3.G u LQ*, Bu Xianzhang et al. Cryptotanshionone For Preventing and Alleviating Altheimer’s Disease , PCT， WO 02/60435 A1, PCT/CN01/01497.
4.G u LQ*, Bu Xianzhang et al. Dihydrofunan Cyclic Tanshionones Used in Treating Hyperammonia and Hepatic Encephalop，PCT，WO 02/55070 A1.
